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RISS 인기검색어
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- 저자 : ( Jaeyoung Ko ) (검색결과 79 건)
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Association between Ultrasonography Findings and Abnormal Karyotypes in Early Pregnancy Loss
( Jaeyoung Pae ),( Jaeyoung Park ),( Sinyoung Kim ),( Rayon Kim ),( Jeongha Wie ),( Hyun Sun Ko ),( In Yang Park ),( Jong Chul Shin ) 대한주산의학회 2020 Perinatology Vol.31 No.2
Objective: Chromosomal abnormality in the fetus is a major cause of early pregnancy loss (EPL). It is considered that maternal age is a risk factor of chromosomal abnormality in the fetus. The objective of this study was to evaluate the association between ultrasonography findings and abnormal karyotypes in EPL. Methods: This retrospective analysis assessed 217 cases of EPL occurring between 2009 and 2018, which have the results of cytogenetic analysis following miscarriage, as well as the ultrasonography finding. The correlations between the ultrasonography findings and the karyotypes were evaluated. Results: Of the 217 cases, after excluding cases with no mitotic cells, karyotypes analysis was performed in 190 cases. The overall rate of abnormal karyotypes was 32.1% (61/190). Mean maternal age was significantly higher in the abnormal karyotype group (35.66±4.22 vs. 33.79±4.02 years, respectively, P=0.006). The embryo/gestational sac ratios was significantly smaller in the abnormal karyotype group (0.3±0.18 vs. 0.43±0.3, P=0.022). In the multivariate logistic regression analysis, smaller embryo/gestational sac ratios (≤0.4) was a significant risk factor of abnormal karyotype (adjusted odds ratio [OR] 2.43, 95% confidence interval [CI]: 1.086-5.437, P=0.031), after the adjustment with the number of previous abortion. The chromosomal abnormality rate was significantly higher in male miscarriage (adjusted OR 2.36, 95% CI: 1.003-5.443, P=0.049). Conclusion: By identifying a predictive factor of chromosomal abnormalities in embryonic abortion, this study presented ultrasonography findings to consider cytogenetic analysis and an easy-to-use cut off value, small embryo/gestational sac ratio (≤0.4) at a patient’s request of chromosomal study in the fetus.
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( Jaeyoung Park ),( Minji Ko ),( Byung Soo Kang ),( Jihyun Park ),( Hyun Sun Ko ),( In Yang Park ) 대한주산의학회 2020 Perinatology Vol.31 No.1
Objective: To evaluate the cerebroplacental ratio (CPR) to predict adverse perinatal outcomes in small-for-gestational-age (SGA) pregnancies. Methods: The study was a retrospective study of cases of pregnant women with SGA babies delivered between 32 and 41 weeks’ gestation, in Seoul St. Mary’s Hospital between January 2009 and December 2015. We analyzed the neonatal adverse outcomes and the risk of emergency cesarean section due to non-reassuring fetal heart rate in pregnancies with norrnal CPR and abnormal CPR in Doppler ultrasonography. Results: The abnormal CPR in SGA pregnancies was significantly associated with neonatal intensive care unit admission (P=0.042) and neonatal seizure (P=0.042), in multivariate logistic regression analysis. In receiver operating characteristic curves, the area under the curve (AUC) of abnormal CPR and severe SGA (less than 5th percentile) was 0.59, with sensitivity of 28.4% and specificity of 90.6% (P=0.038), in the emergency cesarean section due to non-reassuring fetal heart rate. However, between 32-36 weeks’ gestation, AUC of abnormal CPR was 0.7 with sensitivity of 70.6% and specificity of 69.2% (P=0.019) and AUC of abnormal CPR and severe SGA was 0.77, with sensitivity of 64.7% and specificity of 84.6% (P=0.001), in the emergency cesarean section due to non-reassuring fetal heart rate. Conclusion: When SGA is expected after 32 weeks’ gestation, measurement of CPR might be useful in predicting neonatal adverse outcome. Abnormal CPR was highly predictive of cesarean section due to non-reassuring fetal heart rate, in severe SGA, between 32-36 weeks’ gestation.
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고재영(Ko Jaeyoung),장태일(Jang Taeil),박승우(Park Seungwoo) 대한토목학회 2007 대한토목학회논문집 B Vol.27 No.3B
본 연구에서는 HSPF 모형을 이용하여 농촌유역에서의 점원ㆍ비점원에 의한 분변성 대장균 모의의 적용성을 평가하였다. 대상유역으로는 경기도 화성시 발안면과 팔탄면에 위치한 발안 저수지유역의 HP#7 소유역으로 선정하였으며, HP#7의 기상자료, 지형자료, 수문자료 및 대장균 자료를 구축하였다. 대장균 모의를 위한 실측자료는 현장에서의 샘플링 방법과 실험에 의한 오차, 대장균 실험의 경제성 등을 고려하여 실측자료의 상한값과 하한값을 두어 실측자료를 보정하였다. 모형의 매개변수 보정은 2002~2003년의 관측 자료를, 모형의 보정은 2004~2006년의 관측 자료를 활용하였으며, 분석결과 모형의 적용성이 높은 것으로 나타났다. 모형의 보정 과정에서 관측 자료의 불확실성에 따른 문제를 평가하기위하여 유황곡선을 이용한 대장균 부하량곡선을 나타내어 관측 결과와 비교하여 그 적용성을 분석하였다. This paper presents the results from the HSPF model applications for simulating instream fecal coliform concentrations at a rural watershed. The study watershed is the HP#7 subwatershed at the Baran Reservoir watershed, located near Suwon. The coliform concentration data were logically adjusted to reflect sampling frequencies and survival rates from on-site sampling to laboratory analyses. The model parameters were manually calibrated with the observed data from 2002 to 2003, and validated with data from 2004 to 2006. The simulated results were comparable to the observed data, showing that HSPF is applicable to simulating daily coliform loads at the test watershed. Frequency-based load duration curves were developed to assess the uncertainty associated with the conventional time-series based calibration processes. It was shown that the load duration curve generated from HSPF simulation was also similar to that from the observed data.
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Coronavirus Disease 2019 Vaccines and Pregnancy: Present and Future
( Jaeyoung Pae ),( Hyun Sun Ko ) 대한주산의학회 2021 Perinatology Vol.32 No.3
Coronavirus disease 2019 (COVID-19) from severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) infection has shown higher morbidity and mortality in pregnant women, compared to non pregnant women. Until June 2021, among COVID-19 vaccines, two types of messenger RNA (mRNA) vaccines and two types of virus vector vaccines have been available in Korea. However, because pregnant women have been excluded in the preauthorization clinical trials, most countries suggested that pregnant women need to counsel risks of exposure to SARS-CoV-2 and COVID-19 complications, and the benefits and risks of COVID-19 vaccines, at the initial stage of vaccination. In Korea, any COVID-19 vaccine has not been authorized in pregnant women. However, clinical data continuously demonstrate high morbidities and mortality of COVID-19 infection in pregnant women, as well as pregnancy complications including preterm delivery, which can affect neonatal outcomes. After the authorization of COVID-19 vaccines, safety outcome data in pregnant women has been increased. Therefore, recent guidelines of COVID-19 vaccine for pregnant women have been updated, in developed countries. Most guidelines suggest that pregnant women should not be excluded from the COVID-19 vaccination, especially in women with old age, underlying disease, or obesity. Based on the updated data about COVID-19 clinical outcomes in pregnant women and information from clinical trials and from data collected vaccinated pregnant women, strategy and guidelines from multidisciplinary cooperation by government and medical professionals in the department of infection, maternal fetal medicine, and neonatology are ungently required to protect pregnant women and neonates in Korea, in the present and future.
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Ko, Seulki,Kang, Seonghoon,Ha, Mina,Kim, Jaeyoung,Jun, Jae Kwan,Kong, Kyoung Ae,Lee, Won Jin Elsevier 2018 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY Vol.29 No.3
<P><B>Abstract</B></P> <P>A systematic review was conducted to provide an overview of the health effects of occupational radiation exposure from interventional fluoroscopy procedures on medical radiation workers. Among the 34 studies that met the inclusion criteria, most studies were cross-sectional (76%) and published after 2011 (65%) in a handful of countries. Although diverse outcomes were reported, most studies focused on cataracts. Radiation health effects were rarely assessed by risk per unit dose. Interventional radiation medical workers represent a small subset of the population studied worldwide. Further epidemiologic studies should be conducted to evaluate health outcomes among interventional radiation medical workers.</P>
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The Burden of Acute Pesticide Poisoning and Pesticide Regulation in Korea
Ko, Seulki,Cha, Eun Shil,Choi, Yeongchull,Kim, Jaeyoung,Kim, Jong-Hun,Lee, Won Jin KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.31
<P><B>Background</B></P><P>This study aimed to estimate the burden of acute pesticide poisoning and to determine its trend with recently implemented pesticide regulations.</P><P><B>Methods</B></P><P>Disability-adjusted life-years (DALYs) were calculated as the sum of years of life lost (YLLs) and years lived with disability (YLDs) due to acute pesticide poisoning using the methods of the Global Burden of Disease Study 2013. The values of YLLs, YLDs, and DALYs were stratified by sex, age groups, intentionality of poisoning, and causative agents.</P><P><B>Results</B></P><P>From 2006 to 2014, DALYs decreased by 69% (from 69,550 to 21,742). The decreasing tendency of DALYs was especially marked from 2011. The total burden of acute pesticide poisoning was mainly caused by YLLs and intentional pesticide poisoning. The highest DALYs due to acute pesticide poisoning occurred in those in their 40s and 50s; however, the decreased rates of DALYs were higher in those aged 10–49 years than in those aged more than 50 years. Herbicides including paraquat contributed to the largest proportion of total DALYs.</P><P><B>Conclusion</B></P><P>As this is the first study to quantify the burden of acute pesticide poisoning using DALYs, our results provide comprehensive evidence of the importance of using strict regulations to prevent public health hazards due to acute pesticide poisoning.</P>
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Emergency department visits due to pesticide poisoning in South Korea, 2006-2009
Ko, Yousun,Kim, Hyun Joong,Cha, Eun Shil,Kim, Jaeyoung,Lee, Won Jin Informa Healthcare 2012 Clinical toxicology Vol.50 No.2
<P><I>Objectives.</I> The objective of this study is to estimate the numbers and rate of emergency department visits in South Korea that are the result of pesticide poisoning and to describe their epidemiologic characteristics. <I>Materials and methods.</I> Data collected from the National Emergency Department Information System were used to estimate the number of emergency department visits due to pesticide poisoning in South Korea for the period spanning 2006 through 2009. Emergency department visits for pesticide poisoning were defined by ICD-10 codes (T60.0-T60.9). National estimates and their 95% confidence intervals were calculated per 100 000 population. <I>Results.</I> Among the 65 877 total poisoning-related emergency department visits in the data, 11 985 (18.2%) were emergency department visits resulting from pesticide poisoning. During the study period, the annual average rate of emergency department visits for pesticide poisoning was 26.8 per 100 000 population. Intentional pesticide poisoning (51.4%) was more frequent than unintentional. The fatality rate from intentional pesticide poisoning was also higher than that from unintentional or cases where the intention was unknown. In terms of age-specific rates of emergency department visits for pesticide poisoning, they increased with age, as did the gap between men and women. <I>Conclusions.</I> This study provide estimates for emergency department visits due to pesticide poisoning at the national level and suggests that pesticide poisonings, both intentional and unintentional, require significant public health interventions in South Korea.</P>
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