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RISS 인기검색어
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- 저자 : ( Mohamed Hamed Salama ) (검색결과 3 건)
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( Mohamed Hamed Salama ),( Hanan Hanna Rizk ),( Maii Nawara ) 대한산부인과학회 2023 Obstetrics & Gynecology Science Vol.66 No.3
Objective Umbilical artery Doppler ultrasonography is useful for high-risk prenatal surveillance. However, according to a systematic review and meta-analysis by the Cochrane pregnancy and childbirth group, the optimal frequency with which such surveillance should occur remains unclear. In the current study, we aimed to investigate whether performing umbilical artery Doppler on a weekly basis enables earlier detection of changes in utero-placental blood flow than the recommended bi-weekly (i.e., fortnightly) regimen and its impact on perinatal outcomes. Methods This randomized controlled study included 292 high-risk pregnant women in their third trimester who attended the Ain Shams University Maternity Hospital in Egypt from January 2018 to September 2019. The women were randomly assigned to two groups to undergo either bi-weekly or once-weekly umbilical artery Doppler ultrasound. Results In the primary analysis performed according to the intention-to-treat basis, we observed no difference in the primary outcome of fetal admission to the neonatal intensive care unit (NICU) within the first 24 hours (risk difference, -2.63; 95% confidence interval, -12.92 to 7.65). Furthermore, no significant differences in secondary outcomes were observed (apart from stillbirth). Conclusion Weekly umbilical artery Doppler is not superior to bi-weekly surveillance in preventing admission to the NICU and most other studied outcomes. Therefore, the bi-weekly regiment may be more convenient for women and more cost-effective for health care organizations (trial registration: NCT03584763 at clinicaltrials.gov).
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Barakat Mohamed,Donkol Ahmed,Hamed Hesham F. A.,Salama Gerges M. 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.4
This paper presents a new optimization tool-based population parameter called Harris hawks optimizer (HHO) and its application study to fi ne-tune the gains of well-designed proportional-derivative proportional-integral (PD-PI) cascade control to suppress the load frequency control (LFC) issues. The HHO based PID and PD-PI controllers are broadly implemented at two models with many circumstances for each model to ensure the eff ectiveness and the robustness of the proposed scheme at a high load disturbance, nonlinearity, and some critical parameters associated with the interconnected power system. First, a two-area non-reheat power plant is implemented, and the gains of PID and PD-PI controllers are adjusted using the proposed algorithm. In order to introduce extra realistic challenges, the governor-dead band is also modeled to ensure the robustness of the HHO/PD-PI in handling nonlinearity properties. Furthermore, to guarantee the suitability of the proposed HHO/PD-PI, a model with a mixture of power plants is carried out with and without the HVDC link, which is raised for the practical problems of LFC. Simulation results proved that; the proposed techniques HHO/PID and HHO/PD-PI provide superior performance compared to other reported strategies such as DE/PID, TLBO/PID, IGWO/PID, multi-objective/PID, and TLBO/2DOF-PID controllers. Finally, the dynamic investigation has also been completed using the random load pattern in system model-2, which shows the superior performance of HHO/PID and HHO/PD-PI schemes.
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Potential Role for a Panel of Immunohistochemical Markers in the Management of Endometrial Carcinoma
Amany Salama,Mohammad Arafa,Eman ElZahaf,Abdelhadi Mohamed Shebl,Azmy Abd El-Hameed Awad,Sylvia A. Ashamallah,Reda Hemida,Anas Gamal,Abd AlRahman Foda,Khaled Zalata,El-Said M. Abdel-Hady 대한병리학회 2019 Journal of Pathology and Translational Medicine Vol.53 No.3
Background: In order to improve the efficacy of endometrial carcinoma (EC) treatment, identifying prognostic factors for high risk patients is a high research priority. This study aimed to assess the relationships among the expression of estrogen receptors (ER), progesterone receptors (PR), human epidermal growth factor receptor 2 (HER2), Ki-67, and the different histopathological prognostic parameters in EC and to assess the value of these in the management of EC. Methods: We examined 109 cases of EC. Immunohistochemistry for ER, PR, HER2, and Ki-67 were evaluated in relation to age, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage and grade, depth of infiltration, cervical and ovarian involvement, lymphovascular space invasion (LVSI), and lymph node (LN) metastasis. Results: The mean age of patients in this study was 59.8 ± 8.2 years. Low ER and PR expression scores and high Ki-67 expression showed highly significant associations with non-endometrioid histology (p = .007, p < .001, and p < .001, respectively) and poor differentiation (p = .007, p < .001, and p <. 001, respectively). Low PR score showed a significant association with advanced stage (p = .009). Low ER score was highly associated with LVSI (p = .006), and low PR scores were associated significantly with LN metastasis (p = .026). HER2 expression was significantly related to advanced stages (p = .04), increased depth of infiltration (p = .02), LVSI (p = .017), ovarian involvement (p = .038), and LN metastasis (p = .038). There was a close relationship between HER2 expression and uterine cervical involvement (p = .009). Higher Ki-67 values were associated with LN involvement (p = .012). Conclusions: The over-expression of HER2 and Ki-67 and low expression of ER and PR indicate a more malignant EC behavior. An immunohistochemical panel for the identification of high risk tumors can contribute significantly to prognostic assessments.
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