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숙명박물관 브랜드 프로모션을 위한 통합적 브랜드 개발 -2D, 3D, 4D 디자인 프로세스를 중심으로-
길혜경,김보현,오정은,이서연,이지원,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-
본 연구는 여성생활사 중심의 유물 박물관인 숙명박물관의 인지도와 브랜딩의 문제를 해결하기 위해 브랜드·스페이스·마케팅을 활용한 통합 브랜드 개발 프로세스를 제안하는데 목적이 있다. 아울러 본 연구는 박물관의 브랜드를 프로모션하고 그래픽, 제품, 공간의 통합 브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구의 시간적 범위는 2017년 3월부터 6월까지 총 15주간 숙명여대 환경디자인학과 <브랜드·스페이스·마케팅>수업에서 진행된 수업의 결과물로서 4개 팀 중, 1개 팀의 작업물로 한다. 본 연구의 대상적 범위는 ‘숙명여자대학교 숙명박물관'의 2D~4D까지의 전반으로 설정한다. 그 결과, 제품부터 공간까지 숙명박물관의 통합된 브랜딩은 일 관성과 객관성, 스토리성을 얻을 수 있었다. ’숙명박물관'은 학교의 박물관이라는 장점을 극대화시켜 가치와 스토리를 부여하고 하나의 브랜드로 리뉴얼했다는 점에서 의의가 있다. 또한 향후 보편적인 박물관들의 차별화된 브랜드 개발의 참고자료로 활용될 수 있을 것으로 기대하며 브랜드 개발에 있어서 G·I, P·I, S·I의 통합 브랜드 메뉴의 기초 자료로 활용될 것으로 사료된다.
Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
Oh, Chang Joo,Ha, Chae-Myeong,Choi, Young-Keun,Park, Sungmi,Choe, Mi Sun,Jeoung, Nam Ho,Huh, Yang Hoon,Kim, Hyo-Jeong,Kweon, Hee-Seok,Lee, Ji-min,Lee, Sun Joo,Jeon, Jae-Han,Harris, Robert A.,Park, Keu Springer-Verlag 2017 Kidney international Vol.91 No.4
<P>Clinical prescription of cisplatin, one of the most widely used chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated nephrotoxicity. Since details of the underlying mechanisms are not fully understood, we investigated the role of pyruvate dehydrogenase kinase (PDK) in cisplatin-induced acute kidney injury. Among the PDK isoforms, PDK4 mRNA and protein levels were markedly increased in the kidneys of mice treated with cisplatin, and c-Jun N-terminal kinase activation was involved in cisplatin-induced renal PDK4 expression. Treatment with the PDK inhibitor sodium dichloroacetate (DCA) or genetic knockout of PDK4 attenuated the signs of cisplatin-induced acute kidney injury, including apoptotic morphology of the kidney tubules along with numbers of TUNEL-positive cells, cleaved caspase-3, and renal tubular injury markers. Cisplatin-induced suppression of the mitochondria! membrane potential, oxygen consumption rate, expression of electron transport chain components, cytochrome c oxidase activity, and disruption of mitochondrial morphology were noticeably improved in the kidneys of DCA-treated or PDK4 knockout mice. Additionally, levels of the oxidative stress marker 4-hydroxynonenal and mitochondria! reactive oxygen species were attenuated, whereas superoxide dismutase 2 and catalase expression and glutathione synthetase and glutathione levels were recovered in DCA-treated or PDK4 knockout mice. Interestingly, lipid accumulation was considerably OCrossMark attenuated in DCA-treated or PDK4 knockout mice via recovered expression of peroxisome proliferator-activated receptor-a and coactivator PGC-1 alpha, which was accompanied by recovery of mitochondria! biogenesis. Thus, PDK4 mediates cisplatin-induced acute kidney injury, suggesting that PDK4 might be a therapeutic target for attenuating cisplatin-induced acute kidney injury.</P>
35% 과산화수소에 제2인산칼슘를 함유한 치아미백제가 치아의 색과 경도에 미치는 영향
정미애(Mi-Ae Jeoung),오혜승(Hye-Seung Oh),심연수(Youn-Soo Shim) 한국콘텐츠학회 2010 한국콘텐츠학회논문지 Vol.10 No.11
이 연구는 전문가 미백(in-office bleaching)에 사용하는 35% 과산화수소(hydrogen peroxide, HP)를 제2인산칼슘(dicalcium phosphate dihydrate, DCPD)와 혼합하여 치아의 미백 효과와 미세경도를 평가하고자 하였다. 소구치로부터 30개의 치아시편을 제작하여 3군으로 분류하였다(n=10). 35%과산화수소에 DCPD를 0.1, 1wt% 첨가하여 실험군으로 하고 하루 60분간 치아미백을 실시하였다. 치아 미백제에 pH를 측정하였고, 미백 적용한 치아 표면에는 색과 미세경도를 측정하였다. pH는 DCPD 함유한 군에서 DCPD의 함유량이 증가할수록 함유되지 않은 군에 비해 pH 수치가 증가하였다. 색조변화량 (△E)을 비교한 결과, 미백 전에 비해 미백 후 색조 변화를 보였고(p<0.05), 결과적으로 색 변화에 있어 DCPD를 함유한군과 함유되지 않은 군 사이에 통계적으로 유의한 차이는 없었다(p>0.05). 법랑질의 표면미세경도를 분석한 결과, 모든 군에서 미백 후 미세경도의 감소를 보였고(p<0.05), DCPD를 혼합한 군은 함유되지 않은 군에 비해 경도 감소의 폭이 훨씬 적게 나타났다. 이상의 결과로부터 DCPD를 함유한 35%과산화수소의 치아미백제는 치아미백 효과가 있고, pH를 상승시켜서 법랑질의 표면 경도를 덜 감소시키므로 치아미백제의 구성성분으로 실용할 수 있을 것으로 사료된다. The purpose of this study was to evaluate tooth whitening and microhardness after treatments with tooth bleaching agents containing dicalcium phosphate dihydrate (DCPD) and 35% hydrogen peroxide (HP) which were used in-office bleaching. Thirty enamel specimens were obtained from human premolars and randomly divided into 3 groups(n=10). Tooth bleaching agents were prepared with DCPD (0 g for controls, 0.1 g and 1 g for experimental groups) and HP solution (35% HP). All groups were applied to enamel surfaces for 60 min for 1 day. The pH of each tooth bleaching agent was measured. Tooth color, microhardness of enamel surfaces were also measured. The tooth bleaching agents containing DCPD showed a significant increase in pH compared to the ones without DCPD(p<0.05). Paired t-tests showed significant difference in color values of enamel before and after bleaching in all the groups(p<0.05). As a result, changes in color, containing DCPD group does not contain a statistically significant difference between groups was observed.(p>0.05). In all groups, tooth hardness after bleaching showed a significant decrease in microhardness (p<0.05). However, the DCPD concentration increased in the bleaching, microhardness values slightly decreased. Based on the above results, tooth bleaching agents containing DCPD and 35%HP were equally effective. Due to increases in pH and effective reduction of tooth surface decalcification, the surface characteristics are exposed to a reduced degree of negative effects, resulting in fewer constituent enamel alterations. Thus, commercial availability of the constituents of tooth whitening materials can be achieved.
Cha, Jin-Soon,Jeoung, Min-Kyoo,Kim, Jong-Mi,Kwon, Oh-Oun,Lee, Keung-Dong,Kim, Eun-Ju Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.10
The approximate rates and stoichiometry of the reaction of excess sodium tris(diethylamino)aluminum hydride (ST-DEA) with selected organic compounds containing representative functional groups under standardized conditions(tetrahydrofuran, $0{\circ}$) were studied in order to characterize the reducing characteristics of the reagent for selective reductions. The reducing ability of STDEA was also compared with those of the parent sodium aluminum hydride (SAH) and lithium tris(diethylamino)aluminum hydride (LTDEA). The reagent appears to be milder than LTDEA. Nevertheless, the reducing action of STDEA is very similar to that observed previously for LTDEA, as is the case of the corresponding parent sodium and lithium aluminum hydrides. STDEA shows a unique reducing characteristics. Thus, benzyl alcohol, phenol and 1-hexanol evolved hydrogen slowly, whereas 3-hexanol and 3-ethyl-3-pentanol, secondary and tertiary alcohols, were essentially inert to STDEA. Primary amine, such as n-hexylamine, evolved only 1 equivalent of hydrogen slowly. On the other hand, thiols examined were absolutely stable. STDEA reduced aidehydes and ketones rapidly to the corresponding alcohols. The stereoselectivity in the reduction of cyclic ketones by STDEA was similar to that by LTDEA. Quinones, such as p-benzoquinone and anthraquinone, were reduced to the corresponding 1,4-dihydroxycyclohexadienes without evolution of hydrogen. Carboxylic acids and anhydrides were reduced very slowly, whereas acid chlorides were reduced to the corresponding alcohols readily. Esters and epoxides were also reduced readily. Primary carboxamides consumed hydrides for reduction slowly with concurrent hydrogen evolution, but tertiary amides were readily reduced to the corresponding tertiary amines. The rate of reduction of aromatic nitriles was much faster than that of aliphatic nitriles. Nitrogen compounds examined were also reduced slowly. Finally, disulfide, sulfoxide, sulfone, and cyclohexyl tosylate were readily reduced without evolution of hydrogen. In addition to that, the reagent appears to be an excellent partial reducing agent: like LTDEA, STDEA converted ester and primary carboxamides to the corresponding aldehydes in good yields. Furthermore, the reagent reduced aromatic nitriles to the corresponding aldehydes chemoselectively in the presence of aliphatic nitriles. Consequently, STDEA can replace LTDEA effectively, with a higher selectivity, in most organic reductions.
Won, Ga-Yeon,Moon, Bo-Mi,Oh, In-Gyeong,Matsuda, Kiku,Chaudhari, Atul A.,Hur, Jin,Eo, Seong-Kug,Yu, Il-Jeoung,Lee, Young-Ju,Lee, Yun-Sik,Kim, Byeong-Su,Lee, John Hwa Japan Poultry Science Association 2009 Journal of Poultry Science Vol.46 No.3
<P>The colibacillosis caused by avian pathogenic <I>E. coli</I> (APEC) is responsible for a significant loss of productivity and mortality in the poultry industry. The pathogenicity of these bacteria is based on the presence and expression of various virulence factors. In this study, the presence of the 19 virulence-associated genes in APEC was determined using PCR. Among the 118 <I>E. coli</I> isolates from the chickens with colibacillosis, all contained at least one of the 19 genes as approximately 95% of the isolates contained <I>fimC.</I> Interestingly, the <I>clpG</I> gene, which has not been detected in APEC previously, was detected in half of the isolates. The ColV plasmid-associated genes such as <I>colV, tsh, iucC, iucD and iss</I> genes were also detected in 57.6, 55.9, 50.0, 47.5, 47.5 and 41.5% of isolates, respectively. With regard to the fimbrial genes, the <I>papA</I> (14.4%), papC (14.4%) and <I>papG</I> genes (15.2%) were identified at relatively low rates, none of the isolates harbored <I>afa8D, f17A</I> or <I>facA</I>, and only 3 of the isolates (2.5%) contained <I>eaeA.</I> In this study, 94 isolates harbored two or more of the genes, and there were 43 different patterns of gene combination in the isolates. The most common pattern, which was found in 14.4% (17 isolates), was <I>clpG-fimC-iutA-colV-tsh-iucC-iucD-irp2-fyuA-vat-iss.</I> Overall, these results suggest that APEC strains in this area commonly contain multiple virulence factors and approximately half of the APEC strains contained the ColV plasmid-associated genes. Especially, <I>colV</I> and <I>tsh</I> were detected more than half of the isoaltes.</P>