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Gerson Luis Faccin,Edna Regina Amante,Vera Lucia Cardoso Garcia Tramonte,Márcia Teixeira Pinto,Elisabeth Wazlawik 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1
Bran cereals are known to contain substantial concentrations of important nutrients, bioactive compounds, fiber, minerals, proteins, lipids, and vitamins. The vitamins present in rice bran include those of the B complex (B1 and B3), which affect the central nervous system (natural antidepressant and tranquilizer effects) acting in schizophrenia, neuralgia, and fatigue. The elevated plus maze (EPM) test is a model widely used for the study of anxiety in animals. The forced swimming (FS) test is the model used most often for evaluating the antidepressant activity in animal models in pharmacology. This study examined the behavior of 32 male Wistar rats, 21 days old, in the FS and EPM tests after treatment with strawberry- or chocolate-flavored rice bran drink for 28 days. The concentration of adrenocorticotropic hormone in the plasma of the animals was determined at the beginning and end of treatment. The values found (<1.0mg/dL) showed no significant difference between the test and control groups in the periods analyzed. In the EPM, ingesting the chocolate-flavored drink showed an anxiogenic trend in the rats, and the strawberry-flavored rice bran drink led to an anxiolytic profile, although the difference was not statistically significant (P>.05). In the FS test, the duration of immobility of rats in groups consuming rice bran drinks was higher than in the control group, but without a statistically significant difference (P>.05). However, this result may indicate a tendency toward an effect on the central nervous system of the animals after the ingestion of the rice bran beverage.
Lima, Felipe Teixeira,Seba, Viviane,Silva, Gabriel,Torrezan, Guilherme Silva,Polaquini, Carlos Roberto,Pinhanelli, Vitor Caressato,Baek, Seung J.,Fachin, Ana Lú,cia,Regasini, Luis Octavio,Marins MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.7
<P>Curcumin is a potential anticancer drug with poor bioavailability, which limits its clinical use as a therapeutic agent. The aim of this study was a preliminary evaluation of the curcumin analogue CH-5 as a cytotoxic agent in human osteosarcoma cell lines U2OS, MG-63, and Saos-2. CH-5 inhibited cell viability at lower concentrations than curcumin, leading to the induction of apoptosis. The cellular levels of the transcription factors p53 and Sp1 affect the expression of cellular pathways that lead to apoptosis. CH-5 increased p53 protein levels in U2OS cells and reduced Sp1 levels, with a consequent effect on the expression of their target genes DNA methyltransferase 1 (<I>DNMT1)</I> and growth arrest and DNA damage-inducible 45 alpha gene (<I>Gadd45a)</I>. CH-5 repressed <I>DNMT1</I> and increased <I>Gadd45a</I> mRNA expression, which was dependent on p53, as this effect was only observed in the colorectal cancer cell line HCT116 with active p53, but not in the isogenic p53-deficient HCT116 cells. CH-5 also reduced the protein levels of DNMT1, which led to the upregulation of <I>Gadd45a</I>. These results suggest that CH-5 has potentially higher anticancer activity than curcumin, which is associated with the expression of apoptosis-associated genes regulated by the transcription factors Sp1 and p53. Future work on CH-5 will define the therapeutic potential of this compound in vivo.</P>
Definition of a Methodology for an Expedited Assessment of Slope Instability on Volcanic Terrains
( Ana Maria Malheiro ),( Luis Teixeira ),( Paulo Amaral ),( Filipe Marques ),( Jose Vieira ),( Leticia Moniz ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
A project called MACASTAB (co-financed by the Interreg Mac 2014-20 program) is being developed, by a group of technicians from the Canarias, Azores, Madeira and Cabo Verde archipelagos. This project aims to prepare a methodological guide for the natural risk management produced by the instability of volcanic slopes and talus in Macaronesia archipelagos. One of its tasks is the development of charts that can be applied in the referred archipelagos in order to do an expeditious evaluation of slope stability. Given the specificities of the geology of the Azores and Madeira islands, the charts were supported by limit equilibrium analysis methods (e.g. Morgenstern-Price) applied to slopes whose constitution is predominantly formed by soils (an unusual situation in other archipelagos that are in the project). Results of shear strength parameters obtained for volcanic soils on both archipelagos by triaxial compression tests and direct shear tests are presented. Empirical correlation between friction angle and particle size distribution was found with a coefficient of adjustment of 93%. That correlation shows a relationship between the angle of internal friction of a given material and the percentage of gravel and sand. For the preparation of these charts, several stability analyzes were performed with different scenarios (slope gradient and heights, and shear strength parameters), in order to determine the safety factor of slopes in a simple and fast way in the field.
Marzhan Seitovna Kalmakhanova,Jose Luis Diaz de Tuesta,Bakytgul Kabykenovna Massalimo,Helder Teixeira Gomes 대한환경공학회 2020 Environmental Engineering Research Vol.25 No.2
Pillared clays with Zr and Fe/Cu/Zr polycations have been prepared from natural clays found in large deposits of Kazakhstan and assessed as catalysts for the catalytic wet peroxide oxidation (CWPO), using 4-nitrophenol (4-NP) as model compound. The performance of the catalysts was followed by measuring the concentration of 4-NP, H₂O₂ and the total organic carbon (TOC), considering C4-NP = 5 g L<SUP>-1</SUP>, CH₂O₂ = 17.8 g L<SUP>-1</SUP>, Ccat = 2.5 g L<SUP>-1</SUP>, initial pH = 3.0 and T = 50°C. At those selected conditions, the pillared clays showed higher activity than natural clays in the CWPO of 4-NP. The conversion of the model pollutant was complete when Fe/Cu/Zr-PILCs were used, with the TOC removal reaching 78.4% after 24 h with the best Fe/Cu/Zr-PILC. The H₂O₂, 4-NP and TOC time-evolution was well described by a kinetic model based on TOC lumps in three blocks, considering the initial TOC (corresponding to 4-NP), the production of oxidizable intermediates and the formation of refractory products.
Julio Cesar Magalhães,Mariana Gongora,Renan Vicente,Juliana Bittencourt,Guaraci Tanaka,Bruna Velasques,Silmar Teixeira,Gledys Morato,Luis F. Basile,Oscar Arias-Carrión,Fernando A.M.S Pompeu,Mauricio C 대한정신약물학회 2015 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.13 No.1
Objective: The present study sought to analyze the influence of Levetiracetam (LEV) in cognitive performance by identifying the changes produced by LEV in reaction time, in neuropsychological assessment of attention and memory and in absolute theta power in frontal activity. Methods: Twelve healthy subjects (5 men and 7 women; mean age, 30.08 years, standard deviation, 4.71) were recruited for this study. The neuropsychological tests: Trail Making Test (A and B), Digit Span (direct and indirect numerical orders/working memory); Stroop test (inhibitory control of attention); Tower of London (planning and decision-making) and a quantitative electroencephalography were applied in 2 different days after and before the participants ingested the capsule of placebo or 500 mg LEV. Results: A two-way-ANOVA was implemented to observe the interaction between conditions (placebo or LEV 500 mg) and moments (pre- and post-ingestion of LEV or placebo). The data were analyzed by the SPSS statistical package (p<0.05). For the neuropsychological parameter, the Trail Making Test (A) was the only test that showed significant difference for condition in the task execution time (p=0.026). Regarding the reaction time in the behavioral parameter, an interaction between both factors (p=0.034) was identified through a two-way-ANOVA (condition versus moment). Electrophysiological measures showed a significant interaction for electrodes: F7, F3, and FZ. Conclusion: The findings showed that LEV promotes an important cognitive enhancement in the executive functions.
Intraoperative fluid therapy for video-assisted ovariohysterectomy in dogs
Marília Teresa de Oliveira,João Pedro Scussel Feranti,Gabriela Pesamosca Coradini,Rafael Oliveira Chaves,Luis Felipe Dutra Corrêa,Marcella Teixeira Linhares,Roberto Thiesen,Marco Augusto Machado Silva 대한수의학회 2021 Journal of Veterinary Science Vol.22 No.3
Background: Intraoperative fluids are still poorly studied in veterinary medicine. In humans the dosage is associated with significant differences in postoperative outcomes. Objectives: The aim of this study is to verify the influence of three different fluid therapy rates in dogs undergoing video-assisted ovariohysterectomy. Methods: Twenty-four female dogs were distributed into three groups: G5, G10, and G20. Each group was given 5, 10, and 20 mL·kg−1·h−1 of Lactate Ringer, respectively. This study evaluated the following parameters: central venous pressure, arterial blood pressure, heart rate, respiratory rate, temperature, acid-base balance, and serum lactate levels. Additionally, this study evaluated the following urinary variables: urea, creatinine, protein to creatinine ratio, urine output, and urine specific gravity. The dogs were evaluated up to 26 h after the procedure. Results: All animals presented respiratory acidosis during the intraoperative period. The G5 group evidenced intraoperative oliguria (0.80 ± 0.38 mL·kg−1·h−1), differing from the G20 group (2.17 ± 0.52 mL·kg−1·h−1) (p = 0.001). Serum lactate was different between groups during extubation (p = 0.036), with higher values being recorded in the G5 group (2.19 ± 1.65 mmol/L). Animals from the G20 group presented more severe hypothermia at the end of the procedure (35.93 ± 0.61°C) (p = 0.032). Only the members of the G20 group presented mean potassium values below the reference for the species. Anion gap values were lower in the G20 group when compared to the G5 and G10 groups (p = 0.017). Conclusions: The use of lactated Ringer's solution at the rate of 10 mL·kg−1·h−1 seems to be beneficial in the elective laparoscopic procedures over the 5 or 20 mL·kg−1·h−1 rates of infusion.