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정진영,우영운,고봉홍,김재희,홍인표,조동래 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2
In the system using one sensor, to describe accurate situation or conclude from information of one source in difficult. Moreover, sensor noise degrades the belief of decision. Multisensor information system, however, can increase the belief of date by imploying more than one source of information simultaneously. Another advantage of the system is that it can accomplish its task with other sources of information when one source malfunctions. In this paper, we implemented data association methods to identity moving flight targets using distance, probability theory, Dempster-Shafter theory for the low level process in the information fusion system. Data association is to classify information from various sources into data groups depending for the same flight object. Times and errors of these data association methods are analyzed.
Neuroleptic Malignant Syndrome에 합병되어 나타난 급성 신부전증 1예
채영래,백인호,송정중 大韓神經精神醫學會 1990 신경정신의학 Vol.29 No.4
Neuroleptic malignant syndrome(NMS) is an uncommon but fatal idiosyncratic reaction to neuroleptics. It comprises fever, muscular rigidity, altered consciousness and autonomic dysfunction. The most common serious complications of NMS is rhabdomyolysis, which produces acute myoglobinuric renal failure. The authors experienced a schizophrenic male patient with acute renal failure as a sequela of NMS. The patient was 27-year-old man who had received haloperidol for 9 years. Emergency hemodialysis, hydration and diuretics promoted recovery of impaired renal function. The patient survived the acute episode of NMS without any sequela and resumed his treatment with neuroleptics.
Interleukin-5 저해 활성 chalcone 화합물의 유효 입체 구조
이기철,김민석,P. Thanigaimalai,Vinay K. Sharma,박경래,김영수,정상헌 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-
Interleukin(IL)-5 appears to be one of the main proinflammatory mediators among the growing number of cytokines and chemokines that induce eosinophilic inflammation. Previously, our group synthesized a number of chalcone derivatives to determine their inhibitory activity against IL-5. However, the structure-activity relationship (SAR) of these chalcones was somewhat unclear, robably due to presence of three free rotatable bonds. To further, explore the SAR of these chalcones, we synthesized eight 2-(benzylidene)-2,3-dihydroinden-1-ones and 2- benzylidene)-3,4-dihydronaphthalen-1(2H)-ones 6 and evaluated for their inhibitory activity against IL-5. These rigidified chalcones 6 exhibited very weak inhibitory activity against IL-5 compared to chalcones 2. The structures of 6 closely resemble to the stretched conformations of chalcone 2, not effective conformation for the inhibition on IL-5 function.
Kheradmandfard, Mehdi,Kashani-Bozorg, Seyed Farshid,Lee, Jung Seung,Kim, Chang-Lae,Hanzaki, Abbas Zarei,Pyun, Young-Sik,Cho, Seung-Woo,Amanov, Auezhan,Kim, Dae-Eun Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.762 No.-
<P><B>Abstract</B></P> <P>A novel β-type Ti–29Nb–13Ta–4.6Zr (TNTZ) alloy with a low Young's modulus, high bio-corrosion resistance, and excellent biocompatibility has been recently introduced for implant applications. Here, ultrasonic nanocrystal surface modification (UNSM) treatment was applied to TNTZ alloy to improve its wear resistance and biofunctionality. Application of UNSM to a TNTZ alloy resulted in the generation of a nanostructured surface layer. The wear resistance of the UNSM-treated specimen was observed to be more than 7 times higher than that of the untreated one. Cell culture tests indicated that MC3T3 cells adhered and spread more readily on the UNSM-treated specimen than on the untreated one. MTT assays after 1 and 4 days in culture also indicated enhancement of cell proliferation on the UNSM-treated specimen than that of the untreated one. Live/dead assay revealed no significant cytotoxicity in either substrate. The significant improvement of cell adhesion, spreading, and proliferation on the UNSM-treated TNTZ alloy specimen were attributed to both grain refinement and micro-patterned surface effects. These results demonstrate that UNSM-treatment not only improves the wear resistance of TNTZ alloy, but also enhances its biocompatibility, which makes it a strong candidate for applications in medical implants.</P> <P><B>Highlights</B></P> <P> <UL> <LI> UNSM treatment was applied to a β titanium alloy to generate nanostructured surface. </LI> <LI> The wear resistance of the UNSM-treated specimen was significantly improved. </LI> <LI> Treated specimens showed significant improvement of cell adhesion and proliferation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jung, Hyun Young,Kim, Young Lae,Park, Sora,Datar, Aniket,Lee, Hyung–,June,Huang, Jun,Somu, Sivasubramanian,Busnaina, Ahmed,Jung, Yung Joon,Kwon, Young–,Kyun The Royal Society of Chemistry 2013 The Analyst Vol.138 No.23
<P>Here we report the highly effective detection of hydrogen sulfide (H<SUB>2</SUB>S) gas by redox reactions based on single-walled carbon nanotubes (SWCNTs) functionalized with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as a catalyst and we also discuss the important role of water vapor in the electrical conductivity of SWCNTs during the sensing of H<SUB>2</SUB>S molecules. To explore the H<SUB>2</SUB>S sensing mechanism, we investigate the adsorption properties of H<SUB>2</SUB>S on carbon nanotubes (CNTs) and the effects of the TEMPO functionalization using first-principles density functional theory (DFT) and we summarize current changes of devices resulting from the redox reactions in the presence of H<SUB>2</SUB>S. The semiconducting-SWCNT (s-SWCNT) device functionalized with TEMPO shows a very high sensitivity of 420% at 60% humidity, which is 17 times higher than a bare s-SWCNT device under dry conditions. Our results offer promising prospects for personal safety and real-time monitoring of H<SUB>2</SUB>S gases with the highest sensitivity and low power consumption and potentially at a low cost.</P> <P>Graphic Abstract</P><P>We report the highly effective detection of H<SUB>2</SUB>S gas by redox reactions based on SWCNTs functionalized with TEMPO as a catalyst and discuss the important role of water vapor. The s-SWCNT device shows a very high sensitivity of 420% at 60% humidity. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3an01762a'> </P>
Study of complex electrodeposited thin film with multi-layer graphene-coated metal nanoparticles
Young-Lae Cho,Jung-woo Lee,Chan Park,Young-il Song,Su-Jeong Suh 한국탄소학회 2017 Carbon Letters Vol.21 No.-
We have demonstrated the production of thin films containing multilayer graphene-coated copper nanoparticles (MGCNs) by a commercial electrodeposition method. The MGCNs were produced by electrical wire explosion, an easily applied technique for creating hybrid metal nanoparticles. The nanoparticles had average diameters of 10–120 nm and quasi-spherical morphologies. We made a complex-electrodeposited copper thin film (CETF) with a thickness of 4.8 μm by adding 300 ppm MGCNs to the electrolyte solution and performing electrodeposition. We measured the electric properties and performed corrosion testing of the CETF. Raman spectroscopy was used to measure the bonding characteristics and estimate the number of layers in the graphene films. The resistivity of the bare-electrodeposited copper thin film (BETF) was 2.092 × 10–6 Ω·cm, and the resistivity of the CETF after the addition of 300 ppm MGCNs was decreased by 2% to ~2.049 × 10–6 Ω·cm. The corrosion resistance of the BETF was 9.306 Ω, while that of the CETF was increased to 20.04 Ω. Therefore, the CETF with MGCNs can be used in interconnection circuits for printed circuit boards or semiconductor devices on the basis of its low resistivity and high corrosion resistance.
Quantitative evaluation of patient-specific quality assurance using online dosimetry system
Jung, Jae-Yong,Shin, Young-Ju,Sohn, Seung-Chang,Min, Jung-Whan,Kim, Yon-Lae,Kim, Dong-Su,Choe, Bo-Young,Suh, Tae-Suk 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol. No.
<P>In this study, we investigated the clinical performance of an online dosimetry system (Mobius FX system, MFX) by 1) dosimetric plan verification using gamma passing rates and dose volume metrics and 2) error-detection capability evaluation by deliberately introduced machine error. Eighteen volumetric modulated arc therapy (VMAT) plans were studied. To evaluate the clinical performance of the MFX, we used gamma analysis and dose volume histogram (DVH) analysis. In addition, to evaluate the error-detection capability, we used gamma analysis and DVH analysis utilizing three types of deliberately introduced errors (Type 1: gantry angle-independent multi-leaf collimator (MLC) error, Type 2: gantry angle-dependent MLC error, and Type 3: gantry angle error). A dosimetric verification comparison of physical dosimetry system (Delt4(PT)) and online dosimetry system (MFX), gamma passing rates of the two dosimetry systems showed very good agreement with treatment planning system (TPS) calculation. For the average dose difference between the TPS calculation and the MFX measurement, most of the dose metrics showed good agreement within a tolerance of 3%. For the error-detection comparison of Delta4(PT) and MFX, the gamma passing rates of the two dosimetry systems did not meet the 90% acceptance criterion with the magnitude of error exceeding 2 mm and 1.5 au broken vertical bar, respectively, for error plans of Types 1, 2, and 3. For delivery with all error types, the average dose difference of PTV due to error magnitude showed good agreement between calculated TPS and measured MFX within 1%. Overall, the results of the online dosimetry system showed very good agreement with those of the physical dosimetry system. Our results suggest that a log file-based online dosimetry system is a very suitable verification tool for accurate and efficient clinical routines for patient-specific quality assurance (QA).</P>