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( Kyung Hee Jeng ),( Hye Nam Lee ),( Mi Kyoung Kim ),( Mi La Kim ),( Seok Ju Seong ),( Eunah Shin ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.5
Uterine tumor resembling ovarian sex cord tumors (UTROSCT) is an extremely rare type of uterine stromal neoplasm that exhibits prominent sex cord-like differentiation. The clinical characteristics of a UTROSCT are not fully understood. Most reported cases of UTROSCT were treated by hysterectomy with or without bilateral salpingo-oophorectomy; however, a few cases have been treated by only tumor resection in patients who had a strong desire to preserve their fertility. We present a case of UTROSCT with myometrial invasion, which resulted in a successful delivery after the patient was treated by resectoscopic surgery and conservation of the uterus, and a brief review of the literature.
Neuroprotective effects of FK506 against excitotoxicity in organotypic hippocampal slice culture
Lee, Kyung Hee,Won, Ran,Kim, Un Jeng,Kim, Ga Min,Chung, Myung-Ae,Sohn, Jin-Hun,Lee, Bae Hwan Elsevier 2010 Neuroscience Letters Vol.474 No.3
<P><B>Abstract</B></P> <P>FK506 has been originally classified as an immunosuppressant and is known to exhibit neurotrophic actions <I>in vitro</I> and protective effects on some neurological conditions. We investigated the neuroprotective effects of FK506 on kainic acid (KA)-induced neuronal death in organotypic hippocampal slice cultures (OHSCs). After an 18h KA (5μM) treatment, significantly neuronal death was detected in the CA3 region using propidium iodide staining. However, neuronal death was significantly prevented at 24 and 48h after treatment with 0.1μM FK506. Using cresyl violet staining, we also observed that an increased number of CA3 neurons survived in the 0.1μM FK506 group compared to the KA only group. Based on the results of the Western blot analysis, the expressions of 5-lipoxygenase and caspase-3 were reduced 24h after 0.1μM FK506 treatment. The levels of superoxide dismutase (SOD) and phospho-Akt expression were increased by treatment with 0.1μM FK506. These results suggest that FK506 may have a positive role in protecting neurons against cell death in the KA injury model of OHSCs.</P>
Antioxidant Effects on Neuronal Cell Death in Memory and Cognition Area
( Un Jeng Kim ),( Bae Hwan Lee ),( Kyung Hee Lee ) 한국감성과학회 2015 추계학술대회 Vol.2015 No.-
Hippocampus is a part of brain which plays an important role in memory and recognition. Despite of its important role, hippocampus is very sensitive to global reduction in oxygen level. Oxidative stress and mitochondrial dysfunction are known to be primary factors in the progression of various neurodegenerative disorders. Tyrosine phosphatase shows to regulate the various proteins involving in fundamental cellular processes and survival signals. We investigated that the protein tyrosine phosphatase inhibitor, Sodium orthovanadate (SOV), affects neuronal cell survival and neuroprotective signals in hippocampus after oxidative injury. Hippocampal slices were prepared from 6-7 day-old rats using a tissue chopper and placed on a membrane insert. Neuronal cell death, as assessed by propidium iodide (PI) uptake, was significantly reduced by SOV treatment (10 and 25 uM). The SOV-treated group exhibited increased expression of SOD2 which indicates the level of ROS compared with the KA-only group. Furthermore, the phospho-AKT/AKT ratio showed that the level of phospho-AKT was significantly increased in the 25uM SOV-treated group. These results suggest that SOV may protect hippocampal neurons against oxidative stress (NRF-2013R1A1A4A01009332).
The neuronal activity changes by oxidative injury in OHSC using optical imaging system
( Un Jeng Kim ),( Bae Hwan Lee ),( Kyung Hee Lee ) 한국감성과학회 2017 한국감성과학회 국제학술대회(ICES) Vol.2017 No.-
Oxidative stress produces neurotoxicity often related with various CNS disorders. Ascorbic acid (AA) have been shown to have protective effects as anti-oxidants in experimental neurological disorder models such as stroke, ischemia, and epileptic seizures. The present study was conducted to examine the protective effects of AA on kainic acid (KA) neurotoxicity using organotypic hippocampal slice cultures. AA may enhance the protection effect and benefit to improve neuronal plasticity in post-injury. Thus, we investigated that the antioxidant affects neuroprotective signaling and neuroplastic changes in hippocampus after oxidative injury. Electrophysiological and biochemical assays were used to observe changes in synaptic efficacy following electrical and/or pharmacological manipulation of synaptic function. Neuronal cell death, as assessed by propidium iodide (PI) uptake, was reduced by AA treatment compared with KA treatment. AA significantly prevented cell death and inhibited reactive oxygen species (ROS) level, and mitochondrial dysfunction. Optical imaging revealed that KA treatment tended to delay the latency of electrical stimulation and decrease the amplitude of optical signals of synaptic activity. These results suggest that AA may protect hippocampal neurons against oxidative stress and the survived neurons may functional to synaptic plasticity changes. This work was supported by the Basic Science Research Program through NRF of Korea, which is funded by the MEST (2016R1D1A3B02008194) and the Ministry of Science, ICT, and Future Planning (2014R1A2A2A04004407).
박은희(Une-Hee Park),이현우(Hyun-Woo Lee),최성철(Sung-Choul Choi),정경훈(Kyung-Hun Jeng) 한국자동차공학회 2003 한국자동차공학회 지부 학술대회 논문집 Vol.2003 No.10
Numerical investigation of the effects of the velocity was executed in the turbulent flow field. It was found that the pressure drop in the velocity media depends linearly on the face velocity. The flow field in the fluidics valve with constant flow velocity of control port and the varying flow velocity of supply port were simulated by finite volume method. The unsteady wake enhance the tuebulence motion in the cascade passage and influences the flow separation in the suction surface. The resulting in a relative narrow wake and hence the time mean pressure drop on rear face of the trim prism is increased with the control valve trim. A precautionary messure is also preformed to help service engineers.<br/>