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( Weon Ju Lee ),( Soo Yuhl Chae ),( Hyo Sub Ryu1 ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: The effectiveness of ultraviolet (UV) radiation, visible light, or infrared light therapy for the treatment of acne is the subject of ongoing scientific debate. Objective: This study was conducted to investigate changes in sebum production and the expression of inflammatory cytokines, matrix metalloproteinases (MMPs), and antimicrobial peptides (AMPs), following exposure of cultured human sebocytes to UVA radiation and light at wavelengths of 650 nm and 830 nm. Methods: Reverse transcription polymerase chain reaction assays were performed to measure the gene expression levels of inflammatory cytokines (interleukin [IL]-1β, IL-6, IL-8, and tumor necrosis factor-α), MMPs (MMP-1, MMP-3, and MMP-9), and AMPs (psoriasin, hBD-2, hBD-3, and LL-37) in cultured sebocytes after exposure to UVA radiation (2 J/cm2, 3 J/cm2, and 5 J/cm2) and light at wavelengths of 650 nm (14 J/cm2, 29 J/cm2, and 87 J/cm2) and 830 nm (5 J/cm2, 10 J/cm2, and 30 J/cm2). Expression of inflammatory cytokine proteins and sebum production were measured using enzyme- linked immunoassays and a lipid analysis kit, respectively. Results: Exposure of cultured sebocytes to UVA radiation and light at wavelengths of 650 nm and 830 nm did not show a significant increase in the expression of inflammatory cytokines, MMPs, or AMPs. Sebum production was not significantly decreased after exposure to UVA radiation and light at both wavelengths. Conclusion: We propose that UVA radiation, visible light, and infrared light can be used to target Propionibacterium acnes for the treatment of acne, without an increase in the expression of inflammatory biomarkers and sebum production. (Ann Dermatol 27(2) 163∼ 170, 2015)
내분비계 교란물질의 검출계를 이용한 γ-HCH의 미생물에 의한 중간대사산물에 대한 내분비계교란 활성의 평가
이행석,박주석,조은민,문명숙,太田明德,류재천 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1
To develop an efficient degradation system for Endocrine disruptors (EDs), it is necessary to have a good system to evaluate rapidly and accurately endocrine-disrupting activities of suspected chemicals and their degradation products. We previously constructed a co-expression system of GAL4 DNA binding domain (DBD)-human estrogen receptorβ ligand binding domain (hERβ LBD) and Gal4p transcriptional activation domain (TAD)-co-activator SRC1 in Saccharomyces cerevisiae with a chromosome-integrated lacZ reporter gene under the control of CYC1 promoter and GAL4 binding site (Upstream Activating Sequence, UAS). Expression of this reporter gene was dependent on the presence of estrogen or endocrine disruptors in the culture medium. Furthermore, the extent of transcriptional activation by those chemicals correlated with their estrogenic activities measured by other assay systems, indicating that this assay system is efficient and reliable for measuring estrogenic activity. We applied this assay system to measure estrogenic activity of microbial degradation products of γ-hexachlorocyclohexane (γ-HCH) by Sphingomonas paucimobilis. Among the γ-HCH metabolites, 2,5-dichlorohydroquinone (2,5-DCHQ) and chlorohydroquinone (CHQ) had similar estrogenic activities to the original chemical, but hydroquinone (HQ), a metabolite at later stage, had no activity at the concentration of 10^-4M, showing the necessity of evaluation of intermediate metabolites in microbial degradation systems.
( Ju Seok Ryu ),( Donghwi Park ),( Yoongul Oh ),( Seok Tae Lee ),( Jin Young Kang ) 대한소화기기능성질환·운동학회 2016 Journal of Neurogastroenterology and Motility (JNM Vol.22 No.2
Background/Aims The purpose of this study was to develop new parameters of high-resolution manometry (HRM) and to applicate these to quantify the effect of bolus volume and texture on pharyngeal swallowing. Methods Ten healthy subjects prospectively swallowed dry, thin fluid 2 mL, thin fluid 5 mL, thin fluid 10 mL, and drinking twice to compare effects of bolus volume. To compare effect of texture, subjects swallowed thin fluid 5 mL, yogurt 5 mL, and bread twice. A 32-sensor HRM catheter and BioVIEW ANALYSIS software were used for data collection and analysis. HRM data were synchronized with kinematic analysis of videofluoroscopic swallowing study (VFSS) using epiglottis tilting. Results Linear correlation analysis for volume showed significant correlation for area of velopharynx, duration of velopharynx, pre-upper esophageal sphincter (UES) maximal pressure, minimal UES pressure, UES activity time, and nadir UES duration. In the correlation with texture, all parameters were not significantly different. The contraction of the velopharynx was faster than laryngeal elevation. The durations of UES relaxation was shorter in the kinematic analysis than HRM. Conclusions The bolus volume was shown to have significant effect on pharyngeal pressure and timing, but the texture did not show any effect on pharyngeal swallowing. The parameters of HRM were more sensitive than those of kinematic analysis. As the parameters of HRM are based on precise anatomic structure and the kinematic analysis reflects the actions of multiple anatomic structures, HRM and VFSS should be used according to their purposes. (J Neurogastroenterol Motil 2016;22:231-239)
Application and Interpretation of High-resolution Manometry for Pharyngeal Dysphagia
Ryu, Ju Seok,Park, Donghwi,Kang, Jin Young Korean Society of Neurogastroenterology and Motili 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.2
<P>The pharyngeal phase of swallowing is a complex event consisted with subsequent muscular contractions and pressure generation to move a bolus from the mouth to the esophagus. Recently, high-resolution impedance manometry (HRIM) was developed and used for the evaluation of pharyngeal dysphagia. Although HRIM provides precise pharyngeal pressure information, it has yet to be used as part of routine clinical practice for the assessment of dysphagia. The main reasons are thought to be that the test method and result interpretation are not easily applicable and standardized. The anatomical landmarks for HRIM parameters are velopharynx, tongue base, epiglottis, low pharynx, and upper esophageal sphincter. With HRIM, the pressure and timing data could be obtained at a precise anatomical structure. In the present review, we will review how to apply HRIM for the evaluation of pharyngeal dysphagia, including the interpretation of its parameters.</P>
( Ju Seok Ryu ),( Dong Hwi Park ),( Jin Young Kang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.2
The pharyngeal phase of swallowing is a complex event consisted with subsequent muscular contractions and pressure generation to move a bolus from the mouth to the esophagus. Recently, high-resolution impedance manometry (HRIM) was developed and used for the evaluation of pharyngeal dysphagia. Although HRIM provides precise pharyngeal pressure information, it has yet to be used as part of routine clinical practice for the assessment of dysphagia. The main reasons are thought to be that the test method and result interpretation are not easily applicable and standardized. The anatomical landmarks for HRIM parameters are velopharynx, tongue base, epiglottis, low pharynx, and upper esophageal sphincter. With HRIM, the pressure and timing data could be obtained at a precise anatomical structure. In the present review, we will review how to apply HRIM for the evaluation of pharyngeal dysphagia, including the interpretation of its parameters. (J Neurogastroenterol Motil 2015;21:283-287)
Ju-Won Ryu,Myeong Seok Lee,Mi-Jin Yim,Jeong Min Lee,Dae-Sung Lee,김영목,엄성환 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.3
The control of intestinal α-amylase and α-glucosidase is an effective therapeutic strategy for prevention of post-prandial hyperglycemia associated with diabetes mellitus. The objective of this study was to evaluate the anti-diabetes activities of Korean edible seaweed against α-amylase and α-glucosidase, two carbolytic enzymes involved in serum glucose regulation. Of the 41 species initially screened, Cladophora wrightiana var. minor, Eisenia bicyclis, Ecklonia cava, Ishige foliacea, and Ishige okamurae exhibited the strongest inhibitory activities from brown seaweeds. Asparagopsis taxiformis showed the strongest inhibitory effects from red seaweeds. The results of this study suggest that the crude brown seaweed extracts (C. wrightiana var. minor, E. bicyclis, E. cava, I. foliacea, and I. okamurae) and crude red seaweed extracts (A. taxiformis) may have beneficial effects suppressing the rise in postprandial hyperglycemia through the inhibition of α-amylase and α-glucosidase.
Seok-Ju Lee,Seong-Jong Park,Geun-Chang Ryu,Cheol-Woo Lee 대한시과학회 2020 대한시과학회지 Vol.22 No.4
목적 : 본 연구는 청색광 차단 콘택트렌즈 제조에 필요한 benzotriazole을 합성하고, 이를 이용하여 제조한 콘 택트렌즈의 광학적, 물리적 성질에 대하여 알아보고자 한다. 방법 : 청색광 차단 화합물인 benzotriazole을 합성 후 HEMA, EGDMA, AIBN을 공중합하여 청색광 차단 콘 택트렌즈를 제조하였다. 그리고 제조한 콘택트렌즈의 특성을 평가하기 위해 광투과율, 청색광 차단율, 함수율을 측 정하였다. 결과 : 제조한 청색광 차단 콘택트렌즈는 대조군으로 제조한 콘택트렌즈에 비해 우수한 청색광과 자외선 차단 성능을 나타냈으며, benzotriazole의 농도가 높을수록 청색광과 자외선 차단 성능이 높아지는 것을 알 수 있었다. 또한 함수율의 경우 대조군과 비교하여 큰 차이는 없는 것으로 나타났다. 결론 : 제조한 청색광 차단 콘택트렌즈는 기존의 콘택트렌즈가 가지는 물성을 해치지 않으면서 자외선 차단성 능이 뛰어나고 청색광을 줄일 수 있는 콘택트렌즈 제조가 가능할 것으로 사료된다. Purpose : The purposes of this study are to synthesize benzotriazole derivatives for the development of blue light blocking hydrogel contact lenses and to investigate their optical and physical properties. Methods : After benzotriazole, which acts as a blue light blocking compound, was synthesized, blue light blocking hydrogel contact lenses were made by the copolymerizing benzotriazole derivatives, HEMA, and EGDMA monomers in the presence of initiator AIBN. The water content, optical properties, blue light blocking rate and ultraviolet light blocking rate of the manufactured lenses were investigated. Results : The blue and ultraviolet light blocking performance of the manufactured lenses were superior to that of the unmodified control. It was shown that as the density of benzotriazole derivatives increases, the blue and ultraviolet light blocking rate of the resulting lenses are improved. Water content showed no significant difference compared to that of the unmodified control. Conclusion : Manufactured blue light blocking contact lenses can provide a strategy for the development of the contact lenses which are excellent in blue and ultraviolet light blocking performance without deteriorating the physical properties of conventional contact lenses.