http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
身痛逐瘀湯 및 身痛逐瘀湯加味方의 鎭痛 ·消炎 ·解熱 作用에 관한 硏究
孫宗坤,崔昇勳,安圭錫 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1996 東西醫學硏究所 論文集 Vol.1996 No.-
These experiments were undertaken to investigate the effects of Sintongc-hugeotang(身痛逐瘀湯) and Sintongchugeotanggamibang(身痛逐瘀湯加味方) on the artificial arthritis resulted from Carrageenin. Sprague-Dawley rats body weight 200±10g were used and items which determined in the experiment were articular temperature, volume of the edema, amount of analgesic effect, the number of serum leucocyte of the rats. The results were summarized as follows: 1. It was recognized that Sintonchugeotang has an effectively decrease on articular temperature, but Sintongchugeotanggamibang had not an effectively decrease on articular temperature. 2. It was recognized that Sintongchugeotang has an anti-inflammatory effect in paw edema induced by Carrageenin, but there was no remarkable altermations in paw edema after administration of Sintongchugeotanggamibang. 3. It was recognized that Sintongchugeotang and Sintongchugeotanggamibang has an effectively analgesic function on the artificial arthritis resulted from Carrageenin. 4. Leucocyte counts in the serum decreased significantly after administration of Sintongchugeotang and Sintongchugeotanggamibang. According to the above result, it can be concluded Sintongchugeotang and Sintongchugeotanggamibang showed the treatment effect on the arthritis resulted from Carrageenin in rats, and it is suggested that the more interest and study in the security for the clinical use were needed.
Son, Sangkeun,Hong, Young-Soo,Jang, Mina,Heo, Kyung Taek,Lee, Byeongsan,Jang, Jun-Pil,Kim, Jong-Won,Ryoo, In-Ja,Kim, Won-Gon,Ko, Sung-Kyun,Kim, Bo Yeon,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2017 Journal of natural products Vol.80 No.11
<P>Analysis of the genome sequence of <I>Streptomyces</I> sp. KCB13F003 showed the presence of a cryptic gene cluster encoding flavin-dependent halogenase and nonribosomal peptide synthetase. Pleiotropic approaches using multiple culture media followed by LC-MS-guided isolation and spectroscopic analysis enabled the identification of two new chlorinated cyclic hexapeptides, ulleungmycins A and B (<B>1</B> and <B>2</B>). Their structures, including absolute configurations, were determined by 1D and 2D NMR techniques, advanced Marfey’s analysis, and GITC derivatization. The new peptides, featuring unusual amino acids 5-chloro-<SMALL>l</SMALL>-tryptophan and <SMALL>d</SMALL>-homoleucine, exhibited moderate antibacterial activities against Gram-positive pathogenic bacteria including methicillin-resistant and quinolone-resistant <I>Staphylococcus aureus</I>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2017/jnprdf.2017.80.issue-11/acs.jnatprod.7b00660/production/images/medium/np-2017-00660j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np7b00660'>ACS Electronic Supporting Info</A></P>
Son, Sangkeun,Ko, Sung-Kyun,Kim, Seung Min,Kim, Eun,Kim, Gil Soo,Lee, Byeongsan,Ryoo, In-Ja,Kim, Won-Gon,Lee, Jung-Sook,Hong, Young-Soo,Jang, Jae-Hyuk,Ahn, Jong Seog American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.11
<P>Three cyclic lipopeptides, including one known (<B>1</B>) and two new (<B>2</B> and <B>3</B>) compounds, that possess the rare enamide linkage group were discovered from <I>Streptomyces</I> sp. KCB14A132, an actinobacterium isolated from a soil sample collected from Jeung Island, Korea. The NMR and MS-based characterization showed that they differed in the amino acid residues in the peptide backbone. Application of Marfey’s analysis, GITC derivatization, and modified Mosher’s method, as well as ECD measurements provided the absolute configurations of enamidonin (<B>1</B>) and those of new compounds enamidonins B and C (<B>2</B> and <B>3</B>). The two new enamidonin analogues were shown to exhibit antibacterial activity against Gram-positive bacteria including methicillin-resistant and quinolone-resistant <I>Staphylococcus aureus</I>. Furthermore, evaluation of the extraction conditions and a close inspection of the LC-MS chromatograms revealed that the <I>N</I>,<I>N</I>-acetonide unit of the enamidonin family was formed during the acetone extraction process. The chemically prepared deacetonide derivatives of enamidonins were found to lack antibacterial activity, demonstrating that the dimethylimidazolidinone residue is necessary for antibacterial activity.</P> [FIG OMISSION]</BR>
( Jong Min Kim ),( Tae Sung Han ),( Myoung Hwan Kim ),( Daniel S. Oh ),( Seong Soo Kang ),( Gon Hyung Kim ),( Tae Yub Kwon ),( Kyo Han Kim ),( Kyu Bok Lee ),( Jun Sik Son ),( Seok Hwa Choi ) 한국조직공학·재생의학회 2012 조직공학과 재생의학 Vol.9 No.3
The goal of this study was to develop a bioactive hydroxyapatite (HA) scaffold as a calcium phosphatebased bioceramic using drug-loaded polymeric microspheres for bone regeneration. Dexamethasone (DEX) as a model bioactive molecule and poly (lactic-co-glycolic acid) (PLGA) microspheres as a carrier were employed. Polyethyleneimine was coated on DEX-loaded PLGA microsphere surfaces, resulting in a net positively-charged surface. With such modification of the PLGA microsphere surfaces, DEX-loaded PLGA microspheres were immobilized on the negatively charged HA scaffold surfaces. The release profile of DEX over a 4-week immersion study indicated an initial burst release followed by a sustained release. In vivo evaluation of the defects filled with DEX-loaded HA scaffolds indicated that new bone formation was enhanced when compared to defects that were either unfilled or filled only with HA scaffold. This innovative platform for bioactive molecule delivery more potently induced osteogenesis in vivo, which may be exploited in implantable bone graft substitutes for stem cell therapy or improved in vivo performance.
차륜 답면과 레일의 경계영역에서의 마모 특성 (Wear characteristics depended on Wear Index in Wheel-Rail Interface)
안종곤(Jong-Gon Ahn),권석진(Seok-Jin Kwon),손영진(Young-Jin Son),김호경(Ho-Kyung Kim) 한국철도학회 2011 한국철도학회 학술발표대회논문집 Vol.2011 No.5
Wheel and rail wear is a fundamental and complicate problem in railway field. The life of railway is usually limited by wear. The wheel surface is subjected to high normal and tangential contact stress. The removal of material from the surface by wear is function of the sliding and contact stress. In the present paper, the wear characteristic depended on slip rate, contact pressure and temperature are investigated and is used to twin disc tester. The result shows that the wear in wheel-rail interface is remarkably depended on slip rate and contact pressure.
임계결손된 토끼 요골에서 인체 유래 탈회골기질의 골치유 효과
김종민 ( Jong Min Kim ),( Jun Sik Son ),채희열 ( Hee Youl Chai ),지형진 ( Hyeong Jin Ji ),김대중 ( Dae Joong Kim ),강성수 ( Seong Soo Kang ),김근형 ( Gon Hyung Kim ),최석화 ( Seok Hwa Choi ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s
This study was designed to evaluate the effect of pure demineralized cortical bone source (CBS), and CBS and non-demineralized cancellous bone sources (CCBS) on bone healing process. Twenty-one male New Zealand White rabbits were used in this study. The rabbits were anesthetized with zoletil (15 mg/kg, IM) and xylazine (5 mg/kg, IM). An osteoperisteal segmental defect was created on the middle portion of three times as long as the diameter of the diaphysis for creation of critical-sized defect. Rabbits received bilateral segmental radial defect of 15 mm. The created defects were filled in rabbits with human-drived deminerallized bone matrixes (DBM) such as CBS and CCBS. Evaluation consisted of radiographs after surgery and sacrifice, three-dimensional micro-computed tomography (micro-CT) and histopathology. Complications after implantation with CBS and CCBS were not identified. Comparison of the scoring of the radiographs or micro-CT images revealed no significant difference in defect bridging between CBS and CCBS. Bone remodeling of critical-sized radial bone defect was completed at 13 weeks after DBM implantation. In conclusion, the results of this study indicate that DBM may be used in clinical trials for healing of bone defect.