북한이탈주민의 생활실태 조사 : 경기도 부천시 원미구 춘의임대아파트 거주자를 중심으로

오봉욱, 최종복, 권혁철 가톨릭대학교 사회복지연구소 2010 사회복지리뷰 Vol.15 No.-

Stabilized 위성안테나의 PCU 제어알고리즘의 구현

오정환,김종철 慶南專門大學 1998 論文集 Vol.26 No.1

아미노글리코사이드 사용제한에 따른 병원성 균혈증 유발 그람음성간균의 내성변화 및 임상적 의의

오종택,김신우,손종원,도병훈,한승우,신병철,박지현,이종명,김능수 대한감염학회 2003 감염과 화학요법 Vol.35 No.4

목적 : 항균제 오남용으로 인한 내성균의 출현, 약물부작용의 발생 및 약제 비용의 증가는 환자 개인뿐만 아니라 사회적으로 문제가 되고 있다. 본 연구는 항생제의 오남용을 막기 위한 제도의 일환으로 시행한 아미노글리코사이드 사용 제한정책의 비용 효과적인 측면을 조사하고 그람음성간균에 의해 병원성 균혈증이 발생한 환자들을 대상으로 이 정책이 항생제 내성률과 환자 사망률에 미치는 영향을 연구하였다. 방법 : 930병상 규모의 3차 병원인 일개 대학병원에서 아미노글리코사이드 사용제한정책이 시행된 직후인 2002년 3월에서 9월 사이에 그람음성간균(Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Stenotrophomonas maltophilia, Burkholderia cepacia)에 의해 발생한 병원성 균혈증 환자 60명(실험군)과, 이 정책이 시행되기 전에 입원한 환자들 중 균주별로 같은 수만큼 선별한 병원성 균혈증 환자 60명(대조군)의 의무기록을 후향적으로 조사하였다. 결과 : 아미노글리코사이드 사용제한정책이 시행된 시기인 2002년 3월에서 9월 사이에 처방된 아미노글리코사이드 사용량 및 비용을 이 정책이 시행되기 전인 2001년 3월에서 9월 사이와 비교한 결과, 아미노글리코사이드의 사용량(antimicrobial utilization density)은 사용제한 후 225.2에서 130.3으로 42% 감소하였고 약제 비용은 44% 감소하였다. 아미노글리코사이드 사용제한 후 병원성 균혈증을 유발한 그람 음성간균의 이 항생제에 대한 내성률은 유의한 변화를 보이지 않았으며 균혈증과 직접 연관된 사망률도 환자의 나이, 성별, 기저질환 및 원발병소 등을 보정할 경우 유의한 차이를 보이지 않았다(40.4% vs. 24.1%, P=0.11). 결론 : 아미노글리코사이드를 5일을 초과한 사용 시 감염전문가의 사전 승인을 필요로 하는 사용제한정책은 아미노글리코사이드의 사용량과 비용을 유의하게 감소시켰다. 또한 이 정책 시행 후 그람음성간균에 의한 균혈증 환자에서 균혈증으로 인한 사망률과 아미노글리코사이드에 대한 내성률은 유의한 차이가 없었다. Objective : To evaluate the effects of an aminoglycoside restriction policy on expenditures for aminoglycosides, antimicrobial resistance rates and clinical outcome of nosocomial bacteremia caused by Gram-negative bacilli (GNB). Methods : Starting in February, 2002, a prior consultation with an infectious disease specialist for using aminoglycoside antibiotics over 5 days was required in a 930-bed university hospital. In retrospective analysis of medical records 7 months after initiation of the aminoglycoside restriction policy, sixty cases of clinically relevant nosocomial bacteremia caused by GNB were found. These bacteremic patients were compared with sixty, species-matched, control patients with nosocomial Gramnegative bacteremia before the policy for total expenditures for aminoglycosides, susceptibility to antibiotics and clinical outcomes of bacteremia. Results : During the same period of 7 months before and after the restriction policy, total expenditures for aminoglycosides decreased by 44% in cost (from 465,030,841 Won to 259,618,337 Won) and the antimicrobial utilization density of aminoglycosides decreased by 42% (from 225,2 to 130.3). On the other hand, the patterns of antibiotic susceptibility and bacteremia-related in-hospital mortality rates after the policy did not show a significant change, compared with those before the policy. Conclusion : Antibiotic restrictions are among the most popular methods to diminish the practice of antibiotic overuse in hospitals. In this study, requirement for prior approval of aminoglycoside use over 5 days led to a significant decrease in the amount and cost of total aminoglycosides without a significant change in susceptibility patterns and bacteremia-related mortality rates.

기초과학 실험에 관한 학습자료 개발 : 4·5·6학년 새 자연과 교육 과정 4th·5th·6th grade new elementary school science curri culum

오상철,김영호,현종익 濟州敎育大學 科學敎育硏究所 1983 科學敎育硏究誌 Vol.7 No.-

This is a study to develop the obervations and experimental materials for the elementary school 4th.5th.6th grade science curriculum that are carried on effect from this year. The materials which teachers do and the teachers and students can make, by themselves, are as follows: 1) In the field of biology for 4th.5th and 6th grade, 11 kinds of plant observating materials were cultivated. 2) In physics field of sixth units in the text book for 4th.5th and 6th grade, 10 kinds of implements were developed: electric circuit, moving of heat, expansion of heat and body, solute, movement of Earth and Moon, eaergy of Water and Wind.

수은중독의 임상증상과 생물학적 폭로지표간의 연관성에 관한 조사 연구

吳惠淑,金光鍾,車喆煥 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.1

This research focused on the association between clinical symptoms of mercury poisoning and mercury concentration in urine and blood. A total of 100 manual workers and 55 office workers in a fluorescent lamp manufacturing factory were selected and history-taking and physical examination were done from September 1988 to Octorber 1989. The results were as follows : 1. The urinary mercury concentration of manual workers in average was 125.9 ㎍/l(5.0-469.0㎍/l), which showed 10 times higher than that of the office workers, and the blood mercury concentration of manual workers in average was 6.3 ㎍/l00ml(0.2 -60.2 ㎍/l00㎖), which was 6.6 times higher than that of office workers. 2. The frequency of mercury poisoning symptoms appeared was higher in manual workers than in office workers. Among the symptoms, anorexia(33.0%), shyness(15.0%), gingivitis(11.0%) and stomatitis(11.0%) showed significantly higher in manual workers than in office workers. In every item of symptoms, the manual workers showed a higher average of urinary and blood mercury concentration than that of the office workers 3. The average urinary mercury concentration of symptom-holders(shyness, loss of memory and anorexia) among manual workers was higher than that of non-symptom-holders. The average blood mercury concentration of symptom-holders(excessive sweating and blood mercury concentration than that of the office workers. anxiety, loss of weight) was higher than that of non-symptom-holders. 4. Shyness, loss of memory, loss of patience, anorexia, loss of weight, dyspepsia, excessive sweating, respectively showed increase of the number of symptom - holders according to the urinary mercury level. However, there was no increase of the number of symptom-holders according to the blood mercury level.

수은폭로 근로자의 조기 신기능 장해 지표로서의 요중 β-Galactosidase 활성도에 관한 연구

오연희,김광종,천병철,박종태 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

The objective of this study was to evaluate the relationship between β-galactosidase activity in urine, in serum and urinary N-acetyl-β-glucosaminidase activity as an early indicator of renal effect and mercury concentration in urine and blood, reflecting the intensity of exposure to or the amount of body burden of mercury. This study was carried out among 70 workers exposed to mercury vapor and 63 non-exposed workers as a reference. The results were as follows; 1. The mean concentration of urinary mercury(43.5 ㎍/l) in exposed subjects was about nine times higher than that of non-exposed subjects, but the mean values of blood mercury were not different from each other. 2. The mean values of β-galactosidase activity in urine(119.7μmolMU/h/g creatinine) and in blood(73.7 molMU/h/l) of mercury-exposed subjects were significantly higher than those of non-exposed subjects. 3. In mercury-exposed subjects, β-galactosidase activities in urine(r=0.38, P<0.01) and in serum(r=0.26, P<0.05) were correlated to urinary mercury concentration, but not to blood mercury concentration. The urinary excretion of β-galactosidase activity was closely associated with urinary mercury concentration in the result of the multiple regression analysis. 4. The urinary β-galactosidase activity in exposed subjects increased as the urinary mercury increased, and in the exposed subjects with more than 50㎍/l of urinary mercury was highly related to urinary β-galactosidase activity(r=0.47, P<0.05). 5. Among exposed subjects with more than 50㎍/l of urinary mercury, 20.0% of them showed abnormal value of urinary β-galactosidase activity.

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

NDRG2 is one of novel intrinsic factors for regulation of lL-10 production in human myeloid cell

최승철,김광동,김종태,오상석,윤선영,송은영,이희구,조영경,최인표,임종석,김재화 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

금융기관 합병전략에 관한 연구

오종근,오종철 全北産業大學校 産業經營硏究所 1997 産業經營硏究 Vol.5 No.-

아세토니트릴-물 혼합용매에서 Cu(Ⅱ)이온과 거대고리 리간드 간의 반응속도

吳相午,朴裕哲,卞鍾轍 慶北大學校 1986 論文集 Vol.42 No.-

The deprotonation constants of rac-5.7.7.12.14.14-hexamethlyl-1.4.8.11-tetraazacyclo-tetradecane(tetb, L) in acetonitrile-water mixture were studied by the spectrophotometric method. deprotonation constants, K_1^L, K_2^L, K_3^L, and K_4^L were 2.51×10 exp (-13), 3.98×10 exp (-11), 0.16 and 0, respectively. Copper(Ⅱ) reacts with tetb in acetonitrile-water mixture (pH=3.5-5.4) to give [CuL]^2+(blue isomer). At higher pH(ca.8) [CuL]^2+(blue isomer) is slowly converted into [CuL]^2+(red isomer). The kinetics of formation of the blue complex ion have been investigated at 25-35℃ and 0.1M NaClO_4 in acetate buffers. In acetate buffers Rate=k_1[Cu^2+][LH^+]+k_2[Cu(Ac)^+][LH^+]+k_3[Cu(Ac)^+][LH_2^2+] with k_1=1.45×10 exp (5), k_2=2.01×10 exp (4) and k_3=0.45 at [Cu^2+]_t=4.49×10 exp (-4)M. From the temperacture effect on kinetic constant kinetic parameters enthalpy of activation(ΔH^≠) and entropy of activation(ΔS^≠) of reaction were evaluated, their values 25.43 Kcal.mol^-1 and 7.25eu at pH=4.5, respectively. The formation of blue complex ion was controlled by the ΔH^≠, and isokinetic temperature between ΔH^≠ and ΔS^≠ was 364.64K.