Sustaining the Technopolis: The Case of Austin, Texas

Gibson, David V.,Butler, John S. World Technopolis Association 2013 World Technopolis Review Vol.2 No.2

In "Creating the Technopolis: High Technology Development in Austin Texas," Smilor, Kozmetsky, and Gibson (1988) make the case that in the mid-1980s Austin was becoming a globally competitive high tech region. Indeed over the years and into 2013, Austin has established its reputation as a leading entrepreneurial and technology center and "talent magnet." Delegations from across the US and worldwide visit Austin to better understand how this central Texas city went from being a state government and university town to become a fast growing, globally competitive, technology hotspot leading the state and nation in job creation. Central to the concept of the Triple Helix and Technopolis Frameworks is the importance of university, business, and government cooperation. This paper gives examples of mechanisms, processes, and metrics on how The University of Texas at Austin; regional technology industry; federal, state, and local government policies; and support groups all contributed to growing and sustaining the Austin Technopolis.

A Test of the Worker Quality Explanation for the Urban/Non-Urban Wage Gap

John Gibson,Bonggeun Kim 서울대학교 경제연구소 2010 Seoul journal of economics Vol.23 No.4

We conduct a test to determine whether the observed urban/nonurban wage gap is a return to unobservable ability. A new measure of worker quality is added to wage regressions, and the estimated urban premium is compared with the results from the standard human capital measures. This new measure of unobserved ability refers to workers' literacy as assessed by the International Adult Literacy Survey (IALS). Using data from three countries with different population densities and scope of human capital spillovers, we find that controlling for literacy levels does not reduce the size of the urban wage premium, implying that the wage gap is not due to previously unobserved worker quality. We also test whether literacy affects interaction between the urban wage premium and experience, which may proxy for learning-by-doing, and find similarly insignificant changes in the estimates.

CONSTRUCTING MOTIVATION THEORIES : A LOOK AT MASLOW'S METHOD

Gibson, John L. 西江大學校 生活相談室 1979 人間理解 Vol.1 No.-

이 글은 많은 과학자들에게 관심거리가 되고 있는 유기체, 조직체계, 무생물, 그리고 어떠한 상황에서라도 인간은 스스로 주인이라는 독특한 위치에 있음을 알고 있었던 마우스(Maslow)의 심오한 이론이다. 여기서는 마스로우(Maslow)가 발표한 많은 가정, 개념 그리고 전제를 뽑아 논리적인 순서로 재구성 하고 이 이론의 특성을 보여 줄 수 있는 나자신의 예를 덧붙였다. 그 다음에 세계적으로 이름 난 심리학자인 카렌 호나이 (Karen Horney)와 고든 올포드 (Gorden Allport)의 이론과 비교하여 마스로우(Maslow)의 이론이 갖고 있는 주목해 볼만한 특징을 찾아보려고 했다. 마스로우(Maslow)의 인간동기설(Theory of Human Motivation)을 간단하게 약술하고 그 속에 내재한 함축 의미를 밝히면서 마스로우의 이론 체계에 대한 방법론적 측면을 강조하고자 했다. 나는 이글이 모든 사람에게 적용될 수 있는 동기설을 정확하게 설명했다고 독자들이 믿기를 바라지도 않으며 그런 태도는 옳다고 생각하지도 않는다. 오히려 나의 희망은 이 글을 통해서 독자 여러분이 살고 일하는 특정한 문화권과 사회로부터 얻어낸 자료를 기초로, 새로운 이론을 구축하기 위한 창조적인 힘을 얻을수 있는 계기가 되기를 바랄 뿐 이다.

Sustaining the Technopolis: The Case of Austin, Texas

David V. Gibson,John S. Butler 세계과학도시연합 2013 World Technopolis Review Vol.2 No.2

In “Creating the Technopolis: High Technology Development in Austin Texas,” Smilor, Kozmetsky, and Gibson (1988) make the case that in the mid-1980s Austin was becoming a globally competitive high tech region. Indeed over the years and into 2013, Austin has established its reputation as a leading entrepreneurial and technology center and “talent magnet.” Delegations from across the US and worldwide visit Austin to better understand how this central Texas city went from being a state government and university town to become a fast growing, globally competitive, technology hotspot leading the state and nation in job creation. Central to the concept of the Triple Helix and Technopolis Frameworks is the importance of university, business, and government cooperation. This paper gives examples of mechanisms, processes, and metrics on how The University of Texas at Austin; regional technology industry; federal, state, and local government policies; and support groups all contributed to growing and sustaining the Austin Technopolis.

MEASURING INFRARED SURFACE BRIGHTNESS FLUCTUATION DISTANCES WITH<i>HST</i>WFC3: CALIBRATION AND ADVICE

Jensen, Joseph B.,Blakeslee, John P.,Gibson, Zachary,Lee, Hyun-chul,Cantiello, Michele,Raimondo, Gabriella,Boyer, Nathan,Cho, Hyejeon IOP Publishing 2015 The Astrophysical journal Vol.808 No.1

<P>We present new calibrations of the near-infrared (near-IR) surface brightness fluctuation (SBF) distance method for the F110W (J(110)) and F160W (H-160) bandpasses of the Wide Field Camera 3 Infrared Channel (WFC3/IR) on the Hubble Space Telescope. The calibrations are based on data for 16 early-type galaxies in the Virgo and Fornax clusters observed with WFC3/IR and are provided as functions of both the optical (g(475)-z(850)) and near-infrared (J(110)-H-160) colors. The scatter about the linear calibration relations for the luminous red galaxies in the sample is approximately 0.10 mag, corresponding to a statistical error of 5% in distance. Our results imply that the distance to any suitably bright elliptical galaxy can be measured with this precision out to about 80 Mpc in a single-orbit observation with WFC3/IR, making this a remarkably powerful instrument for extragalactic distances. The calibration sample also includes much bluer and lower-luminosity galaxies than previously used for IR SBF studies, revealing interesting population differences that cause the calibration scatter to increase for dwarf galaxies. Comparisons with single-burst population models show that as expected, the redder early-type galaxies contain old, metal-rich populations, while the bluer dwarf ellipticals contain a wider range of ages and lower metallicities than their more massive counterparts. Radial SBF gradients reveal that IR color gradients are largely an age effect; the bluer dwarfs typically have their youngest populations near their centers, while the redder giant ellipticals show only weak trends and in the opposite sense. Because of the population variations among bluer galaxies, distance measurements in the near-IR are best limited to red early-type galaxies. We conclude with some practical guidelines for using WFC3/IR to measure reliable SBF distances.</P>

Measuring Human Capital: Alternative Methods and International Evidence

( Les Oxley ),( Trinh Le ),( John Gibson ) 한국경제학회 2008 The Korean Economic Review Vol.24 No.2

Genetic variation at <i>CYP3A</i> is associated with age at menarche and breast cancer risk: a case-control study

Johnson, Nichola,Dudbridge, Frank,Orr, Nick,Gibson, Lorna,Jones, Michael E,Schoemaker, Minouk J,Folkerd, Elizabeth J,Haynes, Ben P,Hopper, John L,Southey, Melissa C,Dite, Gillian S,Apicella, Carmel,Sc BioMed Central 2014 Breast cancer research Vol.16 No.3

<P><B>Introduction</B></P><P>We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the <I>CYP3A</I> locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.</P><P><B>Methods</B></P><P>We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.</P><P><B>Results</B></P><P>We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; <I>P</I> = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; <I>P</I> = 0.004), respectively (<I>P</I><SUB>trend</SUB> = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (<I>P</I><SUB>trend</SUB> = 0.005) but not cases (<I>P</I><SUB>trend</SUB> = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (<I>P</I><SUB>het</SUB> = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR<SUB>het</SUB> = 0.84, 95% CI 0.75, 0.94; OR<SUB>hom</SUB> = 0.81, 95% CI 0.51, 1.30; <I>P</I><SUB>trend</SUB> = 0.002) but not for those who had their menarche age ≤11 years (OR<SUB>het</SUB> = 1.06, 95% CI 0.95, 1.19, OR<SUB>hom</SUB> = 1.07, 95% CI 0.67, 1.72; <I>P</I><SUB>trend</SUB> = 0.29).</P><P><B>Conclusions</B></P><P>To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.</P>

Characterization and Profiling of Liver microRNAs by RNA-sequencing in Cattle Divergently Selected for Residual Feed Intake

Al-Husseini, Wijdan,Chen, Yizhou,Gondro, Cedric,Herd, Robert M.,Gibson, John P.,Arthur, Paul F. Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.10

MicroRNAs (miRNAs) are short non-coding RNAs that post-transcriptionally regulate expression of mRNAs in many biological pathways. Liver plays an important role in the feed efficiency of animals and high and low efficient cattle demonstrated different gene expression profiles by microarray. Here we report comprehensive miRNAs profiles by next-gen deep sequencing in Angus cattle divergently selected for residual feed intake (RFI) and identify miRNAs related to feed efficiency in beef cattle. Two microRNA libraries were constructed from pooled RNA extracted from livers of low and high RFI cattle, and sequenced by Illumina genome analyser. In total, 23,628,103 high quality short sequence reads were obtained and more than half of these reads were matched to the bovine genome (UMD 3.1). We identified 305 known bovine miRNAs. Bta-miR-143, bta-miR-30, bta-miR-122, bta-miR-378, and bta-let-7 were the top five most abundant miRNAs families expressed in liver, representing more than 63% of expressed miRNAs. We also identified 52 homologous miRNAs and 10 novel putative bovine-specific miRNAs, based on precursor sequence and the secondary structure and utilizing the miRBase (v. 21). We compared the miRNAs profile between high and low RFI animals and ranked the most differentially expressed bovine known miRNAs. Bovine miR-143 was the most abundant miRNA in the bovine liver and comprised 20% of total expressed mapped miRNAs. The most highly expressed miRNA in liver of mice and humans, miR-122, was the third most abundant in our cattle liver samples. We also identified 10 putative novel bovine-specific miRNA candidates. Differentially expressed miRNAs between high and low RFI cattle were identified with 18 miRNAs being up-regulated and 7 other miRNAs down-regulated in low RFI cattle. Our study has identified comprehensive miRNAs expressed in bovine liver. Some of the expressed miRNAs are novel in cattle. The differentially expressed miRNAs between high and low RFI give some insights into liver miRNAs regulating physiological pathways underlying variation in this measure of feed efficiency in bovines.

Software Architecture of KHU Automatic Observing Software for McDonald 30-inch telescope (KAOS30)

Tae-Geun Ji,Seoyeon Byeon,Hye-In Lee,Woojin Park,Sang-Yun Lee,Sungyong Hwang,Changsu Choi,Coyne A. Gibson,John W. Kuehne,Travis Prochaska,Jennifer Marshall,Myungshin Im,Soojong Pak 한국천문학회 2018 天文學會報 Vol.43 No.1

Genome wide QTL mapping to identify candidate genes for carcass traits in Hanwoo (Korean Cattle)

이승환,Julius van der Werf,이상홍,임다정,박응우,Cedric Gondro,윤두학,오성종,김언현,John Gibson,John Thompson 한국유전학회 2012 Genes & Genomics Vol.34 No.1

Meat quality traits are the most economically important traits affecting the beef industry in Korea. We performed a whole genome quantitative trait locus (QTL) mapping study of carcass data in Hanwoo Korean cattle. Two hundred sixty-six Hanwoo steers from 65 sires were genotyped using a 10K Affymetrix SNP chip. The average SNP interval across the bovine genome was 1.5Mb. Associations between each individual SNP and four carcass traits [carcass weight (CWT),eye muscle area (EMA), back fat thickness (BFT), and marbling (MAR)] were assessed using a linear mixed model of each trait. Combined linkage and linkage disequilibrium analysis (LDLA) detected six potential QTL on BTA04, 06, 13,16, 17, and 23 at the chromosome-wise level (P<0.05). Two MAR QTL were detected at 52.2 cM of BTA06 and 46.04cM of BTA17. We identified three genes (ARAP2,LOC539460, and LOC511424) in the QTL region of BTA06and seven genes (RPS14, SCARB1, LOC782103, BRI3BP,AACS, DHX37, and UBC) in the QTL region of BTA17. One significant QTL for CWT was detected at 100 cM on BTA04and the corresponding QTL region spanned 1.7 cM from 99.7to 101.4 cM. For EMA QTL, one significant QTL was detected at 3.9 cM of BTA23 and the most likely QTL interval was 1.4 cM, placing 15 candidate genes in the marker bracket. Finally, two QTL for BFT were identified at 68 cM on BTA13and 24 cM on BTA16. The LPIN3 gene, which is functionally associated with lipodystrophy in humans, is located in the BFT QTL on BTA13. Thus, two potential candidate genes, acetoacetyl-CoA synthetase (AACS) and lipin (LPIN), were detected in QTL regions on BTA17 for MAR and BTA13 for BFT,respectively. In conclusion, LDLA analysis can be used to detect chromosome regions harboring QTL and candidate genes with a low density SNP panel, yielding relatively narrow confidence intervals regarding location.