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Peptide hydrogel with self-healing and redox-responsive properties
D’Souza Areetha,Marshall Liam R.,Yoon Jennifer,Kulesha Alona,Edirisinghe Dona I. U.,Chandrasekaran Siddarth,Rathee Parth,Prabhakar Rajeev,Makhlynets Olga V. 나노기술연구협의회 2022 Nano Convergence Vol.9 No.18
We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.
Software Architecture of KHU Automatic Observing Software for McDonald 30-inch telescope (KAOS30)
Tae-Geun Ji,Seoyeon Byeon,Hye-In Lee,Woojin Park,Sang-Yun Lee,Sungyong Hwang,Changsu Choi,Coyne A. Gibson,John W. Kuehne,Travis Prochaska,Jennifer Marshall,Myungshin Im,Soojong Pak 한국천문학회 2018 天文學會報 Vol.43 No.1