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Culture supernatant proteins of Brucella canis represented potential antigenicity
Jin Ju Lee(Jin Ju Lee),So-Ra Sung(So-Ra Sung),Eun Ji Yum(Eun Ji Yum),Sung Dae Yang(Sung Dae Yang),Min Hoe Lee(Min Hoe Lee),Bang-Hun Hyen(Bang-Hun Hyen),Moon Her(Moon Her),Hee Soo Lee(Hee Soo Lee) 한국예방수의학회 2018 한국예방수의학회 학술대회자료집 Vol.2018 No.-
( Ji Hyen Lee ),( Han Wool Kim ),( Jihei Cha ),( Kyung-hyo Kim ) 대한소아감염학회 2021 Pediatric Infection and Vaccine Vol.28 No.1
목적: Streptococcus agalactiae (group B streptococcus [GBS])은 신생아, 임산부 및 성인에서 침습성 감염의 주요 원인균이다. 면역체계가 손상되거나 약화된 경우, 잘 알려진 10개의 GBS 혈청형 중 흔하지 않은 IV, VI-IX에 의해 침습적인 질환이 발생할 수 있다. 그러나, 지금까지 사람의 혈청 및 정주용 면역글로불린(intravenous immunoglobulin, IVIG) 제제 중 GBS의 흔하지 않은 혈청형에 대한 옵소닌 항체(opsonophagocytic antibody) 활동은 연구되지 않았다. 면역글로불린 치료 요법은 일차 항체 결핍증(primary antibody deficiency, PAD) 환자의 침습적 감염을 치료하거나 예방하는 데 사용된다. 이 연구에서는 면역글로불린에서 GBS에 대한 옵소닌 항체 활성을 평가하고자 한다. 방법: 2015-2016년 국내 두 회사에서 사용가능한 16개 면역글로불린에 대하여 7개 GBS 혈청형 (II 및 IV-IX)에 대한 옵소닌 항체 활성도(opsonic index [OI])를 HL-60 세포와 아기토끼 보체를 사용하여 옵소닌 분석법(opsonophagocytic assay)을 통해 분석하였다. (UAB GBS OPA, http://www.vaccine.uab.edu). 결과: 모든 면역글로불린 제제에서 GBS에 대한 OI의 검출 한계점(≥4)을 초과하였다. 혈청형 VII의 경우, OI 값은 6-136으로 모든 혈청형 중에서 가장 낮았다. IVIG의 최저 수준(trough level)을 추정해볼 때, 일반적인 면역글로불린 용량 (400 mg/kg)은 PAD 환자에게 침습성 GBS 감염을 예방하기 위한 적합한 용량으로 보인다. 결론: 국내에서 사용중인 면역글로불린 제품은 GBS에 대한 높은 수준의 옵소닌 항체 활성을 나타냈다. 면역글로불린은 PAD 환자에게 유용한 치료 또는 예방조치가 될 수 있을 것으로 보인다. Purpose: Group B streptococcus (GBS) is a causative organism of invasive infections in neonates and pregnant women as well as in non-pregnant adults. Among 10 known serotypes of GBS, uncommon serotypes, such as IV and VI to IX, can cause invasive infections in immunocompromised patients. However, opsonophagocytic antibodies against these serotypes in human sera and intravenous immunoglobulin (IVIG) have not yet been studied. IVIG therapy is used to treat or prevent invasive infections in patients with primary antibody deficiencies. Here, we analyzed the activity of opsonophagocytic antibodies against GBS in IVIG preparations. Methods: Opsonophagocytic antibody activity (opsonic index [OI]) against seven GBS serotypes (II and IV to IX) was evaluated in 16 commercially available IVIG preparations using the opsonophagocytic assay (OPA) in HL-60 cells and baby rabbit complement assay during 2015-2016 in South Korea (UAB GBS OPA, at http://www.vaccine.uab.edu). Results: The estimated serum trough levels of OIs against GBS exceeded the limit of detection (≥4) in all IVIG preparations. For serotype VII, the serum levels of OIs were 6-136, the lowest among all serotypes. An IVIG dose of 400 mg/kg was found to be appropriate for immunocompromised individuals to prevent invasive GBS infections. Conclusions: Most immunoglobulin products displayed high levels of opsonophagocytic activity against GBS, except for serotype VII. IVIG preparations could serve as a therapeutic or immunomodulatory agent for immunocompromised individuals.
Pseudohypoparathyroidism type 1b due to paternal uniparental disomy of chromosome 20q: A case report
Ji Hyen Lee,Hae Soon Kim,Gu-Hwan Kim,Han-Wook Yoo 대한의학유전학회 2017 대한의학유전학회지 Vol.14 No.1
Pseudohypoparathyroidism type 1b (PHP 1b) is the result of end organ resistance to parathyroid hormone (PTH) in the absence of any features of Albright’s hereditary osteodystrophy. There are two subtypes of PHP 1b with different genetic mechanisms. One subtype is related to a maternally derived 3kb microdeletion involving STX 16 gene, and is inherited in an autosomal dominant mode. Familial autosomal dominant inheritance of PHP 1b is relatively rare. The other subtype is associated with more extensive loss of imprinting at the GNAS locus that affects at least one additional differential methylated (hypermethylation at neuroendocrine secretory protein and hypomethylation at antisense transcript and or extra-large stimulatory G protein region) without microdeletion of the STX 16 or AS gene. It can be sporadic due to an imprinting defect in the GNAS gene. In our case, an 8-year-old girl was referred for suspected PHP with no feature of Albright hereditary osteodystrophy. Blood test results revealed hypocalcemia and hyperphosphatemia. Elevated PTH was also checked. There was no family history of endocrine or developmental problem. Her intelligence was normal, but she had inferior sociability at that time. Based on above, we diagnosed a rare case of paternal uniparental disomy of the long arm of chromosome 20 as the cause of PHP 1b by microsatellite marker test of chromosome 20.
Pseudohypoparathyroidism type 1b due to paternal uniparental disomy of chromosome 20q: A case report
Lee, Ji Hyen,Kim, Hae Soon,Kim, Gu-Hwan,Yoo, Han-Wook Korean Society of Medical Genetics and Genomics 2017 대한의학유전학회지 Vol.14 No.1
Pseudohypoparathyroidism type 1b (PHP 1b) is the result of end organ resistance to parathyroid hormone (PTH) in the absence of any features of Albright's hereditary osteodystrophy. There are two subtypes of PHP 1b with different genetic mechanisms. One subtype is related to a maternally derived 3kb microdeletion involving STX 16 gene, and is inherited in an autosomal dominant mode. Familial autosomal dominant inheritance of PHP 1b is relatively rare. The other subtype is associated with more extensive loss of imprinting at the GNAS locus that affects at least one additional differential methylated (hypermethylation at neuroendocrine secretory protein and hypomethylation at antisense transcript and or extra-large stimulatory G protein region) without microdeletion of the STX 16 or AS gene. It can be sporadic due to an imprinting defect in the GNAS gene. In our case, an 8-year-old girl was referred for suspected PHP with no feature of Albright hereditary osteodystrophy. Blood test results revealed hypocalcemia and hyperphosphatemia. Elevated PTH was also checked. There was no family history of endocrine or developmental problem. Her intelligence was normal, but she had inferior sociability at that time. Based on above, we diagnosed a rare case of paternal uniparental disomy of the long arm of chromosome 20 as the cause of PHP 1b by microsatellite marker test of chromosome 20.
Oh, Ji-Woong,Lee, Ji-Yong,Lee, Myeong-Sub,Jung, Hyen-Ho,Whang, Kum,Brain Research Group, Brain Research Group The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.2
Objective : This study analyzed the relationship between prognosis and multiple clinical factors of ruptured middle cerebral artery (MCA) aneurysm with intracerebral hemorrhage (ICH), to aid in predicting the results of surgical treatment. Methods : Enrolled subjects were 41 patients with ruptured MCA aneurysm with ICH who were treated with surgical clipping. Clinical factors such as gender, age, and initial Glasgow coma scale were assessed while radiological factors such as the volume and location of hematoma, the degree of a midline shift, and aneurysm size were considered retrospectively. Prognosis was evaluated postoperatively by Glasgow outcome scale. Results : Age and prognosis were correlated only in the groups with ICH over 31 mL or ICH at the frontal lobe or sylvian fissure. When initial mental status was good, only patients with ICH on the temporal lobe had a better prognosis. If the midline shift was less than 4.5 mm, the probability of better prognosis was 95.5% (21 of 22). If the midline shift was more than 4.5 mm, the probability of poor prognosis was 42.1% (8 of 19). Patients with ICH less than 31 mL had higher survival rates, whereas if the ICH was more than 31 mL, 41.2% (7 of 17) had a poor clinical pathway. Conclusion : Even if the initial clinical condition of the patient was not promising, by carefully examining and taking into account all factors, neurosurgeons can confidently recommend surgical treatment for these patients.