Effect of recombinant human epidermal growth factor against scar formation after Cesarean section : a randomized controlled trial

( Jeong Ha Wie ),( Sin Young Kim ),( Woo Jeng Kim ),( Su Been Hong ),( Ji Young Kwon ),( In Yand Park ),( Ji Hye Jo ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: Recombinant human epidermal growth factor(rhEGF) is a cicatrizant that promote wound healing though formation of scar tissue and is used to treat a diabetic foot ulcer. This study aimed to evaluate the effect of topical rhEGF on hypertrophic scar formation by applying it to Cesarean scar. Methods: We conducted a randomized placebo-controlled trial evaluating the efficacy of the rhEGF on hypertrophic scar formation after Cesarean section. Women who underwent Cesarean section by single obstetrician from Apr 2019 to Dec 2019 were randomized. The degree of hypertrophic scar was compared between the rhEGF application group and placebo group at postpartum 6 and 12 week, respectively. Efficacy was determined by modified Vancouver scar scale(mVSS). Results: 64 women were randomized into two arms, 33 topical rhEGF applied group and 31 placebo group. There was no significant difference by maternal age, BMI, nulliparity, hypertension, diabetes, and multifetal pregnancy. There was no significant difference in mVSS evaluated between the two group at postpartum 6 weeks. At postpartum 12 weeks, the rhEGF applied group had better mVSS than the placebo group, with median of 7.0 (Interquartile range(IQR) 6.0-9.0) versus 6.0(IQR 5.0-7.5), respectively (p=0.013). The difference was statistically significant in pigmentation of the mVSS (p<0.001). Conclusion: Applying topical rhEGF to a cesarean scar seems to have the effect of reducing the pigmentation of the scar. Using topical rhEGF might be useful for improving the cosmetic outcomes of Cesarean scar.

Cerclage for sonographic short cervix in singleton gestations without prior spontaneous preterm birth

( Jeong Ha Wie ),( Ji Sun Lee ),( Ji Young Kwon ),( Hyun Sun Ko ),( In Yang Park ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: The aim of this study was to quantify the efficacy of cervical cerclage in preventing preterm birth (PTB) in singleton pregnancies with a short midtrimester cervical length (CL) on transvaginal sonography (TVS) and without prior spontaneous PTB. Methods: This was a retrospective cohort study of women with singleton pregnancy for midtrimester (16+0~27+6weeks) short cervix with CL <25 mm. Out study consisted of women delivered at Seoul St. Marys and Eunpyeong St. Marys hospital between Jan 2013 and Dec 2019. The decision to perform cerclage was based on individual physician preference. Demographic data; information on CL status; medical, obstetric, and social history; cerclage vs no cerclage; and neonatal outcomes were compared. Primary outcome was PTB <37weeks. Secondary outcome was PTB <34 weeks and prolongation of pregnancy latency . The risk of PTB was separately analyzed by dividing the CL into 10, 15, 20, and 25mm or less, respectively. Results: A total of 213 women with short cervix before 27+6weeks of gestation were identified. Among the women with shortened CL <25 mm, 107 women (50.2%) had cervical cerclage. The mean gestational age at delivery was not significantly different between women who performed cerclage (37.0 weeks) vs. those who did not (36.3 weeks). In women with a CL of less than 20mm, the rate of PTB < 37, 34 weeks were significantly lower in the cerclage group : 36.6% vs 19.2%, 21.4% vs 8.0%, respectively (p=0.038, 0.037). The rate of spontaneous PTB < 37 weeks remained significantly after controlling for confounders (adjusted odds ratio 0.37,95% CI 0.16-0.86) The risk of PTB <37 weeks were significantly lower in the cerclage group in women with a CL less than 15mm (odds ratio(OR) 0.26, 95% CI 0.07-0.93). In women with a short CL less than 15 and 10mm before 25 weeks of gestation, the risk of PTB < 37 weeks were significantly lower in the cerclage group (OR[95% CI] 0.14[0.04-0.52], 0.13[0.02-0.89], respectively). The risk of sPTB were higher in the cerclage group(35.0% vs. 25.0%) in women with CL >20mm. Conclusion: In singleton gestations without prior spontaneous PTB but with CL<25mm before 27+6 weeks of gestation, cerclage does not seem to prevent preterm delivery. However, in these pregnancies, cerclage seems to be efficacious at lower CLs, such as 20mm or less, requiring further studies in these subgroups. Given the low quality of evidence, further welldesigned RCTs are needed to confirm the findings of this study.

Association between blood viscosity in preeclampsia and combined fetal growth restriction

( Jeong Ha Wie ),( Sin Young Kim ),( Hyun Sun Ko ),( In Yang Park ),( Jong Chul Shin ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: This study was done to assess the relationship between blood viscosity in normal pregnancies and those complicated with preeclampsia and FGR. Methods: A case-control study involving 60 women with FGR, and 354 uncomplicated women. The FGR group was further subdivided into normotensive and hypertensive women. The blood sampling obtained just before delivery. We compared the maternal blood viscosity and umbilical cord blood viscosity between the three groups. Results: Age, BMI, and maternal weight were comparable in the groups, while gestational age at delivery as well as fetal outcome parameter were statistically significant unfavourable in patients with hypertensive FGR. The mean of the systolic viscosity in women with hypertensive FGR was significantly greater than those with normotensive FGR and uncomplicated women ( 4.696 (±1.044) mP vs4.220 (±0.704)mP, 4.350(±0.824)mP, respectively, p=0.007). The mean oxygen delivery index in women with hypertensive FGR was significantly lower than other 2 group. (8.309(±1.312) vs 8.537(±1.399) vs 8.779(±1.0438), respectively, p=0.045). Conclusion: Increased blood viscosity may be associated with the hypertensive FGR. However, further validation of these findings with more robust multicenter prospective and longitudinal characterization of blood rheology in pregnancy should be carried out.

The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Wie, Jinhong,Kim, Byung Joo,Myeong, Jongyun,Ha, Kotdaji,Jeong, Seung Joo,Yang, Dongki,Kim, Euiyong,Jeon, Ju-Hong,So, Insuk TaylorFrancis 2015 Channels Vol.9 No.4

<P>TRPC4 is important regulators of electrical excitability in gastrointestinal myocytes, pancreatic β-cells and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gα<SUB>i/o</SUB> and Gα<SUB>q</SUB> protein coupled receptor or epidermal growth factor and leptin in particular. However, our understanding of the roles of small G proteins and leptin on TRPC4 channels is still rudimentary. We discuss potential roles for Rasd1 small G protein and leptin in channel activation in addition to their known role in cellular signaling.</P>

중소규모 사업장의 환자의뢰체계 모형 개발

김정연,하은희,박혜숙,안형숙,안진숙,위자형 梨花女子大學校 醫科大學 醫科學硏究所 1999 EMJ (Ewha medical journal) Vol.22 No.2

연구 목적 : 본 연구에서는 중소규모사업장 근로자의 의료이용행태 및 의뢰체계에 대한 필요도를 조사하고, 이 자료를 근거로 이화여자대학교 의과대학 부속 목동병원과 동대문병원을 3차기관으로 하여 중소규모 사업장의 환자의뢰체계의 모형을 만들고자 하였다. 방법 : 1998년 4월부터 5월까지 대한산업보건협회 서울지부의 210개 보건관리대행 사업장 중 57개 사업장을 대상으로 각 사업장당 근로자 5명씩 무작위로 선발하여, 총 근로자 213명을 대상으로 설문조사를 하였다. 설문결과를 바탕으로 대한산업보건협회와 이화의료원의 환자 의뢰체계를 개발하였다.의뢰체계를 1년간 시범운영한 후 근로자들의 만족도를 조사하였다. 결과 : 의료기관 이용시의 불편사항으로는 접수, 예약, 절차 등의 절차가 번거로움과 근무시간과 진료시간의 불일치를 가장 많이 호소하였으며 생산직과 사무직의 차이는 없었다.외부 병원 연계의 필요성에 대하여는 젠체 대상자 중 76.7%가 필요하다고 대답한 반면 거리가 멀다면 68.8%가 이용하지 않겠다고 대답하였다. 의뢰체계가 도움을 주어야 할 내용으로는 가급적 빠른 진료, 질병이나 검사결과에 대한 자세한 설명, 진단과 치료의 신뢰감, 검사결과의 신속한 통보, 회송소견서 발부, 직업적 폭로요인 고려의 순으로 나타났다. 병원이용이 편리한 시간으로 일과 후(64.7%)가 가장 많이 나왔으며 85.6%에서 야간진료가 필요하다고 응답하였다. 조사대상자의 91.9%가 가족들이 진료의뢰체계에 포함되기를 원하였다. 98년 2월부터 99년 1월까지 의뢰체계를 통하여 이대병원을 이용한 총 근로자 수는 30명이었다. 근로자들의 병원서비스에 대한 만족도는 비교적 높게 나타났으나, 후송소견서가 교부, 직업성 요인의 고려는 잘 되지 않은 것으로 나타났다. 결론 : 앞으로 의뢰체계를 활성화하기 위해서는 근로자와 사업장에 대하여는 의뢰체계와 서비스 내용에 대한 정확한 홍보, 병원에서의 야간진료실시, 직업성 질환자의 진료를 위한 임상각과와 예방의학과의 공식적인 의뢰체계 수립이 필요하다고 생각된다. Objectives : This study was designed to develop the referral system of patient in small-sized industries and the medical delivery system in occupational health field. Methods : We sampled randomly 5 workers per each company in 57 companies and investigated the healthcare utilization behavior, the need for referral system. The survey was done from April 1. 1998 to May 30. 1998 and the respondents were 213. On the basis of the results, we planned model for the referral system between Korean Industrial Health Association(KIHA) and Ewha Medical Center(EMC). Results : The complaints of the utilization of medical service are cumbersome process of registration and reservation, and discord between hours of duty and consultation. The referral system is needed in 76.7% of total respondents. 85.6% of workers want the night clinic, and 91.3% want to be included their family in this referral system. We developed the referral system linking KIHA, EMC, and department of preventive medicine of Ewha Woman's University, which based on the result of survey. The service reflect the worker's the healthcare utilization behavior and need for referral system. The number of workers who referred by this system between Feb. 1998 and Jan. 1999 was 30, and replied by EMC after treating was 12. The number of referred patient is very law(30 spells), but the satisfaction of medical service is relatively high. Conclusion : To promote the referral system, it is needed to propaganda the service of referral system to workers and managers of each company, to improve of quality of services of the hospital, and to establish the official referral system between department of preventive medicine of Ewha woman's university and each clinical department of Ewha Medical Center.

일개 농촌지역 주민의 소규모 공장으로 인한 보건생활환경에 관한 인식도 조사

김정연(Jeong-Youn Kim),정윤재(Yun-Jae Jung),성유미(Yu-Mi Sung),하은희(Eun-Hee Ha),위자형(Cha-Hyung Wie) 한국농촌의학 지역보건학회 2000 농촌의학·지역보건 Vol.25 No.1

Inhibition of nitric oxide synthase expression in activated microglia and peroxynitrite scavenging activity by Opuntia ficus indica var. saboten.

RYU Jae-Ha,LEE Ming Hong,KIM Jae Yeon,YOON Jeong Hoon,LIM Hyo Jin,KIM Tae Hee,JIN Changbae,KWAK Wie- Jong,HAN Chang-Kyun 대한약학회 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.2

Pregnancy complications in women with polycystic ovary syndrome

( Jung Hwa Song ),( Woo Jeong Kim ),( Hyun Sun Ko ),( Ki Cheol Kil ),( Youn Hee Kim ),( Jae Eun Shin ),( Jeong Ha Wie ),( Yun Sung Jo ),( Sae Kyung Choi ) 대한산부인과학회 2021 대한산부인과학회 학술대회 Vol.107 No.-

An Experimental Study on the Ultrasonic Machining Characteristics of Engineering Ceramics

Ik Soo Kang,Jeong Suk Kim,Yong Wie Seo,Jeon Ha Kim 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.2

Engineering ceramics have many unique characteristics both in mechanical and physical properties such as high temperature hardness, high thermal, chemical and electrical resistance. However, its machinability is very poor in conventional machining due to its high hardness and severe tool wear. In the current experimental study, alumina (Al₂O₃) was ultrasonically machined using SiC abrasives under various machining conditions to investigate the material removal rate and surface quality of the machined samples. Under the applied amplitude of 0.02㎜ 27㎑ frequency, three slurry ratios of 1:1. 1:3 and 1:5 with different tool shapes and applied static pressure levels, the machining was conducted. Using the mesh number of 240 abrasive, slurry ratio of 1:1 and static pressure of 2.5㎏/㎠, maximum material removal rate of 18.97㎣ /min was achieved. With mesh number of 600 SiC abrasives and static pressure of 3.0㎏/㎠, best surface toughness of 0.76㎛ Ra was obtained.

An Experimental Study on the Ultrasonic Machining Characteristics of Engineering Ceramics

Kang Ik Soo,Kim Jeong Suk,Seo Yong Wie,Kim Jeon Ha The Korean Society of Mechanical Engineers 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.2

Engineering ceramics have many unique characteristics both in mechanical and physical properties such as high temperature hardness, high thermal, chemical and electrical resistance. However, its machinability is very poor in conventional machining due to its high hardness and severe tool wear. In the current experimental study, alumina $(Al_2O_3)$ was ultrasonically machined using SiC abrasives under various machining conditions to investigate the material removal rate and surface quality of the machined samples. Under the applied amplitude of 0.02mm, 27kHz frequency, three slurry ratios of 1:1, 1:3 and 1:5 with different tool shapes and applied static pressure levels, the machining was conducted. Using the mesh number of 240 abrasive, slurry ratio of 1:1 and static pressure of $2.5kg/cm^2$, maximum material removal rate of $18.97mm^3/min$ was achieved. With mesh number of 600 SiC abrasives and static pressure of $3.0kg/cm^2$, best surface roughness of $0.76{\mu}m$ Ra was obtained.