수지침요법이 중학생의 복통 완화에 미치는 효과

강현숙 ( Kyoul Ja Cho ),조결자 ( Hyun Sook Kang ) 경희대학교 동서간호학연구소 2007 동서간호학연구지 Vol.13 No.1

본 연구는 10-12세 사이에서 가장 빈도가 높은 복통(Oh, 1996)의 구급처치 방안으로 수지침이 효과적인지 확인하기 위해 시도하였다. 수지침요법은 손을 몸의 축소판으로 생각하여 수지 안에는 인체의 내장이 있고, 14경맥이 있으므로 이를 자극하여 치료 하는 자극요법으로 수지침요법은 상응점에 가는 침(needle)으로 1mm 깊이의 자극을 주어 치료하는 것을 말한다. 수지침과 같은 상응요법은 수지의 신체 해당부위(상응부)에서 과민 반응점(상응점)이 나타나는 부위에 자극을 주는 방법을 말하므로 수지 안에 있는 복통 상응점을 자극하면 통증이 감소된다(Yoo, 2001). 뿐만 아니라, 수지침은 약물 남용으로 인한 부작용과 내성등에 의한 위험 등 일체의 후유증이 없고 질병예방이 가능하며, 효과가 빠르고 시술이 간편하며 경제적이어서 원할 때 즉시 시술이 가능한 요법이다(Kim & Cho, 2001), 그러므로 학교보건실에서 복통완화를 위한 치료로서의 활용가능성을 검토하기 위하여 학교 보건실에 내방한 중학생을 대상으로 통증완화 효과를 검증하였다. 그 결과 수지침에 의해 주관적으로 느끼는 통증이 완화되었음을 보여주었고, 객관적인 통증척도 중 발한정도는 수지침 요법을 적용한 실험군에서 적용하지 않은 대조군 보다 유의하게 발한이 감소되었다. 또한 객관적인 통증척도인 안면표정과 음성변화에서는 비록 통계적으로는 유의한 차이를 보이지 않았지만 실험군이 대조군보다 통증완화점수의 감소폭이 컸었다. 이는 간헐성 복통 환아에 대한 수지침의 효과 검증결과 통증 강도가 감소하였음을 보고한 Hong(2005b)의 연구결과 와 유사하였다. 또한 두통완화를 위해 수지침을 시술한 결과 주관적 통증 점수와 객관적 통증 영역 중 음성변화 정도가 유의하게 감소하였다고 보고한 Cho와 Kang(2004)의 연구 결과와 복통, 요통 등의 증상을 보인 월경곤란증이 있는 대상자의 경우 수지침 요법이 뜸 요법보다 신속한 효과를 나타낸Kim과 Cho(2001)의 연구, 수지침이 여중생의 생리통 자각증상에 효과를 미치는 것으로 보고한 Moon(2003)의 연구결과에서도 수지침이 통증완화에 효과적이었으므로 본 연구 결과를 지지해주었다. 그러나 연구자마다 대상자들의 연령층이 각기 달랐고, 중학생을 대상으로 한 수지침요법의 효과에 관한 연구는 없었으며, 복통 환아를 대상으로 한 연구는 1편에 불과했기 때문에 본 연구와 정확히 비교하기는 어려웠다. 통증이란 경험하는 사람이 통증이라고 말하는 것은 무엇이나 통증이며 그가 통증이 있다고 말할 때는 언제나 존재 하는 것이다(McCaffery, 1977)고 하여 통증에 관하여 개인의 주관적인 느낌을 강조하고 있다. 객관적인 방법으로 통증을 측정한다고 하여도 수치상 큰 차이를 보이지 않으면 증명하기 어렵다. 그러므로 통증을 경험하고 있는 사람이 수지침 요법을 통해 통증이 완화되었다고 한다면 객관적인 면이 부족해도 본인의 느낌대로 통증이 감소하였다고 평가 할 수 있다. 더군다나 통증이 있을 때 객관적 통증반응 중 안면표정과 음성은 자신의 의지로 어느 정도 조절할 수 있지만 발한은 자신의 의지로 조절하기 어렵다. 따라서 통증의 객관적 반응인 발한정도가 감소되었다고 하는 본 연구의 결과는 비록 객관적 통증 반응인 안면표정이나 음성변화에 차이가 없었지만 이러한 맥락에서 수지침이 통증완화에 도움이 된다고 해석할 수 있다. 그러나 본 연구결과 안위 면에서는 수지침 요법의 효과를 나타내지 않았다. 통증이 완화되면 신체는 자연히 안락한 상태로 될 수 있을 것으로 보았으나 그렇지 못함을 보여주고 있다. 본 연구결과에서 객관적 통증반응이나 안위 면에서 통계적인 유의성이 검증되지 못한 것은 대상자 수가 적은 것과 대상자로부터 연구의 동의를 얻기는 했지만 침습적인 처치에 대한 두려움이 많은 연령층인 중학생이라는 점 등이라고 보아 앞으로는 대상자 수를 늘리며, 다른 연령층을 대상으로 하는 반복연구가 필요하다고 본다. 이상과 같이 본 연구결과 수지침은 복통환자의 주관적으로 느끼는 통증을 감소시키므로 수지침이 복통완화에 어느 정도 효과가 있음을 확인하였다. Purpose: The purpose of this study was to identify the effects of hand acupuncture on relieving of abdominal pain. Method: Fifty-five middle school students who complained abdominal pain were selected as subjects. There were 35 students in the experimental group while 20 students were in the control group. Convenience assignment was used. The experimental group received hand acupuncture treatment which was to puncture corresponding points (epigastric pain A8, A12, A16, K9, F4, E42; lower abdominal pain A1, A4, A6, A8, J1, H2) on both the palm and the back of a hand with disposable acupuncture needles, and then to remove them after a 20-30min. recess during the subjects was in supine position on a bed. Result: Degree of subjective pain decreased statistically in the experimental as compared to the control group. No statistical significant differences were found in objective pain and comfort between experimental and control group. Conclusion: These findings indicate that hand acupuncture is an effective method for reducing abdominal pain. Therefore, hand acupuncture could be considered as an independent nursing intervention for abdominal pain reduction.

적절한 용량 이하의 경구용 향응고제 사용 중 발생한 뇌출혈 환자의 임상 양상

조수진,황흥곤,나찬영,이영탁,최현배,조태구 世宗醫學硏究所 2000 世宗醫學 Vol.17 No.2

스프렌딜 지속정(펠로디핀 5㎎)에 대한 스타핀 지속정의 생물학적동등성

조혜영,강현아,이석,백승희,박은자,최후균,문재동,이용복 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

Felodipine is a calcium antagonist that lowers blood pressure by reducing peripheral resistance by means of a direct, selective action on smooth muscle in arterial resistance vessels. Furthermore, it have been approved for the effective in angina pectoris and cardiac failure. The purpose of the present study was to evaluate the bioequivalence of two felodipine extended release (ER) tablets, Splendil (YuHan Corporation) and Stapin (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). THe felodipine release from the two felodipine formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method at pH 6.5 buffer solution. Twenty six healthy male subjects, 22.73±1.78 years in age and 66.66±7.28 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 5 ㎎ as felodipine were orally administered, blood sample was taken at predetermined time intervals and the concentrations of felodipine in serum were determined using column-switching HPLC method with UV detector. The dissolution profiles of two formulations were similar at pH 6.5 buffer solution. Besides, the pharmacokinetic parameters such as AUG_(t), C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t) and C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Splendil were 2.53%, 1.32% and 18.32% for AUC_(t), C_(max) and T_(mzx), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.86)∼log(1.20) and long(0.89)∼long(1.23) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guidelines for the bioequivalence was satisfied, indicating Stapin ER tablet and Splendil ER tablet are bioequivalent.

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

침지용액이 강낭콩의 조리특성에 미치는 영향

趙銀子,全玄卿 誠信女子大學校 生活文化硏究所 1992 生活文化硏究 Vol.6 No.-

To investigate the characteristics of korean Kidney bean, the effect of soaking solution on water uptake and cooking properties during soaking In distilled water, 0.5% NaCl solution. 0.1% HaHC0_3+0.4% NaCl combination solution, 0.4% NaHC0_3+0.1% NaCl combination solution, 0.5% NaHCO_3 solution at 10˚-50℃ was studies. The weight of kidney bean soaking in various soaking solution increased as function of soaking temperature at 10˚-50℃. Under the 30℃ of soaking temperature, water equilibriumstate of kidney bean In various soaking solution was not reached in 12 hours, however, bean soaking in distilled water at 50℃reached water equilibrium after 11 hours of soaking and that of another four soaking solution reached water equilibrium almost in 7 hours. Water equilibrium content of kidney bean were 117.Ol% soaking in distilled water and 128.33% in 0.5% NaHCO_3, solution. Water uptake rate constant(K) of kidney bean in various soaking solution Increased as function of soaking temperature and the increase of water uptake rate constant was the highest in distilled water and the lowest in 0.5% NaHC0_3 solution. Activation energy for weight gain of kidney bean soaking in various solution at 10~30℃was 1.2 tlmes greater than that of 30˚∼50℃. The z-value of kidney bean soaking at 10˚∼50℃ decrease with increase hydration degree and z-value to reach 40% hydration estimated from weight increase was 122℃at 10˚∼30℃ and 40℃ at 30˚~50℃and z-value of bean in 0.5% NaHCO_3 solution was 82℃ at 10˚~30℃and 58℃ at 30˚∼50℃. Volume increase rate of kidney bean increased as function of soaking temperature and kidney bean soaking at 50℃ in various solution reached volume equilibrium state in 10 hours and among these bean in distilled water reached later than the other solutions. Volume increase rate constant increased with soaking temperature, among these the increase of kidney bean soaking in 0.5%t NaHCO_3 solution was the highest. The z-value of 40% hydration estimated volume increase decreased with increase hydration degree. The time to reach a complete cooking of kidney bean In distilled water was 35 minutes, the longest and the time was reduced to 11, 7, 5 and 3 minutes soaking in 0.5% NaHCO_3.solution. 0.4% NaHCO_3+0.1% NaCl combination solution, 0.1% NaHC0_3+0.4% NaCl combination solution 0.5% NaHCO_3 solution, respectively. When the kidney bean was cooked for 20 minutes after soaking 0.575 NaHC0_3 solution, the cooking rate was faster than that of the other solution. Cooking rate constant of kidney bean in 0.5% NaHCO_3 solutions. Kidney bean in 0.5% NaHCO_3 solution. cooking rate constant of the first stage was the highest. which was 5 times of the constant of the second stage and in distilled water, the cooking rate constant of the first stage was about 7 times of the second stage.

리스페달 정(리스페리돈 2㎎)에 대한 리스펜 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,박찬호,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two risperidone tablets, Risperdal (Janssen Korea Co., Ltd) and Rispen (Myung In Pharm. Co., Ltd), according to the guidelines of Korea Food and Drug Administration (KFDA). The risperione release from the two risperidone formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various of dissolution media (pH 1.2, 4.0, 6.8 butter solution and water). Twenty four healthy male subjects, 23.33±2.10 years in age and 69.24±8.05 kg in body weight, were divided into two groups and a randomized 2×2 crossover study was employed. After one tablet containing 2 ㎎ as risperidone was orally administered, blood was taken at predetermined time intervals and the concentration of risperidone in serum were determined using HPLC method with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Risperdal were 0.20, -1.29 and -11.09% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.90)∼log(1.03) and log(0.84)∼log(1.09) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Rispen tablet and Risperdal tablet were bioequivalent.

一方向凝固시킨 Al-Cu-Mg共晶合金의 機械的 性質에 미치는 時效의 影響

趙顯驥,康晃鎭,趙美子 慶北大學校 1982 論文集 Vol.33 No.-

The microstructure and mechanical properties of unidirectionally solidified Al-Cu-Mg eutectic alloys have been studied in as-grown and aged condition. After unidirectionally solidification, specimens of solution treated and quenched eutectic were at 180°, 230°, 260℃ in a salt bath for various time. The results obtained are as follows; 1) Precipitation on hardening of the ductile phase is a feasible mechanism for strengthening of composites. 2) Mechanical Testing of the tenary eutectic has shown that composite is strengthened about 30 to 50% by ageing. 3) Tensile and compression strength of this composites are 25 and 70kg/㎟ by ageing treatment in growth 0.1mm/min. 4) The unidirectionally solidified structure are changed by ageing. It seems that the low Cu and Mg solute atoms are likely due to epitaxial precipitation onto CuAl_2 lamellar respectively.

中·高等學校 敎科課程中 健康敎育內容에 關한 硏究

趙潔子,姜賢淑 慶熙大學校 1980 論文集 Vol.10 No.-

The purpose of the study was to survey the proportion of the health education contents in the textbook of middle and high schools according to the grades and subjects, and to offer basic resources for reorganization of textbooks and for the utilization of manpower in the near future. This study was reffered to 589 textbooks which were reorganized in 1979 and edited in 1980, and was concentrated upon 38 textbooks contain health education contents. The results of this study is as follows: 1. Health education contents in the textbook of middle school 1) By grade, the order was 1st grade(17.3%), 3rd grade(16.8%), and 2nd grade(6.6%), Major health education items of each grade was of nutrition(32.6%) in the 1st grade, environmental sanitation(45.2%), in the 2nd grade, and anatomy and physiolosy(21.1%) child care(19.2%) in the 3rd grade. 2) By subject, the proportion of Health education contents between Home economics (16.6%) and Health education(15.3%) was similar, but Science(10.3%) shows low proportion. Major health education items of each subject was of Accident and emergency care(17.3%) in the Physical education, Nutrition(30.5%) in the Home economics and Anatomy and physiolosy(55.8%) in the Science. 2. Health education contents in the textbook of high school 1) By subject, the order was Physical education(29.9%), Military drill(26.7%), Home economics(24.1%) and Biology(23.4%), but there was no significant difference. Major health education items of each subject was of Social medicine and health institute(13.7%) Accident and emergency care(13.3%) in the Physical education, Accident and emergency care(55.9%) in the Military drill, Nutrition(40.4%) in the Home economics, and Anatomy and physiology(68.3%) in the Biology. However, there was a difference on quantity and priority of Health education contents according to the characteristics of subject. 2) In the technical department, the order of contents which were related with health education was House hold technical department(93.3% out of subjects in total unit 102-156), Agricultural technical department(41.8% out of 3 subjects in total unit 102-156), Physical technical department(31.5% out of 2 subjects in total unit 102-156), and Industrial technical department(8.6% out of I subject in total unit 114-156). 3. Health education contents according to the educational grade (course) in the textbooks The rate of unit which was contained Health education contents was similar between middle and high school: male; 15-17 unit, female; 24-26 unit out of the total unit 96-105 in the middle school and male; 34-40 unit, female; 42-50 unit out of the total unit 192-210 in the high school. The proportion of contents in the high school was two times higher(25.9%) than in the middle school(13.9%).

최근 10년간 마취에 관한 임상적 고찰 (Ⅲ)

조현숙,김윤희,손수창,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the specificity and the historical trends of the anesthetic agents and anesthetic methods used in Chungnam national university hospital, anesthetic experiences of 53,291 in total performed at Chungnam national university hospital from January 1987 to December 1996 were analized statistically and clinically according to age, sex, surgical department, physical status, elective to emergency surgery, premedicants, induction agents, anesthetic methods, main anesthetic agent, anesthetic technique and muscle relaxants. The results were as follows : L The number of cases has been steadily increased in annually. 2. The distribution of the number of patients according to the age were cases 37,309(70.02%) in the group of 13-60 years. 3. There were 27,448 male (51.5%) and 25,843 female (48.5%) cases. 4. 9,208 cases (17.27%) were OB-GY, 9,162 cases (17.19%) in general surgery, 7,936 cases(14.89%) in orthopedic surgery, and 6,079 cases (11.4%) in ENT in order of numbers. 5. According to the ASA classification of physical status , most of the cases were belonged to the class 1 (38.69%) class 2 (40.33%) class 1E (5.52%) class 2E (5.71%). Almost cases were relatively in good physical status. 6. The number of elective to emergency was 7,833 (89.76%), to 5,458 (10.24%) cases. 7. As premedicants, a group of glycopyrrolate (35.20%) was given most frequently. 8. Thiopental sodium has been mainly used for intravenous induction agent. 9. General anesthesia has been used as main method of anesthesia. 10. Enflurane was the most commonly used anesthetic agent. 11. Vecuronium was the most commonly used non-depolarizing muscle relaxant.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.