여성호르몬대체요법을 받는 폐경 후 여성에서의 혈청 C-reactive Protein 수치 변화

황승욱,최국명 제주대학교 생명과학연구소 2002 제주생명과학연구 Vol.5 No.6

연구배경: 폐경 후 여성에서 여성호르몬 대체요법 치료는 관상동맥질환의 위험을 감소시킨다고 알려져 있지만 최근 발표된 연구에서는 기존에 관상동맥질환을 갖고 있는 폐경 후 여성에서 1년 내의 관상동맥질환의 위험이 증가했다가 시간경과에 따라 위험이 감수한다는 사실을 보여 주었다. 한편 혈청 C-reactive protein(CRP)의 등가는 광상동백질환의 독립적인 위험인자로 인정되고 있다. 이에 저자들은 여성호르몬 대체요법을 받는 폐경 후 여성을 대상으로 여성호르몬 대체요법이 혈청 CRP 수치의 변화와 관련성이 있는가를 알아보기 위해 본 연구를 시행하였다. 방법: 1995년 5월 1일부터 2001년 5월 31일까지 일개대학병원 건강증진센터에서 1년 정도의 간격으로 연속 3회 이상 건강검진을 받은 여성 188명 중에서 의무기록 열람과 전화조사를 통해 40세 이상 70세 미만으로 일개대학병원 가정의학과에서 처음으로 폐경 후 여성호르몬 대체요법을 받기 시작한 여성 40면을 대상으로 연도별로 혈중 CRP 수치의 변화를 분석하였다. 결과: 여성호르몬 대체요법 후의 혈중 CRP 농도는 고혈압 군에서 1년후의 CRP의 증가가 있었으나(P<0.05). 2년 후에는 기저수치에 비해 의미 있는 차이가 없었다. 비고혈압 군에서는 1년 후와 2년 후 모두 의미 있는 차이가 없었다. 결론: 본 연구에서는 특히 고혈압이 있으면서 폐경 후 여성호르몬대체요법을 받는 여성에서 시간적 경과에 따라 혈중 CRP 수치가 단기적으로 증가하였다가 점차 감소하는 경향을 보였다. Background: It was known that postmenopausal estrogen replacement therapy(ESP) decreased the risk of coronary heart disease. A recent study reported that the risk of coronary heart disease had a pattern of increase and decrease during ERT in postmenopausal women with coronary disease. The increase of Serum C reactive protein level was accepted as an independent risk factor of coronary heart disease. In this study, we tried to analyze the relationship between ERT in postmenopausal women and the change of CRP level. Methods: The study population was composed of 40 postmenopausal women who first started HRT in Health Promotion Center of University Hospital from May 5, 1995 to May 31, 2001. We checked their CRP level yearly. Results: In the group composed of postmenopausal women with hypertension, there was significant increase of CRP level(P<0.05) in 1 year ERT. But CRP level in 2 year after ERT was not significantly different from baseline level. In the group composed of postmenopausal women without hypertension. CRP level was not significantly changed 1 year after nor 2 year after. Conclusions: In this study, the CRP level showed the pattern of short-term increase and then decrease with time trend in postmenopausal women with hypertension.

Isolation and Identification of the Antioxidant DDMP from Heated Pear (Pyrus pyrifolia Nakai)

Hwang, In Guk,Kim, Hyun Young,Woo, Koan Sik,Lee, Sang Hoon,Lee, Junsoo,Jeong, Heon Sang The Korean Society of Food Science and Nutrition 2013 Preventive Nutrition and Food Science Vol.18 No.1

We evaluated antioxidant activities of heated pear juice (HPJ) exposed to 120, 130, and $140^{\circ}C$ for 2 hr. HPJ was partitioned using n-hexane, chloroform, ethyl acetate, n-butanol, and water. The ethyl acetate fraction treated at $130^{\circ}C$ for 2 hr showed strong antioxidant activity; thus, this extract was isolated and purified using silica gel column chromatography and preparative high performance liquid chromatography. The structure of the purified compound was determined using ultraviolet and mass spectrometry, $^1H$-nucelar magnetic resonance (NMR), and $^{13}C$-NMR. Antioxidant activities of the isolated compound were evaluated and compared with ${\alpha}$-tocopherol, ascorbic acid, and butylated hydroxytoluene (BHT) using DPPH and ABTS assays. The isolated compound was identified as 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP). The DPPH radical-scavenging activity ($IC_{50}$) of DDMP occurred in the following order: ascorbic acid ($45.3{\mu}g/mL$) > ${\alpha}$-tocopherol ($69.2{\mu}g/mL$) > DDMP ($241.6{\mu}g/mL$) > BHT ($268.0{\mu}g/mL$). Furthermore, DDMP showed strong ABTS radical-scavenging activity (569.0 mg AA eq/g).

Revised-BERD : A Computer Code for Updating Reliability Data Using Bayes´ Theorem Bayes 정리를 이용한 신뢰도 자료개선용 전자계산기 코드

Hwang, Won-Guk,Cho, Dae-Hyung 慶熙大學校 1987 論文集 Vol.16 No.-

로그정규분포를 채택하여 특정 원자력발전소 안전성 계통을 신뢰도 분석을 위한 자료평가의 목적으로 개발된 전산코드 BERD가 개선되고 시험되었다. 모우먼트 일치법과 최대공산법을 이용하여 감마 및 베타 선분포의 모수를 추정하는 옵션이 추가되었다. Revised-BERD를 이용한 시험결과, 로그정규분포가 감마 및 베타분포와 비교하여 보수적임을 보여 주었다. A Computer code, BERD, which accepts only log-normal distribution. has been revised and tested in odrder to update the data for the reliability analysis of safety related systems in a specific nuclear power plant. New options are added to estimate the parameters of gamma and beta prior-distributions facilitating the matching moment and the maximum likelihood methods. The test results using the Revised-BERD show that the log-normal distribution is conservative compared with gamma and beta distributions.

A Comparative Study on the Fault Diagnosis Using Fuzzy Set Concept

Hwang, Won-Guk Korean Nuclear Society 1986 Nuclear Engineering and Technology Vol.18 No.3

본 논문은 Fuzzy관련공식의 역문제에 대한 해석방법론의 비교연구를 제시하고 있다. 여기서 Fuzzy 집합은 완전한 Brouwerian격자에의 투영으로 정의된다. 현재까지 관련공식의 역해석은 세가지 다른 결과로 연구되고 있어, 이를 이용하여 원자력발전소 주급수펌프의 고장진단에 적용하여 검토하였다.

A New Stationary Phase with Improved Ligand Morphology Prepared by Polymerization of Styrene upon Initiator-attached Lichorsorb Silica Particles

Hwang, Dong-Guk,Zaidi, Shabi Abbas,Cheong, Won-Jo Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.12

Use of chain transfer agent attached to silica particles in preparation of polystyrene-based stationary phases

Hwang, Dong Guk,Zaidi, Shabi Abbas,Cheong, Won Jo WILEY-VCH Verlag 2010 Journal of Separation Science Vol.33 No.4

<P>A new stationary phase has been prepared by attaching a new chain transfer agent on silica particles followed by reversible addition-fragmentation chain transfer polymerization. Porous silica particles were reacted with 3-chloropropyltrimethoxysilane followed by sodium diethyl dithiocarbarmate. The silica particles were then allowed to undergo radical polymerization with styrene. The phase had improved ligand morphology to show better separation performance than that of the conventional C18 phase.</P>

Effects of Different Cooking Methods on the Antioxidant Properties of Red Pepper (Capsicum annuum L.)

Hwang, In Guk,Shin, Young Jee,Lee, Seongeung,Lee, Junsoo,Yoo, Seon Mi The Korean Society of Food Science and Nutrition 2012 Preventive Nutrition and Food Science Vol.17 No.4

We investigated the effect of various cooking methods (boiling, steaming, stir-frying, and roasting) and three cooking times (5, 10, and 15 min) on the antioxidant properties of red pepper. Raw and cooked peppers were measured for proximate composition, ascorbic acid (AsA) content, total carotenoid content (TCC), total polyphenol content (TP), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging activities. Results showed that the proximate composition, AsA content, TCC, TP, and antioxidant activities were significantly (p<0.05) affected by the cooking procedure; the loss rate varied among individual compounds. Boiling and steaming significantly reduced AsA content (24.3~66.5%), TP (13.9~54.9%), and antioxidant activity (21.7~60.5%) in red pepper, while stir-frying and roasting slightly reduced AsA content (2.7~25.9%), TP (1.8~4.9%), and antioxidant activity (4.9~17.9%). The highest loss was observed after boiling, followed by steaming, roasting, and stir-frying. Stir-frying and roasting better preserved AsA content, TCC, TP, and antioxidant activity. In conclusion, dry-heat cooking methods such as stir-frying and roasting may be preferred to retain the nutrient compositions and antioxidant properties of red pepper.

Nucleotide sequence analysis of the 5S ribosomal RNA gene of the mushroom tricholoma matsutake

Hwang, Seon-Kap,Kim, Jong-Guk The Microbiological Society of Korea 1995 The journal of microbiology Vol.33 No.2

From a cluster of structural rRNA genes which has previsouly been cloned (Hwang and Kim, in submission; J. Microbiol. Biotechnol.), a 1.0-kb Eco RI fragment of DNA which shows significant homology to the 25S and rRNA s of Tricholoma matsutake was used for sequence analysis. Nucleotide sequence was bidirectionally determined using delection series of the DNA fragment. Comparing the resultant 1016-base sequence with sequences in the database, both the 3'end of 25S-rRNA gene and 5S rRNA gene were searched. The 5S rRNA gene is 118-bp in length and is located 158-bp downstream of 3'end of the 25S rRNA gene. IGSI and IGS2 (partial) sequences are also contained in the fragment. Multiple alignment of the 5S rRNA sequences was carried out with 5S rRNA sequences from some members of the subdivision Basidiomycotina obtained from the database. Polygenetic analysis with distance matrix established by Kimura's 2-parameter method and phylogenetic tree by UPGMA method proposed that T. matsutake is closely related to efibulobasidium allbescens. Secondary structure of 5S rRNA was also hypothesized to show similar topology with its generally accepted eukaryotic counterpart.

산성일기 연구 - 구어적 성격과 문어체의 실현에 대하여 -

황국정 ( Hwang Guk-jeong ) 배달말학회 2021 배달말 Vol.68 No.-

「산성일기」는 작품의 저자, 필사 시기, 필사 동기에 대한 재검토 및 자료의 언어학적 분석과 해석을 중심으로 본 연구를 시작하였고, 연구의 결과를 정리하면 다음과 같다. 산성일기는 청음 김상헌이 전쟁의 폐허 속에서 피폐해져 간 조선 땅의 회복을 위해 처절한 몸부림으로 문학가의 정신을 발휘한 실기류 고발 문학이다. 또한, 전쟁 중의 비참한 심정, 냉혹한 마음 대신 용서의 마음이 드러난 일기체 기록류이다. 이 자료는 근대 초기, 중기의 구어의 실현 양상과 구어 구문의 다양한 유형, 구어문 안에서 실현되는 문어체의 형성 및 그 과정에 대해 알 수 있는 산문기록류이다. 산성일기는 근대 초중반 국어사 자료들과 비교하여 볼 때 구어의 다양한 사례들을 확인할 수 있으며, 구어와 구어문안에 실현된 문어체의 예를 살펴볼 수 있다. 또한, 당시의 구어문 안의 다양한 실현 방식에 대해서도 언어 자료 분석을 통해 살펴보았고, 이로써 근대 초기 국어의 모습을 구어의 모습을 반영한 필사 자료 산성일기를 통해 고찰해 봄으로써 구어문 속의 몇 문어체의 유형과 그 실례에 대해서 구체적으로 논의해 보았다. The sansung il-gi is manuscripts for the description of Korean modern Language. This materials represents on the spoken language of the modern korean language. The author is presumed Kim, sang hun, is a great writer on the Chosun Dynasty. Sansung ilgi shows the value of the speaking and writing.

비균일 조명에서 색도의 국지성에 기반한 색 항등성

황동국(Hwang Dong Guk),이우람(Lee Woo Ram),전병민(Jun Byoung Min) 한국통신학회 2011 한국통신학회 학술대회논문집 Vol.2011 No.11