비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

Al_2O_3를 첨가한 LaFeO_3 박막의 암모니아 가스감지 특성

이복상,조철형,최부천,박기철,마대영,김정규 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

LaFeO_3 thin films with 2%, 5% and 10% A1_2O_3 additives were fabricated by r.f. magnetron sputtering method on Al_2O_3 substrates. Structural, electrical and ammonia gas sensing characteristics of the thin films with different heat treatments were examined. From the XRD results, the compound of LaFeO_3 and Al_2O_3 was not found. Thin film with 5% Al_2O_3 additives, heat-treated at 800℃, showed the sensitivities of about 85% for 100ppm ammonia gas at the working temperature of 300℃. The response time to the ammonia gas was several seconds and the thin film showed good selectivity to NH_3 gas.

엄지발가락에 발생한 건초 섬유종 1예

이경호,조유경,한예원,김진아,김형민,박철종 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

콘크리트 내 철근 부식도의 비파괴 측정을 위한 수치 해석 모델링

이형우,임홍철 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The corrosion state of a reinforcing steel bar in concrete, characterized by the electrical impedance of the interface between the steel bar and the concrete, can be measured indirectly with an array of current and voltage electrodes on the concrete surface. The measured impedance, however, depends on the electrical resistivity of the concrete, the depth and diameter of the steel reinforcing bar as well as the interfacial properties. To relate the measured impedance directly to the interfacial properties, a closed form solution to the governing Poisson's equation for the potentials from arbitrary current sources in the vicinity of the reinforcing bar have been applied to an numerical analysis model. The solution uses an impedance boundary condition for the complex impedance at the steel-concrete interface. The response of an arbitrary corrosion state can be simulated in this model by embedding the appropriate complex, frequency-dependent impedance at the interface and computing the voltage/current response that would be measured for an arbitrary placement of electrodes on the concrete surface. This simulation confirms that important parameters of the interfacial impedance controlling corrosion kinetics such as polarization resistance and double layer capacitance are clearly observed in the measured surface data.

肝蛭(Fasciola hepatica)의 脂質에 關한 硏究

李純炯,宋哲鏞 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1

The present study was undertaken to observe the quality and quantity of lipids in the adult worms of sheep liverfluke, Fasciola hepatica. Lipid extract was done by the methods of Folch et al. (1957) and Kenny (1952), and the the extracted lipid fractions of the worms were separated by thin layer chromatography. Those fractions were also subjected to perform the quantitative analyses of glycerides, cholesterols and phospholipids. The results obtained were summarized as follows. 1. Total amount of glyceride was 45.29㎎ per gram wet weight of worm tissue: the amount of monoglyceride was 4.46㎎; diglyceride, 13.59㎎; and triglyceride, 25.63㎎ per gm wet weight of worm tissue. 2. Total amount of cholesterol was 8.10㎎ per gm wet weight of worm tissue, and the amount of esterified cholesterol(5.21㎎/gm) was much more than that of free cholesterol (2.15㎎/gm). 3. The following 10 phospholipids were detected in the worm tissue of F. hepatica, i.e., lysophosphatidylcholine, phosphatidylinositol, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and three species of unknown phospholipides.

Bacillus thuringiensis var. darmstadiensis 와 var. sotto의 내독소와 Bacillus thuringiensis var. kurstaki가 생산하는 아밀라제의 연구

이형환,김삼찬,황광현,임창로,조용칠,정인명 건국대학교 교육대학원 1991 敎育論叢 Vol.15 No.-

Endotoxin crystals produced by B.thuringiensis var. darmstadiensis cultured in modified GYS medium over 72 h were ovoidal in shape and separated using Renografin gradient centrifugation. The crystal protein bands were observed. When B.thuringiensis var sotto was grown in the modified GYS broth, it entered stationary phase at 8-9 h after inoculation. Proteinaceous crystals were banded at the position in 40% of Renografin gradient. The solubilized crystal proteins were formed by two bands, 130 Kd and 68 Kd in the SDS-PAGE. One plasmid was observed in B.thuringiensis var darmstadiensis and no plasmid in var. sotto in this study. Enzyme activity of amylase produced B.thuringiensis var kurstaki strain in the basal medium was 0.4 units per ml, and was enhanced to 0.6 units per ml in the basal medium contained soluble starch, Ca^++, Mg^++ and Mn^++ ions. Amylase production medium containing soluble starch was suitable for the amylase production and the highest activity appeared at 4-6 h after cultivation at 32℃. The amylase activity obtained by ethanol precipitation was 0.20 units per ml in 0.1 M phosphate buffer. The band of the molecular weight of 50 Kd was observed by SDS-PAGE analysis. Km value of the amylase for the soluble starch was 6.80 mg per ml.

專門大學 體育舞踊科 敎育課程의 開發硏究

李鐵煥,金泰亨,李任仙,姜信和 진주여자전문대학 1986 論文集 Vol.8 No.-

Peripheral, soft tissue odontoma에 관한 증례보고

이종갑,최병재,최형준,이광출 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

1. Peripheral odontoma는 매우 드문 질환으로 확진을 위해서는 생검이 필수적이다. 2. Peripheral odontoma는 치은의 종창을 동반하며 서서히 성장하는 임상적 특징을 가진다. 3. 골내 치아종과 마찬가지로 Peripheral odontoma의 치료로는 완전한 외과적 절제가 추천되고 예후 또한 양호하다. Odontomas, hamartomas of odontogenic origin, are composed of all the structures that make up teeth. The WHO distinguishes odontoma into two types. The complex odontoma is defined as "a malformation in which all the dental tissues are represented, individual tissues being mainly well-formed but occurring in a more or less disorderly pattern." The compound odontoma is defined as "a malformation in which all the dental tissues are represented in a more orderly pattern than in the complex odontoma, so, that the lesion consists of many toothlike structures. Most of these structures do not resemble morphologically the teeth of normal dentition, but in each one enamel, dentine, cementum, and pulp are arranged as in the normal tooth." Almost all odontomas are located intraosseously, but they have occasionally been reported in extrabony location. Peripheral or soft tissue odontomas, those arising outside of the alveolar bone, are very rare. Peripheral or soft tissue odontoma are defined as tumors that demonstrate the histologic characteristics of their intraosseous counterparts but occur solely in the soft tissue covering the toothbearing portion of the mandible and maxilla, When they mature, they appear as a radiopaque mass without the peripheral halo. The final diagnosis should be confirmed by biopsy. The origin of peripheral odontoma is probably related to remnants of the dental lamina in the gingiva. The treatment of choice is complete surgical excision, similarly to intraosseous odontoma and it does not tend to recur. This report presents a case of 5-year-old boy with swelling on labial gingiva of primary central incisor. And it was diagnosed as peripheral odontoma by excisional biopsy.

敎科課程을 中心으로 한 韓日農學系(園藝·食品·獸醫)大學의 敎育現況 調査

李愚升,孫泰華,尹衡植,毛麒喆 경북대학교 1982 새마을 硏究論叢 Vol.2 No.-

The authors studied on the curicullum between Korea and Japan in the deaprtments of horiculture, food technology and veterinary. The results are as follows. 1. In the department of horticulture, professional education period was 3 years in Korea while 2 or 2.5 years in Japan. These results were compared among 3 colleges of Korea and Japan. Credits for graduation was 48-52% for propessional education with submajoring subjects and 45% when majoring subject in Korea, but 54-61% in Japan. Credits for required subjects were 17-29% among credits for graduation in Korea while 28-29% in Japan. 2. Cultural education period is almost 1 year in Korea, but different in Japan. Credits for graduation are as follows; Cultural education is 36-37%, majoring fields 15% and the others 12-13% in Korea while 43-46% for cultural education, 54-57% for majoring field in Japan. Differences were shown among 3 colleges dealt with the department of food technology by locational characteristics in Japan. 3. In the department of Veterinary, collage curicullums were not fixed for the students because of transitional period. Required subjects among 4 colleges were shown as the same tendency in Korea.

하수슬러지 소화조내 음식물쓰레기 투입시 고형물분해에 관한 연구

이영형,성낙창,박출재 동아대학교 환경문제연구소 1998 硏究報告 Vol.21 No.2

This study aims to find a solution to the problem how to treat increasing food waste as time goes on. And this study develops the digesting method of mixing food waste and sewerage sludge as a part of treating food waste. sewerage sludge and food waste were digested in mesophilic condition with the mixing ratio of 1 to 0.1, 1 to 0.3, 1 to 0.5, 1 to 1 and 1 to 2 respectively for 40 days. As the result, the digester(tank) with mixture packing of food waste showed stable in about 11days of digestion period, and in particular, in case of 1 to 0.1 as mixing proportion, removal of VS was the most enormous. The highest chlorine ionic concentration in digestion showed 4700mg/l, which didn't have great effects on removal of VS.