임플란트의 collar design이 변연골과 연조직에 미치는 영향

유현상,강선녀,정창모,윤미정,허중보,전영찬 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

연구 목적: 임플란트 경부가 잘 설계된 경우 양호한 연조직 반응을 통해 변연골을 보존하는데 도움이 된다. 본 실험에서는 연, 경조직 경계부에 가장 가까이 위치하는 임플란트의 collar design이 변연골 변화와 연조직 반응에 미치는 영향을 동물실험을 통해 알아보고자 하였다. 연구 재료 및 방법: 2마리의 건강한 Beagle dog에 임플란트 collar design만 다른 두 종류의 임플란트(Neobiotech Co. Seoul, Korea)를 식립하였다. Collar에 bevel 을 부여한 군(Bevel 군)과 "S"자 형태를 부여한 군(Bioseal 군)으로 나누어 마리 당 7개, 군당 7개, 총 14개의 임플란트를 무작위로 식립한 후 Healing abutment를 즉시 체결하였다. 디지털 표준구내 방사선사진을 이용해 4주 간격으로 총 12주간 근원심 변연골 변화를 관찰하였고, 12주에 희생하여 조직학적 분석을 통해 협설 변연골 흡수 및 임플란트 주변 연조직 반응을 평가하였다. Mann-Whitney test를 통해 동일한 방사선 사진 촬영 시점에서 근원심 변연골 변화량 및 조직계측치를 군 간 비교하였고, Kruskal-Wallis test를 통해 방사선 사진상 근원심 변연골 변화량이 시간에 따른 차이가 있는지 군 내 분석 한 후 Duncan test를 통해 사후 검증하였다(α=.05). 결과: 방사선학적 분석 결과 각 촬영 시점에서 두 군간 근원심 변연골 변화량의 차이를 보이지 않았다(P>.05). 군 내에서 시간에 따른 근원심 변연골의 흡수량을 분석한 결과 Bevel 군에서는 시간에 따른 차이를 보이지 않았으나 (P>.05), Bioseal 군에서는 시간에 따른 차이를 보였으며, 4주및8주와 비교했을 때 12주에서 변연골의 증가를 보였다(P<.05). 조직학적 분석 결과 협설측 변연골 흡수량에서 두 군간 차이를 보이지 않았으나 (P>.05), Bevel 군에 비해 Bioseal 군에서 더 견고한 결합조직부착을 관찰할 수 있었으며, 생물학적 폭경의 값은 두 집단 간 차이를 보이지 않은 반면에 (P>.05), 접합상피부착은 Bevel 군에서 유의하게 길었고, 결합조직부착은 Bioseal 군에서 더 길게 나타났다(P<.05). 결론: Bevel 군에 비해 Bioseal 군에서 결합조직부착은 길게 형성된 반면에 접합상피부착은 더 짧게 나타났으며, 생물학적 폭경과 초기 변연골 흡수에는 차이가 없음을 알 수 있었다. 연조직 반응의 차이가 실제 기능하중 하에서 변연골 변화에 미치는 영향에 대해서 향후 연구가 필요할 것으로 생각된다. PURPOSE. The purpose of this study was to investigate the effects of implant collar design on marginal bone change and soft tissue response by an animal test. MATERIALS AND METHODS. Two types of Implant (Neobiotech Co. Seoul, Korea) that only differs in collar design were planted on two healthy Beagle dogs. The implants were divided into two groups, the first group with a beveled collar (Bevel Group) and the second group with "S" shaped collar (Bioseal group). Standardized intraoral radiographs were used to investigate the mesio-distal change of the marginal bone. Histological analysis was done to evaluate the bucco-lingual marginal bone resorption and the soft tissue response adjacent to the implant. Mann-Whitney test was done to compare the mesio-distal marginal bone change at equivalent time for taking the radiographs and the tissue measurements between the groups. RESULTS. Radiographic and histological analysis showed that there was no difference in marginal bone change between the two groups (P>.05). Histological analysis showed Bioseal group had more rigid connective tissue attachment than the Bevel group. There was no difference in biological width (P>.05). Bevel group showed significantly longer junctional epithelium attachment and Bioseal group showed longer connective tissue attachment (P<.05). CONCLUSION. For three months there were no differences in marginal bone change between the Bevel group and the Bioseal group. As for the soft tissue adjacent to the implant, Bioseal group showed longer connective tissue attachment while showing shorter junctional epithelium attachment. There were no differences in biologic width.

閔翁傳 硏究

姜賢模 한양대학교 한국학연구소 1989 韓國學論集 Vol.15 No.-

Min-Ong Chun (life story)-the story of Min-Ong who is a humorist, satirist and hsa string tongue-is a work of Yun-am (燕岩). In this thesis, Min-Ong Chun was analyzed laying stress on the structural side of work, the personality and constitution of characters, the me- aning of narrative structure, and the consciousness of writer. The structure of Min-Ong Chun is divided into four parts, the introductory part, the development part, the conclusion (denouement) part, and the historical repute(史評 ; 誅時). In the constitution of characters, Min-Ong, I(Yun-am himself), Min-Ong's wife, arguing guest, and attendant person were examined by their charater and role in the work. And the consciousness of write was investigated through an implied meaning and thought in the event classfied by. Yun-am attempted to rouse the contradiction in the social structure and ruling class of the day, which were indulged in highbrow and ideological thought, through the quick-witted person, Min-Ong. Saying in addition, Yun-am expanded his rational and utilitarian manner by this work and established the base for realism.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

李夢鶴 說話의 硏究

姜賢模 한양대학교 한국학연구소 1988 韓國學論集 Vol.13 No.-

This study will be showed How Lee mong hak's(as a rebel) tales (李夢鶴說話) can be understood, and I studied the aspects of narratice structure of failed heroic story. To see the inherent meanings, Lee mong hak (李夢鶴), who was a rebel in history, standed out a hero in oral tales, which is transmitted from generation to generatin and limitted in mainly Buyo province. Because of the historical fact of being failed in Lee's rebellion, the Iim-itaion of his story became konown to differing from any athon heroic oral tales. I did study the narrative stucture to see the narrative model of Lee's failed heroic story. In the aspects of failed heroic story, I, the normal and potential form is showed the mystery birth in birth's story, It. didn't raise the conflict of the world 2. In growing story we found his mystery, the side of a soldier grows up well without a hindrance but the side of a wise was lost the opportunity of acqusition because the destruction of taboos was mode to 3. In action story, the side of a soldier was offirmed but the side of a wise was denied because of the lack of the wisdom 4. The lost stroy was failed in eventually (consequently) the lack of harmony both. This narrative structue of failed heroic story was revealed in initial study, and it will be proved it's approriateness to story failed men's story in many ways.

우리 나라의 정부회계제도에 관한 연구

안현숙,강승모 거제전문대학 1998 論文集 Vol.6 No.-

Governmental accounting has non-profit accounting which is characteristic of budget accounting and fund accounting. The korean governmental accounting has no regular or normal basis of governmental accounting, and has the cash basis of accounting and single-entry bookkeeping system, and lacks integrity and clarity of accounting because the number of special accounting and fund are too large. There is a big problem in the aspect of the usefulness of accounting information in the korean governmental accounting because of no making out the financial statement. As a result, the measurement, bookkeeping, and report have to be made by accural accounting in the korean governmental accounting system like that of the U.S.A. and the basis of governmental accounting has to include accounting principles which has the basis of business accounting.

효율적인 CRM 운영을 위한 고객 요구 집단에 의한 일정계획 수립에 관한 연구

양광모,전현정,강경식 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - The biggest difficulty the small and small business currently face is not to have the effective cusomer management system that is the computerization of management, And, CRM has many problems that make companies confused. As the result, projects are being suspended and budgets cut, plans for introducing CRM suspended or cancelled and many CRM software vendors and technical consulting firms are facing serious management crisis. Yet, this phenomenon can be regarded as an interim one. In fact, some cases that successfully introduced CRM show that CRM is migrating from small scale which is typical when introduced to larger scale through various tests. Therefore, this study tries to segment customer for the solving the problem. And it make efficient customer management. The product process is sequence of all the required activities that a company must perform to develop, and manufacture a product. These activities include marketing, research, engineering design, quality assurance, manufacturing, and a whole chain of suppliers and vendors. The process also comprises all strategic planning, capital investments, management decisions, and tasks necessary to create a new product. manufacturing processes must be created so that the product can be produced in the product facility. Purchasing new equipment and training workers may be required if new technology is to be used. Tools, fixtures, and the sequence of steps in the manufacturing processes must all be developed to allow rapid, high-quality, cost effective production. Also, it may be needed to be rearrange the production facility to adapt to the new manufacturing processes. Therefore, this study tries to proposed that Scheduling by customer needs group for minimizing the problem and reducing inventory, product development time, cycle time, and order lead time.

중소기업 효율성 향상을 위한 품질정보시스템 (Quality Information System) 개발

양광모,전현정,박주식,강경식 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

Abstract - The biggest difficulty the small and small business currently face is not to have the effective operation of management system that is the computerization of management, and the problem is the small and medium-sized company can not afford the expenses caused by maintaining and operating such huge man-powers and facilities. Therefore, in this study, we try to develope the Quality Information System allowing the effective outflow and management of information through the availability lf viewing and managing the information by the level by menas of setting the log-in levels for the operation of information, easy revision or medification in the changed structure and new assignment made and followed by the modularization of program. For the accomplishment of above purpose, the material coding work or process allowing the easy classification of materials by emplyees of the company through the in-house standardization of material classifying standard is the foundation for the fast data processing so, it must be achieved first. And also, the purpose of this study is for inducement of the production management and quality control operated by companies to the computerization and automation, and we try to develop the DB Design allowing the realtime monitoring the ordered quantity to quantity to be delivered and output through a unit of PC and the increased consequence with the other works by monitoring the output at the site through the central PC instead of the system monitoring the output at the site by the manager for accomplishment of this purpose.

금산군 버드내 유역 구비전설의 전승 양상

박종수,강현모 용인대학교 인문사회과학연구소 2007 인문사회논총 Vol.- No.14

본고는 금산군 <버드내 유역의 구비설화>에 수록된 설화들의 전승 양상의 개괄적인 특징을 살펴보았다. 우선 버드내 유역이란 금산군의 하천을 중심으로 분류할 때 금산군 북부지역의 동쪽에서 서쪽으로 흐르는 버드내가 이루고 있는 추부(마전)분지와 산악지역의 조그만 분지를 이루고 있는 진산지역과 복수지역을 통칭한 명칭이다. 이를 행정구역으로 보면 추부면, 진산면, 복수면 지역을 통칭하여 사용하였다. <버드내 유역의 구비설화>는 버드내 유역인 추부면, 진산면, 복수면 지역에서 1992년 7월부터 2006년 12월까지 현지조사 한 자료이다. 이들 자료들은 구연자들이 실제로 일어났던 사실이며 내용이 진실하다고 믿는 314편의 전설과, 사실성 여부와 상관없이 교훈과 흥미를 위주로 한 202편의 민담으로 나누어진다. 버드내 유역에서 조사자료를 총괄하면 전설의 각 하위 유형이 민담에서 가장 많은 ‘슬기와 웃음’ 유형보다 절대적으로 많다. 전설은 발생 목적에 따라 4가지 하위 유형으로 나누어 검토하였는데, 지명유래 89편, 역사전설 59편, 인물전설 72편, 신앙전설 92편이다. 버드내 유역의 구비설화의 특징이나 전승 양상은 금산군의 다른 유역과 비교 검토하였을 때 밝혀질 것이다. 이는 지금까지 조사한 금산군의 하천 유역별 자료들을 정리하여 지역별 구비설화의 특징을 조망하면 가능할 것이다. 또한 다른 시군의 구비설화와 비교 검토하여 금산군만의 특징을 찾아 금산군민의 정체성을 확립하고 지역 발전의 근거를 마련하여야 한다. This book has examined how the tales of <folklores of Kum-san-kun bud-nae area> has transmitted to and what is their character. First of all Bud-nae area is popular name of chu-bu basin which flows from north-east to west of Kum-san area, Jin-san area of small vally and other small villages. This area is called chu-bu-myun, Jin-san-Myun, Bok-su-myun. <Folklores of Kumsankun budnae area> is survey from July, 1992 to December, 2006 in chu-bu-myun, Jin-san-Myun and Bok-su-myun area. Those Data are divided to 314 legends and tales which believed to be true and 202 stories which are not true but interesting stories. When summarizing stories found in Bud-nae area, we can tell, there are 4 main subject and the most popular subject in other legends : wisdom and fun is not included in it. Legend is divided to 4 main subject. There are 89 stories of origins of the villiage name, 59 history , 72 personal stories and 92 stories of gods. And tale is divided to 5 main subject. There are 35 stories of family's ethics, 43 stories of destiny and reason, 51 unrealistic stories, 58 stories of wisdom and fun and 15 stories of animal's world. 15 stories of animal's world are small quantity comparing with other areas We can find more character and the way transmitted to when comparing with legends and tales of other village and area of Bud-nae. This can be solved when we collect the data of riverside areas of Kum-san-gun and find their character of district's legends. And we have to find the original character of Kum-san Kun's legend by comparing with other cities. So we can tell what is the original culture and thinking of Kum-san Kun's people and this will help them to find their true character and develop their own culture.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.