가와사끼 병 환아에서 이상뇌파와 신경학적 합병증 발현과의 연관성에 대한 고찰

박준수,공도연,박경배,민용식,김영창,정순이,이혜경 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

목적 : 가와사끼 병의 뇌파 소견 및 다른 임상인자들과의 연관성을 알아보고자 하였다. 방법 : 1994년 1월부터 1995년 12월 사이에 순천향대학 천안병원 소아과에 입원한 23명의 신경학적으로 정상인 가와사끼 병 환아에게 뇌파검사를 실시하여 이를 검사시기, 성별, 연령, 혈소판, 간기능 검사치, 그리고 동맥류 유무등의 임상인자들과 비교하였다. 결과 : 이상뇌파가 23명중 52.2%인 12명에게서 관찰되었으며, 이상뇌파로는 예파 및 극파, 극·서파 복합 양상과 전반적인 배경파의 서파양상이 나타났다. 뇌파의 검사시기가 진단부터 1주 이내인 경우에 이상뇌파의 빈도가 그 후보다 의미있게 높았으나, 그 밖의 다른 임상인자와의 연관성은 별 의미가 없었다. 결론 : 가와사끼 병 초기에 이상뇌파가 나타나는 것은 비록 신경적 증상은 없지만 중추 신경계가 영향을 받는다는 간접적인 증거로 생각할 수 있어 향후 신경적 합병증 발생 여부에 대한 면밀한 관찰이 필요하다고 생각된다. Purpose : This study is to find out if there is any association between EEG abnormalities in Kawasaki disease with other clinical factors. Methods : We performed EEG in 23 Kawasaki disease patients without any neurologic sign who admitted in Soonchunhyang Chunan Hospital from 1994. 1. to 1995. 12. and compared it with sex, age, platelet count, liver function test and presence of coronary artery aneurysm. Results : Abnormal EEG findings were observed in 12 of 23 patients(52.2%) and as for abnormal EEG findings, sharp, spike, spike & slow wave complex, and generalized slow background activity were noted. When EEG was performed within a week after the diagnosis, the incidence of abnormalities of EEG increased significantly but there was no correlation with other clinical factors. Conclusion : EEG abnormalities in the early stage of Kawasaki disease indicate that although there is no abnormal neurologic signs clinically, central nervous system might be affected and there should be a close observation for the developement of neurologic complication.

당뇨를 동반한 지속외래복막투석 환자에서 발생한 Neisseria sicca 복막염 1예

이혜민 ( Hyae Min Lee ),양인호 ( In Ho Yang ),이선희 ( Sun Hee Lee ),김선혜 ( Seon Hye Kim ),정다운 ( Da Wun Jeong ),정경환 ( Kyung Hwan Jeong ),이상호 ( Sang Ho Lee ),이태원 ( Tae Won Lee ),임천규 ( Chun Gyoo Ihm ),문주영 ( Ju Yo 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.2

Neisseria sicca is a Gram-negative diplococcus found in the human oral mucosa and upper respiratory tract. Although colonization generally does not result in severe infection, some cases of infection have been reported, particularly in immunocompromised individuals. However, Neisseria sicca has not been reported as a pathogen of continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis in Korea. Here we describe a case of CAPD-related peritonitis due to Neisseria sicca in a patient with poorly controlled diabetes mellitus undergoing peritoneal dialysis.

A Pilot Trial of Gemcitabine and Vinorelbine Plus Capecitabine in Locally Advanced or Metastatic Nonsmall Cell Lung Cancer

Lee, Dae Ho,Han, Ji-Youn,Yoon, Seong Min,Lee, Jae Jin,Lee, Hong Gi,Kim, Hyae Young,Yoon, Sung Jin,Hong, Eun Kyung,Lee, Jin Soo Lippincott Williams Wilkins, Inc. 2006 American journal of clinical oncology: cancer clin Vol.29 No.2

OBJECTIVES:: We conducted a pilot study of gemcitabine, vinorelbine and capecitabine combination to evaluate its toxicity and efficacy in chemo-naive patients with locally advanced or metastatic nonsmall cell lung cancer (NSCLC) after a short phase IB trial. METHODS:: Eligible chemo-naive patients with stage IIIB or IV NSCLC received outpatient administration of gemcitabine 900 mg/m and vinorelbine 25 mg/m intravenously on days 1 and 8, every 3 weeks, concurrently with capecitabine 1000 mg/m given orally twice a day on days 1 to 5 and 8 to 12 (dose level I), or days 1 to 6 and 8 to 13 (dose level II). RESULTS:: Between November 2002 and December 2003, 19 patients participated in the study at either dose level I (7 patients) or dose level II (12 patients). The maximum tolerated dose, defined as the dose at which no more than 1 of 6 patients in a cohort experienced a dose-limiting toxicity (DLT) in the first cycle, was not established. However, 1 of 7 patients at dose level I, and 2 of 12 at dose level II experienced DLTs (ie, grade 3 hepatotoxicity in 2 patients, and grade 3 febrile neutropenia in 1 patient). In addition, 2 patients experienced treatment-related pneumonitis requiring mechanical ventilator support after the second course of therapy. Objective tumor response was observed in 5 (26.3%) of 19 patients. Further patient accrual was stopped according to the study design. CONCLUSIONS:: This 3-drug combination showed disappointing antitumor activity against NSCLC with unexpected life-threatening pulmonary toxicity. No further investigation of this regimen is recommended for patients with NSCLC.

Pleural and pulmonary sparganosis : A case report

( Hyae Min Lee ),( Eun Jung Lee ),( Jee Hong Yoo ),( Cheon Woong Choi ),( Yee Hyung Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

High C-reactive protein level is associated with high-risk adenoma

( Hyae Min Lee ),( Jae Myung Cha ),( Jung Lok Lee ),( Jung Won Jeon ),( Hyun Phil Shin ),( Kwang Ro Joo ),( Jin Young Yoon ),( Joung Il Lee ) 대한장연구학회 2017 Intestinal Research Vol.15 No.4

Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk. Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea. Serum CRP level was compared between high-risk and low-risk adenoma groups and independent predictors of high-risk adenoma were analyzed using multivariate regression analysis. Results: Among the 3,309 eligible patients, the high-risk adenoma group had higher serum CRP levels than the low-risk adenoma group (P=0.000). In addition, patients with a high-risk adenoma were more frequently included in the high CRP group than in the low CRP group (8.6% vs. 4.0%, P<0.001). The prevalence of high-risk adenoma was 3.5 times higher in the highest quartile of CRP level (P=0.000) compared with that in the lowest quartile. In logistic regression analysis, a higher quartile CRP level was found to be an independent risk factor for high-risk adenoma (odds ratio, 1.8; 95% confidence interval, 1.3-2.5; P=0.000). Conclusions: High CRP level is associated with high-risk adenoma in both men and women. Our data may support the association between chronic inflammation and colorectal neoplasia, which warrants further investigation. (Intest Res 2017;15:511-517)

Pleural and pulmonary sparganosis : A case report

( Hyae Min Lee ),( Eun Jung Lee ),( Jee Hong Yoo ),( Cheon Woong Choi ),( Yee Hyung Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Sparganosis is a parasite infection caused by the larvae of cestodes in the genus Spirometra. While human sparganosis usually appears as subcutaneous nodules all over the body, it rarely involves the internal organs such as eye, brain, and spinal cord. Herein is presented a case of pulmonary sparganosis accompanying migrating infiltration and pleural effusion, which was confirmed by histological examination. A 57-year-old man was admitted with pleuritic pain lasting for 2 weeks. He had chronic alcoholic pancreatitis. He had eaten both wine-soaked snakes and the flesh of wild boar, and drunken unboiled stream water for past 3 years. At admission, chest x-ray and CT showed 4 x 3 cm sized ill defined mass in left lower lung and ipsilateral pleural effusion. Serum leukocytosis with eosinophilia was found. Analysis of pleural effusion was an exudative effusion with eosinophilia. After 10 days of admission, a new pneumonic infiltration and effusion appeared at right lung zone and previous lesion disappeared on chest radiography. Based on his eating habit, serum ELISA to detect parasite infection was performed and revealed strong positive reaction to sparganosis. For the confirmatory diagnosis and treatment, surgical excision was performed at right lower lobe. Sparganum larva was identified and removed. Histological examination showed that there was fragmented adult worm with characteristic calcareous corpuscle with eosinophilic infiltration and granuloma. On the 5th day after excision, serum eosinophil count was normalized and follow-up chest x-ray in outpatient clinic showed no more pleural effusion and pulmonary infiltration. This is a rare case of sparganosis limited to lungs all over the world. Though it is very rare, the possibility of sparganosis should be considered when eosinophilic pleural effusion and migration infiltration were faced in a patient with plausible history.

웹 기반 의료정보 서비스를 위한 멀티미디어 콘텐츠 저작시스템

이혜정(Hyae-Jung Lee),이민규(Min-Kyu Lee),정영식(Young-Sik Jeong),한성국(Sung-Kook Han),정석태(Suck-tea Joung) 한국컴퓨터정보학회 2005 韓國컴퓨터情報學會論文誌 Vol.10 No.4

인간의 건강한 삶을 위해 의료정보 서비스에 대한 수요가 급증함에 따라 웹 환경에서 상호작용적으로 작동할 수 있는 의료정보 서비스를 위한 멀티미디어 콘텐츠저작 시스템이 필요하다. 본 논문에서는 웹 기반 멀티미디어 지원 언어인 SMIL(Synchronized Multimedia Integration Language)을 이용하여 사용자 친화적 인터페이스 기능을 갖는 SMIL 기반 의료정보 서비스를 위한 멀티미디어 콘텐츠 저작시스템을 개발하였다. 본 논문에서 개발된 저작도구는 부분적으로 작성된 결과를 편집 즉시 재생하고 확인·수정할 수 있으며, 멀티미디어 객체를 간편하게 삽입할 수 있어 다양한 형태의 의료정보 요소를 포함한 멀티미디어 콘텐츠를 쉽게 저작할 수 있다. 또한 사용자의 편리성을 증대시켜 효과적으로 다양한 의료정보 서비스가 제공 가능한 멀티미디어 콘텐츠를 실현할 수 있다. According to the increasing interests of medical information services for healthy living, the multimedia authoring tools for medical information service contents are strongly required. In this paper, a new multimedia authoring tool supporting user-friendly interfaces is implemented, which is based on SMIL(Synchronized Multimedia Integration Language) producing Web-based multimedia contents. The implemented authoring tool in this paper not only provides functionalities to play, verify and modify the partial contents immediately but also offers capabilities to insert multimedia objects into contents with ease. The multimedia contents containing disparate healthcare and medical information can be easily designed with this tool. The enhanced usability of this tool can contribute to the realization of diverse medical information services.

CASE REPORT : Anaphylactic Shock Caused by Ingestion of Polyethylene Glycol

( Sun Hee Lee ),( Jae Myung Cha ),( Joung Il Lee ),( Kwang Ro Joo ),( Hyun Phil Shin ),( Il Hyun Baek ),( Jung Won Jeon ),( Jun Uk Lim ),( Jung Lok Lee ),( Hyae Min Lee ),( Young Hak Cho ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1

Colonoscopy is the current standard method for evaluation of the colon. The diagnostic accuracy and therapeutic safety of colonoscopy depend on the quality of colonic cleansing and preparation. Generally, all these preparations have been demon-strated to be safe for use in healthy individuals without significant comorbid conditions. Based on safety and efficacy concerns, polyethylene glycol (PEG) is most commonly utilized as a bowel preparation solution for colonoscopy. Adverse events in pa-tients receiving PEG are mostly clinically non-significant. However, fatal adverse events rarely have been shown to occur in the few individuals who experience vomiting or aspiration. Anaphylactic shock associated with ingestion of PEG electrolyte solu-tion is an extremely rare fatal complication, and reported mainly in Western countries. Here, we report the first case of anaphy-lactic shock following the ingestion of PEG solution in Korea. (Intest Res 2015;13:90-94)

혈구탐식성 림프조직구증이 동반된 성인형스틸병 1예

김광열 ( Kwang Yeol Kim ),최지영 ( Ji Young Choi ),이민혜 ( Min Hye Lee ),이정록 ( Jung Lok Lee ),양인호 ( In Ho Yang ),이혜민 ( Hyae Min Lee ),조영학 ( Young Hak Cho ),이유호 ( Yu Ho Lee ),이선희 ( Sun Hee Lee ),김동희 ( Dong Hee 전북대학교 의과학연구소 2014 全北醫大論文集 Vol.38 No.1

혈구탐식성 림프조직구증이 동반된 성인 형스틸병은 드물지만 치명적인 결과를 가져올 수 있기 때문에 조기에 병을 진단하고 일찍 적절한 치료를 시작하는 것이 중요하며 저자들은 골수천자 검사로 혈구탐식성 림프조직구증이 동반된 성인형스틸병 예를 경험하였기에 이에 문헌 고찰과 함께 보고하는 바이다. Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology. It is characterized by fever, skin rash, arthralgia, sore throat, hepatosplenomegaly, lymphadenopathy, leukocytosis, liver enzyme elevation, and high serum level of ferritin. Hemophagocyticlymphohistiocytosis is a rarerheumatic disease of life-threatening. Particularly, concomitant hemophagocyticlymphohistiocytosiswith AOSD could induce a fatal outcome. Thus it is important diagnos early and starttreatment. Here, we report a case of AOSD with concomitant hemophagocyticlymphohistiocytosis.

Novel Epigenetic Markers on Chromosome 21 for Noninvasive Prenatal Testing of Fetal Trisomy 21

Lee, Da Eun,Lim, Ji Hyae,Kim, Min Hyoung,Park, So Yeon,Ryu, Hyun Mee Elsevier 2016 The Journal of Molecular Diagnostics Vol.18 No.3

<P>Until now, fetal placenta–specific epigenetic markers for noninvasive prenatal testing of fetal trisomy 21 (T21) have been identified based only on differences in tissue-specific epigenetic characteristics between placenta and maternal blood, but these characteristics have not been validated in T21 placenta. We aimed to discover novel epigenetic markers on chromosome 21 that show a hypermethylated pattern in fetal placenta compared with blood, regardless of the presence of T21. We performed a high-resolution tiling array analysis of chromosome 21 using the methylated-CpG binding domain protein–based method. We identified 93 epigenetic regions that showed fetal placenta–specific differential methylation patterns; among these, three regions showed fetal placenta–specific methylation patterns in T21 placenta samples. The methylation patterns of these three regions in the array were confirmed by bisulfite direct sequencing. The three regions were detectable in first-trimester maternal plasma. Moreover, a combination of their methylation ratio achieved high diagnostic accuracy for noninvasive prenatal testing of fetal T21 by further statistical analysis. These three novel regions with fetal placenta–specific differential methylation patterns on chromosome 21 were identified irrespective of the presence of T21. Our findings suggest that epigenetic characteristics of markers according to the presence or absence of T21 should be considered in the development of noninvasive prenatal testing of fetal T21 using fetal placenta–specific epigenetic markers.</P>