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Chung, Hwa-Jee,Cho, In Sook,Kim, Jee-Hyub,In Dong Su,Hur, Cheol Goo,Song, Ji Sook,Woo, Sung Sick,Choi, Dong-Woong,Liu, Jang Ryol 한국식물학회 2003 Journal of Plant Biology Vol.46 No.3
Researchers have widely adopted the hairy mot culture system as a means for producing secondary metabolites, including ginsenosides from ginseng. Although bacterial genes are involved, the aspects of plant gene expression are unclear. Using a cDNA microarray approach, we identified genes that are differentially expressed in ginseng hairy roots after Agrobacterium rhizogenes infection. Our goal was to gain an initial understanding of the correlation between hairy root morphology and ginsenoside production. Among the 250 genes analyzed here, 63 (including 14 that are unclassified) were differentially expressed in a hairy root line containing a high level of ginsenosides. Of the genes that had been functionally categorized, 29% and 17% were active in metabolism and stress responses, respectively. Most were primarily associated with ribosomal proteins, thereby functioning in protein synthesis and destination. Their expression was down-regulated in hairy roots having less lateral branching. This phenotype may have resulted from the manipulation of metabolic activities by the translational machinery.
Isolation and Characterization of Panax ginseng 14-3-3 Gene Family
( Hwa Jee Chung ),( Joo Young Park ),( In Sook Cho ),( Cheol Goo Hur ),( Dong Woog Choi ),( Jang Ryol Liu ) 한국식물학회 2004 Journal of Plant Biology Vol.47 No.3
14-3-3 proteins are a family of conserved proteins expressed in all eukaryotes. They function as regulators in signaling pathways through protein-protein interaction. These proteins have been implicated in plant metabolism, development, and responses to abiotic and biotic stresses. Here, we isolated six cDNAs encoding 14-3-3 proteins of Panax ginseng, designated as Pg14-3-3, by searching the ginseng EST database. Their degree of amino acid identity ranged from 53 to 84%. Phylogenetic analysis showed that the Pg14-3-3 isoforms can be divided into two groups by early duplication, with one group being further split into three subgroups because of subsequent duplication events. Pg14-3-3s are differentially expressed in various root tissues and leaves, and their transcript levels are up- or down-regulated by either cold.or drought stresses. These results suggest a possible role for Pg14-3-3 proteins in abiotic stress responses.
( Jee Eun Yang ),( Eun Ji Park ),( Hyo Jeong Lee ),( Hyo Jeong Kang ),( Kang Mo Kim ),( Eun Sil Yu ),( Dan Bi Lee ),( Ju Hyun Shim ),( Young Suk Lim ),( Han Chu Lee ),( Young Hwa Chung ),( Yung Sang L 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.1
Background/Aims: The role of prostaglandin E2 (PGE2) in the modulation of cell growth is well established in colorectal cancer. The aim of this study was to elucidate the significance of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) down-regulation on the prognosis of hepatocellular carcinoma (HCC) patients. Methods: The expression of 15-PGDH in HCC cell lines and resected HCC tissues was investigated, and the correlation between 15-PGDH expression and HCC cell-line proliferation and patient survival was explored. Results: The interleukin-1-β-induced suppression of 15-PGDH did not change the proliferation of PLC and Huh-7 cells in the MTS [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay. The induction of 15-PGDH by transfection in HepG2 cells without baseline 15-PGDH expression was suppressed at day 2 of proliferation compared with empty-vector transfection, but there was no difference at day 3. Among the 153 patients who received curative HCC resection between 2003 and 2004 at our institution, 15-PGDH expression was observed in resected HCC tissues in 56 (36.6%), but the 5-year survival rate did not differ from that of the remaining 97 non-15-PGDH-expressing patients (57.1% vs 59.8%; P=0.93). Among 50 patients who exhibited baseline 15-PGDH expression in adjacent nontumor liver tissues, 28 (56%) exhibited a reduction in 15-PGDH expression score in HCC tissues, and there was a trend toward fewer long-term survivors compared with the remaining 22 with the same or increment in their 15-PGDH expression score in HCC tissues. Conclusions: The prognostic significance of 15-PGDH down-regulation in HCC was not established in this study. However, maintenance of 15-PGDH expression could be a potential therapeutic target for a subgroup of HCC patients with baseline 15-PGDH expression in adjacent nontumor liver tissue. (Clin Mol Hepatol 2014;20:28-37)
Plasmaspheric contribution to the GPS TEC
Jee, Geon-Hwa,Lee, Han-Byul,Kim, Yong-Ha,Chung, Jong-Kyun,Cho, Jung-Ho 한국우주과학회 2010 한국우주과학회보 Vol.19 No.1
We performed a comprehensive comparison between GPS Global Ionosphere Map (GIM) and TOPEX/Jason (T-J) TEC data for the periods of 1998~2009 in order to assess the performance of GIM over the global ocean where the GPS ground stations are very sparse. Using the GIM model constructed by CODE at University of Bern, the GIM TEC values were obtained along the T-J satellite orbit at the locations and times of the measurements and then binned into various geophysical conditions for direct comparison with the T-J TECs. On the whole, the GIM model was able to reproduce the spatial and temporal variations of the global ionosphere as well as the seasonal variations. However, the GIM model was not accurate enough to represent the well-known ionospheric structures such as the equatorial anomaly, the Weddell Sea Anomaly, and the longitudinal wave structure. Furthermore, there seems to be a fundamental limitation of the model showing the unexpected negative differences (i.e., GPS < T-J) in the northern high latitude and the southern middle and high latitude regions. The positive relative differences (i.e., GIM > T-J) at night represent the plasmaspheric contribution to GPS TEC, which is maximized, reaching up to 100% of the corresponding T-J TEC values in the early morning sector. In particular, the relative differences decreased with increasing solar activity and this may indicate that the plasmaspheric contribution to the maintenance of the nighttime ionosphere does not increase with solar activity, which is different from what we normally anticipate. Among these results, the plasmaspheric contribution to the ionospheric GPS TEC will be presented in this talk and the rest of it will presented in the companion paper (poster presentation).
Chung, Jong-Kyun,Jee, Geon-Hwa,Lee, Chi-Na 한국우주과학회 2011 Journal of Astronomy and Space Sciences Vol.28 No.4
The total electron content (TEC) using global positioning system (GPS) is analyzed to see the characteristics of ionosphere over King Sejong station (KSJ, geographic latitude 62°13′ S, longitude 58° 47′ W, corrected geomagnetic latitude 48° S) in Antarctic. The GPS operational ratio during the observational period between 2005 and 2009 is 90.1%. The annual variation of the daily mean TEC decreases from January 2005 to February 2009, but increase from the June 2009. In summer (December-February), the seasonal mean TEC values have the maximum of 26.2 ± 2.4 TEC unit (TECU) in 2005 and the minimum of 16.5 ± 2.8 TECU in 2009, and the annual differences decrease from 3.0 TECU (2005-2006) to 1.4 TECU (2008-2009). However, on November 2010, it significantly increases to 22.3 ± 2.8 TECU which is up to 5.8 TECU compared with 2009 in summer. In winter (June-August), the seasonal mean TEC slightly decreases from 13.7 ± 4.5 TECU in 2005 to 8.9 ± 0.6 TECU in 2008, and the annual difference is constantly about 1.6 TECU, and increases to 10.3 ± 1.8 TECU in 2009. The annual variations of diurnal amplitude show the seasonal features that are scattered in summer and the enhancements near equinoxes are apparent in the whole years. In contrast, the semidiurnal amplitudes show the disturbed annual peaks in winter and its enhancements near equinoxes are unapparent. The diurnal phases are not constant in winter and show near 12 local time (LT). The semidiurnal phases have a seasonal pattern between 00 LT and 06 LT. Consequently, the KSJ GPS TEC variations show the significant semidiurnal variation in summer from December to February under the solar minimum between 2005 and 2009. The feature is considered as the Weddell Sea anomaly of larger nighttime electron density than a daytime electron density that has been observed around the Antarctica peninsula.
인공 무기계 구체방수재를 혼입한 콘크리트의 물성에 관한 연구
정지승 ( Jee-seung Chung ),신화철 ( Hwa-cheol Shin ),김진구 ( Jin-gu Kim ) 한국안전학회(구 한국산업안전학회) 2016 한국안전학회지 Vol.31 No.4
In this paper, various of experiments were performed for checking the usefulness of Pozzolan Inorganic Polymer(PIP) Waterproof Admixture. The results of the experiment enabled to set the optimum mixture ratio of PIP waterproof admixture as 3.5%. Then, the test specimen mixed with PIP waterproof admixture was produced and consider whether meeting the quality standard of waterproofing admixture for concrete (KS F 4926) From the results, all the items such as mechanical properties and durability were meet the quality standard of KS. The PIP waterproof admixture concrete shows the high resistance of absorption, permeability and chloride ion penetration thanks to its internal components such as siliceous powder, zinc stearate and dispersive polymer.
KAAACI Guidelines for Allergen Immunotherapy
Lee Hwa Young,이상민,강성윤,Kim Kyunghoon,Kim Ju Hee,Ryu Gwanghui,Min Jin-Young,Park Kyung Hee,Park So-Young,Sung Myongsoon,Lee Youngsoo,Yang Eun Ae,Jee Hye Mi,Ha Eun Kyo,Shin Yoo Seob,Chung Eun Hee,Choi Su 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.6
Allergen immunotherapy (AIT) is a causative treatment for various allergic diseases such as allergic rhinitis, allergic asthma, and bee venom allergy that induces tolerance to offending allergens. The need for uniform practice guidelines in AIT is continuously growing because of the increasing discovery of potential candidates for AIT and evolving interest in new therapeutic approaches. This guideline is an updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT published in 2010. This updated guideline proposes an expert opinion by allergy, pediatrics, and otorhinolaryngology specialists with an extensive literature review. The guideline deals with basic knowledge and methodological aspects of AIT, including mechanisms, clinical efficacy, patient selection, allergens extract selection, schedule and doses, management of adverse reactions, efficacy measurements, and special consideration in pediatrics. The guidelines for sublingual immunotherapy will be covered in detail in a separate article.