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Characterization of new microsatellite markers in mung bean, <i>Vigna radiata</i> (L.)
GWAG, JAE-GYUN,CHUNG, JONG-WOOK,CHUNG, HUN-KI,LEE, JEONG-HEUI,MA, KYUNG-HO,DIXIT, ANUPAM,PARK, YONG-JIN,CHO, EUN-GI,KIM, TAE-SAN,LEE, SUK-HA BLACKWELL 2006 MOLECULAR ECOLOGY NOTES Vol.6 No.4
<P>Abstract</P><P>The present work reports the isolation and characterization of new polymorphic microsatellites in mung bean (<I>Vigna radiata</I> L.). Of 93 designed primer pairs, seven were found to amplify polymorphic microsatellite loci, which were then characterized using 34 mung bean accessions. The number of alleles ranged from two to five alleles per locus with an average of three alleles. Observed and expected heterozygosity values ranged from 0 to 0.088 and from 0.275 to 0.683, respectively. All seven loci showed significant deviations from Hardy–Weinberg equilibrium, whereas only one pairwise combination (GBssr-MB77 and GBssr-MB91) exhibited significant departure from linkage disequilibrium. These newly developed markers are currently being utilized for diversity assessment within the mung bean germplasm collection of the Korean Gene Bank.</P>
아토피피부염의 중증도 평가 방법으로서 Three Item Severity Score의 유용성에 관한 연구
이경은 ( Lee Gyeong Eun ),곽인근 ( Gwag In Geun ),김영호 ( Kim Yeong Ho ),정지아 ( Jeong Ji A ),양승 ( Yang Seung ),황일태 ( Hwang Il Tae ),이혜란 ( Lee Hye Lan ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2004 소아알레르기 및 호흡기학회지 Vol.14 No.1
목적: 아토피피부염은 만성 재발성 염증성 피부염으로서 우리나라에서 빈도가 점차 증가하고 있으나 그 치료는 다양하고 일관성이 없으므로 치료의 표준화가 요구된다. 표준화에 사용될 올바른 치료 방법의 선택과 효과 판정을 위해서는 편리하면서도 객관적인 중등도 평가 도구가 필수적이다. 중증도 평가 방법으로 SCORAD가 널리 알려져 있으나 복잡하고 시간이 오래 걸려서 외래에서 사용하기 어렵다. 이에 저자들은 보다 간결한 TIS score의 유용성을 알아보고자 한 Purpose: Many different scoring systems have been proposed for assessing the severity of atopic dermatitis. The SCORAD (SCORing Atopic Dermatitis) is one of the best validated systems, but is too complicated and time-consuming for routine clinical use. Th
( Dong Heon Lee ),( Ho Eun Gwag ),( So Yun Park ),( Narang Hong ),( Hyung Don Kook ),( Hye Jung Jung ),( Mi Yeon Park ),( Jiyoung Ahn ) 대한피부과학회 2024 대한피부과학회지 Vol.62 No.1
Background: Since the disease burden of atopic dermatitis (AD) understandably increases with its disease severity, studies, especially on the baseline characteristics of severe AD, have been conducted in some countries to deepen the understanding of the disease and, by extension, formulate a relevant national policy. However, research on the baseline characteristics of severe AD in Korea remains insufficient. Objective: To report the baseline demographics and describe the clinical characteristics of adult Korean patients with severe AD, including medical and treatment history, clinical manifestations, disease severity, and laboratory findings, in order to understand the characteristics of severe AD. Methods: A single-center, prospective, non-interventional, observational, longitudinal study of 108 patients with severe AD was conducted between January 2021 and December 2022. Clinical data and patient-reported measures of signs and symptoms of AD were recorded at baseline. Results: The mean Eczema Area and Severity Index score of the patients was 28.5±6.8. The mean pruritus numerical rating scale, Patient-Oriented Eczema Measure, Dermatology Life Quality Index, and Atopic Dermatitis Control Tool scores were 8.1±1.7, 23.6±4.8, 21.9±6.6, and 19.5±3.9, respectively. Although a larger proportion of the head/neck and trunk are affected than both limbs, the key signs of AD were less severe in the head/neck region than in the other regions. Erythema and lichenification were more representative clinical signs of severe AD than induration and excoriation. The baseline data on previous treatments reflected the AD treatment guidelines in Korea. Conclusion: This real-world data will provide dermatologists with a better understanding of severe AD, which will eventually lead to better clinical and health policy decisions for patients with severe AD. (Korean J Dermatol 2024;62(1):29∼41)
Melatonin이 Cisplatin에 의한 신장 독성에 미치는 영향
최혜정 ( Choe Hye Jeong ),신영호 ( Sin Yeong Ho ),문교철 ( Mun Gyo Cheol ),송대규 ( Song Dae Gyu ),김인철 ( Kim In Cheol ),서상혁 ( Seo Sang Hyeog ),곽춘식 ( Gwag Chun Sig ),장은주 ( Jang Eun Ju ),김현철 ( Kim Hyeon Cheol ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.2
목 적 : Cisplantin은 항암제로 널리 사용되나 활성산소를 생성하여 신장 기능 손상 등의 부작용이 있는 것으로 알려져 있긴 강력한 항산화제인 melatonin은 cisplatin에 의한 산장독성을 줄일 수 있을 것이다. Cisplatin에 의한 신장 독성에 대하여 melatonin의 방어 효과를 알아보고자 하였다. 방 법 : 실험군을 대조군인 제 1군, cisplatin 투여군인 제 2군 및 cisplatin과 melatonin을 투여한 제 3군으로 나눈 후 신장 조직의 형태학적 변화와 더불어 산화적 손상에 대한 연구를 수행하였으며 과산화수소, malondialdehyde 및 항산화효소의 활성도를 측정하였다. 결 과 : 혈청 BUN (p<0.001), creatinine 농도 (p<0.001) 및 신장의 과산화수소 생성량은 제 1군에 비해 제 2군에서 증가하였고, 제 2군에 비해 제 3군에서는 감소되었으며, 활성산으로 인한 손상 표지자인 malondialdehyde 농도도 같은 경향을 나타내었다. Creatinine 청소는 제 1군에 비해 제 2군에서 감소를 보였고, 제 2군에 비해 제 3군에서는 증가되었다. 신장의 superoxide dismutase 활성도는 제 1군에서 제 2군에 비해 감소하였고 catalase 활성도는 제 1군에 비해 제 2군에서 증가되었으며, 제 1군에 비해 제 3군에서는 더욱 증가되었다. Glutathione peroxidase는 통계학적으로 의미 있는 변화가 없었다. 또한 광학 현미경 소견을 보면 제 2군의 사구체에서는 특이한 변화가 없었으나, 근위 곱슬 세관은 심한 괴사를 나타내었고, 제 3군의 근위 곱슬 세관에서 중등도의 괴사를 나타내었으며 제 2군보다 경한 변화를 보였다. 결 론 : Cisplatin은 신장에서 superoxide dismutase 활성도 증가와 catalase의 활성도를 저하시켜 과산화수노의 생성을 유도하여 신장 손상을 유발하는 것으로 생각되며, melatonin은 superoxide dismutase 활성도 증가와 catalase 활성도 증가를 유도하여 cisplatin에 의해 유발된 신장 손상을 줄이는 것으로 생각된다. Background : Cisplatin (CP), an antitumor agent widely used in the treatment of cancers, has nephrotoxicity. This side effect is closely related to oxidative stress. In the present study, we attempted to reduce CP-induced nephrotoxicity in rats by administering melatonin, an antioxidant. Methods : Male Sprague-Dawley rats were divided into different groups and were treated as follows : ⑴ saline control; ⑵ CP (16 mg/kg, i.p.); ⑶ CP plus melatonin (10 mg/kg, i.p.). The rats were sacrificed at the 6th day after CP treatment. To evaluate renal damage, BUN, serum creatinine, creatinine clearance and microscopic examination were done. Hydrogen peroxide which is one of the oxygen free radicals, and malondialdehyde which is known as a marker of the oxygen free radical mediated injury, and the activities of the antioxidant enzymes such as superoxied dismutase, catalase, and glutathione peroxidase were also measured. Results : CP-treated rats showed the increase of BUN, serum creatinine, malondialdehyde, hydrogen peroxide and superoxide dismutase (SOD) in kidney. And CP-treated rats also showed the decrease of creatinine clearance and catalase levels. CP-treated rats showed severe tubular necrosis in proximal convoluted tubules under the light microscopic examination. The light microscopic finding and all of the parameters except SOD were restored in the rats injected with CP plus melatonin than those with CP alone. SOD level was higher in the rats injected with CP plus melatonin than that with CP alone. Conclusion : These results suggest that melatonin suppresses CP-induced nephrotoxicity by suppressing the production of reactive oxygen species via the activation of SOD and catalase. (Korean J Nephrol 2004;23(2):205-212)
폐상피세포에서 Triptolide에 의한 NF-κB 의존성 IL-8 유전자 전사활성 억제기전
지영구 ( Ji Yeong Gu ),김윤섭 ( Kim Yun Seob ),윤세영 ( Yun Se Yeong ),김용호 ( Kim Yong Ho ),최은경 ( Choe Eun Gyeong ),박재석 ( Park Jae Seog ),김건열 ( Kim Geon Yeol ),채기남 ( Chae Gi Nam ),곽상준 ( Gwag Sang Jun ),이계영 ( Le 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.1