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Frost, Jennifer M.,Kim, M. Yvonne,Park, Guen Tae,Hsieh, Ping-Hung,Nakamura, Miyuki,Lin, Samuel J. H.,Yoo, Hyunjin,Choi, Jaemyung,Ikeda, Yoko,Kinoshita, Tetsu,Choi, Yeonhee,Zilberman, Daniel,Fischer, R National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.20
<▼1><P><B>Significance</B></P><P>The chromatin remodeling activities of the FACT (facilitates chromatin transactions) complex are required for many cellular functions, including transcription, DNA replication, and repair. Here, we demonstrate that the two FACT subunits, SSRP1 and SPT16, are also required for genome-wide DNA demethylation and regulation of gene imprinting during <I>Arabidopsis</I> reproduction. Without FACT, <I>Arabidopsis</I> seeds undergo abnormal development and exhibit aberrant DNA hypermethylation, including at imprinting control region loci. We show that FACT associates with the DEMETER (DME) DNA demethylase, facilitating DNA demethylation at over half of DME’s targets, specifically those which reside in heterochromatin. These results provide insight into upstream events in the DNA demethylation pathway and reveal the importance of chromatin remodeling for DNA demethylation during <I>Arabidopsis</I> reproduction.</P></▼1><▼2><P>The DEMETER (DME) DNA glycosylase catalyzes genome-wide DNA demethylation and is required for endosperm genomic imprinting and embryo viability. Targets of DME-mediated DNA demethylation reside in small, euchromatic, AT-rich transposons and at the boundaries of large transposons, but how DME interacts with these diverse chromatin states is unknown. The STRUCTURE SPECIFIC RECOGNITION PROTEIN 1 (SSRP1) subunit of the chromatin remodeler FACT (facilitates chromatin transactions), was previously shown to be involved in the DME-dependent regulation of genomic imprinting in <I>Arabidopsis</I> endosperm. Therefore, to investigate the interaction between DME and chromatin, we focused on the activity of the two FACT subunits, SSRP1 and SUPPRESSOR of TY16 (SPT16), during reproduction in <I>Arabidopsis</I>. We found that FACT colocalizes with nuclear DME in vivo, and that DME has two classes of target sites, the first being euchromatic and accessible to DME, but the second, representing over half of DME targets, requiring the action of FACT for DME-mediated DNA demethylation genome-wide. Our results show that the FACT-dependent DME targets are GC-rich heterochromatin domains with high nucleosome occupancy enriched with H3K9me2 and H3K27me1. Further, we demonstrate that heterochromatin-associated linker histone H1 specifically mediates the requirement for FACT at a subset of DME-target loci. Overall, our results demonstrate that FACT is required for DME targeting by facilitating its access to heterochromatin.</P></▼2>
Plasma-Confinement Physics Study in Compact Helical System
stoichi Okamura,A. Fujisawa,A. Shimizu,C. Takahashi,C. Suzuki,H. Iguchi,H. Nakano,H. Matsushita,K. Nagaoka,K. Matsuo,K. Ida,K. Toi,K. Nakamura,K. Matsuoka,M. Yoshinuma,M. Isobe,M. Takeuchi,R. Ikeda,S. 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
In a CHS experiment, various types of transport barrier have been studied. An internal transport barrier (ITB) for electrons in a stellarator was first found in CHS, and the ITB for improved ion confinement was also found. H-mode (edge transport barrier) study in CHS showed many common features in transition to tokamak experiments, although the magnetic surface quantities are very different. Discharges with a combination of ETB and ITB were also found. Two heavy ion beam diagnostics in CHS showed a new direct measurement of zonal flow structure in toroidal confinement. The relation between the fluctuation and the transport barrier was also studied.
( H. M. Kim ),( S. H. Cho ),( D. Fukuda ),( K. Kaneko ),( Y. Nakamura ),( H. S. Kim ),( J. H. Lee ) 대한지질공학회 2016 대한지질공학회 학술발표회논문집 Vol.2016 No.1
Breakage of concrete structures involves a risk the occupational health of those involved in the operation and other general public living in the vicinity due to the noise hazard. It is important to prevent damage from mechanical breakage method to remaining concrete structures, while obtaining efficient resultant fracture are of considerable importance for partially dismantling concrete structures, Therefore, alternative method has been needed to solve these problem. Nakamura et al. (2004) suggested a dynamic breakage system installed utilizing wedged charge holder before curing time of concrete specimen to remove the partial concrete block in short time. Nakamura et al. (2010) was performed to investigate the effect of the charge holder on the fracture plane formation in field-scale blast experiment. This study proposes a numerical method to simulate crack propagation in the field-scale concrete block by means of blasting method. The result shown that the smooth blasting was obtained along the optimal fracture plane was shown in remaining part of concrete specimen. As the field-scale experimental result, the dynamic fracture process analysis(DFPA) (Cho, 2003) assuming the same experimental arrangement was conducted and the fracture mechanism was investigated. Figure 1 shows the finite element layout for the analysis model which has all free face and 2 charge holders installed. the model was divided into triangular elements. The analysis model applied calculation conditions in Table 1.
The Weak Decay Widths of Λ Hypernuclei
H. Bhang,S. Ajimura,K. Aoki,A. Banu,T. Fukuda,O. Hashimoto,J. I. Hwang,S. Kameoka,B. H. Kang,E. Kim,김정호,T. Maruta,Y. Miura,Y. Miyake,T. Nagae,M. Nakamura,S. N. Nakamura,H. Noumi,S. Okada,Y. Okayasu,H. 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
We have measured both the mesonic and nonmesonic weak decay widths of ^(12)_ΛC. For the mesonic decay, we have improved the accuracy of Γ_π^0 so that it reduced the error of Γ_(nm) from ≥10% to ≤5%. For the nonmesonic decay, we have solved the long standing Γ_n/Γ_p puzzle by measuring the ratio 0.51 ± 0.14 in the exclusive measurement. At the same time we have measured the width of the 3-body nonmesonic decay Γ_(2N) = 0.27 ± 0.13 for the first time. Combining the accurate Γ_n/Γ_p ratio and the first measured value Γ_(2N), we have finally obtained the Γ_n and Γ_p themselves taking account of the 3-body process. We have measured all the weak decay widths of _(12)_ΛC so that it provides the first complete set of widths for the investigation of ΔS = 1 baryon-baryon weak interaction.
Nakamura, M.,Choi, K.H.,Choi, S.K.,Do, C.S.,Jun, J.H.,Kwon, H.K.,Lee, S.M.,Moon, R.J.,Yi, K.J.,Jang, I.S. North-Holland ; Elsevier Science Ltd 2010 european journal of pharmacology Vol.635 No.1
Neurons within the periaqueductal gray (PAG) have been implicated in the central regulation of pain signals by affecting the descending inhibitory pathway. Here we report on the functional role of presynaptic kainate receptors within the PAG. Using a conventional whole-cell patch clamp technique, we recorded GABAergic spontaneous miniature inhibitory postsynaptic currents (mIPSCs) from mechanically isolated rat PAG neurons in the presence of 300nM tetrodotoxin and 20@?M dl-2-amino-5-phosphonovaleric acid under voltage-clamp conditions. Kainic acid at a 10@?M concentration significantly increased the frequency of GABAergic mIPSCs without affecting their amplitude, suggesting that kainic acid acts presynaptically to enhance spontaneous GABA release. The kainic acid-induced increase in mIPSC frequency was completely blocked by CNQX, a selective AMPA/kainate receptor antagonist. While neither AMPA nor NMDA affected GABAergic mIPSC frequency, ATPA, a selective agonist of GluR5-containing kainate receptors, increased GABAergic mIPSC frequency in a concentration-dependent manner. The kainic acid-induced increase in mIPSC frequency was completely suppressed either in the presence of 100@?M Cd<SUP>2+</SUP>, a general voltage-dependent Ca<SUP>2+</SUP> channel (VDCC) blocker, or in the Na<SUP>+</SUP>-free external solution. These results suggest that presynaptic kainate receptors have a low permeability to Ca<SUP>2+</SUP>, and that their activation elicits a presynaptic depolarization large enough to activate presynaptic VDCCs. Presynaptic kainate receptors on GABAergic nerve terminals appear to modulate GABAergic transmission, and in doing so may play an important role in the regulation of PAG neuron excitability.
MECHANISMS OF THE NONMESONIC WEAK DECAY OF Λ HYPERNUCLEI AND THE THREE-BODY PROCESS
BHANG, H.,AJIMURA, S.,AOKI, K.,BANU, A.,FUKUDA, T.,HASHIMOTO, O.,HWANG, J. I.,KAMEOKA, S.,KANG, B. H.,KIM, E.,KIM, J. H.,KIM, M.,MARUTA, T.,MIURA, Y.,MIYAKE, Y.,NAGAE, T.,NAKAMURA, M.,NAKAMURA, S. N. World Scientific 2009 Modern Physics Letters A Vol.24 No.11
<P> The long standing Γn/Γp puzzle of NMWD has finally been solved recently. It appears that the reason behind the puzzle was the universal quenching of nucleon yields from the prediction of one-nucleon induced (1N-) NMWD. We have shown that the quenching of nucleon yields can be explained only when we include a fairly large contribution of the three-body process (Γ2N) in Γnm. </P>
The Weak Decay Widths of ?? Hypernuclei
Bhang, H.,Ajimura, S.,Aoki, K.,Banu, A.,Fukuda, T.,Hashimoto, O.,Hwang, J. I.,Kameoka, S.,Kang, B. H.,Kim, E.,Kim, J. H.,Maruta, T.,Miura, Y.,Miyake, Y.,Nagae, T.,Nakamura, M.,Nakamura, S. N.,Noumi, H Korean Physical Society 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.2