Three-Dimensional Seismic Isolation Study of Single-Layer Reticulated Domes by Parameter Analysis

Gui-Bo Nie,Dong-fang Li,Xudong Zhi,Qiang Chen,Fuyang Wang 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.6

Spatial structures, represented by reticulated domes, have developed rapidly in the last several decades due to their reasonable mechanical properties and beautiful structural shape. However, several spatial structure collapses have occurred during the recent frequent earthquakes in China, especially the 2013 Lushan earthquake. These collapses have altered the traditional understanding that the spatial structure has good seismic performance. Real seismic damage cases reveal that a spatial structure in a severe earthquake zone with unreasonable seismic design cannot maintain its functional characteristics; therefore, there is an urgent need for improvements to enhance the seismic performance of spatial structures. This paper proposes a new three-dimensional isolation spring support (TISS). To study the mechanical properties of this support, corresponding experiments were performed, and the constitutive relation of this support was investigated. A simplifi ed fi nite element model of the new TISS was defi ned in ABAQUS to conduct a seismic isolation study of single-layer reticulated domes. And then the infl uence of diff erent parameters on the seismic isolation performance of the TISS was analysed. The parameter analysis results indicated that friction plays an important role in the mechanical properties of the support and thus causes diff erent seismic isolation eff ects under small earthquakes and severe earthquakes. At the same time, because of the design concept of the support, a non-linear relation exists between the seismic isolation eff ect and stiff ness such that under severe earthquakes. On the other hand, the TISS also has preferable isolation performance on the defective reticulated domes. Therefore, the three-dimensional isolation support presented in this paper has preferable application prospects and potential economic benefi ts that could be applied extensively in the three-dimensional isolation area of spatial structures. In addition, the numerical analysis procedure based on ABAQUS can be used to accurately analyse the isolation property and to lay the foundation for the practical function of isolation supports and the seismic design of structures.

Antioxidant, Antimutagenic, and In vivo Buccal Mucosa Cancer Preventive Effects of Fructus Malvae

Gui-Jie Li,Qiang Wang,Yu Qian,Xin Zhao 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4

Fructus Malvae is functional food known forantioxidant, anti-mutagenic, and in vivo anticancer effects. Fructus Malvae extracts demonstrated high antioxidantactivities in DPPH and hydroxyl radical scavenging activityassays. In an Ames mutagenicity test, Fructus Malvaeexhibited antimutagenicty in association with MNNG (Nmethyl-N'-nitro-N-nitrosoguanidine) in Salmonella TyphimuriumTA100 cells. U14 squamous carcinoma cells were injectedinto the buccal mucosa of KM (Kunming) mice. Thewound at the injection site was smeared with a FructusMalvae solution, which was also administered to mice bygavage. Tumor volumes were reduced and tissue sectionanalysis of buccal mucosa cancer and cervical lymph nodetissues showed anti-cancer effects in Fructus Malvaetreated groups. Fructus Malvae possesses good antioxidantand antimutagenic activities and exerts a preventive effectagainst buccal mucosa cancer in vivo.

Preliminary Proteomic Analysis of Indomethacin's Effect on Tumor Transplanted with Colorectal Cancer Cell in Nude Mice

Wang, Yu-Jie,Zhang, Gui-Ying,Xiao, Zhi-Qiang,Wang, Hong-Mei,Chen, Zhu-Chu Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.2

Nonsteroidal anti-inflammatory drugs such as indomethacin (IN) can exert anti-colorectal cancer (CRC) activity through cyclooxygenase independent mechanism, but the exactly biological mechanism is not completely known. Here we use proteomic tools to investigate the molecular mechanism of this action. First, nude mice bearing tumors derived from subcutaneous injection with human CRC cell line HCT116 were randomly allocated to groups treated with or without indomethacin. Later, tumor lumps were incised and then total proteins extracted. After separated with two-dimensional electrophoresis, thirty-one differently expressed spots were found between IN-treated and non-IN-treated groups, of which 25 spots decreased and 6 spots increased in abundance in IN-treated group. Through matrix-assisted laser desorption ionization time of flight mass spectrometry and then NCBInr and SWISS-PROT databases searching, 12 protein spots were finally identified including galectin-1, annexin A1, annexin IV, trancription factor BTF3A, calreticulin. Most of the identified proteins are correlated with tumor's biological prosperities of proliferation, invasion, apoptosis and immunity, or take part in cell's signal transduction. From above we thought that indomethacin can exert its effect on colorectal cancer through regulating several proteins' expression directly or indirectly. Further study of these proteins may be helpful in founding new targets of drugs for cancer chemotherapy.

United Electromagnetic Characteristics and Online Monitoring Method of Static Air-gap Eccentricity of Turbo-Generator

Gui-Ji Tang,Meng-Qiang Ke,Yu-Ling He,Fa-Lin Wang 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.6

The purpose of this paper is to investigate the united Electromagnetic characteristics for the effective monitoring on the static air-gap eccentricity (SAGE) of turbo-generator. Different from other studies, this paper not only studies on the unbalanced magnetic pull (UMP) and the vibration characteristics of the stator and the rotor, but also investigates the harmonic features of the magnetic flux density and the circulating current inside the parallel branches (CCPB). The theoretical calculation, together with the finite-element-method (FEM) simulation and the experiment verification, is taken for a SDF-9 type non-salient generator. It is shown that, when SAGE occurs, apparent doublefrequency UMP and vibrations will be produced both on the stator and the rotor, while the CCPB will have an obvious increment at the 1<SUP>st</SUP> harmonic component. In addition, the amplitude of the magnetic flux density will be of cosine distribution in the circumferential position of the air-gap, while in normal condition it is a constant. Moreover, the pass-band amplitude, together with the 1<SUP>st</SUP> harmonic of the magnetic flux density, will be enlarged as well. These united electromagnetic characteristics can be used as the diagnosis and monitoring criterion for SAGE.

Effect of Joint Stiffness on the Stability of Cable-braced Grid Shells

Xi Wang,Ruo-qiang Feng,Gui-rong Yan,Feng-cheng Liu,Wei-jia Xu 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4

Bolted joints used in cable-braced grid shells are typically semi-rigid joints, and the joint stiffness has a significant effect on the stability of cable-braced grid shells. The effect of joint stiffness on the stability of cable-braced grid shells is studied in this paper. Based on the experimental results of improved bolted joints, finite element models of elliptic paraboloid cable-braced grid shells with bolted joints are established, and spring elements are used to simulate the joint stiffness. The effect of the joint stiffness on the nonlinear buckling load is studied by changing the joint stiffness. The main conclusions are as follows. First, the joint rotational stiffness has a significant effect on the failure mode. When the joint rotational stiffness is small to a certain extent, the failure mode of cable-braced grid shells changes from overall buckling to local buckling. Second, the nonlinear failure mode is similar to the first-order eigenvalue buckling mode and the maximal compression stress distribution. The structural integrity is weakened, and the maximal steel tube compression stress decreases with the decrease of the joint rotational stiffness. The smaller the joint rotational stiffness, the lower the utilization rate of steel strength. The results suggest that the joint stiffness of elliptic paraboloid cable-braced grid shells should not be less than 20% of the rigid joint stiffness.

United Electromagnetic Characteristics and Online Monitoring Method of Static Air-gap Eccentricity of Turbo-Generator

Tang, Gui-Ji,Ke, Meng-Qiang,He, Yu-Ling,Wang, Fa-Lin The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.6

The purpose of this paper is to investigate the united Electromagnetic characteristics for the effective monitoring on the static air-gap eccentricity (SAGE) of turbo-generator. Different from other studies, this paper not only studies on the unbalanced magnetic pull (UMP) and the vibration characteristics of the stator and the rotor, but also investigates the harmonic features of the magnetic flux density and the circulating current inside the parallel branches (CCPB). The theoretical calculation, together with the finite-element-method (FEM) simulation and the experiment verification, is taken for a SDF-9 type non-salient generator. It is shown that, when SAGE occurs, apparent double-frequency UMP and vibrations will be produced both on the stator and the rotor, while the CCPB will have an obvious increment at the $1^{st}$ harmonic component. In addition, the amplitude of the magnetic flux density will be of cosine distribution in the circumferential position of the air-gap, while in normal condition it is a constant. Moreover, the pass-band amplitude, together with the $1^{st}$ harmonic of the magnetic flux density, will be enlarged as well. These united electromagnetic characteristics can be used as the diagnosis and monitoring criterion for SAGE.

Genetic Variations in the HIF1A Gene Modulate Response to Adjuvant Chemotherapy after Surgery in Patients with Colorectal Cancer

Zhang, Yi,Wang, Peng,Zhou, Xing-Chun,Bao, Guo-Qiang,Lyu, Zhuo-Ming,Liu, Xiao-Nan,Wan, Shao-Gui,He, Xian-Li,Huang, Qi-Chao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Background: Hypoxia-inducible factor $1{\alpha}$ (HIF-$1{\alpha}$) plays an important role in regulating cell survival and angiogenesis, which are critical for tumor growth and metastasis. Genetic variations of HIF1A have been shown to influence the susceptibility to many kinds of human tumors. Increased expression of HIF-$1{\alpha}$ has also been demonstrated to be involved in tumor progression. However, the prognostic value of single nucleotide polymorphisms (SNPs) inthe HIF1A gene remains to be determined in most cancer types, including colorectal cancer (CRC). In this study, we sought to investigate the predictive role of HIF1A SNPs in prognosis of CRC patients and efficacy of chemotherapy. Materials and Methods: We genotyped two functional SNPs in HIF1A gene using the Sequenom iPLEX genotyping system and then assessed their associations with clinicopathological parameters and clinical outcomes of 697 CRC patients receiving radical surgery using Cox logistic regression model and Kaplan Meier curves. Results: Generally, no significant association was found between these 2 SNPs and clinical outcomes of CRC. In stratified analysis of subgroup without adjuvant chemotherapy, patients carrying CT/TT genotypes of rs2057482 exhibited a borderline significant association with better overall survival when compared with those carrying CC genotype [Hazard ratio (HR), 0.47; 95% confidence interval (95% CI): 0.29-0.76; P < 0.01]. Moreover, significant protective effects on CRC outcomes conferred by adjuvant chemotherapy were exclusively observed in patients carrying CC genotype of rs2057482 and in those carrying AC/CC genotype of rs2301113. Conclusions: Genetic variations in HIF1A gene may modulate the efficacy of adjuvant chemotherapy after surgery in CRC patients.

Efficacy/Safety of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir with Ribavirin in Asian Patients with Genotype 1b HCV-Infected, Compensated Cirrhosis: ONYX-II SVR 24 Results

( Lai Wei ),( Gui-qiang Wang ),( Yan Luo ),( Chi-jen Chu ),( Seung Woon Paik ),( Jinlin Hou ),( Jun Cheng ),( Qing Xie ),( Zhongping Duan ),( Jia-horng Kao ),( Linda Fredrick ),( Bo Fu ),( Niloufar Mo 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: ONYX-II is a phase 3, open-label study of 3-DAA regimen of OBV/PTV/r and DSV with RBV in treatment-naive and experienced patients with genotype 1b HCV infection and compensated cirrhosis in China, South Korea and Taiwan. SVR12 rate was 100% and the favourable safety profile was shown. The present analysis reports efficacy( SVR24) and safety results. Methods: Patients with chronic GT1b HCV infection and compensated cirrhosis received OBV/PTV/r + DSV + RBV for 12 weeks and will be followed for 48 weeks post-treatment. Efficacy was assessed by SVR12 and SVR24. Safety was assessed as the percentage of patients wi th treatment-emergent adverse events (TEAEs) and laboratory evaluation. Results: Total of 104 patients with chronic GT1b HCV infection (62% female, 100% Asian, 58% treatment-experienced) were enrolled from China (n=63), South Korea (n=21) and Taiwan (n=20). All patients received at least one dose of study drugs. The SVR24 rate was 100% (concordant with SVR12), with no patient relapsing between post-treatment week 12 and 24. Most TEAEs were mild in severity. The most common TEAEs (≥10%) were increased blood bilirubin levels (25%), pruritus (15%), anaemia (14%), asthenia (12%), bilirubin conjugated increased (12%), blood bilirubin unconjugated increased (12%), dizziness (11%) and fatigue (11%). Four patients had serious AEs and all were assessed as not being related to the 3-DAA regimen (one was assessed as being possibly related to RBV). One patient discontinued treatment due to TEAEs (elevations in alanine aminotransferase [ALT], aspartate aminotransferase [AST] and blood bilirubin) after 3 weeks of dosing but achieved SVR12 and SVR24. Laboratory abnormalities ≥ grade 3 were infrequent (ALT: 3%; AST 2%; total bilirubin: 7%). No grade 3 haemoglobin decrease was reported. Conclusions: SVR24 and SVR12 rates were concordant (100%) in HCV GT1b-infected Asian patients with compensated cirrhosis. The regimen was generally well tolerated with mostly mild TEAEs reported.

Preliminary Proteomic Analysis of Indomethacin`s Effect on Tumor Transplanted with Colorectal Cancer Cell in Nude Mice

Yu Jie Wang,Gui Ying Zhang,Zhi Qiang Xiao,Hong Mei Wang,Zhu Chu Chen 한국생활환경학회 2006 BMB Reports Vol.39 No.2

Preliminary Proteomic Analysis of Indomethacin’s Effect on TumorTransplanted with Colorectal Cancer Cell in Nude Mice

Yu-Jie Wang,Hong-Mei Wang,Gui-Ying Zhang,Zhi-Qiang Xiao,Zhu-Chu Chen 한국생화학분자생물학회 2006 BMB Reports Vol.39 No.2