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김기범,나도춘,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
We intended to develope an vibrating intravascular lung assist device(VIVLAD) in order to exchange of efficiently gas transfer of oxygen and carbon dioxide exchange requirements for end-stage acute respiratory distress syndrome (ARDS) patients. However, the clinical study, concluded that more gas exchange was needed for intravascular oxygenation to be clinically effective in ARDS treatment. In this study, we tried to enhance gas exchange on the VIVLAD by using microencapsulation of hemoglobin, as the microencapsulation of hemoglobin reduces blood hemolysis, and perfluorocarbon emulsion(PFC emulsion). As a result, it was shown that the oxygen transfer of hemosome and blood/hemosome mixed solution were higher than that of whole blood. Also, it showed that the carbon dioxide transfer of whole blood/PFC emulsion mixed solution was higher than that of others. Therefore, we determined that hemosome and PFC emulsion could increase oxygen transfer and carbon dioxide transfer, respectively.
Perfluorocarbon 유화액에 의한 혈관 내 폐 보조장치에서의 압력손실과 산소전달
김기범,박재관,김성종,정인수,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
The purpose of this study was to evaluate the effects of the perfluorocarbone emulsion in a novel membrane module that satisfied the limiting factor of minimizing the pressure loss in the intravascular blood flow pattern. It observed the mind on the viscosity that to mix with blood in the ratio of 1:4. The device used a bundle consisted of several hundred hollow fiber having the outside diameter of 380㎛. and the axial jacket length of 600 ㎜. The pressure drop of the membrane module device consisting of 300 hollow fibers was observed 10 ㎜Hg at the flow rate 4 ℓ/min and could be get sphere of pressure drop to apply equipment.
헤모글로빈의 Microencapsulation에 의한 인공적혈구의 산소전달과 용혈도에 관한 연구
나도춘,김기범,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome and hemosome/blood mixed solution was tested by measuring oxygen dissociation curve using blood gas analyzer. Also we were measured about hemolysis of hemosome, hemosome/blood mixed solution and blood by absorptivity method. As a results, the oxygen dissociation curve of hemosome and hemosome/blood mixed solution showed the same figure as the curve of normal red blood cells. Also, the hemolysis of hemosome and hemosome/blood mixed solution was measured less than normal red blood cell. Therefore, the oxygen transfer rate showed high use of hemosome, and hemosome/blood mixed solution rather than normal blood. Because microen- capsulation of normal red blood cells prevent hemolysis of normal red blood cells.
혈관 내 폐 보조장치에서 적혈구의 microencapsulation에 의한 산소전달속도의 향상
박재관,김기범,정경락,장경환 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2002 工學硏究 Vol.33 No.-
In this study, we tried to improve oxygen transfer rate and reduce pressure drop on intravascular lung assist device with microencapsulation of red blood cells, because microcapsulation of red cells reduce blood hemolysis. Hemoglobin was purified from outdated human red blood cells used. Phospholipid was purified from egg yolk. The hemosome was prepared by encapsulation of hemoglobin with phospholipid multilayer, using rotary vacuum evaporator. The function of hemosome was tested by measuring oxygen dissociation curve using blood gas analyzer. Oxygen dissociation curve of hemosome showed the same figure as the curve of normal red blood cells. Pressure drop showed lower use of hemosome rather than normal blood, because viscosity of hemosome are lower than that of normal blood. Also, oxygen transfer rate showed lower use of hemosome rather than normal blood at 2 hour, but it showed higher use of hemosome rather than normal blood after 2 hour. Because microencapsulation of normal red blood cells prevent hemolysis of normal red blood cells.
진동에 의한 혈관 내 폐 보조장치에서의 기체전달의 향상
나도춘,김기범,김성종,정경락 전북대학교 공학연구원 ( 구 전북대학교 공업기술연구소 ) 2003 工學硏究 Vol.34 No.-
When the Microporous hollow fiber membrane(MHFM) was contacted with whole blood, the serum leakage(membrane fouling) was occurred in the MFHM. In general, the MHFM was in use at most intravascular lung assist device(IVALAD) which was often occurred the serum leakage, and these serum leakage were reduced the gas exchange. In this work, we tried to improve gas exchange on the IVALAD by using vibration technique. As a result, it was showed that the vibrating method of this module was very effective due to the reduction of serum leakage on MFHM. Therefore, this method was increased gas exchange, respectively.
자가면역글로불린 G 측정을 위한 표면탄성파 바이오센서에 대한 연구
김기범 ( Gi Beum Kim ),정우석 ( Woo Suk Cheong ),박영란 ( Young Ran Park ),김상진 ( Shang Jin Kim ),김성종 ( Seong Jong Kim ),강형섭 ( Hyung Suk Kang ),김진상 ( Jin Shang Kim ),홍철운 ( Chul Un Hong ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.2
In this study, we have developed shear horizontal(SH) surface acoustic wave(SAW) sensors for the detection of immunoglobulin G(IgG) on the gold coated delay line of SH-SAW devices. As the result of the experiment, we could uniformly immobilize anti-MIgG(mouse IgG) conjugate on the surface of gold. When displaying results of immobilization on the surface of gold using G-anti MIgG conjugate and blocking buffer in frequency shift, G-anti MIgG conjugate showed frequency shift of 75.1 kHz in the initial frequency, and blocking buffer showed frequency shift of 215.7 kHz. When various concentrations of MIgG was added in 100 MHz type sensor, the sensor showed 46.3, 127.45, 161.21 and 262.39 kHz frequency shift at 25, 50, 75 and 100 μg MIgG concentration, respectively.
인공 폐 보조장치 내에서의 유체 유동 모델링에 대한 연구
김기범 ( Gi Beum Kim ),박영란 ( Young Ran Park ),김상진 ( Shang Jin Kim ),홍철운 ( Chul Un Hong ),강형섭 ( Hyung Sub Kang ),김진상 ( Jin Shang Kin ),김성종 ( Seong Jong Kim ),김민호 ( Min Ho Kim ) 한국화학공학회 2011 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.49 No.2
In this study, the characteristic of fluid flow in the new type lung assist devices has been established using computational fluid dynamics(CFD). For the modeling, the hollow fiber was ignored, and vertical types and tangential types were used for the model. Which was to analyze the flow characteristics of the fluid Dow model when there exists 1 and 2 input/output pods, and when the input/output ports is located at the center of the cylinder and at the tangential direction with the cylinder wall. The modeling results showed that it was possible to eliminate no-flow region(stagnant layer) as shown in the vertical type when an inlet and an outlet were installed on the tangential direction of the cylinder as shown in the tangential type. Also, in the tangential type, vortex-type flow appeared as dominant, and it showed a complicated flow not deviated to one side. When the number of input/output was two, there was no deviated flow, and complicated flows were generated all across the tube. From the test result, it was found that input/output of flow was tangential type and complicated flows with no stagnant layer would be generated when there are two inputs/outputs, respectively.