轉型期中國知識分子的政治參與硏究

( Dong Xu Shi ) 국민대학교 중국지식네트워크 2013 중국지식네트워크 Vol.3 No.-

自20世紀70年代末以來,中國社會處於壹個劇烈變動的轉型期。政治,經濟以及社會的變動給當代中國知識分子帶來了深刻的變化,這壹點在知識分子的政治參與行爲上表現得尤爲突出,具體體現在參與動機,參與形勢以及參與特征的發展與變化之中。除深入闡述這些變化外,本文還試圖對影響知識分子政治參與的因素進行深入分析。 Since the late 1970’s, Chinese society is in the transitional period. The political, economic and social changes has brought about profound changes to the contemporary Chinese intellectuals. The development and change of the political participation behavior which include participation motivation, participation forms and participation characteristics of intellectuals was particularly prominent. And this paper also attempts to carry on in-depth analysis to influence factors of intellectuals’ Political Participation.

MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis

Dong-liang Shi,Gui-rong Shi,Jing Xie,Xu-zhao Du,Hao Yang 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.8

Fibroblast-like synoviocytes (FLS) with aberrant expres-sion of microRNA (miRNA) are critical pathogenic regula-tors in rheumatoid arthritis (RA). Previous studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models. In this study, we explored the effects of miR-27a on cell migration and invasion in cultured FLS from RA patients. We found that miR-27a was markedly downregulated in the serum, synovial tissue, and FLS of RA patients. Meanwhile, the expression of follistatin-like protein 1 (FSTL1) was upregulated, which suggests that FSTL1 plays a key role in RA development. The results of a Transwell assay showed that miR-27a inhibited FLS migration and invasion. However, miR-27a inhibition promoted the migration and invasion of FLS. In addition, the down-regulated expression of matrix metalloproteinases (MMP2, MMP9, and MMP13) and Rho family proteins (Rac1, Cdc42, and RhoA) was detected after treatment with miR-27a in RA-FLS by quantitative reverse transcription-PCR and western blot analysis. Then, a luciferase reporter assay validated that miR-27a targeted the 3-untranslated region (3-UTR) of FSTL1. Moreover, miR-27a caused a significant decrease of FSTL1. In addition, the expression of TLR4 and NFκB was inhibited by miR-27a but increased by FSTL1 overexpression. In conclusion, we found that miR-27a inhibited cell migration and invasion of RA-FLS by targeting FSTL1 and restraining the TLR4/NFκB pathway.

MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis

Shi, Dong-liang,Shi, Gui-rong,Xie, Jing,Du, Xu-zhao,Yang, Hao Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.8

Fibroblast-like synoviocytes (FLS) with aberrant expression of microRNA (miRNA) are critical pathogenic regulators in rheumatoid arthritis (RA). Previous studies have found that overexpression or silencing of miRNA can contribute to the development of miRNA-based therapeutics in arthritis models. In this study, we explored the effects of miR-27a on cell migration and invasion in cultured FLS from RA patients. We found that miR-27a was markedly downregulated in the serum, synovial tissue, and FLS of RA patients. Meanwhile, the expression of follistatin-like protein 1 (FSTL1) was upregulated, which suggests that FSTL1 plays a key role in RA development. The results of a Transwell assay showed that miR-27a inhibited FLS migration and invasion. However, miR-27a inhibition promoted the migration and invasion of FLS. In addition, the down-regulated expression of matrix metalloproteinases (MMP2, MMP9, and MMP13) and Rho family proteins (Rac1, Cdc42, and RhoA) was detected after treatment with miR-27a in RA-FLS by quantitative reverse transcription-PCR and western blot analysis. Then, a luciferase reporter assay validated that miR-27a targeted the 3-untranslated region (3'-UTR) of FSTL1. Moreover, miR-27a caused a significant decrease of FSTL1. In addition, the expression of TLR4 and $NF{\kappa}B$ was inhibited by miR-27a but increased by FSTL1 overexpression. In conclusion, we found that miR-27a inhibited cell migration and invasion of RA-FLS by targeting FSTL1 and restraining the $TLR4/NF{\kappa}B$ pathway.

中國公民政治參與制度化建設的歷史轉變

석동욱 ( Dong Xu Shi ) 국민대학교 중국지식네트워크 2015 중국지식네트워크 Vol.6 No.-

中國建國以來公民政治參與的制度化建設發生了幾次轉變:從建國初至十一屆三中全會前, 這一時期初步建立了制度化的參與机制, 但在參與實踐上逐漸走向非制度化;從十一屆三中全會至今, 這一時期逐步建立制度化的參與机制, 但在實踐層面非制度性參與仍占흔大比重。未來要引導公民的政治參與机制走向制度化, 則應進一步構建完善公民政治參與的制度化광架, 同時不斷拓展制度建構的空間。 Since the founding of China, the changes of institutionalization for Citizens`` political participation occurred several times. The first stage is from beginning until The Third Plenary Session of the 11th Central Committee. The system of participation mechanism initially established of the period. But in practice it went to non-institutionalization gradually. The second stage is from The Third Plenary Session of the 11th Central Committee up to now. The system of participation mechanism gradually established. But in practice non-institutional participation still accounted for a large proportion. In the future, to guide the political participation mechanism of the citizens to institutionalization, the institutional framework of improving the citizens`` political participation should be further constructed. At the same time, the space of system construction should be expanded.

A Cluster-Based Countermeasure against MAC Layer Attacks in IEEE 802.11 MANETs

Shi, Fei,Liu, Wei Jie,Jin, Dong Xu,Song, Joo Seok Trans Tech Publications, Ltd. 2013 Applied mechanics and materials Vol.284 No.-

<P>MANETs become a considerable interest nowadays. However, these types of networks are vulnerable to a large group of attacks, e.g., MAC layer attacks. Most of the previous researches related to security issues focus on detection of misbehaviors after it occurred. We propose a new way of thinking to evade occurrence of misbehaviors. A novel clustering algorithm is presented using analytic hierarchy process to elect clusterhead. Afterwards, the clusterhead is required to assign backoff values to originators in its transmission range, which are also the members in the corresponding cluster, rather than permitting the originators to choose backoff values. Meanwhile, the elected clusterhead also monitors whether originators obey the backoff values. With the proposed scheme, the misuse of the backoff in MAC layer in 802.11 DCF can be prevented.</P>

MRI T2-Weighted Imaging and Fat-Suppressed T2-Weighted Imaging Image Fusion Technology Improves Image Discriminability for the Evaluation of Anal Fistulas

Shi-Ting Feng,Mengqi Huang,Zhi Dong,Ling Xu,Yin Li,Yingmei Jia,Huasong Cai,Bingqi Shen,Zi-Ping Li 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.3

Objective: To explore whether MRI fusion technology (combined T2-weighted imaging [T2WI] and fat-suppressed T2WI [T2WI-FS]) improves signal differences between anal fistulas and surrounding structures. Materials and Methods: A total of 32 patients with confirmed diagnoses of anal fistula were retrospectively studied. All available T2WI and T2WI-FS images for each patient were used to generate fusion image (T2WI-Fusion) based on the addition of gray values obtained from each pixel via an MR post-processing work station. The discriminability of fistula, perianal sphincter, and perianal fat in T2WI, T2WI-FS, and T2WI-Fusion images was quantified with Fisher’s scoring algorithm. For subjective visual image assessment by researchers, five-point scale scores were determined using a modified double-stimulus continuous qualityscale test to evaluate T2WI-FS, T2WI, enhanced axial three-dimensional-volumetric interpolated breath-hold examination (3D-VIBE), and T2WI-Fusion sequence images. The differences were subsequently compared. Results: Mean Fisher scores for fistulas vs. sphincters obtained from T2WI-Fusion (FFusion-fistula = 6.56) were significantly higher than those from T2WI (FT2WI-fistula = 3.35) (p = 0.001). Mean Fisher scores for sphincters vs. fat from T2WI-Fusion (FFusion-sphincter = 10.84) were significantly higher than those from T2WI-FS (FSFS-sphincter = 2.57) (p = 0.001). In human assessment, T2WI-Fusion showed the same fistula discriminability as T2WI-FS, and better sphincter discriminability than T2WI. Overall, T2WI-Fusion showed better discriminability than T2WI, T2WI-FS, and enhanced 3D-VIBE images. Conclusion: T2WI and T2WI-FS fusion technology improves signal differences between anal fistulas and surrounding structures, and may facilitate better evaluation of anal fistulas and sphincters.

Cr(VI) Resistance and Removal by Indigenous Bacteria Isolated from Chromium-Contaminated Soil

( Dong Yan Long ),( Xian Jin Tang ),( Kuan Cai ),( Guang Cun Chen ),( Chao Feng Shen ),( Ji Yan Shi ),( Ling Gui Chen ),( Ying Xu Chen ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8

The removal of toxic Cr(VI) by microorganisms is a promising approach for Cr(VI) pollution remediation. In the present study, four indigenous bacteria, named LY1, LY2, LY6, and LY7, were isolated from Cr(VI)-contaminated soil. Among the four Cr(VI)-resistant isolates, strain LY6 displayed the highest Cr(VI)-removing ability, with 100 mg/l Cr(VI) being completely removed within 144 h. It could effectively remove Cr(VI) over a wide pH range from 5.5 to 9.5, with the optimal pH of 8.5. The amount of Cr(VI) removed increased with initial Cr(VI) concentration. Data from the time-course analysis of Cr(VI) removal by strain LY6 followed first-order kinetics. Based on the 16S rRNA gene sequence, strain LY6 was identified as Pseudochrobactrum asaccharolyticum, a species that had never been reported for Cr(VI) removal before. Transmission electron microscopy and energy dispersive X-ray spectroscopy analysis further confirmed that strain LY6 could accumulate chromium within the cell while conducting Cr(VI) removal. The results suggested that the indigenous bacterial strain LY6 would be a new candidate for potential application in Cr(VI) pollution bioremediation.

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway

Dong Zhao,Ming-Yao Gu,Jiu Liang Xu,Li Jun Zhang,Shi Yong Ryu,양현옥 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.1

Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor (TNF)-α, prostaglandin (PG) E2, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated Akt/IKK/NF-κB pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and TNF-α by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting Akt/IKK/IκB/NF-κB pathway and promoting Nrf-2/HO-1 pathway.

Two Kinesins from Arabidopsis, KatB and KatC, Have a Second Microtubule-binding Site in the Tail Domain

( Shi Ling Jiang ),( Ming Li ),( Tao Xu ),( Dong Tao Ren ),( Guo Qin Liu ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.1

Phase Structure and Fine Microstructure of In-Situ Vanadium Carbides in Cast High-Vanadium High-Speed Steel

Xu, Liu-Jie,Wei, Shi-Zhong,Xing, Jian-Dong,Li, Yan,Long, Rui 대한금속ᆞ재료학회 2006 METALS AND MATERIALS International Vol.12 No.5