원발성 위장관 악성 림프종의 임상적 고찰 : 치료 결과를 중심으로

원종호,백승호,홍대식,오도연,박희숙 순천향대학교 1994 논문집 Vol.17 No.4

저자들은 1984년 3월부터 1992년 12월까지 순천향 대학교 부속병원에서 원발성 위장관 악성 림프종으로 진단되었던 23명을 대상으로 다음과 같은 결론을 얻었다. 1. 대상 환자의 나이의 중앙치는 44(23-75)세로 남녀비가 2.8 : 1이었다. 2. 원발병소는 위 10예(43.5%), 소장 8예(34.8%) 및 회맹장 이행부위 5예(21.7%)였고, 병기 Ⅰ??기 8예(34.8%), Ⅱ??기 12예(52.2%), Ⅲ기 2예(8.7%), Ⅳ기 1예(4.3%)였다. 동반된 다른 장기는 주로 복부 임파절이었으며 폐 임파절 침범이 1예 있었고, 간을 침범한 경우가 1예, 위장과 소장에 병발한 경우가 1예 있었다. 조직학적 분류로는 중등도 19예(82.6%) 및 고도 4예(17.4%)였고 10예(43.5%)에서 B 증후가 있었다. 3. 치료를 시행한 20예중 Ⅰ??기 7예는 수술적 치료후 보조항암화학요법을 시행하였으며, Ⅱ??기 13예중 진단적 개복술후 완전절제가 확인된 3예는 보조항암화학요법을, 불완전절제로 확인된 7예는 관해유도 항암화학요법을 시행하였고, 3예는 항암화학요법만을 시행하였다. 4. 치료를 시행한 20예의 생존기간은 중앙치 43(4-100??개월이었으며, 3년 생존율 60.9%, 5년 생존율 40.6%였다. 5. Ⅰ??기 7예의 생존기간은 중앙치 42(11-100??개월이었으며, Ⅱ??, Ⅲ기 13예에서 치료에 대한 완전 관해가 9례(70%), 부분관해(15%), 무반응이 2례(15%)로 관해율은 85%였으며, 생존기간은 중앙치 44(4-52??개월이었다. 6. 완전관해자가 진행시까지의 관해지속기간은 중앙치 43(10-56??개월이었으며, 3년 무병생존율 79.1%, 5년 무병생존율 36.2%였다. Over a 8-year period(March 1984 through December 1992), 23 patients with primary gastrointestinal non-Hodgkin's lymphoma treated at Soonchunhyang University Hospital were analyzed with the following results; 1. The mean age of the patients was 43(23-75) years with male to female ratio of 2.8 : 1. 2. The primary sites of lymphoma were stomach in 10(43.5%), small intestine in 8(34.8%), and ileocecal area in 5(21.7%) and by modified Ann Arbor system, stage Ⅰ?? was 8(34.8%), stage Ⅱ?? was 12(52.2%), stage Ⅲ was 2(8.7%), and stage Ⅳ was 1(4.3%). Histologic classification by Working formulation revealed 19 cases(82.6%) of intermediate grade and 4 cases(17.4%) of high grade. B symptoms were observed in 10 cases(43.5%). 3. Treatments were performed in 20 cases as follows : In 7 cases with stage Ⅰ, complete surgical resection with systemic combined chemotherapy was performed. In 13 cases with stage ⅡE and Ⅲ, complete resection with systemic combined chemotherapy in 3 cases, incomplete resection with combined chemotherapy in 7 cases, and combined chemotherapy only in 3 cases. 4. Median survival duration of 20 treated patients was 43(4-100?? months and 3-year survival rate and 5-year survival rate were 60.9% and 40.6%, respectively. 5. Median survival duration of 7 cases with stage Ⅰ?? was 42 months(11-100??. In 13 cases with stage Ⅱ??, Ⅲ, response to treatment was complete remission in 9(70%), partial remission in 2(15%), and no response in 2(15%) resulting 85% of response rate and median survival duration was 44(4-52?? months. 6. Disease free survival rate of achieving a complete remission was 43(10-56?? months and 3-year disease-free survival rate and 5-year disease-free survival rate were 79.1% and 39.2%, respectively.

전신성 홍반성 루프스 환자에서 발생한 자가 면역성 간염 1례

김준재,백나나,김현정,전태주,서동대,오태훈,최원충 인제대학교 2008 仁濟醫學 Vol.29 No.-

SLE 환자에서 간 효소 수치의 상승은 여러 가지 원인에 의하여 드물지 않게 관찰될 수 있다. 이 중 자가 면역 기전에 의해 발생되는 질환으로 자가 면역성 간염과 SLE에 동반된 간염이 있으며, 두 가지 질환의 감별은 환자의 예후 및 치료에 중요하다. 따라서 간 조직 검사를 포함한 정확한 진단 기준으로 조기에 진단하여야 하며, 이에 따른 적절한 치료를 통해서 간 부전 및 비가역적 간경변증으로 진행을 방지할 수 있을 것으로 사료된다. Patients with systemic lupus erythematosus (SLE) have a 25-50% chance of developing abnormal liver tests in their lifetime and various causes are related to elevation of liver enzyme, such as hepatic involvement of lupus, hepatotoxic drug, viral infection, autoimmune hepatitis and so on. Discrimination of autoimmune hepatitis from SLE-associated hepatitis is important because complications and therapy are quite different, although both are autoimmune syndromes. Here we are presenting a case of SLE patient with type I autoimmune hepatitis proved with liver biopsy.

대뇌 기저핵 신경세포 일차배양에서 망간에 의해 유도된 Appoptosis : 형태학적인 소견

신동훈,김상표,정용욱,배재훈,송대규,백원기 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 실험은 대뇌기저핵의 신경세포를 배양하여 망간(MnCl₂)을 투여한 후 망간독성에 의한 신경세포의 apoptosis를 형태학적인 소견으로 관찰하였다. 방법 : 배양된 신경세포에 0.01에서 10μM Mnc12를 48시간동안 처리한 후 TUNEL (TdT-mediated dUTP Nick End Labelling)법 및 투과전자현미경학적으로 관찰하였다. 결과 : TUNEL방법을 이용하여 관찰한 결과 TUNEL반응에 갈색으로 양성반응을 나타내는apoptotic 세포의 수가 대조군에 비해 MnCl₂를 투여한 군에서 유의하게 높게 나타났으며(P〈0.05), 투과전자현미경학적 소견상 대조군의 신경세포들은 핵인(nucleolus)이 두드러지게 특징적으로 보이면서 핵막과 세포질내 소기관들이 잘 보존되어 있으며, 세포질내망(ER)과 사립체(mitochondria)를 특히 많이 가지고 있었다. Mnc12를 48시간 동안 처리한 군에서 이질염색질(heterochromatin)이 핵막으로 이동하면서 응집되어 있었으며, 핵내 불규칙한 형태의 염색질이 나타나 분절이 진행되는 소견을 보였고, Apoptosis의 가장 특징적인 초기 소견인 막으로 둘러싸인 반달모양의 핵내염색질의 분절편(fragment-ed chromatin)과 주위의 상대적으로 정상적인 소기관으로 구성된 apoptotic body를 관찰할 수 있었다. 결론 : 신경세포에서 망간에 의해 apoptosis가 유도됨을 형태학적인 방법으로 확인할 수 있었으며 망간에 의한 세포사망양상에 apoptosis가 하나의 기전이 될 수 있을 것이다. Objectives : Manganese is cytotoxic to the central nervous system including basal gan-glia. Its toxic mechanism is related to oxidative stress, mediated by toxic free radicals but is specultives. In the present study , we have investigated to manifest apoptosis in man-ganese-induced cytotoxicity in primary neuronal cell culture of rat basal ganglia. Methods : To detect apoptotic neuronal cells were stained by the terminal deoxynu-cleotide (TdT) -mediated dUTP nick end-labelling (TUNEL) method and apoptotic changesin nuclei of neurons were observed by electron microscopy. Results : We showed that TUNEL immunostain showed brownish signal in the nuclei of apoptotic cells and the proportions of apoptotic cells in Manganese treatment groups were more higher than controls. On transmission electron microscopy, there were chromatine condensation with margination toward nuclear membrane and condensation of cyto-plasm in the treated with luM MnCl²for 48 hours in a basal ganglia neurons. Apoptotic bodies were found and consisted of semilunar-like condensed nuclei with relatively intact cytoplasmic organelles. Conclusions : Apoptosis appears to be one mechanism in the manganese-induced net-ronal cell death. Manganese intoxication is a convenient model for apoptosis study.

Poster Exhibition : The Correlation of Small Intestinal Bacterial Overgrowth, Orocecal Transit Time and Gastrointestinal Symptoms in Patients with Liver Cirrhosis (초)

Dae Won Jun,Mi Yeon Chung,Jun Young Jung,Dae Hyung Baek,Byoung Kwan Son,Seong Hwan Kim,Yun Ju Jo,Young Sook Park 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4(S)

Poster Session 1 : Oral Presentation ; Cell Cycle and Cell Death : Modulation of spontaneous apoptosis of neutrophils by amyloid proteins

( Dae Won Baek ),( Hae Young Park ),( Jung Hwa Ban ),( Min Jung Lee ),( Sun Young Lee ),( Jong Young Kwak ) 한국생화학분자생물학회 (구 한국생화학회) 2005 62회 KSBMB Annual Meeting in 2005 Vol.- No.-

Effect of Soil Amendments on Arsenic Reduction of Brown Rice in Paddy Fields

Dae-Won Kang,Da-Young Kim,Ji-Hyock Yoo,Sang-Won Park,Kyeong-Seok Oh,Oh-Kyung Kwon,Seung-Hwa Baek,Won-Il Kim 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.2

There is an increasing concern over arsenic (As) contamination in rice since Codex Committee on Contaminants in Food (CCCF) discuss on maximum levels for As in rice in 2010. This study was conducted to reduce As concentration in rice by soil amendment treatments in paddy field soils contaminated by As. The selected four amendments were poultry manure, agri-lime, steel slag, and gypsum with the addition of 3% or 5% (w/w) on a dry basis. The As reduction effect could not be verified, as a result of the pot test by adding poultry manure to the paddy soil around the mine located in Yesan. Among the agri-lime treated rice cultivated pots, the As concentration increased up to 32.1%. On the other hand, the content of As in the sample pots treated with steel slag and gypsum decreased by 65.4% and 63.4%, respectively. On the basis of the results of these pot experiments, the field test was carried out in the As polluted rice field around the mine located in Yesan, and when the four amendments were treated, the As content in the brown rice reduced in all the amendment treatments compared with the control plot. The As reduction in brown rice of the amendment was confirmed to be higher efficiency by the order of gypsum > steel slag > poultry manure > agri-lime. As a result of pot experiments using paddy soil around the mine located in Seosan, As stabilization efficiency in rice and As reduction effect could not be determined by comparison to the control. From the rice cultivated from agri-lime treated pot, As concentration increased by 15.8% in rice. On the other hand, the As content of the pots treated with steel slag and gypsum decreased by 39.1% and 60.2%, respectively. In conclusion, distinguished As reducing effectiveness could be expected by soil amendment treatments for rice cultivation.

Poster Session 5 : Tumor Biology Developmental Biology Plant Biology Molecular Medicine and Gene Therapy Procaryotic Genetics Biotechnology ; Ginsenosides enhance the transduction efficiency of Tat-superoxide dismutase into mammalian cells and skin

( Dae Won Kim ),( Won Sik Eum ),( Sang Ho Jang ),( Chang Sik Yoon ),( A Yeon Kim ),( Young Hoon Kim ),( Nam In Baek ),( Tae Cheon Kang ),( Moo Ho Won ),( Hyeok Yil Kwon ),( Jung Hoon Kang ),( Oh Shin 한국생화학분자생물학회 (구 한국생화학회) 2003 생화학분자생물학회 춘계학술발표논문집 Vol.2003 No.-

Original Article : Efficacy and safety of entecavir plus carnitine complex (GODEX®)compared to entecavir monotherapy in patient ALT elevated chronic hepatitis B: randomized, multicenter open-label trials. The GOAL study

( Dae Won Jun ),( Byung Ik Kim ),( Yong Kyun Cho ),( Hong Ju Kim ),( Young Oh Kwon ),( Soo Young Park ),( Sang Young Han ),( Yang Hyun Baek ),( Yong Jin Jung ),( Hwi Young Kim ),( Won Kim ),( Jeong He 대한간학회 2013 Clinical and Molecular Hepatology(대한간학회지) Vol.19 No.2

Background/Aims: Carnitine and vitamin complex (Godex®) is widely used in patients with chronic liver disease who show elevated liver enzyme in South Korea. The purpose of this study is to identify the efficacy and safety of carnitine from entecavir combination therapy in Alanine aminotransferase (ALT) elevated Chronic Hepatitis B (CHB) patients. Methods: 130 treatment-na?ve patients with CHB were enrolled from 13 sites. The patients were randomly selected to the entecavir and the complex of entecavir and carnitine. The primary endpoint of the study is ALT normalization level after 12 months. Results: Among the 130 patients, 119 patients completed the study treatment. The ALT normalization at 3 months was 58.9% for the monotherapy and 95.2% for the combination therapy (P<0.0001). ALT normalization rate at 12 months was 85.7% for the monotherapy and 100% for the combination group (P=0.0019). The rate of less than HBV DNA 300 copies/mL at 12 months was not statistically significant (P=0.5318) 75.9% for the monotherapy, 70.7% for the combination and it was. Quantification of HBsAg level was not different from the monotherapy to combination at 12 months. Changes of ELISPOT value to evaluate the INF-Y secretion by HBsAg showed the increasing trend of combination therapy compare to mono-treatment. Conclusions: ALT normalization rate was higher in carnitine complex combination group than entecavir group in CHB. Combination group was faster than entecavir mone-treatment group on ALT normalization rate. HBV DNA normalization rate and the serum HBV-DNA level were not changed by camitine complex treatment.

Poster Session 1 : Modulation of spontaneous apoptosis of neutrophils by amyloid proteins

( Dae Won Baek ),( Hae Young Park ),( Jung Hwa Ban ),( Min Jung Lee ),( Sun Young Lee ),( Jong Young Kwak ) 한국생화학분자생물학회 (구 한국생화학회) 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-

토양 안정화를 처리한 후 재배한 쌀 중 총비소의 저감효과

강대원 ( Dae-won Kang ),김원일 ( Won-il Kim ),박상원 ( Sang-won Park ),백승화 ( Seung-hwa Baek ) 한국환경농학회 2017 한국환경농학회 학술대회집 Vol.2017 No.-

과서 광산 채광활동으로 인하여 생긴 부산물들이 인근 농경지로 혼입되면서 채광활동이 멈춘 지 금까지도 광산 인근 농경지의 비소 오염은 심각한 상황이다. 이러한 휴·폐광산에 대해 적절한 복원작업이 이뤄지지 않는다면 인근 농경지나 하천으로 유입된 오염물질에 의해 많은 환경문제가 발생하게 된다. 따라서 본 연구는 비소와 중금속으로 오염된 농경지 현장에 다양한 안정화제를 처리하여 토양 중 비소와 중금속 안정화 효율 및 작물로의 흡수 저감 효과를 관찰하였다. 본 실험은 충남 예산군에 위치한 학영광산 인근 논토양을 대상으로 비소 및 중금속 안정화제로 널리 사용되고 있는 계분 퇴비, 석회, 제강슬래그, 석고를 각각 3, 5% (w/w) 처리한 다음 벼를 재배하여 비소의 함량을 확 인하였다. 안정화제를 처리하지 않고 재배한 쌀에서는 비소의 총 함량이 0.48±0.02 mg kg^-1 로 확인되었다. 계분퇴비를 3, 5% (w/w) 처리한 처리구에서는 쌀 중 비소 함량이 각각 0.31±0.02, 0.32± 0.03 mg kg-1로 대조구보다 35.1, 33.6% 저감되었고, 농용석회를 3, 5% (w/w) 처리하였을 때 비 소의 함량은 각각 0.37±0.03, 0.4±0.02 mg kg^-1으로 대조구 대비 15.6, 17.8% 저감되었다. 제강 슬래그를 3, 5% (w/w) 처리하였을 때 쌀 중 비소 함량은 0.26±0.02, 0.21±0.01 mg kg^-1으로 대조구 대비 각각 45.7, 46.1% 저감되었다. 마지막으로 석고를 3, 5% (w/w) 처리하였을 때 쌀 중 비소의 함량은 두 함량 처리구 모두 0.21±0.01 mg kg^-1이었고 이는 대조구 대비 54.9, 55.1% 저감되었다. 이 결과로 볼 때 석고를 처리하였을 때 비소의 가장 높은 저감 효율을 확인할 수 있었다. 이는 석고 처리 시 공급되는 Ca과 As의 공침, DOC의 감소로 인한 비소 이동성 감소 등 복합 적인 원인으로 As의 식물 유효도 낮아진 것으로 사료된다.