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정다빈 ( Dabin Jeong ),이강은 ( Kang Eun Lee ),정민진 ( Min Jin Jeong ),문창진 ( Changjin Moon ),김성석 ( Sungsuk Kim ),김재현 ( Jaehyun Kim ),양순옥 ( Sun Ok Yang ) 한국정보처리학회 2020 한국정보처리학회 학술대회논문집 Vol.27 No.2
본 논문은 기계학습 기반 온라인 한글 필기 인식 시스템의 첫 구현 결과를 담고 있다. 한글의 글자는 최소한 하나의 모음을 포함하고 있으며, 이 모음은 대개 직선으로 필기한다는 사전 지식을 활용하여 인식에 적용하고자 한다. 이를 위해 사용자가 온라인으로 필기하면 획 데이터를 획득하여 중성에 해당하는 모음을 찾는 알고리즘을 개발하였다. 제안한 알고리즘에서는, 우선 필기한 글자를 포함하는 사각형 R과 각 획을 둘러싸는 사각형 SR을 생성한 후, 직선을 판별하고, 이 직선들이 모음을 구성하는 후보군을 찾는 과정으로 구성되어 있다. 아직 초기 연구이므로, 다양한 경우에 대한 분석이나 실험 결과는 없지만, 이를 활용하여 온라인 필기 인식 모델에 적용하여 인식 성능을 높이기 위한 추후 연구의 기반으로 활용하고자 한다.
정민진 ( Min Jin Jeong ),정다빈 ( Dabin Jeong ),이강은 ( Kang Eun Lee ),김성석 ( Sungsuk Kim ),양순옥 ( Sun Ok Yang ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
본 논문은 개발하고자 하는 기계학습 기반 한글 필기 인식 시스템의 첫 연구 결과를 담고 있다. 즉, 기계학습을 위해서는 학습용 및 테스트용 필기 데이터가 아주 많이 필요하므로, 이를 수집하고 전처리하는 방법을 제안하였다. 한글의 한 글자는 자음과 모음을 결합하여 생성되는데, 실제 만 개 이상의 글자가 생성될 수 있다. 따라서 각각의 글자 데이터를 수집하는 대신, 수집한 글자 데이터로부터 초성, 중성, 종성을 구분하여 최종적으로 자음, 모음 데이터로 저장하고자 한다. 아직 초기 연구이므로, 다양한 경우에 대한 분석이나 실험 결과는 없지만, 이를 활용하여 온라인 필기 인식 모델에 적용하여 인식 성능을 높이기 위한 추후 연구의 기반으로 활용하고자 한다.
Autophagy activation decreases AGEs in skin cells in vitro and ex vivo
( Kayoung Shin ),( Yeonjae Kim ),( Sungwoo Kim ),( Sekyoo Jeong ),( Hwa-jee Chung ),( Keedon Park ),( Sungha Hwang ),( Dayeon Song ),( Minkyung Shin ),( Dabin Jeong ),( Jeong Ho Park ) 한국피부장벽학회 2023 한국피부장벽학회지 Vol.25 No.2
While the initial generation of AGEs (advanced glycation end products) usually takes place in a time-lapse of hours, it is reported that the complete formation of AGEs after the rearrangement and cross-liking with other proteins requires weeks to years under physiological conditions. However, in pathological conditions such as hyperglycemia, oxidative stress, and higher temperature, it can be accelerated up to hour-scale reaction. While AGEs can mechanically and/or biochemically alters the protein and tissue structures and functions, AGEs can also elicit downstream cellular signaling through binding to the RAGE (receptor for advanced glycation end products). Activation of RAGE induces NF-κB and MAPK pathways and results in the release of various cytokines and matrix metalloproteinases (MMPs). In skin, along with the direct ultraviolet irradiation, exposure to particulate matters (PMs) or smoking can also accelerate the formation of AGEs, which subsequently induces irregular pigmentation, wrinkle formation, and skin barrier dysfunction. Based on the deleterious effects of AGEs on skin aging, significant efforts have been exerted to develop anti-AGE molecules. Most of the currently available anti-AGE molecules, however, focus on the prevention of AGEs through the anti-oxidant property of molecules. Autophagy is a cellular mechanism to maintain cellular homeostasis role by removing dysfunctional cellular organelles and proteins. Recently, it was reported that AGEs removal can be stimulated by autophagy activator treatment in human epidermal keratinocytes. In this study, using a newly developed compound derivative with autophagy stimulating activity and anti-oxidant capacity, we investigated the modulation of AGEs formation and elimination by autophagy activator in vitro and ex vivo. In cultured human epidermal keratinocytes, high glucose- or glyoxal-induced AGEs formation was attenuated by autophagy activator treatment. Removal of BSA-AGE by keratinocytes was also accelerated by autophagy activator. Similar activities were also observed in ex vivo human skin explant model. Interestingly, epidermal expression of RAGE was also down-regulated by autophagy activator treatment. These results suggest that autophagy signaling is closely related to AGEs formation and elimination, and stimulation of autophagic flux can be a new regimen for anti-AGEs therapeutics.
Jeong, Jinyoung,Park, Dabin,Lee, Ji-Hoon OSA OPTICAL SOCIETY OF AMERICA 2016 Applied Optics Vol.55 No.31
<P>We proposed a method of eliminating the bending-induced retardation of a plastic film by coating it with a polymer layer with an opposite birefringence. We coated a polystyrene (PS) or a poly(methyl methacrylate) (PMMA) layer on a polycarbonate (PC) plastic film. The bare PC film is composed of main-chain-type polymers and showed an increase in retardation with bending. The main-chains of the PC polymer are reoriented along the circular arc direction during bending, resulting in a positive birefringence. In contrast, the 11 wt. % PS-coated and the 19 wt. % PMMA-coated PC films showed minimal change in the retardation regardless of the radius of curvature. The PS and the PMMA polymers are of the side-chain-type, and the side-chains were aligned perpendicular to the circular arc direction during bending, resulting in a negative birefringence. Consequently, the bending-induced retardation of the PC film can be compensated by the PS or the PMMA layer during bending of the film. This method of compensating for the bending-induced retardation of the plastic film can be useful for flexible display applications. (C) 2016 Optical Society of America</P>
Kim Dabin,Kim Min Hye,Park Seul Gi,Choi Sujin,Lee Chan Jae,Jung Young Hwa,Choi Chang Won,Shin Myoung-Jin,Song Kyoung-Ho,Kim Eu Suk,Park Jeong Su,Kim Hong Bin,Lee Hyunju 대한소아감염학회 2023 Pediatric Infection and Vaccine Vol.30 No.1
A case of persistent Ralstonia mannitolilytica bacteremia in the neonatal intensive care unit prompted source investigation due to its rarity. After an extensive investigation, a contaminated ultrasonic nebulizer was identified as the source, and the infection was controlled by removing the source. This study emphasizes the importance of further investigations, even in single cases of rare pathogens.