http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Shu-cheng Lin ) (검색결과 36 건)
- 무료
- 기관 내 무료
- 유료
-
-
Ying-Cheng Chiang,Chi-An Chen,Chun-Ju Chiang,Tsui-Hsia Hsu,Ming-Chieh Lin,San-Lin You,Wen-Fang Cheng,Mei-Shu Lai 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.4
Objective: To investigate the changes of incidence and prognosis of epithelial ovarian cancer in thirty years in Taiwan. Methods: The databases of women with epithelial ovarian cancer during the period from 1979 to 2008 were retrieved from the National Cancer Registration System of Taiwan. The incidence and prognosis of these patients were analyzed. Results: Totally 9,491 patients were included in the study. The age-adjusted incidences of epithelial ovarian cancer were 1.01, 1.37, 2.37, 3.24, 4.18, and 6.33 per 100,000 person-years, respectively, in every 5-year period from 1979 to 2008. The age-specific incidence rates increased especially in serous, endometrioid and clear cell carcinoma, and the age of diagnosis decreased from sixty to fifty years old in the three decades. Patients with mucinous, endometrioid, or clear cell carcinoma had better long-term survival than patients with serous carcinoma (log rank test, p<0.001). Patients with undifferentiated carcinoma or carcinosarcoma had poorer survival than those with serous carcinoma (log rank test, p<0.001). The mortality risk of age at diagnosis of 30-39 was significantly higher than that of age of 70 years or more (test for trend, p<0.001). The mortality risk decreased from the period of 1996-1999 (hazard ratio [HR], 0.90; p=0.054) to the period after 2000 (HR, 0.74; p<0.001) as compared with that from the period of 1991-1995. Conclusion: An increasing incidence and decreasing age of diagnosis in epithelial ovarian cancer patients were noted. Histological type, age of diagnosis, and treatment period were important prognostic factors for epithelial ovarian carcinoma.
-
Lin Chang-Gang,Zou Ming-Song,Zhang Hai-Cheng,Qi Li-Bo,Liu Shu-Xiao 대한조선학회 2021 International Journal of Naval Architecture and Oc Vol.13 No.1
To investigate the mechanism of friction-induced vibration and noise of ship water lubricated stern bearings, a two-degree-of-freedom (2-DOF) nonlinear self-excited vibration model is established. The novelty of this work lies in the detailed analysis of influence of different parameters on the stability and nonlinear vibration characteristics of the system, which provides a theoretical basis for the various friction vibration and noise phenomenon and has a very important directive meaning for low noise design of water lubricated stern bearings. The results reveal that the change of any parameter, such as rotating speed of shaft, contact pressure, friction coefficient, system damping and stiffness, has an important influence on the stability and nonlinear response of the system. The vibration amplitudes of the system increase as (a) rotating speed of shaft, contact pressure, and the ratio of static friction coefficient to dynamic friction coefficient increase and (b) the transmission damping between motor and shaft decreases. The frequency spectrum of the system is modulated by the first mode natural frequency, which is continuous multi-harmonics of the first mode natural frequency. The response of the system presents a quasi-periodic motion.
-
Shu Wang,Houpu Yang,Jiajia Guo,Miao Liu,Fuzhong Tong,Yingming Cao,Bo Zhou,Peng Liu,Lin Cheng,Fei Xie,Deqi Yang,Jiaqing Zhang 한국바이오칩학회 2011 BioChip Journal Vol.5 No.1
Neo-adjuvant chemotherapy for breast cancer substantially benefits patients who achieve pathological response. However, clinical or pathological response information can only be obtained a period of time after chemotherapy. The identification of novel bio-markers or the application of new technique that can be used to predict treatment response before che-motherapy would allow therapy to be tailored on an individual patient basis. The purpose of this study is to identify the chemo-sensitivity and chemo-resistance related proteins using antibody microarray profiling, and to develop a multi-protein predictive model for breast cancer. Total protein was extracted from core needle biopsy samples obtained from 15 patients before treatment with neo-adjuvant TA(combination of taxanes and anthracycline) chemotherapy. Protein profiling was analyzed by antibody microarray. 10 pati-ents were used as training set to develop the predictive model using the software PAM(prediction analysis of microarray). Another 5 patients were used as a validation set to test the model. In cross-validation, the mole-cular predictive model showed an accuracy of 90%, in independent validation, the model classified the cases with an accuracy of 80%. In conclusion, the proteomic predictive model has the potential to predict pathological response to neo-adjuvant TA chemotherapy.
-
Evaluation of sewage sludge incineration ash as a potential land reclamation material
Lin, Wenlin Yvonne,Ng, Wei Cheng,Wong, Belinda Shu Ee,Teo, Serena Lay-Ming,Sivananthan, Gayathiri d/o,Baeg, Gyeong Hun,Ok, Yong Sik,Wang, Chi-Hwa Elsevier 2018 Journal of hazardous materials Vol.357 No.-
<P><B>Abstract</B></P> <P>This study evaluated the potential of utilising sewage sludge incineration ash as a land reclamation material. Toxicity assessment of the leachate of the ash was carried out for both terrestrial and marine organisms. Both the fruit fly <I>Drosophila melanogaster</I> and barnacle <I>Amphibalanus amphitrite</I> showed that both bottom and fly ash leached at liquid-to-solid (L/S) ratio 5 did not substantially affect viabilities. The leachate carried out at L/S 10 was compared to the European Waste Acceptance Criteria and the sewage sludge ashes could be classified as non-hazardous waste. The geotechnical properties of the sewage sludge ash were studied and compared to sand, a conventional land reclamation material, for further evaluation of its potential as a land reclamation material. It was found from direct shear test that both bottom and fly ashes displayed similar and comparable shear strength to that of typical compacted sandy soil based on the range of internal friction angle obtained. However, the consolidation profile of bottom ash was significantly different from sand, while that of fly ash was more similar to sand. Our study showed that the sewage sludge ash has the potential to be used as a land reclamation material.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Toxicity of fresh & aged sewage sludge incineration fly & bottom ash was evaluated. </LI> <LI> Terrestrial (fruit fly) & marine organisms (barnacle) were used for toxicity study. </LI> <LI> Leachates of ashes had no adverse toxicity on both fruit fly and barnacle tested. </LI> <LI> Fly ash (compared to bottom ash) had more similar geotechnical properties to sand. </LI> <LI> This study showed the potential in using sewage sludge ashes as fill material. </LI> </UL> </P>
-
Cheng Wei Lu,Shu-Kuei Huang,Tzu Yu Lin,Su-Jane Wang 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission changes induced by 4-aminopyridine (4-AP), by using the in vitro rat hippocampal slice technique and whole-cell patch clamp recordings from CA3 pyramidal neurons. Perfusion with echinacoside significantly suppressed the 4-AP-induced epileptiform activity in a concentration-dependent manner. Echinacoside reduced 4-AP-induced increase in frequency of spontaneous excitatory postsynaptic currents (sEPSCs) but it did not affect the amplitude of sEPSCs or glutamate-activated currents, implicating a presynaptic mechanism of action. Echinacoside also potently blocked sustained repetitive firing, which is a basic mechanism of antiepileptic drugs. These results suggest that echinacoside exerts an antiepileptic effect on hippocampal CA3 pyramidal neurons by simultaneously decreasing glutamate release and blocking abnormal firing synchronization. Accordingly, our study provides experimental evidence that echinacoside may represent an effective pharmacological agent for treating epilepsy.
-
Shu-Jen Chang,Su-Hua Huang,Ying-Ju Lin,Yi-Yun Tsou,Cheng-Wen Lin 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Rheum palmatum, Chinese traditional herb,exhibits a great variety of anti-cancer and anti-virusesproperties. This study rates antiviral activity of R. palmatumextracts and its components against Japanese encephalitisvirus (JEV) in vitro. Methanol extract of R. palmatumcontained higher levels of aloe emodin, chrysophanol, rhein,emodin and physcion than water extract. Methanol extract(IC50 = 15.04 lg/ml) exhibited more potent inhibitoryeffects on JEV plaque reduction than water extract(IC50 = 51.41 lg/ml). Meanwhile, IC50 values determinedby plaque reduction assay were 15.82 lg/ml for chrysophanoland 17.39 lg/ml for aloe-emodin, respectively. Virucidalactivity of agents correlated with anti-JEV activity,while virucidal IC50 values were 7.58 lg/ml for methanolextract, 17.36 lg/ml for water extract, 0.75 lg/ml forchrysophanol and 0.46 lg/ml for aloe-emodin, respectively. In addition, 10 lg/ml of extract, chrysophanol or aloeemodin caused 90 % inhibition of JEV yields in cells andsignificantly activated gamma activated sequence-drivenpromoters. Hence, methanol extract of R. palmatum andchrysophanol with high therapeutic index might be usefulfor development of antiviral agents against JEV.
-
Lu, Cheng-Wei,Huang, Shu-Kuei,Lin, Tzu-Yu,Wang, Su-Jane The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.3
Echinacoside, an active compound in the herb Herba Cistanche, has been reported to inhibit glutamate release. In this study, we investigated the effects of echinacoside on spontaneous excitatory synaptic transmission changes induced by 4-aminopyridine (4-AP), by using the in vitro rat hippocampal slice technique and whole-cell patch clamp recordings from CA3 pyramidal neurons. Perfusion with echinacoside significantly suppressed the 4-AP-induced epileptiform activity in a concentration-dependent manner. Echinacoside reduced 4-AP-induced increase in frequency of spontaneous excitatory postsynaptic currents (sEPSCs) but it did not affect the amplitude of sEPSCs or glutamate-activated currents, implicating a presynaptic mechanism of action. Echinacoside also potently blocked sustained repetitive firing, which is a basic mechanism of antiepileptic drugs. These results suggest that echinacoside exerts an antiepileptic effect on hippocampal CA3 pyramidal neurons by simultaneously decreasing glutamate release and blocking abnormal firing synchronization. Accordingly, our study provides experimental evidence that echinacoside may represent an effective pharmacological agent for treating epilepsy.
-
Kocuria halotolerans sp. nov., an actinobacterium isolated from a saline soil in China.
Tang, Shu-Kun,Wang, Yun,Lou, Kai,Mao, Pei-Hong,Xu, Li-Hua,Jiang, Cheng-Lin,Kim, Chang-Jin,Li, Wen-Jun Society for General Microbiology 2009 International journal of systematic and evolutiona Vol.59 No.6
<P>A Gram-positive actinobacterium, designated strain YIM 90716(T), was isolated from a saline soil sample collected from Ganjiahu Suosuo Forest National Nature Reserve in Xinjiang Province, north-west China. The new isolate contained lysine, glutamic acid and alanine with peptidoglycan type Lys-Ala(3) (variation A3alpha). The major phospholipids were phosphatidylglycerol and diphosphatidylglycerol. The predominant menaqinone was MK-7(H(2)). The major fatty acids were anteiso-C(15 : 0), iso-C(16 : 0) and anteiso-C(17 : 0). The DNA G+C content of strain YIM 90716(T) was 68.0 mol%. Chemotaxonomic properties supported the affiliation of strain YIM 90716(T) to the genus Kocuria. Phylogenetic analysis based on 16S rRNA gene sequences revealed that the organism was related most closely to Kocuria kristinae DSM 20032(T) (96.8 % similarity) and showed lower levels of 16S rRNA gene similarity (<96.5 %) with the type strains of other species of the genus Kocuria. The results of fatty acid analysis and physiological and biochemical tests allowed the genotypic and phenotypic differentiation of strain YIM 90716(T) from its closest relatives. On the basis of data from the present polyphasic study, strain YIM 90716(T) is considered to represent a novel species of the genus Kocuria, for which the name Kocuria halotolerans sp. nov. is proposed. The type strain is YIM 90716(T) (=DSM 18442(T)=KCTC 19172(T)=CCTCC AB 206069(T)).</P>
-
Chang, Shu-Jen,Huang, Su-Hua,Lin, Ying-Ju,Tsou, Yi-Yun,Lin, Cheng-Wen 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Rheum palmatum, Chinese traditional herb, exhibits a great variety of anti-cancer and anti-viruses properties. This study rates antiviral activity of R. palmatum extracts and its components against Japanese encephalitis virus (JEV) in vitro. Methanol extract of R. palmatum contained higher levels of aloe emodin, chrysophanol, rhein, emodin and physcion than water extract. Methanol extract ($IC_{50}=15.04{\mu}g/ml$) exhibited more potent inhibitory effects on JEV plaque reduction than water extract ($IC_{50}=51.41{\mu}g/ml$). Meanwhile, $IC_{50}$ values determined by plaque reduction assay were $15.82{\mu}g/ml$ for chrysophanol and $17.39{\mu}g/ml$ for aloe-emodin, respectively. Virucidal activity of agents correlated with anti-JEV activity, while virucidal $IC_{50}$ values were $7.58{\mu}g/ml$ for methanol extract, $17.36{\mu}g/ml$ for water extract, $0.75{\mu}g/ml$ for chrysophanol and $0.46{\mu}g/ml$ for aloe-emodin, respectively. In addition, $10{\mu}g/ml$ of extract, chrysophanol or aloe emodin caused 90 % inhibition of JEV yields in cells and significantly activated gamma activated sequence-driven promoters. Hence, methanol extract of R. palmatum and chrysophanol with high therapeutic index might be useful for development of antiviral agents against JEV.
ScienceON연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
