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Inhibition of keratinocyte differentiation by cytosolic RNA sensor MDA5
( Changhyeon Kim ),( Dongkyun Hong ),( Mira Choi ),( Yullye Hwang ),( Jaekyung Lee ),( Young Lee ),( Youngjoon Seo ),( Changdeok Kim ),( Jeunghoon Lee ),( Sooil Kim ),( Youngho Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date, many psoriasis-related genes have been discovered, but the role of many important genes has not been well understood. Objectives: The purpose of this study is to uncover possible roles of MDA5 in psoriasis. Methods: Expression of MDA5 was investigated using immunohistochemistry. Then, MDA5 was overexpressed in keratinocytes using a recombinant adenovirus. Results: As a result of immunohistochemical staining, the expression of MDA5 was significantly increased in the epidermis of psoriasis compared to normal skin. Similarly, the expression of MDA5 was increased in imiquimodinduced psoriasiform dermatitis model. In cultured keratinocytes, TLR3 agonist poly(I:C) induced expression of MDA5 at both mRNA and protein levels. When MDA5 was overexpressed using a recombinant adenovirus, poly(I:C)- induced cytokine expression was significantly increased. Finally, MDA5 overexpression significantly inhibited calcium-induced differentiation of keratinocytes. Conclusion: These results suggest that MDA5 increases in psoriasis and negatively regulates keratinocyte differentiation.
이창덕(Changdeok Lee),김경서(Kyeongseo Kim),송만석(Mansuk Song) 한국정보과학회 1994 한국정보과학회 학술발표논문집 Vol.21 No.1
언어의 변화는 각 어휘에 대한 용례에서 드러나고 밝혀지므로 용례는 자연어 연구에 있어 가장 기초가 된다. 본 논문에서는 기존의 용례 색인기의 문제점을 살펴 보고, 대량의 말뭉치에서 실시간에 용례를 추출할 수 있도록 각 용례에 대한 색인을 구성한 용례 색인기를 개발하였다. 또, 다양한 종류의 선택 질의어를 제공하여 제약 조건에 맞는 용례를 추출할 수 있다. 선택 제약의 범위가 주로 인접 어절로 제한되므로 용례에 대한 색인을 여기에 맞게 구성하여 따로 말뭉치를 찾지 않고도 질의 처리가 가능하도록 하였다.
Kwangwoo Cho,Junha Choi,Changdeok Ko,Muhyun Kim,Joohan Lee,Eunhyang Eom,Sung-Hak Cho 한국정밀공학회 2024 International Journal of Precision Engineering and Vol.25 No.2
Glass is widely used for various applications, including flat panel displays, solar panels, architectural windows, and exterior materials. These applications exhibit increasing complexity and improved functionality. In particular, glass substrates used in display panels require diverse forms of processing, prompting the exploration of laser applications to enhance processing quality, yield, and efficiency. This study aims to investigate the feasibility of using a high absorption, 257 nm femtosecond laser for processing glass substrates. The goal is to minimize damage and eliminate the need for post-processing, and ensuring superior quality and cross-sectional features. The analysis focuses on the influence of energy density and laser beam overlap ratio on processing variations. Point, line, and area processing were conducted within the achievable energy density range of 2.4–10.8 J/cm2. The results indicate that as the overlap ratio increases, processing depth, influenced by heat accumulation, exhibits a non-linear growth pattern. Moreover, the phenomenon of excessive processing width, surpassing design specifications, is mitigated by utilizing burst pulses that induce heat accumulation of ultra-short pulse lasers, thereby promoting increased processing depth while restraining width expansion. By comparing the outcomes of glass substrate processing using different laser wavelengths and pulse durations, it is confirmed that employing a 257 nm femtosecond laser minimizes damage, cracks, and chipping in the processed areas, obviating the need for post-processing. This paper presents the pioneering research on glass processing using deep ultraviolet femtosecond lasers. Results indicate that clear glass ablation is achieved without cracks.