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RISS 인기검색어
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- 저자 : ( Brian E Gilbert ) (검색결과 4 건)
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Omenn, Gilbert ,S.,States, David ,J.,Adamski, Marcin,Blackwell, Thomas ,W.,Menon, Rajasree,Hermjakob, Henning,Apweiler, Rolf,Haab, Brian ,B.,Simpson, Richard ,J.,Eddes, J WILEY-VCH 2005 PROTEOMICS -WEINHEIM- Vol.5 No.13
<P>HUPO initiated the Plasma Proteome Project (PPP) in 2002. Its pilot phase has (1) evaluated advantages and limitations of many depletion, fractionation, and MS technology platforms; (2) compared PPP reference specimens of human serum and EDTA, heparin, and citrate-anti-coagulated plasma; and (3) created a publicly-available knowledge base (www.bioinformatics.med.umich.edu/hupo/ppp; www.ebi.ac.uk/pride). Thirty-five participating laboratories in 13 countries submitted datasets. Working groups addressed (a) specimen stability and protein concentrations; (b) protein identifications from 18 MS/MS datasets; (c) independent analyses from raw MS-MS spectra; (d) search engine performance, subproteome analyses, and biological insights; (e) antibody arrays; and (f) direct MS/SELDI analyses. MS-MS datasets had 15 710 different International Protein Index (IPI) protein IDs; our integration algorithm applied to multiple matches of peptide sequences yielded 9504 IPI proteins identified with one or more peptides and 3020 proteins identified with two or more peptides (the Core Dataset). These proteins have been characterized with Gene Ontology, InterPro, Novartis Atlas, OMIM, and immunoassay-based concentration determinations. The database permits examination of many other subsets, such as 1274 proteins identified with three or more peptides. Reverse protein to DNA matching identified proteins for 118 previously unidentified ORFs.</P><P>We recommend use of plasma instead of serum, with EDTA (or citrate) for anticoagulation. To improve resolution, sensitivity and reproducibility of peptide identifications and protein matches, we recommend combinations of depletion, fractionation, and MS/MS technologies, with explicit criteria for evaluation of spectra, use of search algorithms, and integration of homologous protein matches.</P><P>This Special Issue of PROTEOMICS presents papers integral to the collaborative analysis plus many reports of supplementary work on various aspects of the PPP workplan. These PPP results on complexity, dynamic range, incomplete sampling, false-positive matches, and integration of diverse datasets for plasma and serum proteins lay a foundation for development and validation of circulating protein biomarkers in health and disease.</P>
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TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
( Jae Hoon Chang ),( Hongbo Hu ),( Jin Jin ),( Nahum Puebla Osorio ),( Yichuan Xiao ),( Brian E Gilbert ),( Robert Brink ),( Stephen E Ullrich ),( Shao Cong Sun ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Regulatory T cells (Treg cells) control different aspects of immune responses, but how the effector functions of Treg cells are regulated is incompletely understood. Here we identified TNF receptor-associated factor 3 (TRAF3) as a regulator of Treg cell function. Treg cell-specific ablation of TRAF3 impaired CD4 T cell homeostasis, characterized by an increase in the Th1 type of effector/memory T cells. Moreover, the ablation of TRAF3 in Treg cells resulted in increased antigen-stimulated activation of follicular T helper cells (TFH cells), coupled with heightened formation of germinal centers and production of high-affinity IgG antibodies. Although the loss of TRAF3 did not reduce the overall frequency of Treg cells, it attenuated the antigen-stimulated production of follicular Treg cells (TFR cells). TRAF3 signaling in Treg cells was required to maintain high level expression of inducible co-stimulator (ICOS), which in turn was required for TFR cell generation and inhibition of antibody responses. These findings establish TRAF3 as a mediator of Treg cell function in the regulation of antibody responses and suggest a role for TRAF3 in mediating ICOS expression in Treg cells.
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Respiratory Syncytial Virus 감염증을 가진 소아에서 Ribavirin 고농도 단기요법과 기존치료의 비교
안영민(Young Min Ahn),(Janet A . Englund),(Pedro A . Piedra),(Brian E . Gilbert),(Peter Hiatt) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1993 소아알레르기 및 호흡기학회지 Vol.3 No.2
따라서 개선 방법으로 high dose-sho핀 duration ribavirin aemsol (6 gr/100 ml of water over two hours, three time a day)요범이 고안되어 이미 쥐와 만성 폐쇄성 폐질환을 가진 성인에서 그 효력과 안정성이 증명되었고 6명의 소아에서 ribavirin의 혈액과 분비물내의 농도가 기존 치료법과 별 차이가 없는 것으로 나타나 이번 임상 연구에서는 두 방법의 안전성과 유효성을 비교하려고 하였다. 20명의 후드 치료와 12명의 인공호흡기를 통한 흡입을 무작위로 기존 방법(6 gr/300 ml of water over 18 hours a day)과 연구방법으로 나누어 그 두 군 간의 바이러스 배출량, 임상적 지수 변화, 폐기능 검사, 부작용 등을 비교하고 주변환경의 약의 공기 농도 등을 비교하였다. 결과적으로 두 군간의 임상적 지수 호전 속도, 바이러스 배출 감소 속도 둥은 차이가 없었고 엉겨서 막힘등의 부작용은 1예의 후드를 통한 기존 치료군과 2예의 인공호흡기를 통한 고농도군에서 발견되었다. 주위 공기내의 약의 배출 농도는 인공호흡기를 통했을 경우는 두 군 모두 문제가 되지 않을 정도로 낮았지만 후드 사용시는 고농도 단기 치료군에서 기존 치료군보다 의미있게 낮게 측정되었다. 따라서 고농도 단기 치료법은 기존 치료법과 동일하게 안전하고 효과적이면서도 약의 주위 오염 정도를 낮추고, 치료 방법이 용이하여 후드 사용 환자에게는 추천할 만한 방법이나 인공호흡기를 통한 치료에는 조금 더 짧은 연구가 이루어져야 할 것이다. N/A
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Omar Al Jammal,Julian Gendreau,Bejan Alvandi,Neal A. Patel,Nolan J. Brown,Shane Shahrestani,Brian V. Lien,Arash Delavar,Katelynn Tran,Ronald Sahyouni,Luis Daniel Diaz-Aguilar,Kevin Gilbert,Martin H. P 대한척추신경외과학회 2021 Neurospine Vol.18 No.4
Objective: To study the impact of demographic factors on management of traumatic injury to the lumbar spine and postoperative complication rates. Methods: Data was obtained from the National Inpatient Sample (NIS) between 2010–2014. International Classification of Diseases, 9th revision, Clinical Modification codes identified patients diagnosed with lumbar fractures or dislocations due to trauma. A series of multivariate regression models determined whether demographic variables predicted rates of complication and revision surgery. Results: A total of 38,249 patients were identified. Female patients were less likely to receive surgery and to receive a fusion when undergoing surgery, had higher complication rates, and more likely to undergo revision surgery. Medicare and Medicaid patients were less likely to receive surgical management for lumbar spine trauma and less likely to receive a fusion when operated on. Additionally, we found significant differences in surgical management and postoperative complication rates based on race, insurance type, hospital teaching status, and geography. Conclusion: Substantial differences in the surgical management of traumatic injury to the lumbar spine, including postoperative complications, among individuals of demographic factors such as age, sex, race, primary insurance, hospital teaching status, and geographic region suggest the need for further studies to understand how patient demographics influence management and complications for traumatic injury to the lumbar spine.
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