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Oh Minji,Oh Eun Jung,Jung Boseung,Yoo Myung Hoon,Yoo Shin Young,Jung Da Jung,Lee Kyu-Yup 대한청각학회 2023 Journal of Audiology & Otology Vol.27 No.4
Background and Objectives: The guidelines for cochlear implantation (CIs) are expanding, and the number of CI procedures performed on the elderly is increasing. The purpose of this study was to analyze the results and safety of cochlear implantation in the elderly, as well as to evaluate the predictive factors on CI outcomes.Subjects and Methods: The study included 56 patients aged ≥40 years, who received CIs between 2009 and 2020. They were divided into two groups: 27 younger adults (40-64 years) and 29 elderly (>64 years). The study compared their pre- and postoperative speech perception and category of auditory performance (CAP) scores, surgical complications, and hospitalization periods. It also evaluated associated factors in the elderly group by examining categorical and continuous variables and postoperative CAP score.Results: There was a significant improvement in speech recognition tests (both word and sentence) and CAP scores in both groups compared to the pre-implantation scores (<i>p</i><0.001). Postoperative results were slightly lower in the elderly group than in younger adults for sentence recognition and CAP scores, except for word recognition. No significant associated factors were found on postoperative CAP scores, except for etiology. Postoperative CAP significantly improved in the sudden hearing loss group compared to the groups with other etiologies (<i>p</i>=0.045). The elderly group had more comorbidities than that in the younger adult group (<i>p</i>=0.026), but there were no significant differences in postoperative complications and hospitalization periods.Conclusions: While speech recognition and CAP scores were relatively lower in the elderly group compared to the younger adults, the elderly group showed significant improvements in audiological results after CI. Moreover, CI was safe and well tolerated in elderly patients.
( Dongbin Ahn ),( Kyu-yup Lee ),( Eunjung Oh ),( Minji Oh ),( Boseung Jung ),( Da Jung Jung ) 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.2
Background: The study aimed to evaluate the effect of prehydration solution on hearing thresholds after cisplatin chemotherapy. Methods: In this retrospective cohort study, we reviewed the data of patients who underwent ≥3 courses of cisplatin-based chemotherapy for locally advanced head and neck cancers at a tertiary referral center (n=64). The dextrose solution (DW) group (n=26) received 2 L of normal saline and 1 L of 5% dextrose. The Hartmann solution (HS) group (n=38) received 2 L of normal saline and 1 L of HS. Hearing data were measured 1 day before starting the first course of chemotherapy, and again 20 days after the first, second, and third courses of chemotherapy. The severity of hearing loss was evaluated using the Common Terminology Criteria for Adverse Events (CTCAE). Results: Thresholds at all frequencies after chemotherapy were greater in the DW group than in the HS group. The increase in thresholds in 1 to 4 kHz after the third course of chemotherapy was greater in the DW group than in the HS group. CTCAE grades after the second and third courses of chemotherapy were greater in the DW group than in the HS group. Logistic regression showed that the odds ratio for CTCAE grade 3 or 4 after the third course of chemotherapy in the DW group was 4.84 on univariate analysis. Conclusion: Prehydration using a solution with salt was associated with a decrease in change in hearing thresholds after cisplatin chemotherapy in patients with head and neck cancers.
양보승(Boseung Yang),강성일(Sung-il Kang),조강현(Kanghyeon Jo),박석원(Seokwon Park),정진우(Jin-Woo Jung) 한국정보기술학회 2021 Proceedings of KIIT Conference Vol.2021 No.11
본 논문은 콜센터의 상담사와 고객의 대화 내역으로부터 학습하여 점진적으로 상담사를 대체하는 AI 모듈의 설계를 제안한다. 실험에서는 기존에 없던 질문이 들어왔을 때 상담사가 응대하고, 같은 질문이 들어왔을 때 상담사 대신 AI 모듈의 응대로 만족할만한 답변을 할 수 있는가를 측정한다. This paper proposes the design of an AI module that gradually replaces the agent by learning from the conversation history between the agent and the customer in the call center. In the experiment, it is measured whether the counselor responds to a question that has not been asked before, and if the same question is asked, can a satisfactory answer be given by the AI module"s response instead of the counselor.
Kim, Joo Y.,Park, Su J.,Jang, Boseung,Jung, Che-Hun,Ahn, Sung J.,Goh, Chang-Hyo,Cho, Kyoungwon,Han, Oksoo,Kang, Hunseung Blackwell Publishing Ltd 2007 The Plant journal Vol.50 No.3
<P>Summary</P><P>Although glycine-rich RNA-binding protein 2 (GRP2) has been implicated in plant responses to environmental stresses, the function and importance of GRP2 in stress responses are largely unknown. Here, we examined the functional roles of GRP2 in <I>Arabidopsis thaliana</I> under high-salinity, cold or osmotic stress. GRP2 affects seed germination of Arabidopsis plants under salt stress, but does not influence seed germination and seedling growth of Arabidopsis plants under osmotic stress. GRP2 accelerates seed germination and seedling growth in Arabidopsis plants under cold stress, and contributes to enhancement of cold and freezing tolerance in Arabidopsis plants. No differences in germination between the wild-type and transgenic plants were observed following addition of abscisic acid (ABA) or glucose, implying that GRP2 affects germination through an ABA-independent pathway. GRP2 complements the cold sensitivity of an <I>Escherichia coli</I> BX04 mutant and exhibits transcription anti-termination activity, suggesting that it has an RNA chaperone activity during the cold adaptation process. Mitochondrial respiration and catalase and peroxidase activities were affected by expression of mitochondrial-localized GRP2 in Arabidopsis plants under cold stress. Proteome analysis revealed that expression of several mitochondrial-encoded genes was modulated by GRP2 under cold stress. These results provide new evidence indicating that GRP2 plays important roles in seed germination, seedling growth and freezing tolerance of Arabidopsis under stress conditions, and that GRP2 exerts its function by modulating the expression and activity of various classes of genes.</P>
Kim, Jin Sun,Park, Su Jung,Kwak, Kyung Jin,Kim, Yeon Ok,Kim, Joo Yeol,Song, Jinkyung,Jang, Boseung,Jung, Che-Hun,Kang, Hunseung Oxford University Press 2007 Nucleic acids research Vol.35 No.2
<P>Despite the fact that cold shock domain proteins (CSDPs) and glycine-rich RNA-binding proteins (GRPs) have been implicated to play a role during the cold adaptation process, their importance and function in eukaryotes, including plants, are largely unknown. To understand the functional role of plant CSDPs and GRPs in the cold response, two CSDPs (CSDP1 and CSDP2) and three GRPs (GRP2, GRP4 and GRP7) from <I>Arabidopsis thaliana</I> were investigated. Heterologous expression of <I>CSDP1</I> or <I>GRP7</I> complemented the cold sensitivity of BX04 mutant <I>Escherichia coli</I> that lack four cold shock proteins (CSPs) and is highly sensitive to cold stress, and resulted in better survival rate than control cells during incubation at low temperature. In contrast, CSDP2 and GRP4 had very little ability. Selective evolution of ligand by exponential enrichment (SELEX) revealed that GRP7 does not recognize specific RNAs but binds preferentially to G-rich RNA sequences. CSDP1 and GRP7 had DNA melting activity, and enhanced RNase activity. In contrast, CSDP2 and GRP4 had no DNA melting activity and did not enhance RNAase activity. Together, these results indicate that CSDPs and GRPs help <I>E.coli</I> grow and survive better during cold shock, and strongly imply that CSDP1 and GRP7 exhibit RNA chaperone activity during the cold adaptation process.</P>