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Effects of ${\beta}$-Glucan from Aureobasidium pullulans on Acute Inflammation in Mice
Kim, Hyeong-Dong,Cho, Hyung-Rae,Moon, Seung-Bae,Shin, Hyun-Dong,Yang, Kun-Ju,Park, Bok-Ryeon,Jang, Hee-Jeong,Kim, Lin-Su,Lee, Hyeung-Sik,Ku, Sae-Kwang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
The effects of ${\beta}$-glucan isolated from Aureobasidium pullulans were observed on acute xyleneinduced inflammation. ${\beta}$-glucan at a dose of 62.5, 125 or 250 mg/kg were administered once orally to xylene-treated mice (0.03 mL of xylene was applied on the anterior surface of the right ear to induce inflammation), and the body weight change, ear weight, histological profiles and histomorphometrical analyses of ear were conducted upon sacrifce. The xylene was topically applied 30min after dosing with ${\beta}$-glucan. The results were compared to those of diclofenac, indomethacin and dexamethasone ( 15 mg/kg injected once intraperitoneally). All animals were sacrificed 2 h after xylene application. Xylene application resulted in marked increases in induced ear weights compared to that of intact control ear; hence, the differences between intact and induced ear were also signifcantly increased. The histological characteristics of acute inflammation, such as severe vasodilation, edematous charges of skin and infiltration of inflammatory cells, were detected in xylene-treated control ears with marked increase in the thickness of the ear tissues. However, these xylene-induced acute inflammatory changes were significantly and dose-dependently decreased by ${\beta}$-glucan treatment. We conclude that ${\beta}$-glu-can from A. pullulans has a somewhat favorable effect in the reduction of the acute inflamma-tory responses induced by xylene application in mice.
Kim, Bok Hyeon,Lee, Seung Ho,Lin, Aoxiang,Lee, Chang-Lyoul,Lee, Jongmin,Han, Won-Taek The Optical Society 2009 Optics express Vol.17 No.3
<P>The large temperature sensitivity of the Sagnac loop interferometer based on the birefringent holey fiber filled with metal indium was experimentally demonstrated. The temperature sensitivities of the wavelength shift of the interferometer and the birefringence the fiber with indium were measured to be -6.3 nm/K and -3.3x10(-6) /K, respectively. The large temperature sensitivity of the fiber was explained by introduction of the fiber birefringence change originated from the large thermal expansion property of the metal indium at the elevated temperature.</P>
화학보조 전기화학 증착 방법을 적용한 고체산화물 연료전지 금속 분리판 스피넬 보호 코팅
최재린(Je-Lin Choi),홍종은(Jong-Eun Hong),김혜성(Hye-Sung Kim),이승복(Seung-Bok Lee) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7
고체산화물 연료전지(solid oxide fuel cell, SOFC)의 금속 분리판은 단위 전지를 전기적으로 연결하고 인접한 전지에 공급되는 연료와 산소(공기)를 분리하는 역할을 한다. 일반적으로 표면 안정성을 개선하고 공기극의 Cr 피독을 완화하기 위해 Ferrite 계 소재의 분리판 표면을 전도성 산화물로 코팅한다. 특히 분리판 보호에 효과적인 Mn-Co 스피넬 산화물의 고체산화물 연료전지(SOFC) 분리판 적용 코팅에 대한 다양한 연구가 진행되어왔다. 본 연구에서는 Mn-Co 스피넬 산화층을 금속 모재에 균일하게 코팅하기 위하여 화학보조 전기화학 증착법(Chemically assisted electrodeposition, CAED)이라고 하는 새로운 방법을 도입하였고, 이를 통해 고내구성의 Mn-Co 스피넬 산화층을 보다 쉽고 간편하게 형성할 수 있었다. 위 증착법에 의해 형성한 Mn-Co 코팅층의 두께는 약 2 ㎛로, 900℃의 비교적 낮은 열처리 온도에서도 스피넬 상을 형성하였다. 4-point-probe 방법으로 측정한 코팅 층을 포함한 금속 시편의 초기 ASR 은 5.1 mΩcm<sup>2</sup>, 1,000시간 장기 운전 후 증가량은 8.5 mΩcm<sup>2</sup>/kh이었다. Denuder technique에 의해 시험된 풍부한 가습 조건에서 Cr 휘발 속도는 1.3 × 10-10 kgm-2s-1 (100시간 운전, @800℃)으로 코팅하지 않은 금속시편과 비교했을 때 약 10배 이상 작았고, 이는 고온 및 장기 산화분위기에서 Chromia 스케일로부터의 Cr 휘발을 효과적으로 억제할 수 있음을 보여주었다.
Effects of β-Glucan from Aureobasidium pullulans on Acute Inflammation in Mice
Hyeong-Dong Kim,Bok-ryeon Park,Hee-Jeong Jang,Lin-Su Kim,Hyeung-Sik Lee,Sae-Kwang Ku,Hyung-Rae Cho,Seung-bae Moon,Hyun-Dong Shin,Kun-Ju Yang 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
The effects of β-glucan isolated from Aureobasidium pullulans were observed on acute xyleneinduced inflammation. β-glucan at a dose of 62.5, 125 or 250 mg/kg were administered once orally to xylene-treated mice (0.03 mL of xylene was applied on the anterior surface of the right ear to induce inflammation), and the body weight change, ear weight, histological profiles and histomorphometrical analyses of ear were conducted upon sacrifice. The xylene was topically applied 30min after dosing with β-glucan. The results were compared to those of diclofenac, indomethacin and dexamethasone (15 mg/kg injected once intraperitoneally). All animals were sacrificed 2 h after xylene application. Xylene application resulted in marked increases in induced ear weights compared to that of intact control ear; hence, the differences between intact and induced ear were also significantly increased. The histological characteristics of acute inflammation, such as severe vasodilation, edematous changes of skin and infiltration of inflammatory cells, were detected in xylene-treated control ears with marked increase in the thickness of the ear tissues. However, these xylene-induced acute inflammatory changes were significantly and dose-dependently decreased by β-glucan treatment. We conclude that β-glucan from A. pullulans has a somewhat favorable effect in the reduction of the acute inflammatory responses induced by xylene application in mice.
자간증 산모에서 나타나는 모성 합병증과 이를 예측할 수 있는 위험인자에 관한 연구
김문영 ( Moon Young Kim ),한성식 ( Sung Sik Han ),우헌탁 ( Hun Tack Woo ),김유미 ( Yu Mi Kim ),구천회 ( Chun Soe Ku ),이철민 ( Chul Min Lee ),박교훈 ( Kyo Hoon Park ),조용균 ( Yong Kyoon Cho ),최훈 ( Hoon Choi ),김복린 ( Bok Lin 대한산부인과학회 2003 Obstetrics & Gynecology Science Vol.46 No.1
목적 : 자간증 환자에서 모성합병증의 발생률을 알아보고, 이 합병증에 관련된 위험인자를 규명하고 이와 모성 합병증과의 관계를 알아보고자 하였다 연구 방법 : 1989년 8월부터 2002년 2월 사이에 상계 백병원 산부인과에서 자간증을 진단받고 치료받은 환자 23명을 대상으로 하여, 자간증 환자에서 모성합병증의 발생률을 알아보고, 이 합병증에 관련된 위험인자를 규명하고 이와 모성 합병증과의 관계를 알아보고자 하였다. 결과 : 자간증의 발생률은 1/1,79 Objective : To identify risk factors for maternal morbidity in eclamptic woman. Methods : A retrospective analysis was performed on the record of eclamptic woman during from August 1989 to February 2002. Univariate analysis was used to determine which of