Development and assessment of nano drug delivery systems for combined delivery of rosuvastatin and ezetimibe

Metwally Mohamed Ali,El-Zawahry El-Yamani Ibrahim,Ali Maher Amer,Ibrahim Diaa Farrag,Sabry Shereen Ahmed,Sarhan Omnia Mohamed 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.3

Worldwide, cardiovascular disease is the main cause of death, which accordingly increased by hyperlipidemia. Hyperlipidemia therapy can include lifestyle changes and medications to control cholesterol levels. Statins are the medications of the first choice for dealing with lipid abnormalities. Rosuvastatin founds to control high lipid levels by hindering liver production of cholesterol and to achieve the targeted levels of low-density lipoprotein cholesterol, another lipid lowering agents named ezetimibe may be used as an added therapy. Both rosuvastatin and ezetimibe have low bioavailability which will stand as barrier to decrease cholesterol levels, because of such depictions, formulations of this combined therapy in nanotechnology will be of a great assistance. Our study demonstrated preparations of nanoparticles of this combined therapy, showing their physical characterizations, and examined their behavior in laboratory conditions and vivo habitation. The mean particle size was uniform, polydispersity index and zeta potential of formulations were found to be in the ranges of (0.181–0.72) and (–13.4 to –6.24), respectively. Acceptable limits of entrapment efficiency were affirmed with appearance of spherical and uniform nanoparticles. In vitro testing showed a sustained release of drug exceeded 90% over 24 h. In vivo study revealed an enhanced dissolution and bioavailability from loaded nanoparticles, which was evidenced by calculated pharmacokinetic parameters using triton for hyperlipidemia induction. Stability studies were performed and assured that the formulations are kept the same up to one month. Therefore, nano formulations is a suitable transporter for combined therapy of rosuvastatin and ezetimibe with improvement in their dissolution and bioavailability.

Physical Activity and Cancer Prevention: Awareness and Meeting the Recommendations among Adult Saudis

Amin, Tarek Tawfik,Al-Hammam, Abudllah Mohammed,AlMulhim, Nasser Abdullah,Al-Hayan, Mohammed Ibrahim,Al-Mulhim, Mona Mohammed,Al-Mosabeh, Modhahir Jawad,Al-Subaie, Mohammed Ali,Al-Hmmad, Qassem Ahmed Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: There is a scarcity of information about the proportion of the adult Saudi population that meet the recommended guidelines of physical activity (PA) to reduce cancer risk. Moreover, their awareness about the role of PA in cancer prevention is unclear. Objectives: This cross-sectional study aimed at estimating the proportion of adult Saudis meeting the PA guidelines, specifically those recommended by American Cancer Society (ACS) for cancer prevention, and to assess the public awareness about the role of PA in cancer prevention. Materials and Methods: Using a multistage sampling method, 2,127 adult Saudis of both genders were recruited from 6 urban and 4 rural primary health care centers in Al Hassa, Saudi Arabia. Participants were personally interviewed to gather information about their sociodemographic characteristics, searching activity about PA and cancer, and the time spent in leisure time PA (moderate and vigorous)/week using the Global Physical Activity Questionnaire with show cards. Finally, items about the role of PA in cancer risk reduction were inquired. Results: Of the included participants, 11.6% met the recommendations for cancer prevention (${\geq}45$ minutes of moderate-vigorous PA activity/${\geq}5$ days/week or 225 minutes/week). Multivariate regression showed that being male (AOR=1.49, CI=1.09-2.06), <20 years of age (AOR=3.11, CI=2.03-4.76), and unemployed (AOR=2.22, CI=1.57-3.18) were significant predictors for meeting PA recommendations for cancer prevention. Only 11.4% of the sample indicated correctly the frequency and duration of PA required for an average adult to be physically active and while >70% of them indicated the role of PA in prevention of hypertension, coronary heart disease and lowering elevated blood cholesterol, only 18.6% and 21.7% correctly mentioned the role of PA in reducing colon and breast cancer risk, respectively. Poor knowledge was found among those with less than college education and aged ${\geq}50$ years. The level of knowledge was significantly positively correlated with total leisure time PA of the participants. Conclusions: A minority of adult Saudis in Al Hassa was aware about the role of PA in cancer prevention and engaged in sufficient LTPA for cancer risk reduction benefits, highlighting the need for public health actions to include policies and programs that address factors deterring their participation in LTPA and increasing their awareness with remedies to manage the prevalent misconceptions.

Metathesis of 2-pentene over Mo and W supported mesoporous molecular sieves MCM-41 and SBA-15

Mohamed Ali Ibrahim,Muhammad Naseem Akhtar,Ji rí Cejka,Erica Montanari,Hynek Balcar,Martin Kubu,Sulaiman S. Al-Khattaf 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.53 No.-

Molybdenum and tungsten oxides were supported on silica, MCM-22, MCM-41 and SBA-15. XRD and N2 adsorption–desorption revealed that architecture and textural character of supports were preserved. The catalysts were investigated in transformation of 2-pentene at different reaction temperatures. MoO3/ MCM-22 exhibited highest conversions with isomerization and cracking as major reactions. MoO2(acac)2, MoO3 and WO3 supported on MCM-41 and SBA-15 showed metathesis reaction of 2-C5 = producing propylene, C4 = and C6+ =as major products. Catalysts based on MCM-41 exhibited higher activity and stability than SBA-15. Addition of ethylene to 2-C5 = increased selectivity to propylene due to metathesis of ethylene with 2-pentene.

Privatizing public sector companies for maritime transport:assessing the Egyptian experiment

Mohamed M. Ali Ibrahim,KIM Hyun-deok 한국해운물류학회 2004 해운물류연구 Vol.43 No.-

This paper aims at assessing the Egyptian experiment in privatising public sector companies for maritime transport through: first, reviewing the economic thought regarding privatisation and the history of Egyptian public sector; second, researching the role of IMF and the WB programs in privatising public sector in Egypt and developing countries; third, assessing the Egyptian experiment in privatising maritime transport companies which are the Alexandria shipping agencies company and the Arab United stevedoring company.

Management of a Retained Bullet in the Corpora Cavernosa after a Civilian Gunshot Injury: A Rare Scenario

( Ali Abdel Raheem ),( Ibrahim Alowidah ),( Mohamed Almousa ),( Mohamed Alturki ) 대한외상학회 2020 大韓外傷學會誌 Vol.33 No.4

A 24-year-old man presented to King Saud Medical City emergency department with a retained bullet in his penis following a civilian exchange of gunfire. After an initial assessment, the patient was taken to the operating room. Penile exploration was performed, the bullet was extracted successfully, and the corpora cavernosa were repaired properly. A 6-week follow-up showed full healing with preservation of erectile function. Immediate surgical intervention is mandatory as the primary treatment for penile gunshot injury to ensure proper anatomical and functional recovery.

Estimation method for determining surface film conductance during cooling of fish packages

Ibrahim Omer Mohamed,Kassim Ali Abass 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.6

This paper presents an alternative method for determining the surface film conductance of an infinite fish slab subjected to the cooling process. Many methods have been published, but their solutions have inherent appreciable inaccuracy and limitations. The present authors used the temperature histories of five locations within a slab sample of fish, obtained by the experimental investigation part of this work, along with the inverse heat conduction problem (IHCP) technique to develop a correlation for variable surface film conductance. When the above correlation was used for temperature predictions, the predicted and experimentally measured temperature distribution profiles were compared numerically. Better agreement than that implemented by other investigators was achieved. This revealed the accuracy and superiority of the present method, and the limitations of other methods are overcome in this method.

A comparative study of mechanical behavior of ABS material based on UVC sterilization for medical usage

Mohamed A. Aboamer,Doaa H. Elgohary,Ali Abdullah Almukil,Ahmed A. Aboamer,Ibrahim M Alarifi,Mohsen Bakouri,Nader A. Rahman Mohamed 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.7

This study aims to examine the mechanical properties of acrylonitrile butadiene styrene specimens using ASTM 638, 695, and 790. UVC radiation was also used as a sterilizing method. The fused deposition modeling of 3D-printed polymerize with 30 % filling was used to manufacture 30 specimens for tensile, compression, and bending. Half of the specimens were treated with UVC, whereas the other half were not. The chosen dosage of 13.5 J/cm 2 with an exposure time of 48 min corresponds to 3650 sterilization treatments or 10 years of sterilization. The average ultimate stress in the tensile test, compression test, and bending test was 34.5 ± 7.4, 25.4 ± 0.5, and 24.5 ± 2.1 Mpa, respectively. The analysis of variance test shows that UVC radiation has a demonstrable influence on tensile specimens, with a P-value of 0.012, which is less than the significance threshold of 0.05. Thus, the null hypothesis is rejected.

Privatizing Public Sector Companies for Maritime Transport: Assessing the Egyptian Experiment

( Mohamed M. Ali Ibrahim ),( Hyun Deok Kim ) 한국해운물류학회(구 한국해운학회) 2004 해운물류연구 Vol.41 No.-

This paper aims at assessing the Egyptian experiment in privatising public sector companies for maritime transport through: first, reviewing the economic thought regarding privatisation and the history of Egyptian public sector; second, researching the role of IMF and the WB programs in privatising public sector in Egypt and developing countries : third, assessing the Egyptian experiment in privatising maritime transport companies which are the Alexandria shipping agencies company and the Arab United stevedoring company.

Liberalizing Maritime Transport Services: Towards a Fair Liberalization

( Mohamed M. Ali Ibrahim ) 한국해운물류학회(구 한국해운학회) 2003 해운물류연구 Vol.39 No.-

The maritime transport sector is considered as the most liberalized sector due to its international nature, but this fact does not imply that the sector is completely free because still many restrictions are found, some of them imposed by developed countries and - as a reaction - others are imposed by developing countries. The restriction imposed by advanced countries are: barriers to enter into the industry, international cartels, alliances, conferences, restrictions on maritime labour movements and stiff shipping registration conditions. As a reaction, developing countries try to find a way to survive in maritime transport service market through: cargo reservation systems using bilateral agreements. Code of Conduct, subsidization of maritime transport sectors and restriction of the commercial presence in ports. It is worth mentioning that developed countries apply the same restriction practices used by developing countries; it is also noticed that liberalizing transport services negotiations neglect the restrictive practices imposed by developing countries whereas they concentrate on the restriction practices used by developing countries. This concentrate on the restriction practices used by developing countries. his paper aims at discussing the restrictive practices imposed by both developed and developing countries to liberalize maritime transport services on a fair basis.

A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women

Ibrahim Elsehely,Hala Abdel Hafez,Mohammed Ghonem,Ali Fathi,Rasha Elzehery 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.2

Previous studies showed that early age at menarche is associated with increased risk of metabolic syndrome. However, the definition of early menarche at these studies was based on background data in the communities at which these studies was carried on. The aim of this work is to determine a cutoff for age at menarche discriminating presence or absence of metabolic syndrome in overweight/obese premenopausal women. This study included 204 overweight/obese women. Metabolic syndrome was defined according to NCEP-ATP III (National Cholesterol Education Program Adult Treatment Panel III) criteria. Of a total 204 participants, 82 (40.2%) had metabolic syndrome. By using receiver operating characteristic analysis, age at menarche ≤12.25 year discriminated individuals with from those without metabolic syndrome. The area under the curve was 0.76 (95% confidence interval, 0.70 to 0.83). Sensitivity, specificity, negative predictive value, and positive predictive value were 82%, 70%, 85%, and 64%, respectively. Age at menarche ≤12.25 years predicts the presence of metabolic syndrome in overweight/obese women.