Evidence for the Presence of Long-Lived Plasma Cells in Nasal Polyps

Ya-Na Zhang,Jia Song,Guan-Ting Zhai,Hai Wang,Ren-Zhong Luo,Jing-Xian Li,Bo Liao,Jin Ma,Heng Wang,Xiang Lu,Da-Bo Liu,Zheng Liu 대한천식알레르기학회 2020 Allergy, Asthma & Immunology Research Vol.12 No.2

Purpose: Plasma cells and immunoglobulins (Igs) play a pivotal role in the induction and maintenance of chronic inflammation in nasal polyps. During secondary immune responses, plasma cell survival and Ig production are regulated by the local environment. The purpose of the present study was to investigate the presence of long-lived plasma cells (LLPCs) and specific survival niches for LLPCs in human nasal polyps. Methods: Nasal mucosal samples were cultured with an air-liquid interface system and the Ig levels in culture supernatants were analyzed by enzyme-linked immunosorbent assay. The characteristics of LLPCs in nasal polyps were determined by immunohistochemistry and immunofluorescence. The expression of neurotrophins as well as their receptors was detected by quantitative real-time polymerase chain reaction, immunohistochemistry, immunofluorescence, and Western blotting. Results: The numbers of CD138+ total plasma cells and BCL2+ plasma cells were increased in both eosinophilic and non-eosinophilic nasal polyps compared with those in normal tissues. The production of IgG, IgA, and IgE was detected in culture supernatants even after a 32-day culture of nasal polyps. Although the total numbers of plasma cells were decreased in nasal polyps after culture, the numbers of BCL2+ plasma cells remained stable. The expression of nerve growth factor (NGF) as well as tropomyosin receptor kinase (Trk) A, a high-affinity receptor for NGF, was upregulated in both eosinophilic and non-eosinophilic nasal polyps. In addition, BCL2+ plasma cell numbers were positively correlated with NGF and TrkA mRNA expression in nasal mucosal tissues. Polyp plasma cells had the expression of TrkA. Conclusions: Human nasal polyps harbor a population of LLPCs and NGF may be involved in their prolonged survival. LLPCs may be a novel therapeutic target for suppressing the local Ig production in nasal polyps.

The Application of welding numerical simulation on two typical welded structures in railway vehicles

Ya-na, Li,Cheng-tao, Li,Bin, Yuan,Su-ming, Xie Techno-Press 2012 Interaction and multiscale mechanics Vol.5 No.2

The thin-plate structure and the box-beam structure are two typical welded structures in railway vehicles. Because of their structure complexity, bigger size and multi-seams, welding residual distortion which occur in welding process bring unfavorable effect on the quality of welding products manufacturing and service. As a result, welding distortion forecasting and control become an important and urgent research topic in railway vehicles. In this paper, three different numerical methods are presented corresponding to three typical types of welded structures of railway vehicles and welding deformation are simulated. Consistence of numerical results and experimental data proves the correctness of models and feasibility of simulation methods.

시설거주여부 , 기간 , 연령 및 성별에 따른 6 , 7 세 아동의 어휘력

최나야(Na Ya Choi),유안진(An Jin Yoo) 한국아동학회 2002 兒童學會誌 Vol.23 No.1

This study examined the vocabulary competence of institutionalized and home-reared 6- and 7-year-old children with the use of the Revised Picture Vocabulary Test(Dunn & Dunn, 1981; Korean version, Kim et al., 1995), administered to 113 institutionalized children and 124 middle class home-reared children. Results indicated that the vocabulary competence of institutionalized children was inferior to that of home-reared children. Children who had lived in an institution for two years or more scored lower than those who had been institutionalized for a shorter time. 7-year-olds scored higher than 6-year-olds, regardless of institutionalization. Home-reared girls scored higher than home-reared boys, but there was no sex difference between institutionalized children. These findings suggest that efforts should be directed toward improving the linguistic environment of institutionalized children.

소아 심장 CT 검사시 Dual Source CT의 High pitch mode를 이용한 선량감소에 관한 연구

이예나(Ya Na Lee),강헌효(Heon Hyo Kang),손성실(Sung Sil Son),박찬혁(Chan Hyuk Park),현진경(Jin Kyung Hyun),신명호(Myung Ho Shin),김준혁(Jun Hyuk Kim),강동원(Dong Won Kang) 대한CT영상기술학회 2012 대한CT영상기술학회지 Vol.14 No.1

I. Purpose This study examines if accurate images can be realized with less dose than sequential mode, one of the existing methods applying DSCT’s high-pitch mode in pediatric cardiography. II. Materials and Methods For 20 patients who came to our hospital from Jan. 1 to Jun. 30, 2011, a test was carried out using MDCT 128 channel dual source; Somatom Definition Flash (Siemens Medical System: Germany). As the test method, the veins of the lower limbs of the patients were secured and contrast medium of 7ml was injected at 0.3ml/s anda CT scan was carried out about 36 s. later. Af first, sequential mode was used, and then high-pitch mode was followed as follow-up examination. The DLP (Dose Length Product) provided by the equipment and effective dose were compared for the assessment of the dose exposed to the patients, after the CT scan. The effective does was calculated by multiplying children’s chest index: 0.021 of the effective dose rate of EUR16262 (European Guide) to DLP value. The images scaned in high-pitch method were compared and assessed quantitatively by a heart decoding specialist and 2 radiologists if the typical diseases of pediatric cardiacs such as coarctation of aorta, atresia of the pulmonary artery and Tetralogy of Fallot can be assessed. III. Results When it was compared to sequential mode, one of the existing cardiography, the effective dose exposed to the patient had decrease by 32% in high-pitch mode. As a result of a comparison with imaging assessment, it was also evaluated as a better imaging than sequential mode IV. Conclusion Pediatric Cardiography using high pitch in Dual source MDCT showed superior effects on the reduction of exposed does than sequential mode, which is considered a useful testing method. 목적 본 연구에서는 소아 심장 검사 시 DSCT의 High-pitch mode를 적용하여 기존의 검사방법 중 하나인 Sequential mode보다 적은 선량으로도 정확한 영상을 구현할 수 있는지 알아본다. 대상 및 방법 2011년 1월 1일부터 6월 30일까지 본원에 내원한 20명의 환자를 대상으로 하여 MDCT 128 channel dual source; Somatom Definition Flash(Siemens medical system: Germany) 장비를 사용하여 검사를 시행하였다. 검사방법은 환자의 하지에 정맥을 확보하고 조영제를 0.3 ml/s로 7ml를 주입한 후 36초 후에 CT검사를 하였다. 처음에는 Sequential mode로 검사한 후 추적 검사할 땐 High-pitch mode로 검사한다. 환자가 받은 피폭선량의 평가는 선량평가는 CT검사 후 장비에서 제공하는 DLP(dose length product)와 유효선량(effective dose)를 비교하였다. 유효선량은 DLP 값에 EUR16262(European Guide) 유효선량비 중 소아 흉부 지수 0,021을 곱하여 계산하였다. 검사한 영상을 심장 판독 전문의 1명과 방사선사 2명이 high-pitch mode로 검사한 영상을 소와 심장의 대표적 질환인 대동맥협착증, 폐동맥 폐쇄증, 팔로씨 사증을 평가할 수 있는지 비교하여 정성적으로 평가하였다. 결과 기존의 심장 검사방법 중 하나인 Sequential mode와 비교했을 때 High pitch mode로 검사했을 때에 32%의 선량 감소 효과가 있었다. 또한 영상 평가 비교 결과 Sequential mode 보다 좋은 영상으로 평가되었다. 결론 Dual source MDCT로 소아심장 검사를 할 때 high pitch mode를 이용하면 sequential mode로 검사했을 때보다 환아가 받는 피폭선량은 낮고 더 우수한 영상을 획득하여 심장질환을 진단하는데 유용한 검사법으로 사료된다.

가정문해환경, 어머니의 문해신념과 양육효능감이 유아와 어머니의 그림책 읽기 상호작용에 미치는 영향

최나야(Na Ya Choi) 한국아동학회 2012 아동학회지 Vol.33 No.6

The purpose of this study was to investigate the effects of the home literacy environment, mother`s literacy belief and parenting efficacy in terms of the interaction which occurs during reading picture books between mothers and preschoolers. Questionnaires from 378 5-year-olds` mothers in Seoul and Kyunggi province were analysed. The findings from the validated structural equation model constructed with these variables were as follows. First, the home literacy environment, the mother`s literacy beliefs and the mother`s general parenting efficacy affected the quantity, and the quality of interaction whilst reading books with preschoolers. Second, the mother`s efficacy in education and communication had a direct impact on the quantity of the interaction during reading books through the mediation of the home literacy environment, and had an indirect effect on the quality of the interaction whilst reading books, respectively. Third, the mother`s efficacy in communication directly accounted for the quality of the interaction which occurs whilst reading books with children.

초,중,고생의 인터넷 매체언어 태도와 맞춤법 지식이 인터넷 매체언어 사용에 미치는 영향

최나야(Na Ya Choi),한유진(Eu Gene Han) 한국아동학회 2010 아동학회지 Vol.31 No.5

음운론적 인식과 처리능력이 4-6세 유아의 한글 단어 읽기에 미치는 영향

최나야(Na Ya Choi),이순형(Soon Hyung Yi) 한국아동학회 2007 아동학회지 Vol.28 No.4

유아의 시지각 발달과 읽기

최나야(Na Ya Choi) 한국아동학회 2009 아동학회지 Vol.30 No.2

In this study of the relationship between preschoolers' visual perception and reading Hangul words, the 287 participants showed significant developmental change in visual perception between three to five years of age. The researcher developed the computer-based screening Test of Visual Perception for Reading (TVPR). Factor analysis confirmed three factors of TVPR : perception of number, direction, and form constancy. These factors correlated highly with four factors of motor-reduced visual perception of the Korean Developmental Test of Visual Perception (Moon et al. 2003). All factors of TVPR explained reading real words and pseudo words; direction and form constancy perception predicted reading low frequency letters. These findings confirm that preschoolers' skills in visual perception contribute to the reading of words in Hangul.

시설 청소년의 대인관계 특성에 대한 사례 연구

최나야(Choi Na-Ya),유안진(Yoo An-Jin),한유진(Han Eu-Gene) 가정과삶의질학회 2002 가정과삶의질연구 Vol.20 No.2

‘노아의 방주’ 그림책의 형식과 내용에 나타난 다양성

최나야(Choi Na-Ya) 한국어린이미디어학회 2011 어린이미디어연구 Vol.10 No.1

이 연구에서는 노아의 방주 이야기를 소재로 한 유아 대상 그림책의 형식적ㆍ내용적 특성을 살펴보기 위해 노아의 방주를 다룬 국내외의 그림책들 중에서 성경 그림책의 준거에 맞는 22권을 선정하여 분석하였다. 형식적 특성에 있어서, 장르, 판형, 미술적 기법, 인물 표현방법 등에서 상당한 다양성이 나타났다. 이야기책, 글 없는 그림책, 알파벳북, 수세기책, 정보책, 민담 그림책, 환상 그림책 등의 장르와, 일반 평면 그림책, 팝업북, 플랩북, 시리즈 도서 등의 판형이 포함되었고, 수채화, 유화, 컴퓨터 그래픽, 점토 그림, 판화, 그림자 그림, 콜라주 등의 기법이 사용되었으며, 극사실적인 수준에서부터 만화에 가까운 수준까지의 인물 묘사가 이루어졌다. 내용적 특성상, 공란 메우기의 정도에 따라 성경 원문에 가깝게 재회된 그림책, 재화를 통해 원문의 구멍을 메운 그림책, 재화를 통해 새로운 이야기로 재구성된 그림책으로 구분되었다. 원문에 가끼운 그림책에서는 성경의 문장이 쉽게 고쳐지고 핵심적 내용만으로 원문의 플롯이 유지된 반면, 원문의 구멍이 메워진 그림책에서는 성경에 나타나지 않은 배경, 인물, 사건 관련 내용이 상상을 통해 추가되었다. 더 나아가, 서술 시점이나 장르를 바꾸어 줄거리와 관점이 차별된 작품으로 재구성된 그림책들도 있었다. The purpose of this study was to analyze the characteristics of picture books about 'Noah's ark' with respect to the forms and contents. Totally 22 books were selected according to the criteria for good bible picture books. Those books presented a broad variety of genre, format, artistic techniques, and styles of portraying the characters. There were a wordless picture book, an alphabet book, a counting book, folk tale picture books, fantasy picture books, as well as regular storybooks, Volumes included In bible story series and functional format like pop-up or flap books were found. The illustrations were varied from paintings in watercolors or oils to etchings, engravings, shadow representations, clay works, computet graphics, collage and so on. The description of characters was made somewhere between realism and cartoon, The books were classified into 3 types by the degree of filling gaps in the story, The first gtOup of picture books stayed close to the original text of the Bible. In the second gtOup, the authors added contents about setting, characters, or events creatively. The last gtOup of books were tho roughly reconstituted by changing viewpoint or genre and deriving only the cote ideas of Noah's story.