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L929 및 CV1 세포를 사용한 한천중층법에서 치과용 합금의 독성 비교
조욱희,윤일,최석규,김형일 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2
Biocompatability of pure gold, Au alloy, pure titanium, Ti alloy, Ni-Cr alloy, Co-Cr alloy and pure copper was assessed through the agar overlay test using L929 and CV1 cells. Pure gold, pure titanium and Ti alloy had none to mild cytotoxicity, Ni-Cr, Co-Cr and gold alloy had mild to moderate cytotoxicity and pure copper had severe cytotoxicity. Generally, L929 cells were more sensitive to toxic substances than CV1 cells. The application of human gingival fibroblast to the agar overlay method seemed not to be proper.
삼천포 화력발전소 연안의 플랑크톤상을 중심으로한 해양 환경
金世華,李晉煥,洪旭熹 龍仁大學校 1993 용인대학교 논문집 Vol.9 No.-
Impacts of the power plant operation located in the coastal area of Samchonpo were investgated in the view point of the population dynamics of zoo -and phytoplankton five times seasonally during the period from August 7 1990 to August 27 1991. Ninty nine taxa of phytoplankton, representing 2 forma, 1 variety, 79 species and 17 unidentified species belonging to 39 genera were tentatively identified. Phytoplankton standing crops varied with months and stations ranging from 5.8×104cells /l (November 1990, station 5) to 4.83×106cells /l (May 1991, station 4) in surface, ranging from 2.9×105cells /l (Novemver 1990, station 5) to 5.90×106cells /l (May 1991, station 4) in bottom. Dominant species through the present study were Chaetoceros compressus and C. curvisetus in August 1990, Nitzschia pungens in November, Eucampia zodiacus and Skeletonema costatum in February 1991, Leptocylindrus danicus in May, and S. costatum and S. tropicum in August. Causative organisms of red -tide due to diatoms were 24 taxa. Among them, six species occurred throughout the year ; Chaetoceros debilis, Cylindrotheca closterium, Guinardia flaccida, Nitzschia pungens, Rhizosolenia setigera and Skeletonema costatum. Chlorophyll -α was fluctuated ranging from 6.18mg /m3 (August 1990, station 1) to 23. 77mg /m3(February 1991, station 4) in surface, This value of chlorophyll -a might be assumed that eutrophication occurred in studied waters. Twenty two taxa of zooplankton communities, representing 14 copepods, 4 cladocerans, 2 chaetognaths, 1 protozoan and 1 appendicularian were identified. Zooplankton abundance varied with months and stations ranging from 1,677 indiv./m3 to 18,057 indiv./m3.
Case Report : Active Sensitization of Para-tertiary-butylphenol after TRUE Test®
( Hyun Wuk Cha ),( Han Jin Jung ),( Hyun Jung Lim ),( Weon Ju Lee ),( Seok Jong Lee ),( Won Kim ) 대한피부과학회 2013 大韓皮膚科學會誌 Vol.51 No.5
Active sensitization of contact allergen is an uncommon complication of patch test. Para-tertiary-butylphenol (PTBP) is a component of neoprene-based adhesives used in glued leather goods such as shoes, handbags, belts and watchstraps. Contact allergy to PTBP is frequently seen when the patch test is performed. However, active sensitization to PTBP after the patch test is rare. A 23-year-old female patient came to our clinic with a brownish hyperpigmented patch on the belt position of her belly. Pruritic erythematous papules and vesicles developed on the abdomen when she wore new pants 4 months ago. Under the clinical diagnosis of allergic contact dermatitis, the patient was patch tested with the Thin-layer Rapid Use Epicutaneous Test (TRUE Test®). The result showed strong positive reaction to nickel sulphate and thiomersal both on day 2 and 3 after application. Twenty-nine days after the test, the patient noticed pruritus on the TRUE Test® area. Thirty-four days after the test, an erythematous square-shaped plaque studded with tiny vesicles developed at the PTBP patch test site. This strongly suggests that the reaction to PTBP is occurred. She was diagnosed with an active sensitization to PTBP. We report a rare and interesting case of active sensitization to PTBP after TRUE Test®.
Jung Wuk Lee,Changyu Choi,Jihyung Kim,Sohee Lee,Jina Kim,Yoonji Lee,Kyung Hoon Min 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.3
The gene amplifi cation of human epidermalgrowth factor receptor 2 (HER2) plays an essential role in theproliferation and progression of several cancers. However,HER2 inhibitors such as lapatinib strongly suppress wildtypeEGFR, resulting in severe adverse eff ects. Therefore,there is an unmet need for highly selective HER2 inhibitors. In this study, we describe the design and synthesis of novelquinazoline derivatives that exhibit enhanced selectivity forHER2 over wild-type EGFR. Structure–activity relationshipanalysis indicated that the selectivity for HER2 over EGFRdepends on the aniline moiety at C-4 and the substituentsat C-6 in the quinazoline derivatives. Compound 7c withan IC 50 of 8 nM for HER2 exhibited signifi cantly higherselectivity for HER2 over EGFR, with a 240-fold improvementover lapatinib. In addition, the synthesized compoundsexhibited anti-proliferative activity in the nanomolar rangeagainst SKBR3, a human breast cancer cell line that overexpressesHER2.
A Study on the Social Finance in Jeju
Dong-Wuk Kim,Kwang-Woong Choi,Sang-Yum Kang 제주대학교 관광과경영경제연구소 2020 産經論集 Vol.40 No.2
Purpose: The system of financial institutions and funds that can support Jeju s social and economic enterprises is in poor condition. In addition, the government of the Moon Jae-in has introduced various policies on social finance through the joint ministry of the government, but Jeju s social and economic enterprises are not able to respond promptly to the flow of financial policies. Therefore, this study aimed to find out the policy demands of Jeju s social economy-related funds and Jeju s social financial system by identifying the financial status, current situation, and difficulties of social economy companies in Jeju. Research design, data, and methodology: Along with a survey of Jeju s social and economic organizations, we wanted to find out the current status of the operation of the social and economic organization loan and guarantee programs through a visit to major policy and financial suppliers.Through surveys of Jeju s social and economic organizations and interviews with major policy and financial institutions, more than 50 middle and senior executives related to finance and finance, such as certified social enterprises and social cooperatives located in Jeju Island, were surveyed. It was distributed and collected from September 2018 to October 2018 as a direct survey interview and online survey method. Results: As a result of demand analysis, respondents recognized that the external financing environment improved compared to the previous year, but the social and economic organizations in Jeju do not understand the characteristics of the social economic organization or the conventional practices of existing financial institutions. It was confirmed that the work behavior still felt physical and psychological disorders and difficulties. Conclusions: These results identified the policy demands of Jeju s social economy-related funds and Jeju s social finance system and suggested alternatives. The related ordinances need to be enacted, and it is necessary to establish friendly financial support for social and economic organizations and a financial support system for each stage of growth of social enterprises. In addition, it is necessary to introduce a credit evaluation system that reflects the social value of the funding method, various loan repayment systems, and social economic organizations, and to foster Jeju-style social financial intermediaries