삼첨판 기계식 인공판막 대치술을 포함한 세 차례 개심술을 시행한 환자에서 대심정맥을 통한 영구 박동조율기 이식 1예 보고

김재욱,이진호,최주원,김우식,김용인 인제대학교 백병원 2003 仁濟醫學 Vol.24 No.2

A 26-year-old man. who had undergone three times open heart surgeries including tricuspid mechanical valve replacement 4 months before, with general weakness and mild dyspnea was admitted. He presented a third degree atrioventricular block on the electrocardiogram and required permanent pacemaker implant. We successfully implanted a permanent pacemaker transvenously with a ventricular lead introduced into the great cardiac vein via coronary sinus to stimulate the left ventricle, an atrial lead in the right atrium, and his symptoms improved.

Estimation of Energy Consumption for Mobile Software using UML State Machine Diagram

Jae-Wuk Lee,Doohwan Kim,Jang-Eui Hong 보안공학연구지원센터 2013 International Journal of Software Engineering and Vol.7 No.5

Engineered Phage Matrix Stiffness-Modulating Osteogenic Differentiation

Lee, Hee-Sook,Kang, Jeong-In,Chung, Woo-Jae,Lee, Do Hoon,Lee, Byung Yang,Lee, Seung-Wuk,Yoo, So Young American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.5

<P>Herein, we demonstrate an engineered phage mediated rmatrix for osteogenic differentiation with controlled stiffness by cross-linking the engineered, phage displaying Arg-Gly-Asp (RGD) and His-Pro-Gln (HPQ) with various Concentrations of streptavidin or polymer, poly(diallyldirnethylammonium)chltiride (PDDA). Osteogenic gene expressions showed that they were specifically increased when MC3T3 cells were cultured, on the stiffer phage matrix than the softer one. Our phage matrixes can be easily functionalized using chernical/gerietic engineering and-Used as a stem cell tissue matrix stiffness platform for modulating differential cell expansion and differentiation.</P>

Estimation of Energy Consumption for Mobile Software using UML State Machine Diagram

Lee, Jae-Wuk,Kim, Doohwan,Hong, Jang-Eui Global Vision Press 2013 International Journal of Software Engineering and Vol.7 No.5

PFOA-induced metabolism disturbance and multi-generational reproductive toxicity in <i>Oryzias latipes</i>

Lee, Jin Wuk,Lee, Jae-Woo,Kim, Kyungtae,Shin, Yu-Jin,Kim, Jieun,Kim, Suhkmann,Kim, Heejung,Kim, Pilje,Park, Kyunghwa Elsevier 2017 Journal of hazardous materials Vol.340 No.-

<P><B>Abstract</B></P> <P>The aims of this study were to examine multi-generational reproductive toxicity and metabolism disturbances in <I>Oryzias latipes</I> exposed to 0.3, 3, and 30mg/L PFOA for 259-day. The highest concentration of PFOA suppressed fecundity over three generations from F0 to F2 and sac-fry survival rate in F2 generation, indicating that PFOA resulted in multi-generational reproductive toxicity <B>(<I>p<</I> </B> <B>0.05)</B>. Histologically, in F1 and F2 generations, <I>O. latipes</I> exposed to 30mg/L PFOA revealed accelerated gonad development, and the atrophy and degeneration of thyroid follicular cell. Glucose content showed the highest increase in both genders in all metabolites. However, alanine, glutamine, threonine, and lactate content, which are converted into glucose showed decline tendency, suggesting that PFOA led to gluconeogenesis. Change of osmolyte content affecting osmosis such as a decrease of male <I>myo</I>-inositol (<I>m</I>-Ino), an increase of female trimethylamine <I>N</I>-oxide (TMAO) and an increase of male dimethylamine (DMA) suggest that PFOA might affect osmoregulation of <I>O. latipes</I>. Oxaloacetate of male fish and succinate of female fish showed significant alterations, indicating that PFOA may affect energy metabolism differently by sex. These findings will help elucidate the toxicity of PFOA in diverse biological responses including metabolism change.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PFOA can affect carbohydrate metabolism and osmoregulation of <I>Oryzias latipes</I>. </LI> <LI> Glucose content can be used as a biomarker for PFOA exposure in <I>Oryzias latipes.</I> </LI> <LI> PFOA caused histological abnormality in gonad and thyroid follicular cell. </LI> <LI> PFOA caused multi-generational reproductive toxicity in <I>Oryzias latipes</I>. </LI> </UL> </P>

Estimating Power Consumption using SysML Parametric Diagram for Energy-Efficient Software Constraints

Jae-Wuk Lee,Jang-Eui Hong 중소기업정보기술융합학회 2014 중소기업융합학회 국제학술대회논문집 Vol.1 No.1

Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty

Lee, Su Hun,Son, Dong Wuk,Shin, Jun Jae,Ha, Yoon,Song, Geun Sung,Lee, Jun Seok,Lee, Sang Weon The Korean Neurosurgical Society 2021 Journal of Korean neurosurgical society Vol.64 No.5

Many studies have focused on pre-operative sagittal alignment parameters which could predict poor clinical or radiological outcomes after laminoplasty. However, the influx of too many new factors causes confusion. This study reviewed sagittal alignment parameters, predictive of clinical or radiological outcomes, in the literature. Preoperative kyphotic alignment was initially proposed as a predictor of clinical outcomes. The clinical significance of the K-line and K-line variants also has been studied. Sagittal vertical axis, T1 slope (T1s), T1s-cervical lordosis (CL), anterolisthesis, local kyphosis, the longitudinal distance index, and range of motion were proposed to have relationships with clinical outcomes. The relationship between loss of cervical lordosis (LCL) and T1s has been widely studied, but controversy remains. Extension function, the ratio of CL to T1s (CL/T1s), and Sharma classification were recently proposed as LCL predictors. In predicting postoperative kyphosis, T1s cannot predict postoperative kyphosis, but a low CL/T1s ratio was associated with postoperative kyphosis.

관점지향 개발 방법론을 지원하기 위한 SysML의 확장

이재욱 ( Jae-wuk Lee ),김두환 ( Doo-hwan Kim ),홍장의 ( Jang-eui Hong ) 한국정보처리학회 2010 한국정보처리학회 학술대회논문집 Vol.17 No.2

관점지향 개발 방법론은 시스템의 중복된 요소를 최소화 하여 높은 수준의 모듈화를 달성하기 위한 기법으로 그 적용 범위를 넓히고 있다. 특히 최근에는 임베디드 시스템 개발에 관점지향 개발 방법론을 적용한 사례가 증가하고 있다. 많은 임베디드 시스템들이 SysML과 같은 설계 언어를 이용하여 하드웨어와 소프트웨어를 동시에 설계하고 통합하는 방식으로 개발되고 있다. 그러나 이러한 하드웨어와 소프트웨어를 고려한 설계 언어들은 구조적 개발 방법론이나 객체지향 개발 방법론에 초점을 두고 있기 때문에 관점지향 개발 방법론을 지원하기에 많은 한계가 있다. 따라서 본 연구에서는 임베디드 시스템 개발에 관점 지향 개발 방법론을 지원하기 위해 확장된 SysML을 제안한다.

Energy Bad Smells 기반 소모전력 절감을 위한코드 리팩토링 기법

이제욱 ( Jae Wuk Lee ),김두환 ( Doo Hwan Kim ),홍장의 ( Jang Eui Hong ) 한국정보처리학회 2016 정보처리학회논문지. 소프트웨어 및 데이터 공학 Vol.5 No.5

최근 스마트폰, 태블릿과 같은 기기의 사용량이 증가하면서, 이에 탑재되는 소프트웨어는 더욱 복잡해지고 규모가 커지고 있다. 배터리의 전력으로 구동되는 모바일 기기들은 전력 공급의 한계로 인해 운용시간을 증가시키는 것이 중요한 이슈이다. 최근에는 소프트웨어 동작이 하드웨어 구동을 통해 전력 소모를 일으킨다는 점에서, 효율적인 동작 패턴을 갖는 소프트웨어 개발에 대한 연구들이 진행되고 있다. 그러나 모바일기기에 탑재되는 소프트웨어는 그 개발 주기가 짧은 경우가 많아 최적화와 전력 소모량을 반영하기 어려운 경우가 많다. 따라서 본 연구에서는 소모전력 절감을 위한 코드 리팩토링 기법을 제안하여, 소프트웨어 개발 및 유지보수에서 보다 용이하게 저전력 요구사항을 충족시키고자 한다. 이를 위해 전력 소모량을 감소시킬 수 있는 코드 패턴에 대하여 Energy Bad Smell을 식별하고, 이를 제거하기 위한 새로운 코드 리팩토링 기법을 제안하며, 실험을 통해 그 효용성을 검증하였다. While the services of mobile devices like smart phone, tablet, and smart watch have been increased and varied, the software embedded into such devices has been also increased in size and functional complexity. Therefore, increasing operation time of mobile devices for serviceability became an important issue due to the limitation of battery power. Recent studies focus on the software development having efficient behavioral patterns because the energy consumption of mobile devices is caused by software behaviors which control the hardware operations. However, it is often difficult to develop the embedded software with considering energy-efficiency and behavior optimization due to the short development cycle of the mobile services in many cases. Therefore, this paper proposes the refactoring techniques for reducing energy consumption, and enables to fulfill the energy requirements during software development and maintenance. We defined energy bad smells with the code patterns that can excessively consume the energy, and our refactoring techniques are to remove these bad smells. We performed some case studies to verify the usefulness of our refactoring techniques.

외전근 부전 환자에서 구속형 라이너를 이용한 인공 고관절 재치환술

이경재(Kyung-Jae Lee),민병우(Byung-Woo Min),배기철(Ki-Cheor Bae),손은석(Eun-Seok Son),이시욱(Si-Wuk Lee),이석중(Seok-Jung Lee),임경환(Kyung-Hwan Lim) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.4

목적: 인공 고관절 재치환술 중 외전근 부전 소견을 보인 환자에서 구속형 라이너 사용 결과를 알아보고자 하였다. 대상 및 방법: 재치환술 중 외전근 부전 소견으로 구속형 라이너를 사용하고 2년 이상 추시 관찰이 가능하였던 30예를 대상으로 하였다. 남자 14예, 여자 16예였으며 평균 추시 기간은 4.6년이었다. 재탈구나 삽입물의 무균성 해리가 발생한 경우를 구속형 라이너의 실패로 정의하였다. 임상적으로 Harris 고관절 점수 및 보행능력을, 방사선적으로 골용해, 무균성 해리 및 기타 합병증의 발생 유무를 조사하였다. 결과: 추시 기간 중 구속형 라이너의 실패는 4예(13.3%)에서 발생하였으며 재탈구 2예, 비구컵 무균성 해리 2예였다. Harris 고관절점수는 술 전 평균 38.3점에서 술 후 평균 73.4점으로 향상되었으며, 최종 추시 시 보행능력의 호전을 보인 경우가 20예(66.7%)였다. 합병증으로 감염 1예, 삽입물 주위 골절 1예가 발생하였다. 결론: 인공 고관절 재치환술 시 외전근 부전 소견을 보이는 환자에서 구속형 라이너는 만족할 만한 재탈구 예방 효과를 보였으나 삽입물의 해리 등에 대한 좀 더 장기간의 연구가 필요할 것으로 생각된다. Purpose: The purpose of this study was to evaluate clinical and radiographic results of revision total hip arthroplasty with constrained liner in patients with abductor insufficiency. Materials and Methods: In this study, 30 patients treated with constrained liner during revision total hip arthroplasty due to abductor insufficiency were evaluated after minimum 2-year follow-up. There were 14 men and 16 women and the mean follow-up period was 4.6 years. Re-dislocation and aseptic loosening of the implant were defined as a failure of the constrained liner. Harris hip score and ambulatory function were evaluated as a clinical parameter and osteolysis, aseptic loosening of the implant and other complications were evaluated as a radiologic parameter. Results: During the follow-up period, there were 4 cases (13.3%) of constrained liner failure including two cases of re-dislocation and two cases of acetabular cup aseptic loosening. The average Harris hip score was improved from 38.3 points preoperatively to 73.4 points at last follow up. At the final follow-up, there were 20 cases (66.7%) of improvement in ambulatory function. There was 1 case of infection and 1 case of periprosthetic fracture. Conclusion: Use of a constrained liner during revision total hip arthroplasty showed satisfactory results for prevention of re-dislocation in patients with abductor insufficiency. However longer term studies on loosening of implants are needed.