양식장 배출물 발효물의 어류 사료 첨가에 따른 넙치, Paralichthys olivaceus의 혈액학적 변동에 미치는 영향

강주찬,지정훈,송승엽,문상욱,강지웅,이영돈,김세재 한국어병학회 2004 한국어병학회지 Vol.17 No.1

본 연구는 우리나라 주요 양식어류인 넙치, Paralichthys olivaceus를 대상으로 육상수조식양식장 배출물 발효물의 어류 사료 첨가에 따른 혈액학적 변동에 미치는 영향을 검토하였다. 젖산균 및 효모를 사용하여 발효한 양식장 배출물의 이화학적 분석을 실시하였고, 발효물을 0.1, 0.5, 1.0 및 5.0% 농도로 8주간 투여하였다. 투여 4주째 및 8주째에 각 투여 구간별로 혈액학적 항목을 중심으로 그 차이를 확인하였다. 배출물 발효농도별 유의한 차이는 나타나지 않았지만, 분석시기에 따른 적혈구수, 혈색소 농도 및 혈색소 지수가 증가하는 경향을 나타내었으나, 주요 혈청 무기 및 유기성분은 배출 발효물 농도별로 유의한 차이는 나타나지 않았다. 또한 혈청 효소학적 조사에서는 조사시기별로 변동은 나타났지만, 동일 조시시기에서 각 구간별 유의한 차이는 나타나지 않았다. 따라서 이러한 육상 약식장 유래의 배출물 발효산물에 대한 다양한 방면의 연구가 진행되어야겠다. Effects of oral administration with fermented product from sewage in land-based seawater fish farm on haematological disturbance in the olive flounder, Paralichthys olivaceus was investigated. After 4 weeks of conditioning with a basal diet, fish were divided into 4 groups and provided experimental diet (0.1,0.5, 1.0 and 2.0%) supplement of fermented sewage for 80 days. Proximal analysis was performed for the product of sewage which was fermented by lactic acid and yeast. RBC count, hemoglobin concentration and hematocrit value were increased according to the treated periods, however, no statistical difference was observed between control and treatment groups. There were no significant difference in serum organic, inorganic compounds and enzyme activities between control and treatment groups. This study hypothesized that the supplement of fermented product from sewage in land-based seawater fish farm might be an additive sup plement for source of fish diet in view of haematological examination. Recycling of the sewage may be an economic artificial sources of diet for fish aquaculture practices.

食餌性 蛋白質이 臟器內 G.P.T. 및 G.O.T. 活性에 미치는 影響

吳承浩,黃致燁,李萬祚,柳五龍 中央醫學社 1971 中央醫學 Vol.21 No.2

This study was designed to observe the change of G.P.T. and G.O.T. activities in organs according to the lapse of time after taking some diets. The subjects were 54 pure male albino rats weighing 270-280g. They were divided into the standard diet group, the high protein diet group and the high carbohydrate diet group, and were re divided into 1 hour group, 3 hours group and 6 hours group, according to the lapse of time after taking some diets. Each animal was sacrificed on the corresponding day, and G.P.T. and G.O.T. activities in the liver,. kidney and serum were determined. The results were summarized as follows: 1. The G.P.T. activity in the liver changed markedly when 1 and 3 hours passed since taking some diets. 2. The G. O. T activity in the liver was higher in the standard diet group than in the high protein diet group and the high carbohydrate diet group, in all periods after taking some diets. 3. The G.P.T. activity in the kidney was greatly lower in the lapse of 6 hours than in the lapse of 1 hour. 4. The G.P.T. and G.O.T. activities in the serum showed no great change.

Clinical Usefulness of Serial Neutrophil Geletinase-Associated Lipocalin as a Predictor for Aki

( Jung Yeop Lee ),( Seung Yong Park ),( Yeong Hun Choe ),( So Ri Kim ),( Seoung Ju Park ),( Heung Bum Lee ),( Yong Chul Lee ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Plasma neutrophil geletinase-associated lipocalin (NGAL) has been regarded as one of the valuable markers of development of acute kidney injury (AKI) in ICU admitted patients. However, clinical significance of short-term change of plasma NGAL was not clearly investigated. Methods: 50 patients who admitted intensive care unit (ICU) was included by prospective manner. We analyzed plasma NGAL level by Triage immunoassay on ICU admitted time and 12 hours after. Change of estimated glomerular filtration rate (by MDRD equation) and need of renal replacement therapy was investigated. Patients with chronic kidney disease were excluded. Results: Persistent elevation of plasma NGAL above 1,000 ng/mL on 0 and 12 hours was significantly associated with need for early renal replacement therapy. Patient with increased level of NGAL at 12 hours showed unfavorable outcome which is related to renal replacement therapy or progressive renal impairment (13/25; 48% of patients). Conversely, 2/17 (11.8%) of patients had poor renal outcome when NGAL decrease more than 20% from baseline at 12 hours after ICU admission. On multivariate analysis, baseline NGAL and ΔNGAL0-12 hr was independent predictors of unfavorable renal outcome. However, ΔNGAL0-12 hr did not significantly correlated with the change of glomerular filtration rate between day 1 and day3. Conclusions: Our data suggest that measurement of early serum NGAL change may be useful marker in predicting the renal impairment and need for renal replacement therapy in intensive care unit.

Pressure-induced metathesis reaction to sequester Cs.

Im, Junhyuck,Seoung, Donghoon,Lee, Seung Yeop,Blom, Douglas A,Vogt, Thomas,Kao, Chi-Chang,Lee, Yongjae American Chemical Society 2015 Environmental science & technology Vol.49 No.1

<P>We report here a pressure-driven metathesis reaction where Ag-exchanged natrolite (Ag16Al16Si24O80·16H2O, Ag-NAT) is pressurized in an aqueous CsI solution, resulting in the exchange of Ag(+) by Cs(+) in the natrolite framework forming Cs16Al16Si24O80·16H2O (Cs-NAT-I) and, above 0.5 GPa, its high-pressure polymorph (Cs-NAT-II). During the initial cation exchange, the precipitation of AgI occurs. Additional pressure and heat at 2 GPa and 160 °C transforms Cs-NAT-II to a pollucite-related, highly dense, and water-free triclinic phase with nominal composition CsAlSi2O6. At ambient temperature after pressure release, the Cs remains sequestered in a now monoclinic pollucite phase at close to 40 wt % and a favorably low Cs leaching rate under back-exchange conditions. This process thus efficiently combines the pressure-driven separation of Cs and I at ambient temperature with the subsequent sequestration of Cs under moderate pressures and temperatures in its preferred waste form suitable for long-term storage at ambient conditions. The zeolite pollucite CsAlSi2O6·H2O has been identified as a potential host material for nuclear waste remediation of anthropogenic (137)Cs due to its chemical and thermal stability, low leaching rate, and the large amount of Cs it can contain. The new water-free pollucite phase we characterize during our process will not display radiolysis of water during longterm storage while maintaining the Cs content and low leaching rate.</P>

Reliability Improvement of Controller Area Network Using Self-Organizing Network

Kee-Min Kim,Seoung-Yeop Kim,Minh-Thao Nguyen,Jae-Han Park,Moon-Hong Baeg,Hyun-Sik Ahn 한국자동차공학회 2010 한국자동차공학회 학술대회 및 전시회 Vol.2010 No.11

Controller Area Network (CAN), an asynchronous serial bus network, is widely used in industry for embedded applications. Because of its performance and low cost, it is also being considered in automated manufacturing and process control environments to interconnect intelligent devices, such as modern sensors and actuators. In order to achieve the utmost safety of data transfer, power measures for error detection, signal and self-checking are implemented in every CAN node. Unfortunately, CAN, in its current form, is not able to either inform existing nodes about appearance of new nodes or warn remaining nodes that certain nodes were broken down. This paper addresses this problem and proposes a method to improve reliability of CAN by adding a Self-Organizing Network (SON).

Immobilization of Large, Aliovalent Cations in the Small‐Pore Zeolite K‐Natrolite by Means of Pressure

Lee, Yongjae,Lee, Yongmoon,Seoung, Donghoon,Im, Jun‐,Hyuk,Hwang, Hee‐,Jung,Kim, Tae‐,Hyun,Liu, Dan,Liu, Zhenxian,Lee, Seung Yeop,Kao, Chi‐,Chang,Vogt, Thomas WILEY‐VCH Verlag 2012 Angewandte Chemie Vol.124 No.20

<P><B>Hochdruck‐Ionenaustausch</B> an dem kleinporigen Zeolith K‐Natrolit ermöglicht die Immobilisierung von nominell nicht austauschbaren aliovalenten Kationen wie dreiwertigem Europium. Eine Probe, an der bei 3.0(1) GPa und 250 °C ein Ionenaustausch vorgenommen wurde, enthält ungefähr 4.7 Eu<SUP>III</SUP>‐Ionen pro Elementarzelle, was einem Austausch von über 90 % der K<SUP>+</SUP>‐Ionen entspricht (siehe Bild).</P>

A Case Study of the Cause and Characteristics of Sulfidic Material and Gas Generation in the Underground Repository System

Jin-Seok Kim,Seoung Yeop Lee,Sang-Ho Lee,Jang-Soon Kwon 한국방사성폐기물학회 2021 한국방사성폐기물학회 학술논문요약집 Vol.2021 No.11

에탄올 투여 랫드에서 곰취 열수 추출 발효물이 간 독성에 미치는 영향

유근형(Keun-Hyung Yu),이선엽(Sun-Yeop Lee),양현모(Hyun-Mo Yang),함영안(Young-Ahn Ham),이수응(Soo-Ung Lee),채승완(Seoung-Wan Chae),이용진(Yong-Jin Lee) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.10

본 연구는 항산화 활성이 우수한 것으로 알려진 곰취의 활용 가치를 높이고 향후 건강기능식품 소재로서의 가능성을 확인하고자 에탄올 동물모델에서의 간 기능 개선 효과를 연구하였다. 실험기간 동안 실험동물의 체중 증가량 및 간 무게의 경우 처리군 간 유의적인 차이는 없었다. 혈청 중 GGT(γ-glutamyl transferase), AST(aspartate aminotransferase), ALT(alanine aminotransferase) 및 LDH(lactate dehydrogenase) 측정 결과 대조군에서 정상식이군과 비교하여 유의하게 증가하였다(P<0.05). 곰취 열수 추출물(100, 200, 400 mg/kg BW) 및 발효물(400 mg/kg BW) 투여군에서 대조군과 비교하여 GGT 수치가 유의하게 감소하였으며(P<0.05), 곰취 열수 추출물(200, 400 mg/kg BW) 및 발효물(100, 200, 400 mg/kg BW) 투여군에서 대조군과 비교하여 AST 수치가 유의하게 감소하였다(P<0.05). 곰취 열수 추출물 및 발효물 모든 투여군에서 대조군과 비교하여 ALT 및 LDH 수치가 유의하게 감소하였다(P<0.05). 혈청 중 총 콜레스테롤 측정 결과 정상식이군과 대조군 간의 유의적인 차이는 없었으나 발효물 투여군(200, 400 mg/kg BW)에서 대조군과 비교하여 유의하게 감소하였다(P<0.05). HDL(high density lipoprotein)-콜레스테롤 측정 결과 정상식이군과 대조군 간 유의적인 차이는 없었으나, 발효물 투여군(200, 400 mg/kg BW)에서 대조군과 비교하여 유의하게 감소하였다(P<0.05). 곰취 열수 추출물 및 발효물의 경우 대조군과 비교하여 LDL(low density lipoprotein)-콜레스테롤이 감소하는 것으로 나타났으나 유의적인 차이는 없었다. 중성지방의 경우 정상식이군과 비교하여 대조군에서 증가하는 것으로 나타났으나 유의적인 차이는 없는 것으로 나타났으며, 곰취 열수 추출물(400 mg/kg BW) 및 발효물(200, 400 mg/kg BW) 투여군에서 감소하는 것으로 나타났으나 유의적인 차이는 없었다. 총 콜레스테롤 함량 중 HDL-콜레스테롤 함량 비율 및 동맥경화지수를 조사한 결과 모든 처리군 간에 유의적인 차이는 없었다. 간 조직 내 superoxide dismutase(SOD) 활성을 측정한 결과 발효물 투여군(400 mg/kg BW)에서 대조군과 비교하여 유의하게 증가하였다(P<0.05). 간 조직 내 과산화지질의 분해산물인 malondialdehyde(MDA) 측정 결과 에탄올을 단독 투여한 대조군에서 MDA 함량이 가장 높게 나타났으며, 발효물을 투여한 모든 농도에서 MDA 함량이 유의적으로 감소하였다(P<0.05). 간 조직의 병리학적 분석 결과 모든 처리군에서 간문맥에 염증이 거의 관찰되지 않았고 곰취 열수 추출물 및 발효물 처리군에서 대조군과 비교하여 지방증 등이 개선되는 경향을 보였으나 유의적인 차이는 없는 것으로 나타났다. 곰취 열수추출 발효물의 투여가 혈청 GGT, AST, ALT 및 LDH 활성을 유의적으로 감소시켜 간 기능 개선 효과가 있음을 확인할 수 있었으며, 간 조직 내 SOD 활성을 증가시키고 지질과산화 반응을 억제시킴으로써 알코올로 인한 간 손상을 완화시키는 데 효과적일 것으로 사료되며, 향후 건강기능식품 소재로 이용 가능할 것으로 사료된다. This study was conducted to determine the effects of fermented water extracts from Ligularia fischeri (LAF) on reduction of hepatotoxicity induced by ethanol in rats. Ethanol-treated Sprague-Dawley rats were divided into the following eight groups: ethanol-treated group (control), ethanol and ursodeoxycholic acid-treated group (positive control), ethanol and non-fermented water extracts from Ligularia fischeri (LA)-treated groups [100, 200, and 400 mg/kg BW (body weight)], ethanol and LAF-treated groups (100, 200, and 400 mg/kg BW). γ-Glutamyl transferase activities of the ethanol+LA-treated (100, 200, and 400 mg/kg BW) groups and ethanol+LAF-treated (400 mg/kg BW) group decreased significantly compared to those in the control group (P<0.05). Aspartate aminotransferase activities of the ethanol+LAF-treated (100, 200, and 400 mg/kg BW) groups and ethanol+LA-treated (200 and 400 mg/kg BW) groups decreased significantly compared to those in the control group (P<0.05). Alanine aminotransferase and lactate dehydrogenase activities of all groups significantly decreased compared to those in the control group (P<0.05). The total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels of all groups tended to decrease compared to those in the control group, but the differences were not significant. Superoxide dismutase activity of liver tissues was enhanced in the ethanol+LAF-treated (400 mg/kg BW) group (P<0.05). The contents of malondialdehyde in liver tissues decreased in the ethanol+LAF-treated groups (P<0.05). All treated groups showed well preserved lobular architectures with no evidence of steatosis or liver damage compared to the control group. As the results of this study, LAF may improve the plasma lipid profile and alleviate hepatic damage by ethanol.

Effects of Oral Administration with Fermented Product from Sewage in land-based Seawater Fish Farm on Haematological of Olive Flounder, Paralichtys olivaceus

Kang, Ju-Chan,Jee, jung-Hoon,Song, Seoung-Yeop,Moon, Sang-Wook,Kang, ji-Woong,Lee, Young-Don,Kim, Se-Jae 부경대학교 수산과학연구소 2004 硏究業績集 Vol.29 No.-

600 kJ SMES 모델 코일의 설계와 Stress 해석

박명진(Myung-Jin Park),곽상엽(Sang-Yeop Kwak),이승욱(Seoung-Wook Lee),김우석(Woo-Seok Kim),한승용(Seoung-Young Hahn),최경달(Kyeong-Dal Choi),한진호(Jin-Ho Han),이지광(Ji-Kwang Lee),정현교(Hyun-Kyo Jung),성기철(Ki-Chul Seong),한송엽(S 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7

본 논문은 600 kJ SMES 모델 코일의 설계와 전자기력에 의한 모델코일의 스트레스의 해석에 관한 연구 결과를 나타낸다. 모델 코일의 설계에 적용된 초전도 선재는 77 K, 자기자계 하에서 115 A인 강화 선재이며, 모델 코일은 두 개의 팬케이크 코일로 구성한 모듈 코일 3개를 적층한 형태로 총 6개 더블 팬케이크 코일로 구성되어있다. 모델 코일의 임계전류는 전류를 인가하였을 때 코일에서의 최대 수직방향 자장을 이용해 Load Line을 나타내고, 이를 운전온도인 20 K에서의 B-IC 곡선에 적용하여 결정하였으며 236 A이다. 운전전류는 임계전류의 80 %인 165 A로 결정하였으며, 이는 n-value 손실을 고려한 값이다. 또한 해석적 방법을 이용해 코일에 전류를 인가하였을 때 전자기력에 의한 모델 코일의 radial stress와 hoop stress를 계산하여 나타내었다.