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박형일,신석주,이헌창,장서일,김태옥 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3
The runaway reaction was analyzed experimently and theoretically at the batch styrene suspension polymerization process. In the experiments, the reaction temperature with time was measured at various experimental conditions. According to the experimental results, the risk of the runaway reaction was increased with increasing the ratio of the monomer(styrene, M) to the dispersion medium(water, W), the concentration of the initiator(BPO), and the monomer mass, respectively. And simulation results showed that the runaway reaction was significantly affected by the reaction rate constant of the propagation and that the phenomena of the runaway reaction occurred at about 70% conversion. Also, we found that the runaway reaction did not occur under the operation condition of below 0.5 for M/W, approximate 3 wt% BPO, and below 75℃ for the cooling temperature.
Joo Myung Lee,Ki Hong Choi,Joon-Hyung Doh,Chang-Wook Nam,Eun-Seok Shin,Masahiro Hoshino,Tadashi Murai,Taishi Yonetsu,Hernán Mejía-Rentería,Tsunekazu Kakuta,Javier Escaned,Bon-Kwon Koo 대한심장학회 2020 Korean Circulation Journal Vol.50 No.10
Background and Objectives: Recent guideline recommends evaluation using of coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) in patients with functionally insignificant stenosis. We evaluated clinical implications of CFR and IMR in patients with high fractional flow reserve (FFR) and deferred revascularization. Methods: A total of 867 patients (1,152 vessels) consigned to deferred revascularization who underwent comprehensive physiologic assessments were enrolled. Patients with high FFR (>0.80) were categorized by CFR (≤2) and IMR (≥23 U). Clinical outcome was assessed by patient-oriented composite outcome (POCO), a composite of any death, myocardial infarction (MI), and revascularization at 5 years. Results: Patients with low CFR (≤2) showed significantly greater risk of POCO than those with high CFR (>2) in both high-FFR (p=0.024) and low-FFR (p=0.034) groups. In patients with high FFR, those with low CFR and high IMR (overt microvascular disease) displayed the greatest risk of POCO overall (p=0.015), surpassing those with high CFR and low IMR (HR, 2.873; 95% CI, 1.476–5.594; p=0.002) and showing significantly greater risk of cardiac death or MI (HR, 5.662; 95% CI, 1.984–16.154; p=0.001). Overt microvascular disease was independently associated with POCO in the high-FFR population (HR, 2.282; 95% CI, 1.176–4.429; p=0.015). Conclusion: Among patients with deferred revascularization, those with low CFR showed significantly greater risk of POCO than those with high CFR, regardless of FFR. In patients with high FFR, those with overt microvascular disease showed significantly greater risk of POCO and cardiac death or MI at 5-year, compared with the others. Trial Registration: ClinicalTrials.gov Identifier: NCT03690713
The Effects of the Humidity and Thickness on YBCO Film Prepared Using the TFA-MOD Method
Seok Hern Jang,Jun Hyung Lim,Kyung Min Yoon,Seung Yi Lee,Kyu Tae Kim,Eui Cheol Park,Jinho Joo,Seung-Boo Jung,Hyoungsub Kim Institute of Electrical and Electronics Engineers 2007 IEEE transactions on applied superconductivity Vol.17 No.2
<P>This study examined the epitaxial growth of YBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7-x</SUB> (YBCO) films on (00l) LaAlO<SUB>3</SUB> substrates prepared by metal organic deposition (MOD) using a trifluoroacetate (TFA) solution. The effects of humidity (0-20% of P<SUB>H2O</SUB>) and film thickness (0.4-2.1 mum) on the phase formation, texture, and microstructures of the YBCO films were examined by X-ray diffraction, pole-figure, and scanning electron microscopy (SEM). The microstructure and resultant critical properties varied remarkably with humidity. With increasing humidity, the amount of the second phase (BaF<SUB>2</SUB>) decreased, the degree of texture was enhanced, and consequently the critical current (I<SUB>C</SUB>) and temperature (T<SUB>C</SUB> ) were improved. In the case of multi-coated films, the I<SUB>C</SUB> value increased from 35 to 152 A/cm-width with an increasing number of coatings from one to three, while the corresponding critical current density (J<SUB>C</SUB>) was in the range of 0.9-1.5 MA/cm<SUP>2</SUP> . Both the I<SUB>C</SUB> and J<SUB>C</SUB> decreased when an additional coating was applied due to microstructural degradation.</P>
Jeong, Jae Seok,Lee, Kyung Bae,Kim, So Ri,Kim, Dong Im,Park, Hae Jin,Lee, Hern-Ku,Kim, Hyung Jin,Cho, Seong Ho,Kolliputi, Narasaiah,Kim, Soon Ha,Lee, Yong Chul BMJ Publishing Group 2018 Thorax Vol.73 No.8
<P><B>Background</B></P><P>Respiratory fungal exposure is known to be associated with severe allergic lung inflammation. Airway epithelium is an essential controller of allergic inflammation. An innate immune recognition receptor, nucleotide-binding domain, leucine-rich-containing family, pyrin-domain-containing-3 (NLRP3) inflammasome, and phosphoinositide 3 kinase (PI3K)-δ in airway epithelium are involved in various inflammatory processes.</P><P><B>Objectives</B></P><P>We investigated the role of NLRP3 inflammasome in fungi-induced allergic lung inflammation and examined the regulatory mechanism of NLRP3 inflammasome, focusing on PI3K-δ in airway epithelium.</P><P><B>Methods</B></P><P>We used two in vivo models induced by exposure to <I>Aspergillus fumigatus</I> (<I>Af</I>) and <I>Alternaria alternata</I> (<I>Aa</I>), as well as an <I>Af</I>-exposed in vitro system. We also checked NLRP3 expression in lung tissues from patients with allergic bronchopulmonary aspergillosis (ABPA).</P><P><B>Results</B></P><P>Assembly/activation of NLRP3 inflammasome was increased in the lung of <I>Af</I>-exposed mice. Elevation of NLRP3 inflammasome assembly/activation was observed in <I>Af</I>-stimulated murine and human epithelial cells. Similarly, pulmonary expression of NLRP3 in patients with ABPA was increased. Importantly, neutralisation of NLRP3 inflammasome derived IL-1β alleviated pathophysiological features of <I>Af</I>-induced allergic inflammation. Furthermore, PI3K-δ blockade improved <I>Af</I>-induced allergic inflammation through modulation of NLRP3 inflammasome, especially in epithelial cells. This modulatory role of PI3K-δ was mediated through the regulation of mitochondrial reactive oxygen species (mtROS) generation. NLRP3 inflammasome was also implicated in <I>Aa</I>-induced eosinophilic allergic inflammation, which was improved by PI3K-δ blockade.</P><P><B>Conclusion</B></P><P>These findings demonstrate that fungi-induced assembly/activation of NLRP3 inflammasome in airway epithelium may be modulated by PI3K-δ, which is mediated partly through the regulation of mtROS generation. Inhibition of PI3K-δ may have potential for treating fungi-induced severe allergic lung inflammation.</P>
한국인 갑상선 유두상암종 환자에서 XPC-PAT 유전자 다형
안유헌(You Hern Ahn),이형석(Hyung Seok Lee),이용섭(Yong Seop Lee),김희옥(Hee Ok Kim),이근영(Keun Young Lee),태경(Kyung Tae) 대한두경부종양학회 2006 대한두경부 종양학회지 Vol.22 No.2
Background and Objectives :Thyroid carcinoma is the sixth commonest cancer in Korea and the papillary carcinoma is the most common type(88%) of the malignant thyroid tumors. Bulky DNA adducts formed by the carcinogens are repaired by DNA repair process, but failure to repair this DNA damage can cause mutations in oncogenes and tumor suppressor genes resulting in tumor formation. The xeroderma pigmentosum group C ( XPC ) gene is essential for this repair procedure and the XPC-PolyAT ( PAT ) polymorphisms may alter DNA repair capacity(DRC) and genetic susceptibility to cancer. Subjects and Methods :In a case-control study of 113 Korean patients with pathologically diagnosed thyroid papillary carcinoma and 65 control subjects, we investigated the association between the three XPC-PAT gene polymorphisms and thyroid papillary cancer susceptibility. Results :The frequency of the variant XPC-PAT allele was lower in the cases(0.349) than in the controls (0.423), but the difference was not significant(p=0.140). Using logistic regression adjusting for age and sex, risk for thyroid papillary cancer was not increased in the XPC-PAT -/+ and XPC-PAT +/+ compared to XPC-PAT -/- (adjusted overall odds ratio[95% confidence intervals ; 95%CI]=0.52[0.26-1.03] and 0.62 [0.22-1.75], respectively; trend test, p=0.167). Conclusion :There are no relationship between the XPC-PAT polymorphism and the risk of thyroid papillary carcinoma in Korean population. Based on our results, XPC-PAT polymorphism do not modulate genetic susceptibility to thyroid papillary cancer.
Fabrication of YBCO film approached by the ‘211 process’ in the TFA-MOD method
Lim, Jun Hyung,Jang, Seok Hern,Joo, Jinho,Kim, Hyoungsub,Lee, Hee-Gyoun,Hong, Gye-Won,Kim, Chan-Joong IOP Publishing Ltd 2006 Superconductor science & technology Vol.19 No.4
<P>We fabricated YBCO film using a new approach to the TFA-MOD method. In the fabrication process, Y<SUB>2</SUB>Ba<SUB>1</SUB>Cu<SUB>1</SUB>O<SUB><I>x</I></SUB> and Ba<SUB>3</SUB>Cu<SUB>5</SUB>O<SUB>8</SUB> powders were used as precursors (the so called ‘211 process’), instead of Y-, Ba-, and Cu-based acetates, and dissolved in trifluoroacetic acid followed by calcining and firing heat treatment. Consequently, we successfully synthesized YBCO film and evaluated the phase formation, texture evolution, and critical properties as a function of the calcining and firing temperature and humidity, in order to explore its possible application in coated conductor fabrication.</P><P> The films were calcined at 430–460 ?C and then fired at 750–800 ?C in a 0–20% humidified Ar–O<SUB>2</SUB> atmosphere. We observed that the amount of BaF<SUB>2</SUB> phase was effectively reduced and that a sharp and strong biaxial texture formed under a humidified atmosphere, leading to increased critical properties. In addition, we found that the microstructure varied significantly with the firing temperature; the grains grew further, the film became denser, and the degree of texture and phase purity varied as the firing temperature increased. For the film fired at 775 ?C after calcining at 460 ?C, the critical current was found to be 39?A?cm<SUP>−1</SUP>?width (the corresponding critical current density is 2.0?MA?cm<SUP>−2</SUP>), which was probably attributable to such factors as the enhanced phase purity and out-of-plane texture, the moderate film density and grain size, and the crack-free surface. </P>
생활용품에서의 방출오염물질 측정ㆍ평가를 위한 5㎥챔버시스템 개발 및 성능평가
강효석(Kang Hyo-Seok),윤동원(Yoon Dong-Won),김지헌(Kim Ji-Hern),박종익(Park Jong-Ik),임용태(Lim Yong-Tae),홍성민(Hong Sung-Min) 한국건축친환경설비학회 2008 한국건축친환경설비학회 학술발표대회 논문집 Vol.- No.-
Poor indoor air quality has been focused as related in exposure to chemical pollutants in the air as effecting health risk for residences. Recently it is common for the design strategies to reduce the chemicals by selecting low emission materials and products. Some of the serious pollutants are focused on as the emission sources from home appliances. This study shows the characteristics of large scaled test chamber system. After constructing emission test chamber(5㎡ of air volume), various kinds of measurement has been performed to establishing the specification of the test chamber system. The results shows the reliable data for the accuracy of test chamber and suggest some test protocol for measurement of chemicals emitted from home appliances and furniture.