http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Mizue Tanaka,Soichiro Itoh,Yasuhiro Takeuchi 대한골다공증학회 2018 Osteoporosis and Sarcopenia Vol.4 No.3
Objectives: We compared the effectiveness of bisphosphonates combined with activated vitamin D administered for therapy of aromatase inhibitor-induced osteoporosis after a breast cancer operation and primary postmenopausal osteoporosis through propensity score matching. Methods: Forty-eight postmenopausal patients with estrogen receptor-positive early breast cancer, who had postoperative adjuvant treatment with aromatase inhibitors and whose T-score of bone mineral density (BMD) decreased below 2.5 (AI group), and 48 patients of primary postmenopausal osteoporosis (PO group) enrolled in this retrospective observational study. They were administered monthly risedronate or minodronate, and daily alfacalcitol or eldecalcitol were combined. Their BMD (L2e4, LBMD), serum-corrected calcium, serum phosphate, tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BAP), estimated glomerular filtration rate, urine calcium/creatinine ratio, intact-parathyroid hormone, and 25-hydroxy vitamin D were measured before treatment and until 24 months. Results: L-BMD values increased with time compared with the baseline values in each group, and there was no significant difference in the groups. Percentage value of TRACP-5b decreased rapidly after 6 months and maintained low level until 24 months in both groups. Percentage value of BAP in the AI group decreased continuously until 24 months. In contrast, the percentage change in the PO group plateaued after 6 months. Conclusions: It is suggested that monthly oral bisphosphonate combined with activated Vitamin D is an effective therapy to increase BMD in the aromatase inhibitor-induced osteoporosis after breast cancer operation. Monitoring of kidney function and concentration of Ca in blood and urine may be necessary
Mizue Tanaka,Soichiro Itoh,Yoshiharu Kato 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.3
The purpose of this study was to investigate the causes of failure to return to the pre-fracture place of residence at hospital discharge following an operation for a hip fracture and to continue medical treatment for osteoporosis. Herein, we discuss methods for improving discharge protocols for these patients. We examined patients who sustained osteoporotic fractures and were operated on for a hip fracture between 2001 and 2003 (83 males and 386 females; 81.2 ± 9.0 years old) and between 2011 and 2013 (121 males and 462 females; 83.1 ± 9.3 years old). In a follow-up study, we examined patients who moved into our related rehabilitation institution over a 3-year period, from 2011 to 2013. The incidence of hip fractures had increased from 2001e2003 to 2011e2013 in both genders, and it tended to increase in patients greater than 80 years of age in male and 90 years of age in female. The most common destination residence after discharge from the rehabilitation institution was the pre-fracture place of residence. The Barthel Index at discharge from the rehabilitation institution was significantly lager in patients who returned to the pre-fracture place of residence compared to those who returned to nursing home and our hospital. These results suggest improved mobility and ADL level of patients enable them to return to the pre-fracture place of residence. We propose the construction of a feedback system that aids in a medical pass to increase the ambulant consultation rate for orthopedics and prevent fragile fractures.
Mizue Tanaka,Yukio Nakamura,Soichiro Itoh,Yoshiharu Kato 대한골다공증학회 2017 Osteoporosis and Sarcopenia Vol.3 No.1
Objectives: This is an open labeled and retrospective cohort study which compared the effectiveness and safety of ibandronate (IBN) and minodronate (MIN) combined with eldecalcitol (ELD) in primary osteoporosis of women. Methods: One hundred and forty-eight primary osteoporotic women were classified into 3 groups; 1) intravenous IBN combined with oral ELD (IBN þ ELD group, N ¼ 50; 81.8 ± 6.2 years), 2) oral MIN combined with oral ELD (MIN þ ELD group, N ¼ 50; 77.2 ± 6.9 years) and 3) oral ELD alone (ELD group, N ¼ 48; 75.0 ± 8.3 years). For statistical analysis, lumbar spine bone mineral density (L-BMD), hip total bone mineral density (H-BMD), serum corrected calcium (Ca), serum inorganic phosphorus (iP), intact-parathyroid hormone (PTH), tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BAP), serum homocysteine (Hcy), estimated glomerular filtration rate (eGFR) and urine calcium / creatinine (Ca/Cr) ratio were measured until 12 months after the start of therapy. Results: L-BMD values increased significantly in both IBN þ ELD and MIN þ ELD group, however, H-BMD increased significantly in the IBN þ ELD group only. TRACP-5b values decreased rapidly during the first 6 months in both IBN þ ELD and MIN þ ELD group. However, BAP value in the IBN þ ELD group decreased more gradually compared with that in the MIN þ ELD group. Both serum Ca value and urine Ca/ Cr ratio tended to increase, and the eGFR value decreased significantly in each group. Conclusions: IBN combined with ELD administration can act more effectively to increase BMD compared with MIN combined with ELD administration. Differences of decreasing rate in TRACP-5b and BAP value may lead to differences of increased rate of BMD in the IBN þ ELD and MIN þ ELD group. Because many cases of osteoporosis are elderly persons associated with chronic kidney disease, monitoring of kidney function and concentration of Ca in blood and urine is essential.
Um, Ik-Hwan,Lee, Ji-Youn,Fujio, Mizue,Tsuno, Yuho Royal Society of Chemistry 2006 Organic & biomolecular chemistry Vol.4 No.15
<P>A kinetic study is reported for the reactions of 4-nitrophenyl X-substituted benzoates (1a–l) and Y-substituted phenyl benzoates (2a–l) with two anionic nucleophiles (OH<SUP>−</SUP> and CN<SUP>−</SUP>) and three amines (piperidine, hydrazine, and glycylglycine) in 80 mol% H<SUB>2</SUB>O–20 mol% dimethyl sulfoxide (DMSO) at 25.0 ± 0.1 °C. Each Hammett plot exhibits two intersecting straight lines for the reactions of 1a–l with the anionic nucleophiles and piperidine, while the Yukawa–Tsuno plots for the same reactions are linear. The Hammett plots for the reactions of 2a–l with hydrazine and glycylglycine demonstrate much better linear correlations with <I>σ</I><SUP>−</SUP> constants than with <I>σ</I>° or <I>σ</I> constants, indicating that the leaving group departure occurs at the rate determining step (RDS). On the contrary, <I>σ</I><SUP>−</SUP> constants result in poorer Hammett correlation than <I>σ</I>° constants for the corresponding reactions with OH<SUP>−</SUP> and CN<SUP>−</SUP>, indicating that the leaving group departure occurs after the RDS for the reactions with the anionic nucleophiles. The large <I>ρ</I><SUB>X</SUB> value (1.7 ± 0.1) obtained for the reactions of 1a–l with the anionic nucleophiles supports the proposal that the reactions proceed through an addition intermediate with its formation being the RDS.</P> <P>Graphic Abstract</P><P>Reactions proceed through an addition intermediate. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b607194e'> </P>
Effect of a dynamic absorber on friction-induced vibration of a rectangular plate
Hiroki Mori,Oleksandr Mikhyeyev,Takuo Nagamine,Mizue Mori,Yuichi Sato 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1
When a plate-like object is rubbed by rubber, friction-induced vibration is generated. To reduce the friction-induced vibration, we experimentally investigate the characteristics of the vibration of a rectangular glass plate. The results show that the frequency of the frictioninduced vibration is almost the same as the natural frequency of a glass plate. The vibration is generated when the natural frequency of a rubbing system is close to that of a glass plate. We then examine the effect of a dynamic absorber mounted on the glass plate. The results demonstrate that the damping of a dynamic absorber is effective for suppressing the friction-induced vibration. Numerical simulation is also performed using a simplified analytical model. The calculated results agree qualitatively with the experimental ones.
Muto, Momotaro,Nakata, Hirotaka,Ishigaki, Kenichi,Tachibana, Shion,Yoshida, Moe,Muto, Mizue,Yanagawa, Nobuyuki,Okumura, Toshikatsu The Korean Gastric Cancer Association 2021 Journal of gastric cancer Vol.21 No.3
The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.