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Liu, Lian-Ke,Wu, Heng-Fang,Guo, Zhi-Rui,Chen, Xiang-Jian,Yang, Di,Shu, Yong-Qian,Zhang, Ji-Nan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Objective: Lung cancer is one of the malignant tumors with greatest morbidity and mortality around the world. The keys to targeted therapy are discovery of lung cancer biomarkers to facilitate improvement of survival and quality of life for the patients with lung cancer. Translationally controlled tumor protein (TCTP) is one of the most overexpressed proteins in human lung cancer cells by comparison to the normal cells, suggesting that it might be a good biomarker for lung cancer. Materials and Methods: In the present study, the targeted efficacy of dihydroartemisinin (DHA) on TCTP expression in the A549 lung cancer cell model was explored. Results and Conclusions: DHA could inhibit A549 lung cancer cell proliferation, and simultaneously up-regulate the expression of TCTP mRNA, but down-regulate its protein expression in A549 cells. In addition, it promoted TCTP protein secretion. Therefore, TCTP might be used as a potential biomarker and therapeutic target for non-small cell lung cancers.
The Dynamic Relationship between the NFT Index and Macroeconomic Factors in Korea
Ke-Qin Liu,Ai-Lian Bian 한국무역연구원 2023 무역연구 Vol.19 No.3
Purpose – This study attempts to analyze the dynamic relationship between the NFT index and macroeconomic factors, and make effective suggestions using research methods in the field of management finance. Design/Methodology/Approach – The study sample was from January 2020 to March 2023. The variables used in the analysis were based on monthly time series data, measured on the basis of the Metaverse–NFT Index (MVNX) index released by Wavebridge Limited in Korea to reflect the growth trend of the NFT market, money supply, US dollar–won exchange rate, gross domestic product, consumer price index, and other macroeconomic indicators. The analytical tools in this study included a unit root test based on the VAR model, the Johansen cointegration Test, Granger causality test, impulse response analysis, and variance decomposition. These methods are very effective in analyzing time series data. Findings – The results of the analysis show that macroeconomic factors, such as money supply, exchange rate, GDP, and consumer price index are important sources of information in predicting the NFT index. Research Implications – The results of this study are expected to provide practical information for NFT users, virtual asset trading platforms, investors, and policymakers related to NFT ecology. Furthermore, this study’s findings are of great significance, being the first global study to explore the relationship between NFTs and macroeconomic factors.
Room-temperature tensile strength and thermal shock behavior of spark plasma sintered W-K-TiC alloys
Ke Shi,Bo Huang,Bo He,Ye Xiao,Xiaoliang Yang,Youyun Lian,Xiang Liu,Jun Tang 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.1
W-K-TiC alloys with different titanium carbide concentrations (0.05, 0.1, 0.25, 0.5, 1, 2) wt.% werefabricated through Mechanical Alloying and Spark Plasma Sintering. The effects of the addition of nanoscaledTiC particles on the relative density, Vickers micro-hardness, microstructure, crystal information,thermal shock resistance, and tensile strength were investigated. It is revealed that the doped TiC nanoparticleslocated at the grain boundaries. The relative density and Vickers micro-hardness of W-K-TiCalloys was enhanced with TiC addition and the highest Vickers micro-hardness is 731.55. As the TiCaddition increased from 0.05 to 2 wt%, the room-temperature tensile strength raised from 141 to353 MPa. The grain size of the W-K-TiC alloys decreased sharply from 2.56 mm to 330 nm with theenhanced TiC doping. The resistance to thermal shock damage of W-K-TiC alloys was improved slightlywith the increased TiC addition
Cheng, Ke,Zhao, Yu-Jun,Liu, Lian,Wan, Jing-Jing Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: Tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) plays a very important role in the development and progression of cancer. Many epidemiological studies have evaluated associations between the TNF-${\alpha}$ 238 G/A polymorphism and hepatocellular carcinoma (HCC) risk, but the published data are inconclusive. Therefore, we performed the present meta-analysis. Methods: Electronic searches of several databases were conducted for all publications on the association between TNF-${\alpha}$ 238 G/A polymorphism and HCC through July 2012. Asummary odds ratio (OR) with its 95% confidence interval (CI) were calculated to evaluate the strength of this association. Results: Eleven case-control studies with a total of 1,572 HCC cases and 1,875 controls were finally included in this meta-analysis. Overall, the TNF-${\alpha}$ 238 G/A polymorphism was significantly associated with increased risk of hepatocellular carcinoma in three genetic comparison models (For A versus G: OR 1.32, 95%CI 1.04-1.69, P = 0.02, $I_2$ = 40%; for AG versus GG: OR 1.32, 95%CI 1.02-1.71, P = 0.03, $I_2$ = 40%; for AA/AG versus GG: OR 1.33, 95%CI 1.03-1.72, P = 0.03, $I_2$ = 41%) when all studies were pooled. Subgroup analysis by ethnicity further showed that there was a significant association between the TNF-${\alpha}$ 238 G/A polymorphism and risk of HCC in Asians under three genetic comparison models (For A versus G: OR 1.30, 95%CI 1.00-1.68, P = 0.05, $I_2$ = 45% for AA/AG versus GG: OR 1.31, 95%CI 1.00-1.71, P = 0.05, $I_2$ = 46%). Conclusions: This meta-analysis provided convincing evidence that the TNF-${\alpha}$ 238 G/A polymorphism is associated with increased susceptibility to HCC. However, more well-designed studies with large sample size are needed to validate this association in Caucasians.
Hai Lian Xiao,Fang Fang Jian,Ke Jie Zhang 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.4
Two modifications of the α and β forms of propyl mercaptan nickel(II) cluster, [Ni6(SCH2CH2CH3)12], have been synthesized and their crystal structures have been determined by single-crystal X-ray diffraction. The alkyl groups are away from Ni6 ring in α form whereas they are near to the Ni atom in β form. The distance of Ni-H in β form [2.576(5) Å] is much shorter than that in α form [3.101(2) Å]. In the crystal lattice of β form, the whole structure forms a flower shape.
Qiang Wang,Lian Liu,Sheng Zhang,Yingzi Ming,Shu Liu,Ke Cheng,Yujun Zhao 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Fulminant hepatic failure (FHF) refers to the rapid development of severe acute liver injury with impaired synthetic function and encephalopathy in people with normal liver or well-compensated liver disease. This study aimed to investigate the function of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) on the proliferation and apoptosis of hepatocytes in FHF. Our results revealed that lncRNA NEAT1 was upregulated in cell and animal models of FHF induced by D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Overexpression of lncRNA NEAT1 resulted in elevated hepatocyte apoptosis and impaired large tumor-suppressor kinase 2 (LATS2) expression and proliferation. Functional analysis revealed that knockdown of lncRNA NEAT1 inhibited hepatocyte apoptosis and induced proliferation both in vitro and in vivo. RNA immunoprecipitation and chromatin immunoprecipitation assays demonstrated that lncRNA NEAT1 recruited enhancer of zeste homolog 2 (EZH2) to the LATS2 promoter and repressed LATS2 expression. Furthermore, ectopic expression of LATS2 increased proliferation and inhibited hepatocyte apoptosis by regulating the Hippo/Yes-associated protein (YAP) signaling pathway. Taken together, our findings indicate that lncRNA NEAT1 might serve as a novel target for FHF therapy due to its regulation of H3K27me3 methylation-dependent promotion of LATS2.
Xiao, Hai Lian,Jian, Fang Fang,Zhang, Ke Jie Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.4
Two modifications of the ${\alpha}\;and\;{\beta}$ forms of propyl mercaptan nickel(II) cluster, [$Ni_6(SCH_2CH_2CH_3)_{12}$], have been synthesized and their crystal structures have been determined by single-crystal X-ray diffraction. The alkyl groups are away from $Ni_6$ ring in $\alpha$ form whereas they are near to the Ni atom in $\beta$ form. The distance of Ni-H in $\beta$ form [2.576(5) $\AA$] is much shorter than that in $\alpha$ form [3.101(2) $\AA$]. In the crystal lattice of $\beta$ form, the whole structure forms a flower shape.
Ningtao Wang,Tingting Shi,Ke Peng,Zhipeng Lian,Yiyong Li,Qing Wang,Wen Chen,Bolin Huang 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.4
Fuzzy logic model and entropy model are useful for the geohazard susceptibility zonation in Jianshi County of Qingjiang River Basin. In this paper, the same impact factors were chosen and the geohazard samples were considered in two cases with quantitative analysis method. The first case 162 geohazards chosen as samples and the other one all of 182 geohazards chose as samples. The authors completed the susceptibility zonation in the two different cases using the two models in order to analysis the effects of the two models. The results of the two models in different cases were almost the same in space, except small differences in some areas. The entropy model was more accurate for the analysis of relationship between impact factors and geohazards, but not stable for different geohazard samples. The fuzzy logic model was better for less geohazard samples. According to the analysis process, it was found that the fuzzy γ operation was the best which was defined in terms of the fuzzy algebraic product and the fuzzy algebraic sum. The results of fuzzy logic model were most useful when γ was 0.20. The fuzzy logic model and entropy model were useful for the geohazard susceptibility which was scientific and useful for the government to manage the geohazards and make the preliminary development plans.
Yong He,Zhi Lian,Chuan-Ke Zhang,Min Wu 제어·로봇·시스템학회 2016 International Journal of Control, Automation, and Vol.14 No.1
This paper is concerned with the problem of delay-dependent stability criteria for Takagi-Sugeno systemswith time-varying delay. The less conservative delay-dependent stability criteria in terms of linear matrix inequalitiesare obtained by constructing a novel augmented Lyapunov-Krasovskii functional. In order to further improvethe stability conditions, the free- matrix-based integral inequality is employed. Finally, several numerical exampleson time-delay stability analysis are given to demonstrate the effectiveness and the merits of the proposed methods.