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韓醫學的 診斷類型에 따른 韓藥方劑의 抗癌 및 免疫調節作用에 미치는 影響
朴鐘鉉,金楨氾,崔昇勳,安圭錫 대한동의병리학회 1994 동의생리병리학회지 Vol.9 No.1
연구배경 : 암은 사망의 주요한 원인이 되는 질환으로서, 우리나라에 있어서도 급격히 증가하는 추세이다. 한의학에서는 암의 유형을 크게 간울기체형, 기체혈어형, 비허습담형, 음허내열형 등으로 분류하고 있는데, 각 유형에 응용할 수 있는 소요산, 소복축어탕, 사군자탕, 육미지황탕의 항암효능을 비교 연구함으로써, 암치료에 대한 한약재의 임상활용도를 높이고자 함. 방법 : Mouse에 Sarcoma-180으로 복강암을 유발한 후, 약제를 21일 간 투여하고 생존율, T cell, B cell, 혈청항체가, IL-2 생산능, NK cell의 세포살상능을 측정하였다. 결과 : 생존기간의 연장효과는 모든군에서 증가하는 경향이 있었으나 유의성이 없었고, T cell 및 B cell은 모든군에서 증가하였으며, 임파구 증식반응 및 IL-2 생산능은 사군자탕과 육미지황탕에서, NK cell 활성도는 소복축어탕 엑기스 투여군에서 유의성이 있었다. 결론 : 이상으로 보아 이들 처방은 면역조절작용을 통한 항암효과가 있을 것으로 볼 수 있으며, 변증분형에 따라 처방을 달리해야 함을 알 수 있다. In order to investigate the effects of Formules according to Pattern Identification on anti-tumor and immunodulatory reaction to the ICR and C57BL/6 mice which have abdominal tumor after Sarcoma-180 cells were transplanted, the extracts of herbal medicines above mentioned were orally administered to the mice for 21 days to observe the extention of survial duration of the mice, quantitation of T cells and B cells, productivity of interleukin-2, lymphocytes transformation, hemagglutinin titer and hemolysin titer and activity of splenic natural killer cells. The results are summarized as follows ; 1. In the effect of life extention, all groups appeared to survive longer than the Control group, which are not meaningful. 2. Considering T cell and B cell content, all groups had a meaningful increase in both T cell and B cell (P<0.01). 3. Considering serum antibody titer was no significant difference between all groups. 4. In lymphocyte transformation marked a significant increase the sijunzitang-medicated mice group, marked a significant (P<0.01), and showed a significant increase the mice group medicated with Liuweidihuangtang (P<0.05). 5. As for the productivity of interleukin-2, showed a significant increase the mice group medicated with Sijunzitang ans Liuweidihuangtang (P<0.05). 6. In the effect of activity of NK cells, Shaofuzhuyutang-medicated mice group had a meaningful increase (P<0.05).
益胃升陽湯 및 加減方이 家兎의 摘出腸管 運動에 미치는 影響
李學宰,盧永範,柳道坤,韓宗鉉,康舜洙 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1
In order to investigate the action of Radix Bupleuri and Radix Cimicifugae in Yikwiserugyangtang(益胃升陽湯), Yikwiseungyangtang was divided into six samples : Sample Ⅰ : Yikwiseungyangtang Sample Ⅱ : Water extract of Yikwiseungyangtang excluded R.Bupleuri and R.Cimicifugae. Sample Ⅲ : Water extract of Yikwiseungyangtang excluded R.Cimicifugae. Sample Ⅳ : Water extract of Yikwiseungyangtang excluded R.Bupleuri. Sample Ⅴ : Water extract of Yikwiseungyangtang increased R.Bupleuri and R.Cimicifugae to 3.75g Sample Ⅵ : Water extract of R.Bupleuri and R.Cimicifuage. Effects of Yikwiseungyangtang and its variants on the contractile force of isolated rabbit ileums are as follows : 1. Yikwiseungyangtang was significantly increased the contractile force of isolated rabbits ileum. 2. The contractile of Yikwiseungyangtang was significantly inhibited by atropine. 3. The contractile force of Yikwiseungyangtang was not inhibited by cyproheptadine. 4. In the contraction of Norepinephrine(10^-3M), Sample Ⅱ, Sample Ⅵ and Sample Ⅴ were increased the contractile force than that of Sample Ⅰ. 5. In the contraction of acetylcholine (10^-3M), no change observed in contractile force than that of Sample Ⅰ.
심장엽,안종영,김상범,허강인 東亞大學校 附設 情報通信硏究所 1995 情報通信硏究所論文誌 Vol.3 No.1
본 논문에서는 포-만트 vocoder를 구성하여 한국어 음성 합성을 연구하였다. 포-만트 vocoder의 구성에 필요한 합성파라메터로서는 스펙트럼 모멘트법에 의한 포-만트 주파수, 최적 Comb법에 의한 피치 주파수, 단시간 평균에너지와 단시간 평균진폭, 대역폭, 음원파형, 가우시안 백색잡음이다. 합성실험은 남성 화자가 발성한 음절, 단어, 문장 등의 음성데이터를 이용하였다. 청취결과, 유무성음에 대해 각각 Rosenberg의 음원파형과 삼각파를 음원으로 적용한 경우가 우수하였다. This paper studies on a method of Korean speech synthesis by composing formant VOCODER. The parameters of speech synthesis are formant frequencies by spectrum moment method, pitch frequencies by optimum Comb method, short time average energy, short time average amplitude, bandwidth, excitation wave and gaussian white noise. In this paper, synthesis is performed using speech data which are syllable, word and sentence spoken by man. Synthesis results are good in case of using Rosenberg & Triangle wave respectively as voice source.
흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과
권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6
The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.
한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고
양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.
Inhibitory effects of Angelicae Gigantis Radix on osteoclast formation
Kil, Jong-Seob,Kim, Myung-Gyou,Choi, Hye Mi,Lim, Jong-Pil,Boo, Yungmin,Kim, Ee-Hwa,Kim, Jeung-Beum,Kim, Hye Kyung,Leem, Kang-Hyun John Wiley Sons, Ltd. 2008 Phytotherapy research Vol.22 No.4
<P>Angelicae Gigantis Radix (AGR) is one of the most widely used herbal medications. AGR is the dried root of Angelica gigas Nakai (Umbelliferae), which is known as Korean angelica. This study investigated the effects of AGR on osteoclast formation using primary bone marrow cells. TNF-&agr; treatment increased tartrate-resistant acid phosphatase (Trap) positive cells and Trap activity in bone marrow cells. However, AGR significantly decreased both TNF-&agr;-induced Trap positive cells and Trap activity. RT-PCR analyses revealed that AGR decreased mRNA levels of Trap and matrix metalloproteinase-9 in TNF-&agr;-treated bone marrow cells. In addition, AGR decreased TNF-&agr;-induced activation of NF-&kgr;B. These results suggest that AGR has an inhibitory effect on the formation of osteoclasts and its effect is partially related to the NF-&kgr;B pathway. Copyright © 2008 John Wiley & Sons, Ltd.</P>
이종우(Jong-Woo Lee),황종규(Jong-Gyu Hwang),정의진(Eui-Jin Joung),정철범(Chul-Beum Jung) 한국철도학회 2000 한국철도학회 학술발표대회논문집 Vol.- No.-
In railway train operations, a braking distance between two trains must be controlled on their speeds to avoid rear end collisions. The distance is decided by some parameters such that propulsion and braking performance of trains, gradient and etc. When determining this block distance, it is important to consider the two aspects that safety insurance at train running and increase of train running frequency. In this paper, we showed a methodologies of equiblock by consideration gradients and calculated optimal block speeds on the basis of the equivalent block distance.
이종우(Jong-Woo Lee),정의진(Eui-Jin Joung),황종규(Jong-Gyu Hwang),정철범(Chul-Beum Jung) 한국철도학회 2000 한국철도학회 학술발표대회논문집 Vol.- No.-
Headway calculation is a important mean to evaluate railway system performance. A accurate headway calculation can be needed to headway reducing being achieved line capacity increasing by regulating signals spacing without any line construction. This paper introduced the theories and algorithms of calculating headways on wayside, multi step, one step braking and moving block signalling systems and showed some results of headways.