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      • KCI등재

        Three Dimensional Nylon Cushioning Composite Fabrics: Manufacturing Technique and Property Evaluations

        Jia-Ci Jhang,Ting Ru Lin,Yu-Chun Chuang,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.3

        It is trendy to use polymers with different forms in a diversity of fields. This study uses nylon fibers and lowmelting-point polyester (LMPET) fibers or low melting point polylactic acid (LMPLA) fibers to fabricate three-dimensionalnylon/LMPET and nylon/LMPLA cushioning composite fabrics employing the nonwoven manufacturing. The employmentof needle punching process and thermal treatment reinforce the cushioning composite fabrics, and the subsequent thermalbonding points strengthen the mechanical properties effectively. In comparison to pure nylon nonwoven fabrics, the nyloncushioning composite fabrics exhibit higher tensile strength by 2.3 times regardless of whether it is a nylon/LMPET or nylon/LMPLA cushioning composite fabric. Similarly, based on the hammer rebound rate measurement, when the 3D cushioningcomposite fabrics are composed of 20 wt% of LMPLA fibers or 80 wt% of LMPET fibers, the hammer rebound rate reaches20 %, which is 1.4 times greater than that of the control group. Additionally, the composite fabrics that are composed of80 wt% of LMPLA fibers or 40 wt% of LMPET fibers also demonstrate higher compression recovery than the control group.

      • A Theory Thermal Growth Control Techniques of High Speed Spindles

        Chang,Ching-Feng,Ling,Chao-Shui,Chao, Ching-Yi,Chen, Jin-Jia,Chen,Tsair-Rong 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

        A motorized high speed spindle has very complicated dynamics consisting of non-stationary and speed-related thermal characteristics. Many studies have been reported with different designs to control or monitor spindle’s thermal growth with limited results, whereas the application of High Speed Machining (HSM) demands “zero tolerance”no matter the range of speed or material to be machined. This paper proposes a direct displacement measuring system, which is a considerable improvement as compared with many taking inaccurate readings through a traditional thermo coupler, to accurately monitor and compensate the thermal growth associated with motorized high speed spindles. This direct displacement measuring system optimizing a high speed synchronous feedback system will meet the tolerance and performance expected in HSM applications. Based on the introduction of Foucault current, a design for an accurate thermal growth is outlined.

      • KCI등재

        Ni/Au-Gate In0.45Al0.55As/In0.53Ga0.47As/InAlGaAs/GaAs Metamorphic High-Electron-Mobility Transistors

        Ching-Sung Lee,Dong-Hai Huang,Jun-Chin Huang,Ke-Hua Su,Wei-Chou Hsu,Yeong-Jia Chen 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.4

        A -doped In0.45Al0.55As/In0.53Ga0.47As/InAlGaAs/GaAs metamorphic high electron mobility transistor (MHEMT) using a Ni/Au-gate electrode has been successfully fabricated and demonstrated. Compared to conventional Au-gate devices with identical structures, the proposed device improves the kink-effect-related output conductance, the gate-voltage swing, the current drive capability, the breakdown characteristics, and the device power performance. Experimentally, a high extrinsic transconductance of 309 mS/mm, a high drain-source saturation current density of 573 mA/mm, an improved gate-voltage swing of 1.05 V with a corresponding saturation current density of 314 mA/mm, a high saturated output power of 11.3 dBm, and a high power gain of 23.8 dB with a power-added efficiency of 39.2 % are obtained for a 0.65 × 200 μm2 gate at 300 K. In addition, the measured fT and fmax are 49.1 and 61.7 GHz, respectively.

      • SCOPUSKCI등재

        Probiotics: The Next Dietary Strategy against Brain Aging

        Jia-Sin Ong,Lee-Ching Lew,Yan-Yan Hor,Min-Tze Liong 한국식품영양과학회 2022 Preventive Nutrition and Food Science Vol.27 No.1

        Owing to their long history of safe use, probiotic microorganisms, typically from the genus Lactobacillus, have long been recognized, especially in traditional and fermented food industries. Although conventionally used for dairy, meat, and vegetable fermentation, the use of probiotics in health foods, supplements, and nutraceuticals has gradually increased. Over the past two decades, the importance of probiotics in improving gut health and immunity as well as alleviating metabolic diseases has been recognized. The new concept of a gut-heart-brain axis has led to the development of various innovations and strategies related to the introduction of probiotics in food and diet. Probiotics influence gut microbiota profiles, inflammation, and disorders and directly impact brain neurotransmitter pathways. As brain health often declines with age, the concept of probiotics being beneficial for the aging brain has also gained much momentum and emphasis in both research and product development. In this review, the concept of the aging brain, different in vivo aging models, and various aging-related benefits of probiotics are discussed.

      • KCI등재

        Bamboo Charcoal/Quick-Dry/Metallic Elastic Knits: Manufacturing Techniques and Property Evaluations

        Jia-Horng Lin,Chih Hung He,Mong-Chuan Lee,Yueh-Sheng Chen,Ching-Wen Lou 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7

        Protective clothing with electromagnetic shielding effectiveness (EMSE) is a functional textile, which shieldselectromagnetic waves to protect the human body from the far infrared rays. Traditional EMSE garments primarily usemetallic plates for reflecting electromagnetic interference (EMI). However, they also have disadvantages of a heavy weight,easy corrosion, and high production cost. In this study, three different functional yarns are combined, during which the twistnumber of metallic wires is changed for a better shielding effect. A crochet machine is used to fabricate functional elasticknits with the metallic composite yarns as the warp- and weft-inlaid yarns. The test results show that double (D) functionalelastic knits exhibit EMSE of above 20 dB when the EMI are between 1.0 and 3.0 GHz. In addition, the knit structure canimprove breaking tensile strength by 170 % and increases bursting strength by 58 %, but undermines the tear strength by10 %. Although changing twist number of metallic composite yarns does not affect water absorption rate along the weftdirection, it helps increasing elastic recovery rate by 3.1 %, water absorption rate along the warp direction by 106 %, farinfraredemissivity by 2.3 %, water vapor transmission rate by 20 %, and air permeability by 6 %.

      • KCI등재

        Photodynamic antibacterial micro/nanofiber composite membrane with high efficiency and low resistance filtration performance for medical protective materials

        Jia-Horng Lin,Lu Yang,Xianjin Hu,Haokai Peng,Haitao Ren,Ting-Ting Li,Ching-Wen Lou 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-

        Bacterial infection is one of the major threats to human health worldwide, posing a great challenge to thedevelopment of medical protective materials with efficient filtration and long-lasting antimicrobial properties. In this study, electrospinning technology and non-woven fabrics were combined to construct amicro/nano-structured photodynamic rechargeable and storable antibacterial filtration composite membrane. The filtration efficiency of the composite membrane is as high as 99.99% for 0.5–5 lm particles,and the resistance pressure drop is 85 Pa. In addition, the release of OH and H2O2 from the compositefilm reached 5326.16 lg/g and 711.93 lg/g, respectively. After 7 cycles of quenching, the charging capacityretains more than 70 % of the original. It showed good antimicrobial properties even when storedunder dark conditions for one month. The bactericidal efficiency of the composite membrane againstE. coli and S. aureus exceeded 99% under both dark and light conditions. The development of this simpleand clean micro/nanofiber membrane provides a new idea for exploring photoactive antimicrobial andfiltration materials for medical protection.

      • SCIESCOPUSKCI등재

        Platelet-Derived Growth Factor Receptor-α Subunit Targeting Suppresses Metastasis in Advanced Thyroid Cancer In Vitro and In Vivo

        ( Ching-ling Lin ),( Ming-lin Tsai ),( Yu-hsin Chen ),( Wei-ni Liu ),( Chun-yu Lin ),( Kai-wen Hsu ),( Chien-yu Huang ),( Yu-jia Chang ),( Po-li Wei ),( Shu-huey Chen ),( Li-chi Huang ),( Chia-hwa Lee 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.5

        Thyroid cancer is the most common endocrine malignancy. Patients with well-differentiated thyroid cancers, such as papillary and follicular cancers, have a favorable prognosis. However, poorly differentiated thyroid cancers, such as medullary, squamous and anaplastic advanced thyroid cancers, are very aggressive and insensitive to radioiodine treatment. Thus, novel therapies that attenuate metastasis are urgently needed. We found that both PDGFC and PDGFRA are predominantly expressed in thyroid cancers and that the survival rate is significantly lower in patients with high PDGFRA expression. This finding indicates the important role of PDGF/PDGFR signaling in thyroid cancer development. Next, we established a SW579 squamous thyroid cancer cell line with 95.6% PDGFRA gene insertion and deletions (indels) through CRISPR/Cas9. Protein and invasion analysis showed a dramatic loss in EMT marker expression and metastatic ability. Furthermore, xenograft tumors derived from PDGFRA geneedited SW579 cells exhibited a minor decrease in tumor growth. However, distant lung metastasis was completely abolished upon PDGFRA gene editing, implying that PDGFRA could be an effective target to inhibit distant metastasis in advanced thyroid cancers. To translate this finding to the clinic, we used the most relevant multikinase inhibitor, imatinib, to inhibit PDGFRA signaling. The results showed that imatinib significantly suppressed cell growth, induced cell cycle arrest and cell death in SW579 cells. Our developed noninvasive apoptosis detection sensor (NIADS) indicated that imatinib induced cell apoptosis through caspase-3 activation. In conclusion, we believe that developing a specific and selective targeted therapy for PDGFRA would effectively suppress PDGFRA-mediated cancer aggressiveness in advanced thyroid cancers.

      • KCI등재

        Acupuncture for ventilator-dependent patients at a hospital-based respiratory care center: A randomized controlled trial

        Jia-Ming Chen,Wan-Li Chiang,Bin-Chuan Ji,Ruei-Jhe Jhang,Pei-Hsin Chen,Ya-Lun Li,Che-Ju Chang,Sung-Yen Huang,Tsung-Chieh Lee,Chia-Yun Chen,Ching-Hsiung Lin,Sheng-Hao Lin 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.4

        Background: In intensive care units, mechanical ventilation is an important therapy to help patients with dysp- nea. However, long-term ventilator dependence would consume huge medical resources and increase the risk of morbidity and mortality. The aim of the study was to examine the efficacy of the acupuncture combined with western medical care on ventilator parameters in ventilator-dependent patients. Methods: In this clinical trial, 80 ventilator-dependent patients aged 20 to 80 years old were randomly assigned to acupuncture group and control group in the respiratory care center (RCC) of Changhua Christian Hospital. Besides regular medical care and therapy, participants in the acupuncture group received acupuncture therapy at the same 17 acu-points for 20 minutes once a day, a total of 12 sessions. The ventilator parameters were recorded to evaluate the respiratory efficiency for all participants. The primary outcome was rapid shallow breathing index (RSBI), and secondary outcomes were respiratory rate (RR), tidal volume (TV) and ventilation per minute (MV). Results: Though there was no significant difference in the parameter between the acupuncture group and the control group, we found the trend of decreasing RSBI in the acupuncture group. In subgroup analyses, the mean of RSBI significantly decreased 16.02 (with the SD in 60.84) in acupuncture group, while it increased 17.84 (with the SD in 39.38) in control group (p = 0.036) after 12 sessions. Conclusion: Acupuncture treatment can improve breathing ability of patients with respirator dependence in respiratory care center.

      • KCI등재

        Current-in-plane Tunneling Measurement through Patterned Contacts on Top Surfaces of Magnetic Tunnel Junctions

        Ching-Ming Lee,Lin-Xiu Ye,Jia-Mou Lee,Yu-Cyun Lin,Chao-Yuan Huang,J. C. Wu,Masakiyo Tsunoda,Migaku Takahashi,Te-ho Wu 한국자기학회 2011 Journal of Magnetics Vol.16 No.2

        This study reports an alternative method for measuring the magnetoresistance of unpatterned magnetic tunnel junctions similar to the current-in-plane tunneling (CIPT) method. Instead of using microprobes, a series of point contacts with different spacings are coated on the top surface of the junctions and R-H loops at various spacings are then measured by the usual four-point probe method. The values of magnetoresistance and resistance-area products can be obtained by fitting the measured data to the CIPT theoretical model. The test results of two types of junctions were highly similar to those obtained from standard CIPT tools. The proposed method may help to accelerate the process for evaluating the quality of magnetic tunnel junctions when commercial CIPT tools are not accessible.

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