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거대세포형의 간세포암종을 지닌 의사 : An autopsy case 1 예 보고
이병육,곽정식,이상한,임재원 大韓法醫學會 1996 대한법의학회지 Vol.20 No.1
Giant cell variant of hepatocellular carcinoma is well recognized?. However, it is sufficiently rare to warrant reporting, especially when this malignant tumor invade and metastasize extensively. According to Peters?, about 14% of hepatocellular carcinoma contain giant cells, but one composed mostly of giant cells must designated as giant cell variant. We experienced an autopsy case of giant cell variant of hepatocellular carcinoma composed mostly of pleomorphic malignant giant cells, with diffuse invasion of abdominal organs and metastasis to the mesentery and transverse colon.
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두 장의 방사형 격자에 의해 나타나는 무아레 무늬를 이용한 지구 자기장 모델의 시각화
이재호,육근철 공주대학교 과학교육연구소 2002 과학교육연구 Vol.33 No.-
눈에 보이지 않는 현상에 대한 개념을 형성하는데 도움을 주는 측면에서 주기적 구조물에 의해 만들어지는 무아레 무늬를 교육 자료로 활용하고자 한다. 두 장의 방사형 격자를 이용하여 『전기·자기』 단원에서 자기장과 전기장의 개념형성과 지구자기장의 시각화 및 새로운 모델 제시에 도움을 주고자 한다. 이들 주기적 구조물에 의해 만들어지는 무아레 무늬를 물리교육에 활용하면 물리교과에 대한 흥미를 유발시킬 수 있을 뿐만 아니라 학생 스스로 창의적인 아이디어를 낼 수 있는 기회를 가질 수 있는 측면에서 교수 학습 효과를 높일 수 있는 한 방안이 될 것이다. A major cause for an earth magnetic field is explained by the Dynamo theory in the present day. Dynamo theory is that an earth magnetic fields is caused by the convection current occurs in the out core. That is, original reason of an earth magnetic field is made by dipoles in the earth. The shape of an earth magnetic field is resemblant with shape of a magnetic field occurred around a bar magnet. The shape of an earth magnetic field just likes the shape of a magnetic field occurred around a bar magnet. The new moire fringes formed by superimposed two radial gratings can be displayed equipotential magnetic surface. Therefore, We are going to visualize an earth magnetic field by using moire fringes formed by superimposed two radial gratings. As a results, we obtained the following three results by this study. The first, We developed that moire fringes formed by two radial gratings can be present the scalar magnetic equipotentials in the magnetic field. The second, we found out the similarity between the moire fringes formed by two radial gratings and an earth magnetic field formed by dipoles. The third, we developed educational materials that it can become help to students explain an earth magnetic field using the moire fringes formed by two radial gratings. This materials may contribute greatly to improve the teaching-learning effect. Finally, we emphasized that earth magnetic field must be appeared a circle type neither hyperbolic nor ellipse.
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스포츠 현장에서 사고 분쟁해결을 위한 법적 구조 및 그 효용성 분석
박형상,육조영,김우규,이재봉,유관호,이무연,박태민,이신언 한국스포츠리서치 2005 한국 스포츠 리서치 Vol.16 No.2
1. The purpose of this study is to reflect reality of sports to legal structure. This author classified types of sports related accidents as match accidents, school accidents, leisure and living sports accidents. Out of such accidents common factors such as 'the provider of virtue' and 'user' could be deduced and this author reviewed what kinds of obligations must be shouldered by these people respectively. In particular this author stressed the fact that disproportionate emphasis is placed on malfeasance in disposition of dispute over the sports accidents. Malfeasance is a method for seeking relief through money after the accident. However default in an obligation enables supplementary completion when it is not performed or imperfectly performed. Thus if object which must be performed is providing safety then it is possible to secure safety prior to accident. Furthermore at such time mistake of the debtor can not become a factor. For this reason this line of thinking has the following merits: (1) In comparison with constitution of malfeasance default of an obligation has long prescription. It seems that such fact was a motivation for saving obligation for safety consideration by making it fall under the principle of faith. (2) Default of an obligation is not an obligation for ordinary attention which is cause of malfeasance but it takes up issue with obligation for attention required for performance. Game organization, sponsor and spectators etc. shares certain sense of identity and are demanded to have manners. As method for evaluation of such relationship of faith it may be possible to impose a special kind of obligation for attention and it will be close to constitution of default of an obligation. (3) Imposing obligation for provision clarifies that such responsibility belongs to game organizations promoting sports to which anyone can participates or to national or public organizations, sponsor, schools which induced such sports as a part of its educational programs, installer who made people use it as leisure facility or person in charge for its management. (4) It is also applicable to umpires, players or spectators who use field of sports. It is possible to reflect reality whereby these people specifically relate themselves to sports. In consequence it will be possible to make people feel the necessity of expanding the principals of sports from 'doers' to 'watchers.' (5) The obligation of provision is an obligation under the principle of faith therefore mutual negotiation may be expected to clarify such fact. It may be also evaluated by effectuation of users' self-determining right. 2. If the above mentioned structure is provided then, although it is limited to sports, students who are subjects of instruction, seminar attendants, and furthermore players who finished games may be obligated to bear responsibility for safety consideration under the principle of faith. Accordingly level of relief for considerable number of victims may be increased as cases of treating even borrowed materials as default of obligation being expanded. 3. As scope of responsibility becomes more clearer it will be possible to prevent disputes while securing more safety as rules and regulations become more clearly enacted or new contract is signed or existing contract is revised.
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십이지장 궤양 환자와 만성 위염 환자의 염증 분포의 차이 및 H. pylori 집락도와 염증도의 상관관계
유광하,진춘조,박형석,이재동,김예리,윤성욱,이수인,윤호상 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
An inflammatory difference between the gastric antrum, body and fundus was studied in 39 H.pylroi positive duodenal ulcer and 29 H. pylori chronic gastritis patients. Also we studied correlation of H. pylori colony count and inflammatory severity. Patients with newly diagnosed duodenal ulcer and chronic gastritis were endoscoped and two biopsy secimens each taken from the antrum, body and fundus. Although intestinal metaplasia in antrum and inflammatory activity in fundus were more severe in chronic gastritis patients. another inflammatory difference was equally likely to be found between two groups. There was no definite histological inflammatory difference between duodenal ulcer and chronic gastritis patients. A positive correlation was found between the number of H. pylori and the severity of inflammation.
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Toll-like Receptors and Innate Immunity
Yuk, Jae-Min,Jo, Eun-Kyeong The Korean Society for Microbiology 2011 Journal of Bacteriology and Virology Vol.41 No.4
Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogen- and modified self-derived molecules, TLRs trigger intracellular signaling cascades that involve various adaptor proteins and enzymes, resulting in the generation of proinflammatory and antimicrobial responses through the activation of transcription factors such as nuclear factor-${\kappa}B$. TLR-dependent signaling pathways are tightly regulated during innate immune responses by a variety of negative regulators. This review focuses on the newly described regulation of TLR-dependent signaling pathways, and emphasizes the roles of TLRs in innate immunity. Efforts to modulate these regulatory pathways and signaling molecules may result in the development of new therapeutic strategies through TLR-based therapy.
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Yuk, Sim Bum,Lee, Jae Moon,Namgoong, Jin Woong,Sakong, Chun,Hwang, Tae Gyu,Kim, Se Hun,Lee, Woosung,Kim, Jae Pil Applied Science Publishers 2019 Dyes and pigments Vol.171 No.-
<P><B>Abstract</B></P> <P>Perylene diimides (PDIs) have been used in various industries, especially in devices such as organic light-emitting diodes, organic semiconductors, and thin-layer organic photovoltaics, because of their excellent optical and electrical properties and outstanding thermal stability. In addition, PDIs are suitable for black matrix and black bank materials, which require wide and strong absorption of visible light, for use in display panels. Research has been conducted to apply solution-processed PDI on the black matrix and black bank film fabrication. However, due to the low solubility of PDI, industrially required optical properties have not been achieved. In this study, diphenyl-linked PDI dimers were synthesized and evaluated on their optical properties and thermal stability for solution-processed black matrix. The solubility of the synthesized dimers was improved compared to that of monomers as intermolecular interaction reduced by two PDI cores in a molecule that is rotated at a specific angle. Five kinds of dimeric and monomeric PDIs were synthesized with bay substituents of different electron donating power. The absorption range of the dyes was red-shifted as the electron donating power of the substituents increased, and the fluorescence of the dyes was quenched by intramolecular charge transfer (ICT). In a solution state, dimers showed enhanced absorbance and thermal stability and enlarged absorption range as compared to the monomers. Hybrid-type black matrices using dimeric PDIs and carbon black showed high thermal stability, flat surface condition, and low dielectric constant. Additionally, the optical density of the black matrices, which was not satisfactory in the previous study, was greatly improved (up to 2.755) because of the increased dye content due to highly soluble dimeric PDIs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Highly soluble dimeric perylene dyes were synthesized and used as colorant of black matrix. </LI> <LI> The optical and physical properties of the dimers were measured in comparison with the monomers. </LI> <LI> A higher optical density was obtained than the previous studies due to enhanced solubility of the dyes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Yuk, Jae-Min,Shin, Dong-Min,Song, Kyoung-Sub,Lim, Kyu,Kim, Ki-Hye,Lee, Sang-Hee,Kim, Jin-Man,Lee, Ji-Sook,Paik, Tae-Hyun,Kim, Jun-Sang,Jo, Eun-Kyeong Landes Bioscience 2010 AUTOPHAGY Vol.6 No.1
<P>The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before ionizing radiation (IR) resulted in increased cell death in a caspase-independent manner. Treatment with BCG/CWS plus IR resulted in the induction of autophagy in colon cancer cells. Either the autophagy inhibitor 3-methyladenine or knockdown of beclin 1 or Atg7 significantly reduced tumor cell death induced by BCG/CWS plus IR, whereas the caspase inhibitor z-VAD-fmk failed to do so. BCG/CWS plus IR-mediated autophagy and cell death was mediated predominantly by the generation of reactive oxygen species (ROS). The c-Jun NH(2)-terminal kinase pathway functioned upstream of ROS generation in the induction of autophagy and cell death in HCT116 cells after co-treatment with BCG/CWS and IR. Furthermore, toll-like receptor (TLR) 2, and in part, TLR4, were responsible for BCG/CWS-induced radiosensitization. In vivo studies revealed that BCG/CWS-mediated radiosensitization of HCT116 xenograft growth is accompanied predominantly by autophagy. Our data suggest that BCG/CWS in combination with IR is a promising therapeutic strategy for enhancing radiation therapy in colon cancer cells through the induction of autophagy.</P>
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