구강내 편평상피암에 관한 임상적 연구

정붕희,김재승 단국대학교 치의학연구소 1990 논문집 Vol.2 No.-

A clinical study of selected patients with intraoral squamous cell carcinoma which were managed in the Department of Oral Oncology of Korea Cancer Center Hospital from January 1982 to August 1989 was done. And following results were obtained. 1. Males were involved more than females by intraoral squamous cell carcinoma in a ratio of 4:1, and most of the cases occurred in the 7th and 6th decades (69%). 79% of total patients and 92.5% of males were. 2. The mean duration of symptomatic period was 5.9 months. 3. The common symptoms were swelling (/3%), pain (40%), ulceration (33%), and trismus (23%). 4. In the histologic findings, well differentiation comprised 58.0%. 5. The primary sites were the upper alveolar mucosa (32%), the floor of the mouth (21%), the lower alveolar mucosa (19%), tongue (14%), retromolar trigone (8%), palate (7%) and buccal mucosa (3%). 6. According to TNM system, StageⅠ, Stage Ⅱ, Stage Ⅲ, and Stage Ⅳ comprised 4%, 15%, 32% and 49% respectively. 7. In the management of intraoral squamous cell carcinoma, surgeries were done in the 32 cases, 23 cases of which were managed by radiation therapy or chemotherapy concurrently. And radiation therapy alone was received in 35 cases. 8. Overall 3 and 5-year survival rates without regarding to stage were 27.6% and 21.4%. 9. 3-year survival rate of female patients was 47.2% and that of male patients was 22.6%. 10. 5-year survival rate was 53.9% for "early" cancer (stage Ⅰ and Ⅱ) and 15.6% for "advanced" cancer (stage Ⅲ and Ⅳ). Survival rate of patients in the early stages of cancer appeared to be higher than that of patients with stage Ⅲ and Ⅳ (P<0.005).

주의력결핍/과잉운동 장애 아동의 상대적 뇌 혈류에 미치는 Methylphenidate의 효과 : SPECT 관심 영역법 연구

김붕년,이재성,조수철,이동수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 순수 ADHD 환아 32명을 대상으로 하여 MPND치료 전후에 있어서의 상대적 뇌 혈류량의 변화를 관심영역법을 사용하여 정량적으로 측정하였다. 이를 통해, MPND 치료에 의한 혈류 변화의 양상을ADHD환아에서 관찰하고자 하였고, 이를 통해 약물 작용기건의 일부를 이해하려 하였다. 방법: 약물투여를 받지 않고 있으며, 다른 어떤 신체적, 정시과적인 진단도 받지 않은 32명의 환아군에대해, WISC, LNNB등 심리검사를 실시하였고, 환아군의 문제 행동에관한 정보를 얻기 위해, 환아 부모를 대상으로 해서는, CBCL, DBDS, YCI, CPRS를 실시하였고, 교사를 대상으로 해서는 CTRS를 실시하였다. 이러한 평가과정을 거쳐, 정상기능 범위의 순소 ADHD 아동만을 대상군으로 선정하여 첫번째SPECT를 촬영하였고, 약 6주간의 약물 치료를 MPND로 실시하였으며, 이후 두번째 SPECT 촬영과 각종 척도 평가를 다시 한번 실시하였다. 매 환자마다 치료 전후의 SPECT 영상을 얻은 후, OML 20,40, 60mm 상방 세 단면에 관심영역을 치정하여 정량화된 상대적 혈류량을 구했고, 치료전후의 차이를 서로 비교하였다. 결과: OML 20mm 상방 단면에서는, 유의미한 혈류량 증가가 없었다. OML 상방 40mm의 단면상에서, 피질부에서는 좌우 측부 전두엽에서, 피질하 구조물에서는 좌우측 미상핵과 시상에서 유의한 혈류 증가가 있음이 확인되었다. OML 상방 60mm에서 단면에서는 12개의 관심 영역 모두에서 아무런 차이도 보이지 않았다. 결론: 8세에서 12세까지 ADHD 아동군에서 MPND 치료에의해, 전전두엽과, 시상, 미상핵에서의 혈류량 이 증가됨 확인되었으며, 이러한 혈류량의 변화는 최근 연구에서 증명되고 있는 전전두엽-시상-비상핵-전전두엽 회로 이상의 기능적 회복이라는 치료 기전을 뒷받침해주는 소견으로 생각되었다. 향후 다른 영상도구를 통한 추시가 필요하리라 생각된다. 중심단어:주의력결핍 과잉운동장애·SPECT 관심영역법·MPND 치료 전후의 변화. Objectives: This study was conducted to find out topographic changes of cerebral perfusion between pretreatment and posttreatmet state via region of interest method by Single Photon Emission Computed Tomography(SPECT). Method: By DSM-Ⅳ criteria, we selected 32 patients with pure Attention Deficit Hyper-activity Disorder(ADHD) through various assessment scales, psychometric tools and neuropsy-chological batteries. All the patients with ADHD were studied by TCnm-HMPAO Brain SPECT, before methylphenidate(MPND) treatment and after 6 weeks treatment. Three transaxial brain slices delineating anatomically defined region of interest at approximately 20, 40, 60mm above the orbitomeatal line(OML) were used, with the average number of counts for each region of interest normalized to the area of cerebellar maximal uptake. Results: In the plane 20mm above OML, None of areas showed significant perfusion changes. In the plane 40mm above OML, lefe and right prefrontal areas, caudate and thalamic areas showed increased relative perfusion compared to pretreatment state. In the plane 60mm above OML, there were no increases in all regions of interest. Conclusion: The MPND treament improved cerebral blood flow in some specific brain regions : prefrontal lobe, caudate and thalamic area. We found neuroanatomical action sites of MPND might be the pathophysiologic sites of ADHD which had been proved in previous studies. These findings implied that MPND treatment could correct the underlying pathologic brain dysfunction of ADHD. KEY WORDS:SPECT ROI method·ADHD·Pre and posttreatment by MPND.

大邱市 公園綠地의 利用率및 需要分析에 關한 硏究

嚴鵬勳,崔宰榮 효성여자대학교 새마을연구소 1990 새마을硏究論文集 Vol.10 No.-

서울시 아동을 대상으로 한 주의력결핍과잉행동장애의 선별기준에 대한 연구

양영희,김재원,김예니,조수철,김붕년 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : The purpose of this study is to investigate a cut-off value for screening children with ADHD in community based sample using the Korean Child Behavior Checklist (K-CBCL) and the Korean ADHD Rating Scale (K-ARS). Methods : Children aged 6 to 8 (n=661) participated in this study. The K-CBCL and the K-ARS were used as the screening instruments. Diagnoses were confirmed through the Diagnostic Interview Schedule for Children Version Ⅳ (DISC-Ⅳ). Results : Of the 189 subjects who underwent the DISC-Ⅳ, 26 subjects were diagnosed as ADHD. In the K-CBCL, scores in the attention problems, externalizing problems and total behavioral problems were positively correlated with the total score of the K-ARS. The K-ARS-Parent version (K-ARS-P) and above three scales in the K-CBCL showed significant screening validity in the ROC curve analysis. The reasonable level of sensitivity, specificity, and negative predictive value were obtained in the total scores ≥90^(th) percentile in the K-ARS-Parent and ≥60T scores in the K-CBCL attention problems. The optimal level of specificity, positive predictive value and negative predictive value were obtained when combined the K-CBCL (≥60T scores in the attention problems and ≥63T scores in the total problems) and the total scores ≥90^(th) percentile in the K-ARS-P. Conclusion : The combined use of the K-CBCL and the K-ARS-P may serve as useful screening methods for ADHD children.

한국인 주의력결핍 과잉행동장애 아동에서 도파민 D4 수용체 유전자의 Variable Number of Tandem Repeats (VNTR) 다형성과 Methyphenidate 치료 반응간의 연관성

천근아,김붕년,조수철,김재원,황준원,신민섭,홍강의 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.6

Objectives : In the present study, we investigate the association between homozygosity of the 4-repeat allele (4/4) at the DRD4 and the response to the treatment with MPH in Korean children with ADHD. Methods : The present study included 71 children with ADHD (8.231.78 years) from two children's psychiatric clinics in South Korea. All drug-naive children with ADHD were treated with MPH for about 8 weeks. The subjects who showed improvement of over 50% compared with the baseline ARS score after 8 weeks of treatment were termed as the 'good response' group. The subjects who showed an improvement of less than 50% were considered as the 'poor response' group. After genotyping for DRD4 were performed, we investigated correlation between homozygosity for 4-repeat allele at DRD4 and the response to MPH treatment. Results : We found that while 79.5% (31/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 68.8% (22/32) of the subjects without homozygosity of 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their parents (χ²= 16.762, df= 1, p<0.01). We also found that while 61.5% (24/39) of the subjects with homozygosity of 4-repeat allele at DRD4 showed good response to MPH treatment, 87.5% (28/32) of the subjects without homozygosity of the 4-repeat allele at DRD4 showed poor response to MPH treatment according to ARS scores assessed by their teachers (χ²= 17.698, df= 1, P<0.01). Conclusion : Our findings support an association between the homozygosity of 4-repeat allele and a good response to MPH in ADHD of Koreans.

주의력결핍과잉행동장애와 Alpha-1C-Adrenergic 수용체 유전자와의 연관성에 대한 연구

조수철,김재원,김붕년,황준원,박미라,김순애,조대연,유희정,정운선,손정우,박태원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : Neurobiological and pharmacological research has suggested that the dysregulation of the central noradrenergic systems might be involved in the pathophysiology of ADHD. The aim of this study was to examine the association of the alpha-1C-adrenergic receptor gene (ADRA1C) with ADHD in Korean subjects. Methods : In a case-control study, we assessed 186 DSM-IV ADHD probands and 150 normal controls. One hundred and eight trios were studied in a family-based association analysis. Psychiatric diagnoses were derived through structured diagnostic interviews. For the clinical evaluation of the ADHD subjects, the Child Behavior Checklist (CBCL), the ADHD Rating Scale-IV (ARS) and the Junior Temperament and Character Inventory (JTCI) were administered. A computerized continuous performance test (CPT) was used to measure the inattention and impulsivity of the ADHD children. Results : There were no significant differences in the genotype or allele frequencies of the ADRA1C PstI polymorphism between the ADHD and control group (p>0.05). The transmission disequilibrium test (TDT) analysis observed no evidence for biased transmission of any of the alleles of the PstI polymorphism. There were no significant differences in the CPT or JTCI profiles between those ADHD subjects with the CC genotype and those with the other (CT+TT) genotypes at the PstI polymorphism. Conclusion : The results of this study do not support the ADRA1C as a major genetic susceptibility factor in ADHD.

대학문화 정착방향에 관한 연구(기업문화적 관점에서)

장병집,김재붕 충주대학교 학생생활연구소 2001 學生生活硏究 Vol.8 No.-

종업원들의 멘토관계와 조직유효성에 관한 연구

박종헌,김재붕 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.0201

In recent years, a scholars and a managers in business have taken a more interest on the mentorship in organizations. Mentorship is one of the way to promote mutually beneficial relationship between the individual and the organization and have been recognized as one of the important managerial means to improve the organizational effectiveness such as organizational commitment, job satisfaction, job involvement. A mentor is a trusted and experienced employee who serves as a role model, provides support, direction, and feedback to the young employee on the variety problems in organization, and increase the visibility of the protege to decision-makers in the organization who may influence career opportunities etc. As the mentorship give rise to attention on individual or organizational problems, it may be an effective managerial method to improve organizational commitment, job satisfaction, job involvement etc. The purpose of this study is to examine a theory on mentorship and organizational effectiveness, and the organizational benefits of mentorship.

구강저에 발생한 단독형 신경섬유종

김용각,유현석,곽재근,김규영,정붕희 大韓顎顔面成形再建外科學會 1990 Maxillofacial Plastic Reconstructive Surgery Vol.12 No.3

Benign neural sheath neoplasms are not common in the maxillofacial region. These lesions can occur as solitary tumors, or they can affect many sites in the form of multiple neurofibromatosis. A solitary neurofibroma is seldom undergo sarcomatous transformation, since solitary neurofibroma is relatively radioresistant and its recurrence rate seems to be low, the treatment of choice is surgical excision. This case showed a solitary neurofibroma in the left side of the floor of mouth which occurred in a 33 - year -old female. The tumor was excised. And there is no evidence of disease. She is satisfied in function and esthetic aspect.

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.