miR-124 Inhibits Growth and Invasion of Gastric Cancer by Targeting ROCK1

Hu, Cong-Bing,Li, Qiao-Lin,Hu, Jian-Fei,Zhang, Qiang,Xie, Jian-Ping,Deng, Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

MicroRNAs (miRNAs) act as critical regulators of genes involved in many biological processes. Aberrant alteration of miRNAs have been found in many cancers, including gastric cancer (GC), but the molecular mechanisms are not well understood. Herein, we investigated the role of miR-124 in GC. We found that its expression was significantly reduced in both GC tissue samples and cell lines. Forced expression of miR-124 suppressed GC cell proliferation, migration, and invasion. Furthermore, the Rho-associated protein kinase (ROCK1) was identified as a direct target of miR-124 in GC cells. Finally, silencing of ROCK1 showed similar effects as miR-124 overexpression, while supplementation of ROCK1 remarkably restored the cell growth and invasion inhibited by miR-124. Together, our data demonstrate that miR-124 acts as a tumor suppressor by targeting ROCK1, and posit miR-124 as a novel strategy for GC treatment.

Gender-independent efficacy of mesenchymal stem cell therapy in sex hormone-deficient bone loss via immunosuppression and resident stem cell recovery

Bing-Dong Sui,Ji Chen,Xin-Yi Zhang,Tao He,Pan Zhao,Chen-Xi Zheng,Meng Li,Cheng-Hu Hu,Yan Jin 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Osteoporosis develops with high prevalence in both postmenopausal women and hypogonadal men. Osteoporosis results in significant morbidity, but no cure has been established. Mesenchymal stem cells (MSCs) critically contribute to bone homeostasis and possess potent immunomodulatory/anti-inflammatory capability. Here, we investigated the therapeutic efficacy of using an infusion of MSCs to treat sex hormone-deficient bone loss and its underlying mechanisms. In particular, we compared the impacts of MSC cytotherapy in the two genders with the aim of examining potential gender differences. Using the gonadectomy (GNX) model, we confirmed that the osteoporotic phenotypes were substantially consistent between female and male mice. Importantly, systemic MSC transplantation (MSCT) not only rescued trabecular bone loss in GNX mice but also restored cortical bone mass and bone quality. Unexpectedly, no differences were detected between the genders. Furthermore, MSCT demonstrated an equal efficiency in rectifying the bone remodeling balance in both genders of GNX animals, as proven by the comparable recovery of bone formation and parallel normalization of bone resorption. Mechanistically, using green fluorescent protein (GFP)-based cell-tracing, we demonstrated rapid engraftment but poor inhabitation of donor MSCs in the GNX recipient bone marrow of each gender. Alternatively, MSCT uniformly reduced the CD3+T-cell population and suppressed the serum levels of inflammatory cytokines in reversing female and male GNX osteoporosis, which was attributed to the ability of the MSC to induce T-cell apoptosis. Immunosuppression in the microenvironment eventually led to functional recovery of endogenous MSCs, which resulted in restored osteogenesis and normalized behavior to modulate osteoclastogenesis. Collectively, these data revealed recipient sexually monomorphic responses to MSC therapy in gonadal steroid deficiency-induced osteoporosis via immunosuppression/anti-inflammation and resident stem cell recovery.

The Relationship of Reading Attitudes between L1 and L2 in Middle School Learners

Bing Hu-seung 21세기영어영문학회 2010 21세기영어영문학회 학술대회 Vol.2010 No.09

재만한인의 국적문제에 대한 연구 - 1900년대 초 한,청 양국의 갈등을 중심으로 -

유병호 ( Bing Hu Liu ) 수선사학회 2002 史林 Vol.18 No.-

논문 : 금강산국제관광특구 연구

유병호 ( Bing Hu Liu ) 서울대학교 통일평화연구원 2014 통일과 평화 Vol.6 No.1

2011년 4월 29일에 북 정부는 금강산지역에 “조선금강산국제관광특구”를 설립하고 동시에 현대그룹의 금강산관광 독점권을 취소한다고 선포하였다. “금강산특구”는 아직 출발에 불과하므로 방대한 발전계획을 실현할 수 있을지는 역사의 검증을 거쳐야 한다. 북의 특수한 상황에 맞는 발전방식을 찾는 것은 매우 복잡하고 어려운 과정이다. 사회주의 계획경제체제를 견지하면서도 시장경제를 발전 및 도약시키는 것은 현재 북이 당면한 주요한 문제이다. 시장경제원리를 어떻게 계획경제체제에 접목시키는가 하는 것은 3대 경제특구(라선, 황금평, 금강산)의 앞에 놓인 문제이며, 그 성공 여부에 관계되는 중대한 문제이다. 적어도 이 문제에서 “금강산특구”는 이미 선명하게 첫 발자국을 내딛었다. Kumgang Zone was designated “Mount Kumgang International Tourism Special Zone” and the South Korean Hyundai Group was deprived of its monopoly on tapping Mount Kumgang tourism in an announcement by the North Korean Government on April 29, 2011. Since the “Mount Kumgang Special Zone” is at an incipient stage, the possibility of materializing its ambitious blueprint is subject to the argumentation of history. With its unique national conditions, North Korean is bound to find an appropriate development pattern even though it is an extremely complicated and arduous task. For the current North Korean economy, the crux is to develop and invigorate market-oriented economy while adhering to socialist planned economy. For the three major special economic zones (Rason, Hwanggumpyong, and Kumgang), it is imperative to apply the principle of market-oriented economy to planned economy as this move is closely linked to the success of the three special economic zones. In this respect, the “Mount Kumgang Special Zone”, at least, has taken a clear-cut stand and made the first move forward.

The Relationships of Reading Attitudes between L1 and L2 in Middle School Learners

빙후승 ( Hu Seung Bing ) 21세기영어영문학회 2010 영어영문학21 Vol.23 No.3

The primary aim of the study was to examine the differences in L1 and L2 reading attitudes. It furthermore explored the relationship between the components of reading attitude and students` English proficiency. A total of 199 students from intact reading classes in middle school participated. Collected data using Reading Attitude questionnaire and Students` English proficiency scores were analyzed by descriptive statistics, factor analysis, reliability coefficients, correlations, and t-test. Results identified four factors of reading attitude in both L1 and L2: anxiety, comfort, practical value, and self-perception. The study indicated that the affective domain of reading attitude transfer from L1 to L2 and learners` beliefs and thinking about practical values is more likely to transfer from L1 to L2 than their emotions such as anxiety and comfort. But L2 proficiency does not affect this transfer, in which the linguistic threshold hypothesis would predict if this hypothesis were applied to the affective domain. Though this hypothesis explains the transfer of cognitive domain of reading, these findings provided that cognitive and affective domains of reading relate differently in L1 and L2. The notion of a linguistic threshold does not apply to transfer of reading attitudes from L1 to L2. Furthermore, there are different degrees of transferability among different attitude components. These results are in consistent with the claim concerning transferring of reading attitudes from L1 to L2.

The Blood Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hepatocellular Carcinoma Receiving Sorafenib

Zheng, You-Bing,Zhao, Wei,Liu, Bing,Lu, Li-Gong,He, Xu,Huang, Jian-Wen,Li, Yong,Hu, Bao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Background and Aim: Increasing evidence correlates the presence of systemic inflammation with poor survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced HCC who received sorafenib monotherapy. Methods: A total of sixty-five patients with advanced HCC, not eligible for locoregional therapy, treated with sorafenib were enrolled. Potential prognostic factors such as age, gender, tumoral characteristics, performance status and NLR were analyzed. Results: Median OS and TTP for the entire cohort were 10.0 months (95%CI, 7.6-12.3 months) and 4.5 months (95% CI, 4.0-4.9 months). The mean NLR at baseline was 2.89. The median OS of patients with a high NLR (>4) was 6.5 months (95%CI, 5.2-7.7 months) compared with 12.5 months (95%CI, 9.9-15.0) for patients with a normal NLR (${\leq}4$) (P=0.01). Age ${\leq}65$, NLR>4, extrahepatic metastases and vascular invasion were all predictors of poorer overall survival. Multivariate analysis showed that NLR > 4, vascular invasion and extrahepatic metastases were independent predictors of poorer overall survival. The median TTP of patients with a high NLR was 2.5 months (95%CI, 1.4-3.6 months) compared with 4.5 months (95%CI, 3.9-5.1 months) for patients with a normal NLR (P=0.012). Conclusions: High baseline NLR was associated with worse OS and TTP for patients with advanced HCC treated with sorafenib.

가부장적 리더십이 직무만족에 미치는 영향: 순응형 팔로워십의 매개효과를 중심으로

호일빙(Yi Bing Hu),김현정(Hyun Jeong Kim),이사름(SaReum Lee) 피터드러커 소사이어티 2018 창조와 혁신 Vol.11 No.1

본 연구에서는 가부장적 리더십이 직무만족에 미치는 영향과 이들의 관계에서 순응형 팔로워십의 매개역할에 대한 실증연구를 수행하였다. 중국 강소성에 위치한 중소기업 직원 222명의 직원을 대상으로 실시되었으며, 위계적 다중 회귀분석을 사용하여 가부장적 리더십과 직무만족의 관계에서 순응형 팔로워십의 매개역할을 증명하였다. 중국 중소기업의 가부장적 리더십은 직무만족과 순응형 팔로워십에 정(+)의 영향을 미치는 것으로 나타났고, 순응형 팔로워십 역시 직무만족에 정 (+)의 영향을 미치는 것으로 나타났다. 순응형 팔로워십은 가부장적 리더십과 직무 만족 간에 부분매개효과가 있는 것으로 나타났다. 본 연구는 가부장적 리더십이 순응형 팔로워십을 매개로 직무만족에 영향을 주는 연구모델을 제시하였다는 이론적 시사점이 있다. 또한 조직 내 가부장적 리더와 순응적 팔로워의 역학관계를 통하여 기존의 전통적 리더십을 대체하거나 보완할 수 있는 리더십으로 가부장적 리더십을 제안하고자 한다. This article indicates how paternalistic leadership effects on job satisfaction. Using a sample of 222 employees employed by a Small and Medium-sized Enterprises (SMEs) in Jiangsu Province, China, we examined whether conformist followership mediated the effects of paternalistic leadership on job satisfaction. Results from hierarchical multiple regression analyses showed that paternalistic leadership was positively related to job satisfaction and conformist followership. The relation between paternalistic leadership and job satisfaction was mediated by conformist followership. Implications for research and practice of our findings are discussed.

METRIC THEOREM AND HAUSDORFF DIMENSION ON RECURRENCE RATE OF LAURENT SERIES

Hu, Xue-Hai,Li, Bing,Xu, Jian Korean Mathematical Society 2014 대한수학회보 Vol.51 No.1

We show that the recurrence rates of Laurent series about continued fractions almost surely coincide with their pointwise dimensions of the Haar measure. Moreover, let $E_{{\alpha},{\beta}}$ be the set of points with lower and upper recurrence rates ${\alpha},{\beta}$, ($0{\leq}{\alpha}{\leq}{\beta}{\leq}{\infty}$), we prove that all the sets $E_{{\alpha},{\beta}}$, are of full Hausdorff dimension. Then the recurrence sets $E_{{\alpha},{\beta}}$ have constant multifractal spectra.

Stiffness modeling of a family of 6-DoF parallel mechanisms with three limbs based on screw theory

Bing Liang,Hongjian Yu,Zongquan Deng,Xiaojun Yang,Hong Hu 대한기계학회 2010 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.24 No.1

The stiffness modeling of a family of six degrees of freedom (DoF) parallel mechanisms with configurations of 3-RUPU is presented. The mobility of the mechanisms is firstly analyzed, and then the stiffness analysis and modeling of the family of mechanisms is developed by a novel screw-theory based method. The method employs screw theory as a tool for force analysis and deformation analysis. Based on the developed stiffness model, two global flexibility indices, which refer to the maximum and minimum singular values of compliance matrix, are introduced to evaluate the compliance of parallel mechanisms. Finally, a case study is presented to demonstrate the effectiveness of the method in analyzing and evaluating the stiffness behavior of the presented parallel mechanisms.