漢方治療用 藥材의 地域特産性 調査硏究 : 生産 및 消費構造를 中心으로

辛民敎,柳聖圭,柳熙英 圓光大學校 1980 論文集 Vol.14 No.2

According to my research on the subject the followings are the conclusions: (Ⅰ)We should study regional characteristics of productions. (Ⅱ)We need the investigation and analysis of the soil and herb's qualities. (Ⅲ)And also we should study the comparative research on the subject of fertilization and herb's qualities. (Ⅳ)The fact that time of partial harvest of each herbs is how effective on qualities should be investigated. (Ⅴ)The improvements of herb's storage and market system form should be considered seriously. (Ⅵ)For the purposes of the analysis of essential efficacies and economic circumstances about oriental medical herbs, I would like summarize as follows as my conclusions. 1. I proposed, already, introduced synthetically established larger planting areas according to the studies of environmental biology and its medical plnats and economics, constituting 91 kinds including Ostericum Koreana. 2. According to the conclusion that 87 kinds of Korean products and 157 foreign products under comparative researches, I found out that producing of other many medical herbs could be productive in Korean wasted lands considering those herbs can grow even on the sandy lands in foreign countries which are successful in prod-ucing fruitful plants. 3. It is well-known fact that the efficacies of every medical herbs are depend upon temperature, water permeabilty, basic fertilization and after-fertilization. Skin groups should be collected at June or July, medical groups full-bloom or little bit later, flower groups full-bloom or after that, all herbal medicine full-bloom time, the roots in March or September, the fruits or seeds in September or October. 4. All medical herb products should be controlled under the sponsor of Monopoly Bureau just as ginseng. 5. According to the reports of WHO it is learned that oriental medicines have impricated and natural meanings, and after the early 1970 the exports of Korean medical herbs to foreign countries showed very encouraging. 6. At any rate, above mentioned facts must be handled at the government(ROK) level.

소 질병의 혈액화학적 연구

김덕환,이교영,이경갑,최희인,오사메 사토시,이찌조 시게루 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-

In prder to clarify the changes of serum chemical values(AST, CPK and LDH activities)and LDH isoenzyme fractions in frequent occuring some diseases of dairy cows, total 48 cows(40 patients: 18 with downer cow syndrome, 17 with abomasal displacement and 5 with acute mastitis and 8 controls: clinically healthy cows) were examined. The results obtained were as follows: 1. In changes of total serum enzyme activities of patients group, increase of serum AST(P<0.001), CPK(P<0.01) and LDH activities(P<0.01)were observed in groups of downer cow syndrome and abomasal displacement, respectively by comparison with control group. Increase of AST only was found in group of acute mastitis(P<0.05). 2. In LDH isoenzyme fractions, increase of LDH₁(P<0.01), LDH₂(P<0.05), LDH₃(P<0.01), LDH₄(P<0.01) and LDH_5(P<0.01)fractiona was observed in group of downer cow syndrome and also marker increase of LDH4 and LDH5 fractions was noted in this group. The increase of LDH₁, LDH₂ amd LDH₃ (P<0.01)fractions was found in group of abomasal displacement, but group of acute mastitis showed similar result to that of control group.

그레이브스 병 치료 후 재발 위험 인자에 관한 연구

이영창,유명희,윤석기,변동원,서교일,김극배 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.2

연구 배경 : 그레이브스 병에 대한 항갑상선제 치료후 적절한 치료 여부 평가 및 재발 위험성을 예측하기 위하여 여러 가지 예후 판정 인자들이 연구되어 왔으며, 이러한 인자들 중 TRH(thyrotropin-releasing hormone) 자극 시험이 가장 믿을 만한 검사중에 하나로 알려져 있다. 그러나 TRH 자극 검사가 정상으로 나와도 재발하는 경우가 많으며, 현재로는 이러한 경우에 재발을 예측하는 예후 인자에 대한 연구는 전무한 실정이다. 금번 연구에서는 TRH 자극 시험 후 TSH(thyroid stimulating hormone)가 정상적인 반응을 보인 환자를 대상으로 재발 및 관해여부를 예측할 수 있는 인자들을 찾고자 하였다. 대상 및 방법 : 항갑상선제제 치료 종료후 TRH 자극 시험을 시행하였던 그레이브스 병 환자 총 84명 중, 정상적인 TSH 반응을 보이면서 1년 이상 추적 관찰이 가능하였던 32명의 환자를 대상으로 하였다. 처음 진단 시와 치료 종료 시에 T3(triiodothyronine), T4(thyroxine), T3/T4 비, TSH, TRAb, Anti-TPO Ab(anti-thyroperoxidase antibody)를 측정하였으며, 치료 종료 2개월후에는 TRH 자극 검사를 하여 TSH 증가폭(△TSH) 및 유리 T_(3) 증가폭(△FT_(3))을 구하였다. 모든 측정치는 평균±표준편차로 표시하였으며, SPSS software를 이용하여 Student's paired t-test, chi-square test, Wilcoxon signed ranks test를 시행하였고, 유의 수준 0.05 이하를 통계적으로 유의하다고 판단하였다. 결과 1) 총 32명의 환자 중 재발한 환자(Group Ⅰ)는 22명(69%) 이었으며, 재발한 환자(Group Ⅱ)는 10명(31%) 이었다. 2) 진단 초기 총T3 치는 Ⅰ 군에서 342.0±126.2ng/dl, Ⅱ 군에서 493.0 ±142.2 ng/dl로 Ⅱ군에 비해 유의하게 증가되었다(p<0.05). 3) Anti-TPO Ab는 Ⅰ군에서 2.9±4.4, Ⅱ군에서 22.3±22.3 U/mL로 나타나 Ⅱ군에서 유의하게 증가되었다.(p<0.05) 4) 양군에서 치료 종료후 재발시 대부분의 환자가 1년 이내에 재발하였다. 5) TRH 자극· 검사후 유리 T3 증가폭 및 TSH 증가폭은 양군간에 차이가 업ㅅ었다(1.5±0.9 vs 1.2±1.0 pmol/L, 12.54±7.56 vs 11.23±4.21 mU/L, p>0.05) 결론 : TRH 자극 검사후 정상적인 TSH 반응을 보인 환자에서 재발 및 관해여부를 치료 초기 T3 및 치료 종료시 Anti-TPO Ab로 예측할 수 있었으며, 이들 측정치가 증가해 있을수록 재발의 가능성이 많음을 알 수 있었다. 또한 투약 중단후 초기 12개원의 추적기간 동안 관해가 유지되면 그 이후엔 재발의 가능성이 현저히 줄어 들었으며, 이 후 좀더 많은 환자들을 대상으로 하는 장기적인 추적연구가 진행 되어야 할 것으로 사료된다. Background : Many studies were undertaken to find parameters that could predict the clinical course of patients with Graves' disease after withdrawal of antithyroid drugs. In many parameters, TRH (thyrotropin-releasing hormone) stimulation test and T3 suppression test were considered to be one of the most reliable for predicting remission. But recently, some studies showed that the measurement of free T3 and FT3 are to be a more accurate than other thyroid function test. In this study, we measured T_(3), T_(4), T_(3)/T_(4), TSH (thyroid stimulating hormone), TRAb (TSH receptor antibody), FT3 and other known useful parameters to compare the factors influencing the relapse of Graves disease after antithyroid medication. Patients and methods : Among the 84 Graves' disease patients who had done the TRH stimulation test after withdrawal of antithyroid medication, we examined 32 patients who showed normal TSH response and followed up more than one year. T_(3), T_(4), T_(3)/T_(4), TSH and TRAb levels were measured at the time of diagnosis and at the end of therapy. Serum TSH and FT_(3) levels were measured after TRH stimulation, after two months of withdrawal of medication. Statistical evaluation was Performed by SPSS software in combination with Student's Paired t-test, chi-square test, Wlicoxon signed-ranks test. p-value less than 0.05 was considered to be significant. Results 1. In the 32 patients with Graves disease, 10 patients(31%) relapsed(Group Ⅰ) and 22 Patients(69%) remained in remission(Group Ⅱ). 2. Initial serum T3 level was significantly higher in group Ⅰ than group Ⅱ(342.0 ±126.2 vs. 493.0±142.2 ng/dl, p<0.05). 3. Anti-TPO Ab level was significantly higher in group Ⅰ than group Ⅱ(22.3±22.3 vs 2.9±4.4 U/mL, p<0.05). 4. In group Ⅰ and Ⅱ most patients showed relapse within 1 year after antithyroid medication. 5. After TRH stimulation test, serum FT_(3), and TSH level were not significantly different between group I and Ⅱ(p>0.05). 6. Serum T_(4), T_(3)/T_(4), TSH, TRAb levels were not significantly different from group Ⅰ and Ⅱ. Conclusion : In this study, we found increased relapse rate in the patients with Graves' disease whose initial serum T3 and anti-TPO Ab levels were high, so these parameters could be used to predict the relapse of Graves' disease. In the case of more than 12 months remission period after withdrawal of antithyroid medication, no relapse wsa observed in this study, but study should be done in the large population of patients with Graves' disease.

정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

양성 갑상선 결절에서 티록신 억제 요법의 효과

윤석기,김철희,김영선,변동원,서교일,유명희 대한내분비학회 2000 Endocrinology and metabolism Vol.15 No.4·5

갑상선 종양에서 thrombin receptor (PAR-1)의 발현 양상

박지영,목지오,김여주,박형규,김철희,변동원,서교일,유명희,조현득,오미혜,김상진 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

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항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

Effect of P-Glycoprotein and DNA Contents in Acute Leukemic Cells on Morphological Remission Rate

Kwon, Hi Jeong,Han, Kyung Ja,Lee, Kyo Young,Kang, Chang Suk,Kim, Won Il,Shim, Sang In CATHOLIC MEDICAL CENTER 1992 Bulletin of the Clinical Research Institute Vol.20 No.1

The effect on prognosis of overexpression of P-glycoprotein and cellular DNA contents in leukemic blasts are still controversial. Using flow cytometry we investigated P-glycoprotein and DNA content in leukemic blasts and the effect on the morphological remission rate of acute leukemia. The results were as follows; 1. Twelve out of all 58 cases (20.7%) revealed P-g1ycoprotein expression. Morphological remission rate was lower in cases with P-glycoprotein expression (2/12; 16.7%) than in cases without P-glycoprotein expression (24/45; 53.3%). 2. DNA content was analyzed in the same cases, and 7 cases (12.1%) revealed aneuploidy. The cases with aneuploidy (0/6; 0%) showed lower morphological remission rate than cases with diploidy (26/51; 51.0%). 3. P-glycoprotein expression was not related to BNA ploidy pattern, and was not related to S-phase fraction. From the above results, we consider P-glycoprotein expression and cellular DNA content as separate prognostic factors and recommend analysis of P-glycoprotein expression and DNA content previous to leukemia chemotherapy.

광주·전남의 구급대 활동분석 및 발전방안

박희진,오용교 한국응급구조학회 1997 한국응급구조학회지 Vol.1 No.1

This study is to suggest some developmental policies by analyzing the activities of first aid party in Kwanagju and Chonnam regions for two years from Jan. 1, 1994 to the end of December. 1995. First, the residents in Kwangju and Chonnam regions have the sufficient benefits of emergency medical center, but it will be desirable that general hospital should be established and managed in Kohung peninsula which forms the wide island area far away from big cities. Second, the classification of the degree of severe case in the field by rescue members should be strengthened as the means which can reduce the number of patients transferred to the emergency room and the legal method which rescue members can select the medical agency. Third, children less than 10 are most frequent emergent patients and it is due to parent's indifference and children's insensibility to safety. So the safety education in the course of infant and elementary education should be strengthened and the method which can keep the self safety through the legal system. Fourth, to increase the rate of emergency measure by rescue members, the reasons of fail of emergency treatment are suggested, the treatment results of each rescue member are analyzed every year and it is desirable that the system which can evaluate the personal ability should be introduced. Fifth, the medical accidents occurred in the case of medical act by rescue members must take the legal responsibility, but such a problem can be solved with the compensation of insurance system by government. Sixth, to reduce the time required for transfer, traveling service system for the fixed period in beach should be complemented and extended more and service system at ordinary times should be examined at mountains, the area of traffic jams and large special industrial park. Seventh, since service system with one team of two members of 119 rescue party in expressway cannot be mobilized when multiple accidents occur at the same time, it is considered that service system of two teams of four members should be extended. Eighth, first-aid service in expressway is conducted with rescue and emergency treatment by the rescue party at the same time, but the professional rescue lacks and it may result in the injury of patients. Therefore the creation of rescue party in expressway is the urgent problem.

Charge Migration Analysis of 3D SONOS NAND Flash Memory Using Test Pattern

Jun-Kyo Jeong,Jae-Young Sung,Hee-Hoon Yang,Hi-Deok Lee,Ga-Won Lee 대한전자공학회 2020 Journal of semiconductor technology and science Vol.20 No.2

In this study, new test patterns to evaluate the charge migration in 3D SONOS NAND flash memory are suggested. The charge migration in Si3N4, the charge trapping layer of SONOS is an important factor affecting the performance of the memory. To analyze the charge migration based on the proposed test pattern, the device was fabricated with a capacitor structure, and the charge loss and retention properties were measured by capacitance-voltage analysis. The charge loss due to lateral migration and vertical migration can be separately calculated using the test pattern. In addition, the activation energy was extracted to identify the cause of charge migration. This study is expected to contribute to the reliability problem of charge migration of 3D NADN Flash memory.