AI 기술을 적용하여 동물 입양을 위한 새로운 서비스 디자인 생성

Guo,Haoyue,Zhang Muxin,Chen Xie,Li Yueyi,Liang Lan,Pan Young Hwan 한국서비스디자인학회 2020 한국서비스디자인학회 학술대회자료집 Vol.2020 No.-

Reduction of fatty acid flux at low temperature led to enhancement of β-carotene biosynthesis in recombinant Saccharomyces cerevisiae

Liang Sun,Fei Shang,Chang-Qing Duan,Guo-liang Yan 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.7

Transferring the recombinant S. cerevisiae T73-63 from 30 oC to 4 oC resulted in 41.4% increment of β-carotene concentration (3.96mg/g dry cell weight) relative to that of 30 oC, which was accompanied with the accumulation of fatty acid and ergosterol. The comparisons of the transcriptional levels of mevalonate pathway genes indicated that the expressions of HMG1, ERG9, ERG19, ERG20 and IDI1 at 4 oC were all higher than those of 30 oC, respectively. This suggested that increased transcriptions of mevalonate pathway genes contribute to the improvement of β-carotene production at low temperature. We also found that supplementation of 30mg/L triclosan, an inhibitor of fatty acid synthesis, led to further 28.3% enhancement of β-carotene concentration (4.94mg/g DCW), which was 18.8% higher than that of 30 oC with the same concentration of triclosan. The higher expressional levels of HMG, ERG19 and ERG20 and the simultaneous increment of ergosterol content (17.8%) suggested that more carbon source was transferred from fatty acid synthesis to mevalonate pathway under the circumstance of appropriately blocking fatty acid synthesis at low temperature (4 oC), which resulted in a higher increment of β-carotene production compared to that of 30 oC. The results of this study collectively suggest that the combination of reducing temperature and adding fatty acid synthesis inhibitors is a potential approach to improve the production of desirable isoprenoid compounds such as carotenoids.

Comparison of Concurrent Chemoradiotherapy Followed by Adjuvant Chemotherapy Versus Concurrent Chemoradiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma: a Meta-analysis of 793 Patients from 5 Randomized Controlled Trials

Liang, Zhong-Guo,Zhu, Xiao-Dong,Zhou, Zhi-Rui,Qu, Song,Du, You-Qin,Jiang, Yan-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Purpose: The main objective of the present study was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy followed by adjuvant chemotherapy compared with concurrent chemoradiotherapy alone in the treatment of locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. Randomized controlled trials (RCTs) that compared concurrent chemoradiotherapy followed by adjuvant chemotherapy with concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma were included. Meta-analysis was performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Five studies were included. Risk ratios of 1.02 (95%CI 0.89-1.15), 0.93 (95%CI 0.72-1.21), 1.07 (95%CI 0.87-1.32), 0.95 (95%CI 0.80-1.13) were observed for 3 years overall survival, 5 years failure-free survival, 5 years locoregional failure-free survival and 5 years distant metastasis failure-free survival. There were no treatment-related deaths in both groups of five studies. Hematologic and gastrointestinal toxicity were the most significant for patients during adjuvant chemotherapy. The level of evidence was low. Conclusion: Compared with concurrent chemoradiotherapy alone, concurrent chemotherapy followed by adjuvant chemotherapy did not improve prognosis. More toxicity was found during adjuvant chemotherapy.

A new model and testing verification for evaluating the carbon efficiency of server

Liang Guo,Yue Wang,Yixing Zhang,Caihong Zhou,Kexin Xu,Shaopeng Wang 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.10

To cope with the risks of climate change and promote the realization of carbon peaking and carbon neutrality, this paper first comprehensively considers the policy background, technical trends and carbon reduction paths of energy conservation and emission reduction in data center server industry. Second, we propose a computing power carbon efficiency of data center server, and constructs the carbon emission per performance of server (CEPS) model. According to the model, this paper selects the mainstream data center servers for testing. The result shows that with the improvement of server performance, the total carbon emissions are rising. However, the speed of performance improvement is faster than that of carbon emission, hence the relative carbon emission per unit computing power shows a continuous decreasing trend. Moreover, there are some differences between different products, and it is calculated that the carbon emission per unit performance is 20-60KG when the service life of the server is five years.

The Apparent Digestibility of Corn By-products for Growing-finishing Pigs In vivo and In vitro

Guo, Liang,Piao, Xiangshu,Li, Defa,Li, Songyu Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.3

Two trials in vivo and in vitro were conducted, in vivo to determine the apparent digestibility of gross energy, crude protein, dry matter, acid detergent fiber, neutral detergent fiber and apparent digestible energy in 10 corn by-products. In vivo the diets included one basal corn diet, four corn gluten meal diets, four corn distillers dried grains with solubles diets and two corn distillers dried grains diets using the different methods, 12 crossbred barrows weigh $40{\pm}$1.6 kg were allocated into individual metabolic crate, according to a $6{\times}6$ Latin square design. In vitro using flask technique, filter bag technique and dialysis tubing technique, the digestibilities of gross energy, crude protein and dry matter in corn gluten meal and corn distillers dried grains with solubles were investigated. Pepsin, pancreatin, intestinal fluid, rumen fluid and cellulase were used in incubation. The results showed that correlation coefficient was 0.73 in corn distillers dried grains with solubles between the digestibility of crude protein and acid detergent fiber in vivo (p<0.01); and correlation coefficient was 0.68 in corn distillers dried grains with solubles between the digestibility of gross energy and neutral detergent fiber in vivo (p<0.01). Apparent digestible energy (DE) of corn by-products in pig total tract was predicted by the percentage of crude protein (CP) and the content of gross energy (GE) in feedstuff. The equation: DE=5,601.09+26.69$\times$CP %-0.5904$\times$GE, ($R^2=0.72$). In vitro, filter bag technique was more convenient; furthermore, the digestibility for the treatments (pepsin+pancreatin+rumen fluid and pepsin+pancreatin+cellulase) was better.

Estimation of Sensible Heat Flux using Thermal Infrared Data in the Arid Area

Guo,Xue-Liang,Chung,Yong-Seung 한국교원대학교 환경과학연구소 2000 환경연구논문집 Vol.- No.5

중국 서부의 사막과 오아시스 지역에서 eddy 상관 방법을 이용 현열 flux (H)와 지면의 열적외선 온도 (??) 관측을 수행하여 H와 ??-??(??2m 높이의 기온)의 관계를 정량화 하였다. 연구결과에 의하면, 오아시스와 사막지역의 불안정한 대기조건에서는 ??-??차이로부터 H를 계산 할 수 있는 간단한 관계가 이용될 수 있다. 풍속이 강할 때는 H와 ??-??관계가 풍속에 큰 영향을 받는다. 이에 관련된 풍속의 효과는 열적외선 자료를 이용하여 현열 flux의 정확한 산출에 활용될 수 있음이 제안되었다. The relationship between H and (??-??) (?? being the air temperature at 2 m) was established in this study from the measurements of eddy fluxes of sensible heat (H), and surface thermal infrared temperature (??) both in desert and oasis area of western China. Results show that under unstable condition a simple relationship can be used to estimate H from the difference(??-??) overoasis area and desert region. The relationship between H and(??-??) was greatly influenced when wind speed was high. The effect of wind speed on this relationship was suggested to consider in accurate estimation of sensible heat flux using thermal infrared data.

Raindrop Category Numerical Modeling on Microphysical Process of Precipitation Formation of Stratiform Cloud in Northern China

Guo,Xue-Liang,Huang,Mei-Yuan,Chung,Yong-Seung,Zhou,Ling 한국교원대학교 환경과학연구소 2000 환경연구논문집 Vol.- No.5

중국 북부지방의 관측자료와 강우 category model을 이용하여 강수 발생의 미세과정과 전형적인 층운 3가지 종류가 형성될 때의 빙정 역할이 분석되었다. 종류 Ⅰ는 강한 전선면의 광범위한 상승에 따른 층운의 형성으로서 강우의 발생은 주로 수증기의 침전과 상층 구름 속 빙정위의 riming과정에 좌우된다. 이때 빙정은 높은 구름에 매우 큰 농도로 존재하여 강수의 형성에 중요한 역할을 하며 이 구름 종류의 seeder-feeder 과정으로 고려된다. 종류 Ⅱ는 저기압 규모의 수렴에 의해 형성되는 층운으로서 riming에 의해 성장되는 빙정과정에 따라 발생되는 강수이다. 종류 Ⅲ은 약한 전선면상에 발생되는 광범위한 상승 기류에 동반되어 낮은 구름층에서 형성된다. 구름 방울들의 충돌과 구름 방울 및 빗방울 사이의 충돌은 이런 강우 형성의 중요 과정임이 밝혀졌다. Based on the observations in northern China, the microphysical process of precipitation formation and the role of ice crystal playing in this process for three kinds of typical stratiform clouds are analyzed using rain category model. Results show that for type one, namely stratiform cloud system formed by widespread lifting of a strong frontal surface, the original formation of rainfall depends mainly on vapor deposition and riming process on ice particles from aloft. Ice crystal has a high number concentration in high level of cloud due to the lower temperature and plays a very important role in the formation of precipitation and shows clearly the "seeder-feeder" process in this kind of cloud; For type two, namely stratiform cloud system produced by cyclonic scale convergence which provides liquid water, the primary precipitation is due to the process of ice crystal growing by riming; Type three is the shallow layer cloud system associated with widespread lifting of a weak frontal surface system.

Tri-Axial Confining Numerical Test and Settlement Analysis of the Gravel Layer

Liang Zhang,Zhengwei Guo,Zheng Liang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.9

The discrete element method (DEM) is used according to the discreteness of the gravel layer to analysis the gravel particle. This paper presents simulations of tri-axial experiment tests and settlement of gravel layer. The stress-strain curves of gravel layer were analysed with different confining pressure through tri-axial numerical test, and the effect with different particle parameters and confining pressures was analysed. The numerical model of gravel layer after the excavation was established by the DEM to statistically analyse the settlement of gravel layer. The analyses results show that confining pressure corresponds to axial pressure that be destroyed of gravel particle model. The static friction coefficient has little effect on the failure of the tri-axial confining experimental model. The experiment model with various particle sizes need higher axial stress that be destroyed than the same particle size. During the collapse of the gravel stratum, the gravels are closer to the top of the hole which have a larger shift of settlement and a faster sedimentation rate. If the gravel are further away from top of the hole which have a smaller shift of settlement and slower sedimentation rate. The settlement of gravel causes the forces variation in all directions.

Induction Chemotherapy Followed by Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy with or without Adjuvant Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: Meta-analysis of 1,096 Patients from 11 Randomized Controlled

Liang, Zhong-Guo,Zhu, Xiao-Dong,Tan, Ai-Hua,Jiang, Yan-Ming,Qu, Song,Su, Fang,Xu, Guo-Zeng Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

Purpose: To evaluate the efficacy and toxicity of induction chemotherapy followed by concurrent chemoradiotherapy (the treatment group) versus concurrent chemoradiotherapy with or without adjuvant chemotherapy (the control group) for locoregionally advanced nasopharyngeal carcinoma. Methods: The search strategy included Pubmed, Embase, the Cochrane Library, China National Knowledge Internet Web, Chinese Biomedical Database and Wanfang Database. We also searched reference lists of articles and the volumes of abstracts of scientific meetings. All randomized controlled trials were included for a meta-analysis performed with RevMan 5.1.0. The Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to rate the level of evidence. Results: Eleven studies were included. Risk ratios of 0.99 (95%CI 0.72-1.36), 0.37 (95%CI 0.20-0.69), 1.08 (95%CI 0.84-1.38), 0.98 (95%CI 0.75-1.27) were observed for 3 years overall survival, 3 years progression-free survival, 2 years loco-regional failure-free survival and 2 years distant metastasis failure-free survival. There were no treatment-related deaths in either group in the 11 studies. Risk ratios of 1.90 (95%CI 1.24-2.92), 2.67 (95%CI 0.64-11.1), 1.04 (95%CI 0.79-1.37), 0.98 (95%CI 0.27-3.52) were found for grade 3-4 leukopenia, grade 3-4 thrombocytopenia, grade 3-4 mucous membrane, and grade 3-4 hepatic hematologic and gastrointestinal toxicity, the most significant toxicities for patients. Conclusion: Compared with the control group, induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated but could not significantly improve prognosis in terms of overall survival, loco-regional failure-free survival or distant metastasis failure-free survival.

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis

Liang Li,Zhang Fengmei,Feng Naibo,Kuang Biao,Fan Mengtian,Chen Cheng,Pan Yiming,Zhou Pengfei,Geng Nana,Li Xingyue,Xian Menglin,Deng Lin,Li Xiaoli,Kuang Liang,Luo Fengtao,Tan Qiaoyan,Xie Yangli,Guo Fen 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Osteoarthritis (OA) is a full-joint, multifactorial, degenerative and inflammatory disease that seriously affects the quality of life of patients due to its disabling and pain-causing properties. ER stress has been reported to be closely related to the progression of OA. The inositol-requiring enzyme 1α/X-box-binding protein-1 spliced (IRE1α/XBP1s) pathway, which is highly expressed in the chondrocytes of OA patients, promotes the degradation and refolding of abnormal proteins during ER stress and maintains the stability of the ER environment of chondrocytes, but its function and the underlying mechanisms of how it contributes to the progression of OA remain unclear. This study investigates the role of IRE1α/ERN1 in OA. Specific deficiency of ERN1 in chondrocytes spontaneously resulted in OA-like cartilage destruction and accelerated OA progression in a surgically induced arthritis model. Local delivery of AdERN1 relieved degradation of the cartilage matrix and prevented OA development in an ACLT-mediated model. Mechanistically, progranulin (PGRN), an intracellular chaperone, binds to IRE1α, promoting its phosphorylation and splicing of XBP1u to generate XBP1s. XBP1s protects articular cartilage through TNF-α/ERK1/2 signaling and further maintains collagen homeostasis by regulating type II collagen expression. The chondroprotective effect of IRE1α/ERN1 is dependent on PGRN and XBP1s splicing. ERN1 deficiency accelerated cartilage degeneration in OA by reducing PGRN expression and XBP1s splicing, subsequently decreasing collagen II expression and triggering collagen structural abnormalities and an imbalance in collagen homeostasis. This study provides new insights into OA pathogenesis and the UPR and suggests that IRE1α/ERN1 may serve as a potential target for the treatment of joint degenerative diseases, including OA.