http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
자발적 또는 강제적 운동이 알츠하이머병 유발 쥐의 인지기능에 미치는 영향
최근훈(Choi, Geun-Hoon),장래근(Jang, Lae-Geun),송영주(Song, Young-Ju),정유진(Jung, Eu-Jin),박현(Park, Hyon) 한국체육과학회 2019 한국체육과학회지 Vol.28 No.3
Comparison of the level of bio-molecular components related with the working of GABA from reactive astrocytes through different types of exercise was performed. For the exercise of STZ induced AD rats activity wheel was used for voluntary exercise and treadmill was used for forced exercise for 6 weeks. To equalize the amount of exercise, the voluntary exercise was performed ahead, and then the forced exercise was given. For the analysis, hippocampus, astrocytes around hippocampus, and blood were used. Cognitive function was evaluated with the radial-arm maze and step-down avoidance apparatus. Exercise groups showed a significant improving compared to non-exercise group(p<.05). GFAP expression was significantly decreased in exercise groups, and the lowest value showed in the voluntary exercise group(p<.001). In GABA, analogous pattern to GFAP was observed. Corticosterone level, forced exercise showed an increase (p<.05), while voluntary exercise showed a decrease compared to non-exercise STZ group(p<.01). The expression of SIRT1 protein showed no significant difference between non-exercise groups, however voluntary exercise group showed a significant increase compared to non-exercise group and to forced exercise group(p<.001). With these results, we were able to assume that exercise can reduce the conversion of astrocytes to reactive form and can drop the GABA concentration with an increase of SIRT1 protein in the brain. It may be interpreted as that any kind of exercise could be beneficial to AD. However, a meaningful difference exist between the forced and the voluntary type of exercise on their effects on GABA and stress in AD subjects. Results made us to assure that properly programmed exercise should be developed in consideration of the specific disease as well as AD. We also can suggest that well-designed human studies on memory impairment in AD with specifically designed exercise programs reflect characteristics of exercise as forced or voluntary type are needed to clarify this matter.
Phylogenic Relationships of Rubus Species Revealed by Randomly Amplified Polymorphic DNA Markers
Eu, Gee-Suck,Chung, Byung-Yeoup,Bandopadhyay, Rajib,Yoo, Nam-Hee,Choi, Dong-Geun,Yun, Song-Joong The Korean Society of Crop Science 2008 Journal of crop science and biotechnology Vol.11 No.1
Korean cultivated bramble, which is known as Bokbunja-ddal-gi is regarded to be originated from Korea native Rubus coreanus. However, little scientific evidence and significant morphological differences between Korean cultivated bramble(KCB) and R. coreanus throw doubt on the ancestry of KCB. This study was carried out to obtain phylogenetic information on KCB by comparing its nuclear genomic background with those of R. coreanus, black(R. occidentalis) and red(R. idaeus) raspberry, blackberry(R. lanciniatus) and R. crataegifolius. A total of 99 random amplified polymorphic DNA(RAPD) markers were generated and used for phylogenetic analysis of 76 Rubus accessions. Accessions of each species were grouped into each distinct subclade by the RAPD markers at a similarity coefficient of about 0.59. The KCB subclade formed a clade with R. occidentalis and R. crataegifolius subclades at a similarity coefficient of 0.47. The R. coreanus subclade formed a clade with R. idaeus, R. lanciniatus and R. crataegifolius subclades at a similar similarity coefficient. Only one KCB accession from Hoengsung was included in R. coreanus subclade. The accession shows leaf and flower characteristics different from the rest of the KCB accessions. The phylogenetic relationship inferred from the RAPD markers suggests that the nuclear genomic background of KCB accessions which show morphological similarity to black raspberry is more closely related to black raspberry than to R. coreanus. This brings about the need for close scientific evaluations on the ancestry of KCB at both morphological and molecular levels.
DNA methylation and not allelic variation regulates STAT6 expression in human T cells
Kim, Eu-Gene,Shin, Hyun-Jin,Lee, Chang Geun,Park, Hye-Young,Kim, Yoon-Keun,Park, Heung-Woo,Cho, Sang-Heon,Min, Kyung-Up,Cho, Mi-La,Park, Sung-Hwan,Lee, Chang-Woo Springer-Verlag 2010 Clinical and experimental medicine Vol.10 No.3
Chung, Eu Jin,Jo, Eun Ju,Yoon, Hwan Sik,Song, Geun Cheol,Jeon, Che Ok,Chung, Young Ryun Society for General Microbiology 2011 International journal of systematic and evolutiona Vol.61 No.10
<P>Two Gram-reaction-negative, yellow-orange-pigmented, rod-shaped bacterial strains, designated YC6722(T) and YC6723(T), were isolated from rhizosphere soil samples collected from rice fields in Jinju, Korea. Strains YC6722(T) and YC6723(T) grew optimally at 25-30 °C and at pH 7.0-8.5. Phylogenetic analyses of 16S rRNA gene sequences showed that strain YC6722(T) was most closely related to Sphingomonas jaspsi TDMA-16(T) (96.6???% sequence similarity) and strain YC6723(T) was related most closely to Sphingomonas aquatilis JSS7(T) (96.9???%). The two strains contained ubiquinone-10 (Q-10) as the major respiratory quinone system and sym-homospermidine as the major polyamine. The G+C contents of the genomic DNA of strains YC6722(T) and YC6723(T) were 63.3 and 61.0 mol%, respectively. The major fatty acid was C(18???:???1)??7c. The polar lipids detected in the two strains were phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycerol, sphingoglycolipid, phosphatidyldimethylethanolamine and other unknown lipids. On the basis of their phylogenetic positions, and their biochemical and phenotypic characteristics, strains YC6722(T) and YC6723(T) represent two novel species of the genus Sphingomonas, for which the names Sphingomonas oryziterrae sp. nov. (???=???KCTC 22476(T) ???=???DSM 21455(T)) and Sphingomonas jinjuensis sp. nov. (KCTC 22477(T) ???=???DSM 21457(T)) are proposed.</P>
Core and body surface temperature changes during sledge hockey competition
Jung, Eu-Jin(정유진),Jang, Lae-Guen(장래근),Choi, Geun-Hoon(최근훈),Park, Hyon(박현) 한국체육과학회 2017 한국체육과학회지 Vol.26 No.2
슬래지 하키는 아이스하키의 한 종류로서 주로 하지기능에 장애를 가진 사람들 사이에서 행해지는 스포츠이다. 이러한 슬래지 하키는 아이스하키와 거의 비슷한 운동 강도와 체력을 요구하기 때문에 슬래지 하키는 장애인 스포츠 중에서도 가장 높은 지구력을 요구하는 종목이라고 알려져 있다. 그러나 척수장애인들과 절단장애인들의 경우, 운동 중 체온조절 기전은 장애가 없는 일반인들과는 다르기 때문에 척수장애와 절단장애를 가진 슬래지 하키 선수들은 격렬한 운동 중 발생하는 열 스트레스에 노출될 가능성이 일반 운동선수들 보다 크다. 따라서 본 연구의 목적은 슬래지 하키 경기 중의 척수장애와 절단장애를 가진 선수들을 포함한 슬래지 하키 선수들의 심부온도와 체표면 온도를 관찰함으로써 그들이 열 스트레스에 얼마나 노출되는지 파악하는 것이다. 척수장애와 절단장애를 포함한 9명의 슬래지 하키 선수들이 이 연구에 참여하였으며 대상자들의 심부온도와 체표면 온도는 시합 전, 중, 후에 측정하였다. 측정결과 각 피리어드 후와 시합 종료 직후 10분 시점의 심부온도가 시합 전의 심부온도보다 유의하게 증가하였다. 체표면 온도의 경우, 각 피리어드 종료 후의 체표면 온도는 시합 전의 체표면 온도보다 유의한 증가가 나타났다. 또한 장애를 가지고 있지 않은 사람들과 비교했을 때 슬래지 하키 선수들은 더 높은 심부온도의 변화가 나타났다. 따라서 본 연구의 결과는 척수장애와 절단장애를 포함한 슬래지 하키 선수들의 경우 고강도의 운동 시, 장애를 가지고 있지 않은 일반인들 보다 심부온도의 조절에 어려움이 있다고 사료된다.
이명근(Myung-Geun Lee),오유진(Eu-Gene Oh) 한국컴퓨터정보학회 2011 한국컴퓨터정보학회 학술발표논문집 Vol.19 No.2
이 연구에서는 프로젝트 기반 초등수학교육에서 학업성취도와 수학적 태도에 대한 학습양식의 효과를 분석하였다. 이 연구는 프로젝트 기반 초등수학교육이 어떤 양식의 학습자에게 학업성취도와 수학적 태도 신장에 더 효과적인지 검증하여, 학습자 중심교육 환경 설계에 시사점을 제공하는데 목적이 있다. 104명의 초등학생을 대상으로 Kolb의 자기보고식 검사지를 사용하여 분산자, 융합자, 수렴자, 적응자 학습양식으로 분류하고, 4주간 12차시에 걸쳐 프로젝트 기반 수학교육을 실시하였다. 연구결과, 학습양식이 학업성취도와 수학적 태도 향상에 효과를 나타내었다. 프로젝트 기반 초등수학교육은 수렴자 학습양식의 학업성취도 향상에 효과적인 것으로 판단되었다. 또한, 수학적 태도의 세부요인에서는 수렴자 학습양식의 자신감, 목적의식 신장과 융합자 학습양식의 흥미신장에 효과적인 것으로 판단되었다.