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김동출,신은택,이동명,이윤경,기근홍 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Bilateral renal agenesis is an uniformly lethal malformation occurring in 1-2/10000 birth. This condition is associated with severe oligo-hydroamnios, intrauterine growth retardation, pulmonary hypoplasia and extrarenal anomalies. We experience a case of bilateral renal agenesis associated with agenesis of both ureters and bladder, and single umbilical artery. But the infant had normal pulmonary development. Specific IgM for herpes virus in maternal serum was detected.
배양 Caco-2 세포 단층막 실험계에서 트란스페린과 옥시다아제효소 포합체의 세포막투과
김동출,김지혜 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Transport study of horseradish peroxidase and transferrin-horseradish peroxidase conjugate was performed using an in vivo Caco-2 cell cultured monolayer grown on a polycarbonate membrane of Transwell^ⓡ. Horseradish peroxidase was not transported across Caco-2 cell monolayer. Transferrin-horseradish peroxidase conjugate was transported through Caco-2 monolayer. The apparent membrane permeability coefficient(P_app) of transferrin horseradish peroxidase conjugate was 6.54×10^-7cm/sec in the presence of 50μg/ml brefeldin-A. These results suggest the transferrin receptor mediated transcytosis of transferrin-horseradish peroxidase conjugate across Caco-2 cell monolayer.
녹차의 주성분인 에피갈로카테킨 갈레이트의 흰쥐에서의 약물속도론적 연구
김동출,임재수 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Pharmacokinetics of epigallocatechin gallate(EGCG) was studied following i.v. bolus and oral administration in rats. The values of systemic clearance(CL) were 67.9±5.2 and 26. 5±1.4ml/min/kg following i.v. bolus administration of 1mg and 5mg EGCG, respectively. The values of volume of distribution at steady state (Vss) were 380±56 and 835±84ml/kg after i.v. bolus administration of 1mg and 5mg EGCG, respectively. The decrease in the value of CL and the increase in the value of V_ss as a function of EGCG dose (1mg to 5mg) suggest saturable mechanism(s) responsible for the distribution and elimination of EGCG. The fraction absorbed of EGCG after oral and intraduodenal administration of GTC were 13% and 22% of the dose, respectively. This result suggests a considerable degradation or elimination of EGCG in the gastrointestinal absorption after oral administration in rats.
흰쥐의 대퇴동맥 혈전 모델에서의 스트렙토키나제-덱스트란 포합체의 혈전용해효과의 평가
김양우,김동출 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
To evaluate the thrormbolyuc activity of streptokinase-dextran conjugate, a rat model of arterial thrombosis was used Briefly. the femoral artery was exposed and a filter paper saturated with 70% FeCl_3 situation was placed around the femoral artery in order to stop the blood flow six minutes after the stop of the blood flow in the femoral artery, strep-tokinase (10000~30000 units per rat)or streptokinase-dextran conjugate (5000~17000 units per rat) was administered by bolus injectionthrough the femoral vein Then the blood flow in the femoral artery was monitored using a Doppler laser flow meter The bolus administration of streptokinase-dextran conjugate could restore the blood flow in the femoral artery in the dose range of 5000~17000 units per rat A good correlation between the dose of streptokinase-dextran conjugate and the total thrombolyne effect was observed In addition, the lag time between the injection of streptokinase -dextran donjugate and the restoring of the blood flow was decreased as the dose of streptokinase-dextran conjugate increased. These resules show the supenor beneficiat effect of streptokicase-dextran conjugate compared with the inconjugated streprokinase with respect to the elongation of thrombolytic activity, the admanistration method(single injection versus continuous infusion) and the reduced dose necesarry for a equivalent thrombolytic effect .
손백락,김동출,조정원 충남대학교 약학대학 의약품개발연구소 2008 藥學論文集 Vol.23 No.-
Despite the advantages of drug delivery through the skin, such as easy accessibility, convenience, prolonged therapy, avoidance of the liver first-pass metabolism and a large surface area, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept was introduced known as microneedles and could be pierced to effectively deliver drugs using microsized needles in a minimally invasive and painless manner. This review suggests that a biocompatible microneedle might be a suitable tool for transdermal drug delivery system of hydrophilic molecules with possible applications to macromolecules such as proteins and peptides.
녹차의 주성분인 에피갈로카테킨 갈레이트의 정맥주사후 흰쥐에서의 약물속도론 연구
임재수,황성주,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-
The pharmcacokinetic study of epigallocatechin gallate was performed following iv bolus administration in Sprague-Dawley rats. The values of systemic clearance (CL) were 68±5 and 27±1 ml/min/kg following iv bolus administration of 1 mg and 5 mg EGCG, respectively. The values of volume of distribution at steady state were 380 and 835 ml/kg body weight after iv bolus administration 1mg and 5mg EGCG, respectively. The decrease in the value of CL and the increase of Vss as a function of dose suggest saturable pharmacokinetics of EGCG in rats.
심희옥,이선영,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-
A reversed phase HPLC method was developed and validated for the determination of spironolactone in human plasma. Fenoprofen was used as an internal standard. Calibration curves were linear in the concentration range of 2.5~200 ng/㎖. The coefficient of variation of the intra- and inter-day precision were below 15%. The coefficient of variation of the accuracy were below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 100 ㎎ of spironolactone. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(12hr) was 158.9±69.9 ngㆍhr/㎖, C_(max) was 42.2±14.9 ng/㎖, T_(max)was 1.79±0.60 hr, t_(1/2) was 2.72±0.87 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of spironolactone.
박희찬,윤민혁,김동출,권준택,권광일 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-
The purpose of this study was to estimate the pharmacokinetics of quinidine sulfate in healthy Korean The parameters were examined on 16 volunteers who received a oral single dose(200mg quinidine sulfate). After dosing. blood samples were collected for a period of 24 hours. Plasma samples were analyzed for quinidine sulfate and DL-propranolol hydrochloride(internal standard) by HPLC/UV. The pharmacokinetic parameters (AUC_(0-24hr), AUC_(inf). C_(max), T_(max), K_(a), K_(el), t_(1/2), Vd/F and Cl/F) were calculated from the plasma quinidine sulfate concentration-time data of each volunteer. The computer program "WinNonlin" was used for compartmental analysis. One compartment model with first order input, first order output was chosen as the appropriate pharmacokinetic model. The pharmacokinetic parameters(AUC_(0-24hr). AUC_(inf). C_(max), T_(max), K_(a), K_(el), T_(1/2), Vd/F and Cl/F) calculated 9.47±2.24 ㎍·hr·㎖^(-1), 10.95±2.62 ㎍·hr·㎖^(-1), 0.93±0.16 ㎍/㎖, 1.56±0.45 hr, 1.10±0.36 hr^(-1), 5.17+0.90 hr, 162.38±33.36 L and 22.27±5.35 L/hr, respectively.