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손백락,김동출,조정원 충남대학교 약학대학 의약품개발연구소 2008 藥學論文集 Vol.23 No.-
Despite the advantages of drug delivery through the skin, such as easy accessibility, convenience, prolonged therapy, avoidance of the liver first-pass metabolism and a large surface area, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept was introduced known as microneedles and could be pierced to effectively deliver drugs using microsized needles in a minimally invasive and painless manner. This review suggests that a biocompatible microneedle might be a suitable tool for transdermal drug delivery system of hydrophilic molecules with possible applications to macromolecules such as proteins and peptides.