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양충용,이진훈,이서울,정복희,노상균,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2
저자들은 brodifacoum성분의 지속형 효과를 갖은 항응고제인 쿠마린계 살서제를 정확한 용량을 추정할 수는 없지만 다회의 약물 복용 17일 후 뇌실질출혈이 발생한 증례를 문헌 고찰과 함께 보고하는 바이다. 지금껏 쿠마린계의 지속형 항응고성 살서제의 약물 중독이 알려져 있다. 이러한 약물은 vitamin K₁ 2,3-epoxide 환원효소를 억제하여 vitamin K₁과 연속적으로 vitamin K₁ 의존성 응고인자 Ⅱ, Ⅶ, Ⅸ, Ⅹ의 합성을 억제하고 이로써 출혈 경향을 증가시킨다. 이 증례를 토대로 향후 출혈성 환자 특히 선행 질환이 없는 젊은 뇌실질출혈 환자에서 원인을 감별진단 함에 있어 환자의 약물 중독 가능성과 치료에 대한세심한 주의가 필요할 것으로 생각한다. Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.
전성운,홍충의,김동수 경성대학교 공학기술연구소 2005 공학기술연구지 Vol.12 No.-
The quality of a food is judged by the consumer according to its appearance, taste and texture. Especially among them, color is recognized as a major factor affecting food acceptance. This study was performed in order to develop a new yanggaeng products having beautiful appearances, attractive flavors, lower calories and healthier functions. We have investigated on the quality characteristics and storage stability of sweet jelly beans(colored yanggaengs) prepared by adding with natural ingredients, such as fruit juices and green tea powder. To obtain various colors and flavors, different ingredients were used such as fruit juices made directly from cherry(red color), orange(orange color, or yellow color), grapes(dark violet color). Also green tea powder(leekgreen color) was purchased from a market. Yanggaengs were prepared by adding these fruit juices or green tea powder, which Azuki bean powder as sediment, non-calorie sugar, and agar-agar products, etc. Color, texture profile analysis, sensory evaluation, viable cell count, and the strength of sample yanggaengs were examined to assess their acceptability for commercial use. In conclusion, the new colored yanggaengs could possess better appearances, flavors and healthier functions, compared with commercial products sold in market. Additionally, they could have lower calories because sugar was not used as a sweetener.
Changes in Content of Catalpol, Verbascoside and Aucubin in Period and Site of Rehmannia glutinossa
Chung Oui Hong(홍중의),Sang Hoon Lee(이상훈),Jong Won Han(한종원),Kyung Ho Ma(마경호),Yae Jin Kim(김예진),Sung Cheol Koo(구성철),Woo Moon Lee(이우문),Ei Hyun Kim(김이현),Jae Ki Chang(장재기),Sin Hee Han(한신희) 한국약용작물학회 2019 한국약용작물학회 학술대회논문집 Vol.2019 No.1
Hong, Chung-Oui,Lee, Hyun Ah,Rhee, Chae Hong,Choung, Se-Young,Lee, Kwang-Won Japan Society for Bioscience, Biotechnology, and A 2013 Bioscience, biotechnology, and biochemistry Vol.77 No.1
<P>Considering the growing evidence of the presence of antioxidant compounds in plant extracts, the objectives of this study were to identify antioxidant compounds in Lindera obtusiloba Blume (Lauraceae) and to evaluate their antimelanogenic activities on B16F10 melanoma cells. Organic solvent fractions were separated from L. obtusiloba extracts (LOE). The ethyl acetate fraction (LOE-E) was significantly active against oxidative damage induced by tert-butyl hydroperoxide in primary rat hepatocytes. Two single purified compounds, quercitrin (quercetin-3-O-α-L-rhamnopyranoside) and afzelin (kaempferol-3-O-α-L-rhamnoside), were identified by HPLC and NMR. These compounds were evaluated for antioxidant activities by 1,1-diphenyl 2-picrylhydrazyl (DPPH) radical scavenging assay and ferric reducing antioxidant power (FRAP) assay, and for their antimelanogenic activities by tyrosinase inhibitory assay melanin formation inhibition assay and Western bolt analysis for the signaling pathway. The significant effects of quercitrin on antioxidant and antimelanogenic activities, and signal modulation of ERK and MITF in B16F10 melanoma cells were observed. This is the first report to identify quercitrin in L. obtusiloba and its whitening effect.</P>
생강나무(Lindera obtusiloba Blume) 잎 70% 에탄올 추출물의 단회와 14일 반복투여 독성시험의 안전성 평가
홍충의(Chung-Oui Hong),서문영(Young Seomun),구윤창(Yun-Chang Koo),남미현(Mi-Hyun Nam),이현아(Hyun Ah Lee),김지훈(Ji-Hoon Kim),왕증(Wang-Zeng),양성용(Sung Yong Yang),이성희(Sung-Hee Lee),노수환(Su Hwan No),이광원(Kwang-Won Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.10
생강나무는 한국, 일본, 중국 등지에서 자생하며 열, 복통, 타박상, 출혈 등에 민간요법으로 사용되어온 식물이다. 이 논문의 목적은 오래전부터 민간요법으로 사용되어온 생강나무 잎의 안전성을 평가하고자 생강나무 잎 70% 에탄올 추출물을 암수 각 군당 5마리씩 5000(단회투여 독성시험), 0, 500, 1000, 2000(14일 반복투여 독성시험) ㎎/㎏의 용량으로 단회경구투여와 14일 반복경구투여를 실시하여 15일간의 사망률, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액 생화학적 검사를 실시하였다. 시험기간 중 사망동물은 암수 모든 시험군에서 관찰되지 않았으며, 일반증상, 체중변화, 조직병리, 혈액학적 및 혈액생화학적 검사에서 투여와 관련된 변화는 관찰되지 않았다. 이상의 결과로 보아 생강나무의 단회투여 독성은 5000 ㎎/㎏ 용량을 상회하며, 14일 반복투여의 최고용량인 2000 ㎎/㎏ 용량에서도 아무런 독성이 나타나지 않는 것으로 보아 최대무독성량은 이 농도를 상회하는 것으로 판단된다. 이로써 생강나무는 안전한 소재로서 식재료 또는 건강기능식품의 원료로서도 사용이 가능하다고 볼 수 있다. Lindera obtusiloba Blume (LO), which is widely distributed in Korea, Japan and China, has traditionally been used as a popular folk medicine for the treatment of fever, abdominal pain, bruise and extravation. The purpose of this study was to examine the toxicities of the single and 14-day repeated doses in Sprague-Dawley rats orally administrated with LO at doses of 0, 500, 1000, 2000 (14-day repeated toxicity test) and 5000 (single toxicity test) mg (dry weight)/㎏ of body weight/day. The results showed that there was no difference in body weight change, food intake, water consumption, or organ weight among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally administered LO and the control group, there was no statistical significance in hematological test or serum biochemical values. There were no evidences of histopathological alteration as well as abnormal gross finding mediated by single and 14 days treatments with LO. These results suggest that no observed adverse effect level (NOAEL) of the oral application of LO was considered to be more than 2000 mg/kg in rats under the conditions employed in this study.
Residual analysis of veterinary drugs in bovine and equine muscle by targeted sampling plan in 2022
Sunjin Park(Sunjin Park),Chung-Oui Hong(Chung-Oui Hong),Se-Hyung Kim(Se-Hyung Kim),Jihye Kim(Jihye Kim),Inhae Jeon(Inhae Jeon),Seon-Young Lee(Seon-Young Lee),Moon Her(Moon Her),Sung-Won Park(Sung-Won 한국예방수의학회 2023 예방수의학회지 Vol.47 No.2
The Animal and Plant Quarantine Agency conducts a targeted sampling plan and analysis for veterinary drugs within the country every year. Target compounds included tetrachlorvinphos as an organophosphate, diminazene as an anti-infective medication, ketoprofen as a nonsteroidal anti-inflammatory drug, triclabendazole and clorsulon as flukicides in 2022. These compounds were not included in National Residues Program (NRP), despite their high sales ranking. A total of 94 bovine muscle samples and 20 equine muscle samples were collected from various locations across the country. The analysis of target compounds in muscle was performed using LC-MS/MS coupled with Food code 8.3.1 revised in 2022. A 2 g sample of muscle tissue was extracted using a water: acetonitrile (1:4, v/v) solution, then cleaned up with C18 and hexane saturated with acetonitrile. Compounds were separated with C18 column and mobile phases consisted of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). All analytes exhibited good linearity with correlation coefficients (R2) higher than 0.992. The limit of quantification (LOQ) of these compounds ranged from 0.21 to 2.79 μg/kg except for diminazene (3.85~6.86 μg/kg). The average recoveries of these analytes were 89.45~129.13% in muscle at spiked level of 10 or 20 μg/kg. Relative standard deviations (%) (intra-day and inter-day) were lower than 20% for all target compounds, except for diminazene and triclabendazole, whose intra-day RSD % was slightly higher than 20% in equine muscle. Testing confirmed that all 94 bovine and 20 equine muscle samples from 9 provinces were free from residues of veterinary drugs. Monitoring of compounds not included in the NRP should continue to ensure consumer health and food safety.